熊符博士

教授，博士生导师

教研室副主任

电子邮件:xiongfu@smu.edu.cn

电话：020-61648510

通讯地址：广东省广州市白云区沙太南路1023号（510515）

研究方向

人类遗传性疾病的分子机制及预防研究

研究关键词

牙本质发育异常（dentin dysplasia）、牙釉质发育不全（amelogenesis imperfecta）、腓骨肌萎缩症（Charcot-Marie-Tooth disease）、地中海贫血（Thalassemia）

代表性论著

1.Cheng Huang, Zong Rui Shen, Jin Huang, Shun Chang Sun, Di Ma, Mei Yi Li, ZhiKui Wang, Ying Chun Zheng, Zhuo Jun Zheng, Fei He, Xiaoyuan Xu, Ziang Li, Bo Yang Zheng, Yue Mao Li, Xiang Min Xu*, Fu Xiong*. C1orf194 deficiency leads to incomplete early embryonic lethality and dominant intermediate Charcot-Marie-Tooth disease in a knockout mouse model.Human Molecular Genetics, 2020,June 27.(小类II区，IF：5.10)

2.Sun SC, Ma D, Li MY, Zhang RX, Huang C, Huang HJ, Xie YZ, Wang ZJ, Liu J, Cai DC, Liu CX, Yang Q, Bao FX, Gong XL, Li JR, Hui Z, Wei XF, Zhong JM, Zhou WJ, Shang X, Zhang C, Liu XG, Tang BS, Xiong F*, Xu XM*. Mutations in C1orf194, encoding a calcium regulator, cause dominant Charcot-Marie-Tooth disease. Brain. 2019; 142(8):2215-2229. (小类1区，IF:11.814)

3.Pan Y, Lu T, Peng L, Chen Z, Li M, Zhang K, Xiong F*, Wu B*. Vacuolar protein sorting 4B regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells through the Wnt-β-catenin signalling pathway. Artif Cells NanomedBiotechnol. 2019; 47(1):2575-2584.（小类II区，IF：4.462）

4.Sun H, Xiao G, Zhang J, Pan Z, Chen Y, Xiong F. Rapid simultaneous detection of bla oxa-23, Ade-B, int-1, and ISCR-1 in multidrug-resistant Acinetobacter baumannii using single-tube multiplex PCR and high resolution melting assay. Infect Drug Resist. 2019; 12:1573-1581.（小类II区，IF：3.443）

5.Lu T, Li M, Xu X, Xiong J, Huang C, Zhang X, Hu A, Peng L, Cai D, Zhang L, Wu B, Xiong F*. Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders. Int J Oral Sci. 2018;10(3):26. (小类II区，IF:4.138)

6.Miao Y, Xiong J, Zhang X, Huang H, Yu L, Chen J, Deng W, Xu H, Liu R, Xiang C, Xu X, Xiong F*. Genetic diagnosis of polycystic kidney disease, Alport syndrome and thalassemia minor in a large Chinese family. Clin Sci (Lond). 2017;131(19):2427-2438.（小类II区，IF5.220）

7.Yang Q, Chen D, Xiong F*, Chen D, Liu C, Liu Y, Yu Q, Xiong J, Liu J, Li K, Zhao L, Ye Y, Zhou H, Hu L, Tian Z, Shang X, Zhang L, Wei X, Zhou W, Li D, Zhang W, Xu X*.A splicing mutation in VPS4B causes dentin dysplasia I.J Med Genet.2016;53(9):624-33. (小类II区，IF：5.65)（共同通讯作者以及共同第一作者）

8.Xiong F, Ji Z, Liu Y, Zhang Y, Hu L, Yang Q, Qiu Q, Zhao L, Chen D, Tian Z, Shang X, Zhang L, Wei X, Liu C, Yu Q, Zhang M, Cheng J, Xiong J, Li D, Wu X, Yuan H, Zhang W, Xu X*. Mutation in SSUH2 Causes Autosomal Dominant Dentin Dysplasia Type I. Hum Mutat. 2017;38(1):95-104. (小类II区，IF：5.089)

9.Xiong F, Huang Q, Chen X, Zhou Y, Zhang X, Cai R, Chen Y, Xie J, Feng S, Wei X, Xiao Q, Zhang T, Luo S, Yang X, Hao Y, Qu Y, Li Q, Xu X.A Melting Curve Analysis-Based PCR Assay for One-Step Genotyping of β-Thalassemia Mutations A Multicenter Validation.J MolDiagn. 2011 Jul;13(4):427-35.(小类II区，IF：5.553)

10. Xiong F, Xiao S, Peng F, Zheng H, Yu M, Ruan Y, Li W, Shang Y, Zhao C, Zhou W, Chen H, Chamberlain JS, Fang L, Zhang C*. Herpes simplex virus VP22 enhances adenovirus-mediated microdystrophin gene transfer to skeletal muscles in dystrophin-deficient (mdx) mice. Hum Gene Ther. 2007;18(6):490-501.（小类II区，IF：4.514）

代表性课题

学术任职

中华医学会医学遗传学分会委员、副秘书长，广东省医学会医学遗传学会副主任委员，基础遗传学组组长，广东省遗传学会常务理事、秘书长，广东省地中海贫血防治协会分子诊断委员会副主任委员

执教课程（课程及教材建设）

《医学遗传学》、《基因组学》

荣誉奖励

2011，国家科技进步二等奖（8/10）、

2013，军队科技进步二等奖（3/9））