赵冰夏 博士

副研究员，博士生导师

电子邮件: bingxiaz@foxmail.com

电 话：020-61647272

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

赵冰夏，男，副研究员，2015年博士毕业于上海交通大学，同年进入南方医科大学基础医学院肿瘤研究所工作，从事纳米医学方向研究，主要研究方向为多模态成像技术引导的肿瘤靶向诊疗一体化分子探针、肿瘤靶向递送系统、纳米放疗增敏剂等的研究与应用。主持国家自然科学基金2项，广东省基础与应用基础研究基金1项，在SMALL、CHEM ENG J、ACTA PHARM SIN B、NANO RESEARCH、J NANOBIOTECHNOL、ACS APPL MATER INTER、ACTA BIOMATER、NANOSCALE等期刊上发表SCI论文多篇，主要学术任职包括广东省精准医学应用学会纳米医学分委会委员、中国抗癌协会纳米肿瘤学专业委员会会员、Chinese Chem Lett 青年编委等。

研究方向

多模态成像技术引导的肿瘤靶向诊疗一体化分子探针的研发；

肿瘤靶向递送系统的研究与应用

纳米放疗增敏剂的开发和应用

研究关键词

诊疗一体化；纳米医学；放疗增敏；药物递送；纳米生物材料；

theranostics; nanomedicine; radiosensitization; drug delivery; nanoscale biomaterials

代表性论著

1.Kai Zhu#, Zede Wu#, Qiuyu Li, Meirong Hou, Honglei Hu, Shuting Zheng, Li Qi, Yikai Xu*, Chenggong Yan*, Bingxia Zhao*, Immune microenvironment-reshaping Au@Bi2Te3 nanoparticles for spectral computed tomography/photoacoustic imaging-guided synergetic photo/radio/immunotherapy. Nano Research, 2022, DOI:10.1007/s12274-022-4645-3. 中科院小类1区, IF= 10.269, TOP期刊

2.Chao Peng #*, Yu Liang# , Ning Su# , Siwen Chen , Yanqun Chen, Dong Wu, Bin Wu, Yang Zhang , ZiTing Xu, Si Zheng and Yingjia Li*, Bingxia Zhao*，Dual Nanoenzymes Loaded Hollow Mesoporous Organotantalum Nanospheres for Chemo-Radio Sensitization. Journal of Controlled Release, 2022, 347, 369-378中科院小类1区, IF= 11.467, TOP期刊

3.Meirong Hou, Kai Zhu, Honglei Hu, Shuting Zheng, Zede Wu, Yunyan Ren, Bin Wu, Li Qi, Dong Wu, Yikai Xu*, Chenggong Yan*, Bingxia Zhao*, Rapid Synthesis of ‘Yolk-Shell’-Like Nanosystem for MR Molecular and Chemoradio Sensitization. Journal of Controlled Release, 2022, 347, 55-67中科院小类1区, IF=11.467, TOP期刊

4.Weihong Guo#, Zhian Chen#, Zhenhao Li, Huilin Huang, Yingxin Ren, Bingxia Zhao*, Guoxin Li*, Yanfeng Hu*, Improved immunotherapy for gastric cancer by nanocomposites with capability of triggering Dual-Damage of Nuclear/Mitochondrial DNA and cGAS/STING-Mediated innate immunity, Chemical Engineering Journal, 2022, 443, 136428,, 中科院小类1区, IF=16.744, TOP期刊

5.Yu Liang^#; Chao Peng^#; Ning Su^#; Qiuyu Li; Siwen Chen; Dong Wu; Bin Wu; Yang Gao; Ziting Xu; Qing Dan; Si Zheng; Bingxia Zhao*; Yingjia Li*; Tumor microenvironments self-activated cascade catalytic nanoscale metal organic frameworks as ferroptosis inducer for radiosensitization, Chemical Engineering Journal, 2022, 437,135309, 中科院小类1区, IF=16.744, TOP期刊

6.Honglei Hu^#; Shuting Zheng^#; Meirong Hou; Kai Zhu; Chuyao Chen; Zede Wu; Li Qi; Yunyan Ren; Bin Wu; Yikai Xu*; Chenggong Yan; Bingxia Zhao*; Functionalized Au@Cu-Sb-S Nanoparticles for Spectral CT/Photoacoustic Imaging-Guided Synergetic Photo-Radiotherapy in Breast Cancer., International Journal of Nanomedicine, 2022, 17: 395-407, 中科院小类2区，IF= 7.033

7.Yu Liang^#; Li Zhang^#; Chao Peng^#; Shiyu Zhang; Siwen Chen; Xin Qian; Wanxian Luo; Qing Dan; Yongyan Ren; Yingjia Li*; Bingxia Zhao*; Tumor microenvironments self-activated nanoscale metal organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy, Acta Pharmaceutica Sinica B, 2021, 11(10): 3231-3243, 中科院小类1区, IF= 14.911, TOP期刊

8.Weihong Guo^#*, Zhian Chen^#, Xiaoli Feng^#, Guodong Shen, Huilin Huang, Yanrui Liang, Bingxia Zhao*, Guoxin Li*, and Yanfeng Hu*, Graphene oxide (GO)-based nanosheets with combined chemo/photothermal /photodynamic therapy to overcome gastric cancer (GC) paclitaxel resistance by reducing mitochondria-derived adenosine-triphosphate (ATP). Journal of Nanobiotechnology, 2021. 19(1): 146. 中科院小类2区，IF= 9.429, TOP期刊

9.Weihong Guo^#, Zhian Chen^#, Jiajia Chen^#, Xiaoli Feng^#, Yang Yang, Huilin Huang, Yanrui Liang, Guodong Shen, Yu Liang, Chao Peng, Yanbing Li, Guoxin Li, Wenhua Huang*, Bingxia Zhao*, and Yanfeng Hu*, Biodegradable hollow mesoporous organosilica nanotheranostics (HMON) for multi-mode imaging and mild photo-therapeutic-induced mitochondrial damage on gastric cancer. Journal of Nanobiotechnology, 2020. 18(1): 99. 中科院小类2区，IF=9.429, TOP期刊

10.Chao Peng^#; Yu Liang^#; Yanqun Chen^#; Xin Qian; Wanxian Luo; Siwen Chen; Shiyu Zhang; Qing Dan; Li Zhang; Miaosheng Li; Miaomiao Yuan; Bingxia Zhao*; Yingjia Li*; Hollow Mesoporous Tantalum Oxide Based Nanospheres for Triple Sensitization of Radiotherapy. ACS Applied Materials & Interfaces, 2020, (12): 5520-5530, Supplementary Cover，中科院小类2区，IF=10.383, TOP期刊

11.Meirong Hou^#, Chenggong Yan^#, Zelong Chen, Qingliang Zhao, Miaomiao Yuan, Yikai Xu*, and Bingxia Zhao*, Multifunctional NIR-responsive poly(vinylpyrrolidone)-Cu-Sb-S nanotheranostic agent for photoacoustic imaging and photothermal /photodynamic therapy. Acta Biomaterialia, 2018. 74: 334-343. 中科院小类2区，IF=10.633，TOP期刊

12.Zhian Chen^#, Yanrui Liang^#, Xiaoli Feng^#, Yu Liang, Guodong Shen, Huilin Huang, Zhaoyu Chen, Jiang Yu, Hao Liu, Tian Lin, Hao Chen, Dong Wu, Guoxin Li, Bingxia Zhao*, Weihong Guo*, and Yanfeng Hu*, Vitamin-B12-conjugated PLGA-PEG nanoparticles incorporating miR-532-3p induce mitochondrial damage by targeting apoptosis repressor with caspase recruitment domain (ARC) on CD320-overexpressed gastric cancer. Materials Science & Engineering C-Materials For Biological Applications, 2021. 120: 111722. 中科院小类3区，IF=8.457，TOP期刊

13.Wancheng Chen^#, Xuefei Wang^#, Bingxia Zhao^#, Rongjun Zhang, Zhen Xie, Yi He, Ali Chen, Xiaofang Xie, Kaitai Yao*, Mei Zhong*, and Miaomiao Yuan*, CuS–MnS2 nano-flowers for magnetic resonance imaging guided photothermal /photodynamic therapy of ovarian cancer through necroptosis. Nanoscale, 2019. 11(27): 12983-12989. 中科院小类2区，IF=8.307，TOP期刊

代表性课题

1. 国家自然科学基金委员会，面上项目，82072056，肿瘤微环境自激活级联反应诱导铁死亡纳米制剂的开发及其在乳腺癌治疗中的应用，55万元，2021/01-2024/12，在研，主持

2. 国家自然科学基金委员会，青年科学基金项目，81601550，生物伪装化的近红外荧光/CT 多模态成像探针的制备及其肿瘤靶向光热/化学协同治疗的应用研究，17万元，2017/01-2019/12，已结题，主持

3. 广东省基础与应用基础研究基金委员会，广东省自然科学基金-面上项目，2021A1515011882，新型铁死亡诱导纳米制剂在增敏肿瘤放射治疗中的研究与应用，10万元，2021-01至2023-12，在研，主持

学术任职

中国抗癌协会纳米肿瘤学专业委员会会员

广东省精准医学应用学会纳米医学分委会委员

中国化学快报《Chinese Chemical Letter》第三届青年编委会委员

执教课程（课程及教材建设）

《系统肿瘤学》

公共选修课《肿瘤学前沿》