潘瑞远 博士

教授，博士生导师

电子邮件：panruiyuan168@sina.com

通讯地址：广东省广州市白云区沙太南路1023号南方医科大学粤港澳大湾区脑科学与类脑研究中心（510515）

个人简介

潘瑞远，博士毕业于中国科学院生物物理研究所，军事医学研究院博士后，2022年入选中国科协青年人才托举工程项目，南方医科大学粤港澳大湾区脑科学与类脑研究中心2023年高层次引进人才。长期从事神经精神疾病（如阿尔茨海默病、抑郁症等）的发病机制和转化应用研究，重点关注胶质细胞能量代谢调控、表观遗传修饰、神经炎症以及肠-脑轴在神经系统疾病中的作用和机制，探究这些疾病的潜在治疗靶点和干预策略。相关工作以第一或通讯作者发表在Cell Metabolism, Nature Aging, Science Advances, Pharmacological Research等国际知名期刊上，获国家发明专利授权4项。担任Neural Regeneration Research等杂志审稿人，中国神经科学学会、生理学会会员。

研究方向

1. 阿尔茨海默病发病机制和干预策略

2. 胶质细胞代谢与神经炎症调控分子机制

3. 肠-脑轴在神经系统疾病中的作用和机制

研究关键词

阿尔茨海默病，胶质细胞，神经炎症，能量代谢，表观遗传，肠-脑轴

Alzheimer’s disease, Glial cells, Neuroinflammation, Energy metabolism, Epigenetics, Gut-Brain axis

代表性文章

1. Rui-Yuan Pan^#; Lin He^#; Jing Zhang; Xinhua Liu; Yajin Liao; Ju Gao; Yang Liao; Yuhan Yan; Qianqian Li; Xuehong Zhou; Jinbo Cheng; Qu Xing; Fangxia Guan; Jie Zhang; Luyang Sun*; Zengqiang Yuan*; Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease, Cell Metabolism, 2022, 34(4): 634-648.e6 (IF=31.37, highlighted by Nature Chemical Biology and Molecular Neurodegeneration)

2. Rui-Yuan Pan^#*; Jing Zhang^#; Jinlei Wang; Yingyi Wang; Zhihui Li; Yang Liao; Yajin Liao; Chenggang Zhang; Zhiqiang Liu; Lijuan Song; Jiezhong Yu; Zengqiang Yuan*; Intermittent fasting protects against Alzheimer’s disease in mice by altering metabolism through remodeling of the gut microbiota, Nature Aging, 2022, 2(11): 1024-1039 (IF=N/A, commented by Yvonne M. Nolan in Nature Aging)

3. Qianqian Li; Caixia Jia; Hongxing Wu; Yajin Liao; Ke Yang; Shuoshuo Li; Jing Zhang; Jinlei Wang; Guo Li; Fangxia Guan; Elaine Leung; Zengqiang Yuan*; Qian Hua*; Rui-Yuan Pan*; Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and biological validation, Pharmacological Research, 2022, 185: 106489-106489 (IF=10.33)

4. Lige Leng*; Ziqi Yuan; Rui-Yuan Pan; Xiao Su; Han Wang; Jin Xue; Kai Zhuang; Ju Gao; Zhenlei Chen; Hui Lin; Wenting Xie; Huifang Li; Zhenyi Chen; Keke Ren; Xiao Zhang; Wenting Wang; Zi-Bing Jin; Shengxi Wu; Xinglong Wang; Zengqiang Yuan; Huaxi Xu; Hei-Man Chow; Jie Zhang*; Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance, Nature Metabolism, 2022, 4(10): 1287-1305 (IF=19.89)

5. Rui-Yuan Pan^#; Xiang-xi Kong^#; Yong Cheng; Lu Du; Zhen-chao Wang; Chao Yuan; Jin-bo Cheng; Zeng-qiang Yuan; Hai-yan Zhang*; Ya-jin Liao*; 1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis, Acta Pharmacologica Sinica, 2021, 42(11): 1769-1779 (IF=7.16, cover story)

6. Yang Liao; Qu Xing; Qianqian Li; Jing Zhang; Rui-Yuan Pan*; Zengqiang Yuan*; Astrocytes in depression and Alzheimer’s disease, Frontiers of Medicine, 2021, 2021(15): 0-829–841 (IF=9.93)

7. Shuoshuo Li; Jun Li; Rui-Yuan Pan; Jinbo Cheng; Qinghua Cui; Jianxin Chen; Zengqiang Yuan; Sodium rutin extends lifespan and health span in mice including positive impacts on liver health., British journal of pharmacology, 2021, 2021: 1-14 (IF=9.47)

8. Jinbo Cheng^#*; Yuan Dong^#; Jun Ma; Rui-Yuan Pan; Yajin Liao; Xiangxi Kong; Xiaoheng Li; Shuoshuo Li; Pingfang Chen; Liang Wang; Ye Yu; Zengqiang Yuan*; Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology., Science Advances, 2021, 7(35): 0-eabe3600 (IF=14.98)

9. Rui-Yuan Pan; Jun Ma; Xiang-Xi Kong; Xiao-Feng Wang; Shuo-Shuo Li; Xiao-Long Qi; Yu-Han Yan; Jinbo Cheng; Qingsong Liu; Wanzhu Jin; Chang-Heng Tan; Zengqiang Yuan*; Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance, Science Advances, 2019, 5(2): 15 (IF=14.98)

10. Jun Ma^#; Xiaolong Qi^#; Chaojuan Yang; Rui-Yuan Pan; Shukun Wang; Junbing Wu; Li Huang; Hong Chen; Jinbo Cheng; Rong Wu; Yajin Liao; Lanqun Mao; Fengchao Wang; Zhiying Wu; Jianxiong An; Yun Wang; Xia Zhang; Chen Zhang; Zengqiang Yuan*; Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors, Molecular Psychiatry, 2018, 23(4): 883-891 (IF=13.44)

研究课题与基金

1. 南方医科大学高层次人才引进启动基金，2023-2至2026-1，主持

2. 中国博士后科学基金，2020-09至2022-09，主持

荣誉奖励

2022年入选中国科协青年人才托举工程项目

招生招聘计划

课题组长期招聘研究生、博士后和研究助理，具有神经生物学、生物化学与分子生物学研究背景的优先考虑。欢迎对阿尔茨海默病等神经退行性疾病发病机制和干预策略研究感兴趣的优秀青年学者加入我们研究团队。