周爱冬

教授、博士生导师

教研室主任

电子邮件: aidern0927@smu.edu.cn

电 话：020-61648214

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

南方医科大学教授、博导。中山大学获博士学位，此后在美国德克萨斯大学MD安德森癌症中心神经外科从事多年的研究工作，任博士后和讲师。主要从事原发胶质母细胞瘤以及肺癌/乳腺癌脑转移的发生机制和转化研究。近年来以通讯作者或一作在Nat Cell Biol、JCI，PNAS、Cell Rep Med、Adv Sci、Sci Adv、Cancer Res等杂志发表研究论文，研究工作它引3000余次（包括被Science、Cell、Nat Med等期刊）。广东省“珠江人才”计划和南方医科大学海外高层引进人才，中国神经学会神经肿瘤分会委员、广东省精准医学会神经肿瘤分会常委、精准医学会转移分会常委，主持多项国家基金项目研究，同时是Sci Transl Med、Nat Commun、Adv Sci等二十余种领域内知名期刊的评审专家。

研究方向

（1）胶质瘤免疫微环境与肿瘤耐药和复发；

（2）肺癌/乳腺癌脑转移的分子机制及新型干预药物开发；

（3）溶酶体异常与肿瘤代谢/免疫。

近年代表性论文

1. Yu Zeng, Liqian Zhao, Kunlin Zeng, Ziling Zhan, Zhengming Zhan, Shangbiao Li, Hongchao Zhan, Peng Chai, Cheng Xie, Shengfeng Ding, Yuxin Xie, Li Wang, Cuiying Li, Xiaoxia Chen, Daogang Guan, Enguang Bi, Jianyou Liao, Fan Deng, Xiaochun Bai, Ye Song, Aidong Zhou. TRAF3 Loss Protects Glioblastoma Cells from Lipid Peroxidation and Immune Elimination via Dysregulated Lipid Metabolism. JCI, In press, 2025.

2. Wang L, Li C, Zhan H, Li S, Zeng K, Xu C, Zou Y, Xie Y, Zhan Z, Yin S, Zeng Y, Chen X, Lv G, Han Z, Zhou D, Zhou D, Yang Y, Zhou A*. Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity. Cell Rep Med. 2024 May 21;5(5):101533.

3. Li S, Chen Y, Xie Y, Zhan H, Zeng Y, Zeng K, Wang L, Zhan Z, Li C, Zhao L, Chen X, Tan Y, Wang Z, Bu J, Song Y, Deng F, Zhou A*. FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing. Adv Sci (Weinh). 2023 Nov;10(33):e2303561.

4. Kunlin Zeng#, Yu Zeng#, Hongchao Zhan#, Ziling Zhan, Li Wang, Yuxin Xie, Yanqing Tang, Cuiying Li, Yanwen Chen, Shangbiao Li, Ming Liu, Xiaoxia Chen, Li Liang, Fan Deng, Ye Song, Aidong Zhou*. SEC61G assists EGFR-amplified glioblastoma to evade immune elimination. PNAS, 2023 Aug 8;120(32):e2303400120.

5. Yu Zeng, Yonghua Cai, Peng Chai, Yangqi Mao, Yanwen Chen, Li Wang, Kunlin Zeng, Ziling Zhan, Yuxin Xie, Cuiying Li, Hongchao Zhan, Liqian Zhao, Xiaoxia Chen, Xiaoxia Zhu, Yu Liu, Ming Chen*, Ye Song*, Aidong Zhou*. Optimization of cancer immunotherapy through pyroptosis: Apyroptosis-related signature predicts survival benefit and potential synergy for immunotherapy in glioma, Front. Immunol, 2022, 13.

6. Zelong Han#, Ming Liu#, Yuxin Xie#, Kunlin Zeng, Ziling Zhan, Yanwen Chen, Li Wang, Xiaoxia Chen, Yaxin Luo, Yu Zeng, Hongchao Zhan, Yingzhuo Lin, Keqin Zhang, Xiaoxia Zhu, Side Liu, Xiaobei Luo*, Aidong Zhou*. Cell Death Discov. 2022 Nov 4;8(1):445.

7. Li Ma, Kangyu Lin, Guoqiang Chang, Yiwen Chen, Chen Yue, Qing Guo, Sicong Zhang, Zhiliang Jia, Tony T Huang, Aidong Zhou*, Suyun Huang*. Aberrant activation of β-catenin signaling drives glioma tumorigenesis via USP1-mediated stabilization of EZH2. Cancer Res, 2019 Jan 1;79(1):72-85.

8. Linlin Li#, Aidong Zhou#, Yanjun Wei, Feng Liu, Peng Li, Runping Fang, Li Ma, Sicong Zhang, Longqiang Wang, Jinze Liu, Hope T Richard, Yiwen Chen, Hengbin Wang, Suyun Huang. Critical role of lncEPAT in coupling dysregulated EGFR pathway and histone H2A deubiquitination during glioblastoma tumorigenesis, Sci Adv, 2022, 8(40): :eabn2571.

9. Aidong Zhou#, Kangyu Lin#, Sicong Zhang, Yaohui Chen, Nu Zhang, Jianfei Xue, Zhongyong Wang, Kenneth D Aldape, Keping Xie, James R Woodgett, Suyun Huang. High-level nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitination by USP22. Nat Cell Biol. 2016 Sep;18(9):954-66.

10. Aidong Zhou, Kangyu Lin, Sicong Zhang, Li Ma, Jianfei Xue, Saint-Aaron Morris, Kenneth D Aldape, Suyun Huang. Gli1-induced deubiquitinase USP48 promotes glioma tumorigenesis by deubiquitinating and stabilizing Gli1. EMBO Rep (2017) 18, 1318-1330.

专利

周爱冬;王力;杨勇;李翠莹. 一种小鼠肺癌脑转移细胞株LLC-BMT3及其构建方法和应用, 202210086902.6 (授权）。

课题

1. 国家自然科学基金面上项目，2025.01-2028.12, 主持；

2. 国家自然科学基金面上项目，2019.01-2023.12，主持；

3. 广东省人才计划项目，主持；

4. 南方医科大学高水平大学建设高层次人才引进经费（第三层次），主持。

学术任职

中国神经学会神经肿瘤分会委员；

广东省精准医学会神经肿瘤分会、肿瘤转移分会委员；

欧美同学会医师协会神经肿瘤分会委员；

美国癌症协会会员(AACR Membership)；

Sci Transl Med、Nat Commun、Adv Sci等二十余种领域内知名期刊的评审专家

执教课程（课程及教材建设）

医学细胞生物学（Medical Cell Biology）