邹志鹏，博士

教授

博士生导师

博士后合作导师

电子邮件:zzp@smu.edu.cn

电 话：020-61647584

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

2020.01至今 南方医科大学基础医学院 教授

2013.01-2019.12 南方医科大学基础医学院 副教授

2006.09-2012.12 南方医科大学基础医学院 讲师

研究方向

骨骼与心血管系统的交互调控机制及新药筛选；骨骼的机械应力转导通路；染色质结构蛋白液相-液相分离在骨与软骨细胞分化中的作用机制；骨与软骨发育及退行性病变（骨质疏松及骨性关节炎）的发生机制。

研究关键词：骨质疏松；骨关节炎；动脉硬化；心力衰竭；机械应力；信号转导；生物分子凝聚体；表观遗传修饰

代表性论著

1. Wenquan Liang, Tiantian Wei, Le Hu, Meijun Chen, Liping Tong, Wu Zhou, Xingwei Duan, Xiaoyang Zhao, Weijie Zhou, Qing jiang, Guozhi Xiao, Weiguo Zou, Di Chen*, Zhipeng Zou*(并列通讯作者), Xiaochun Bai*. An integrated multi-omics analysis reveals osteokines involved in global regulation. Cell Metabolism. 2024 May 7;36(5):1144-1163.e7.（配有preview，中国科学报报导）

2. Yan Gong, Ziqi Li, Shitian Zou, Daizhao Deng, Pinglin Lai, Hongling Hu, Yongzhou Yao, Le Hu, Sheng Zhang, Kai Li, Tiantian Wei, Xiaoyang Zhao, Guozhi Xiao, Zifeng Chen, Yu Jiang, Xiaochun Bai*, Zhipeng Zou*(最末通讯作者). Vangl2 controls chaperone mediated autophagy to balance osteogenic differentiation of mesenchymal stem cells. Developmental Cell. 2021 Jul 26;56(14):2103-2120.e9. doi: 10.1016/j.devcel.2021.06.011. (F1000 prime推荐, BioArt报导)

3. Yan Gong#, Shitian Zou#, Daizhao Deng#, Liang Wang#, Hongling Hu, Zeyou Qiu, Tiantian Wei, Panpan Yang, Jielong Zhou, Yu Zhang, Weiliang Zhu, Xiaoling Xie, Zhengquan Liao, Jun Yang, Sheng Zhang, Anling Liu, Yu Jiang, Zhipeng Zou*(并列通讯作者), Xiaochun Bai*. Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma. Developmental Cell. 2023 Feb 6;58(3):192-210.e11.doi: 10.1016/j.devcel.2022.12.012. (BioArt报导)

4. Mingqiang Lai#, Wu Zhou#, Wenchong Zou#, Lianlian Qiu, Zhaoyu Liang, Wanyi Chen, Yiqing Wang, Bin Guo, Chaoran Zhao, Sheng Zhang, Pinglin Lai, Le Hu, Xiaolin Liu, Yu Jiang, Yinghua Chen, Min-jun Huang*, Xiaochun Bai*, Zhipeng Zou*(最末通讯作者). Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells. Nature Communications, 2025 Jun 4;16(1):5206. doi: 10.1038/s41467-025-60474-1. Nature Reviews Endocrinology的Year in Review专题综述将本文的重要发现“Olfm4同时调控棕色脂肪的感觉和交感神经支配”列为棕色脂肪领域的年度关键进展。

5. Mingqiang Lai^#, Wenchong Zou^#, Zelong Han^#, Ling Zhou, Zeyou Qiu, Juan Chen, Sheng Zhang, Pinglin Lai, Kai Li, Yue Zhang, Li Liang, Yu Jiang, Zhipeng Zou*(并列通讯作者), Xiaochun Bai*.Tsc1 regulates tight junction independent of mTORC1. Proc Natl Acad Sci U S A. July 27, 2021; 118 (30) e2020891118; https://doi.org/10.1073/pnas.2020891118. (1区)

6. Min Xiao^#, Wuju Zhang, Wen Li, Linlin Mao, Jincheng Yang, Le Hu, Sheng Zhang, Yaling Zheng, Anling Liu, Qiancheng Song, Yuhua Li, Guozhi Xiao, Zhipeng Zou*(并列通讯作者), Xiaochun Bai*. Osteocytes regulate neutrophil development through IL-19: A potent cytokine for neutropenia treatment. Blood. 2021 Jun 24;137(25):3533-3547. doi: 10.1182/blood.2020007731. (IF: 22.113，1区，配评述).

7. Wenquan Liang*, Ru Feng, Xiaojia Li, Xingwei Duan, Shourui Feng, Jun Chen, Yicheng Li, Junqi Chen, Zezheng Liu, Xiaogang Wang, Guangfeng Ruan, Su'an Tang, Changhai Ding, Bin Huang*, Zhipeng Zou*(并列通讯作者), Tianyu Chen*.A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression. Nature Communications, (2024) 15:8792.

8. Ting Wang , Chaoran Zhao, Jiahuan Zhang , Shengfa Li , Youming Zhang , Yan Gong , Yingyue Zhou , Lei Yan , Sheng Zhang , Zhongmin Zhang , Hongling Hu , Anling Liu* , Xiaochun Bai* , Zhipeng Zou*(最末通讯作者).Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9. iScience, 2024 Feb 16, 27(2), 108857

9. Ming Xie# , Jun Zheng#, Yao Yu#, Qishen Yang#, Zhipeng Zhou, Jingwen Xue, Benlin Wang, Yifeng Qiu, Zhangrui Zhu, Qi Sun, Xinhang Shi, Wentai Shangguan, Leqian Li, Zhipeng Zou*(并列通讯作者), Jie Zhao*, Peng Wu*. Gut symbiont-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury. Cell Rep Med, 2025 Oct 21;6(10):102373.

10. Xiaojun Lin#, Qiuyi Sun#, Ling Zhou#, Minhong He, Xiaoying Dong, Mingqiang Lai, Miao Liu, Yongchun Su, Chunhong Jia, Zelong Han, Side Liu, Hang Zheng, Yu Jiang, Hui Ling, Mangmang Li, Juan Chen^*, Zhipeng Zou^*(并列通讯作者), Xiaochun Bai^*. Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses. Mucosal Immunol. 2018 Nov;11(6):1663-1673

11. Kai Li, Panpan Yang, Yuwei Zhang, Yue Zhang, He Cao, Peilin Liu, Bin Huang, Song Xu, Pinglin Lai, Guanghua Lei, Jia Liu, Yujin Tang^*, Xiaochun Bai^*, Zhipeng Zou^*(最末通讯作者). DEPTOR Prevents Osteoarthritis Development via Interplay with TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes. Journal of Bone and Mineral Research. 2021 Feb;36(2):400-411. (IF 6.741，1区)

代表性课题

1、 区域创新发展联合基金重点支持项目，衰老的成骨细胞分泌FABP3和WIF1失衡促进心衰及其机制研究，U25A2046, 2026/01-2029/12, 259万元，主持

2、 国家重点研发计划重点专项，依托骨质疏松数据标识服务平台开发脊柱-关节退变无创分子标志物新技术, 2022YFC2502903, 2022/11-2025/12, 274万元，主持

3、 国家自然科学基金面上项目，TSC1控制紧密连接形成的作用和机制研究，32071125，2021/01 -2024/12，58万元，主持

4、 国家自然科学基金面上项目，OLFM4在老年性骨质疏松发生中的作用和机制研究，31771311，2018/01-2021/12，60万元，主持。

5、 广东省自然科学基金面上项目，ZFP143应力转导阻滞导致骨关节炎发生及其机制, 2026/01-2028/12, 10万元，主持。

学术任职

国际华人骨盐协会（ICMRS）终身会员；国家基金委评委；教育部科研发展中心专家库成员；中国康复医学会修复重建外科专业委员会再生医学转化组第二届委员；中国生理学会会员。受邀为Developmental Cell, Nature communications, Cell death and differentiation, Advanced Science, Cell Reports Medicine, Cell Reports, Molecular Therapy, iScience等主流国际期刊同行评议。

执教课程（课程及教材建设）

讲授研究生和本科生细胞生物学课程(含留学生全英课程)。主编十四五规划新形态教材-《分子医学实验.医学细胞生物学实验教程》（华中科技大学出版社），参编思政教材《分子医学思政教育教学指南》章节《细胞分化》（科学出版社）。参与指导的基础临床创新研究获第八届全国大学生基础医学创新研究论坛暨实验设计大赛总决赛金奖。