荣知立 教授

发布时间:2017-08-21 浏览次数:

荣知立 博士

教授,博士生导师

肿瘤研究所所长,皮肤病医院皮肤病研究所所长


电子邮件: rongzhili@smu.edu.cn

电 话:无

通讯地址:广东省广州市白云区沙太南路1023号(510515)



个人简介

教授,博士生导师,海外高层次人才青年计划专家,南方医科大学肿瘤研究所所长,南方医科大学皮肤病医院皮肤病研究所所长。清华大学生物学学士、博士,美国加州大学圣迭戈分校(UCSD)博士后。主要研究方向为结合基因编辑技术、小鼠模型、人源类器官和病人样本,研究肺和皮肤的再生医学。以通讯作者或第一作者在Cell Stem Cell, Nucleic Acids Research, Nature Communications, Protein & Cell, Cell Reports, Journal of Investigative Dermatology等学术期刊发表论文26篇,发表论文总引用2900余次;参与撰写基因编辑专著1部,申请国际PCT专利3项,中国发明专利10项(授权5项);曾任国际SCI期刊 Journal of Gene Medicine副主编,主持和参与国家科技重大专项、国家自然科学基金重点和面上项目、广东省和广州市重点项目等多项课题。


研究方向

干细胞与再生医学,基因编辑技术开发

Stem cell and regenerative medicine,Gene editing


研究关键词

Gene editing, Lung organoid, Skin disease


代表性论著

1. Xu, Y. *, #, Zhang, J. #, Hu, Y. #, Li, X. #, Sun, L., Peng, Y., Sun, Y., Liu, B., Bian, Z.*, Rong, Z. * Single-cell transcriptome analysis reveals the dynamics of human immune cells during early fetal skin development. Cell Reports 36, 109524 (2021)

2. Huang, H. #, Hu, Y. #, Huang, G., Ma, S., Feng, J., Wang, D., Lin, Y*., Zhou, J*., Rong, Z.* Tag-seq: a convenient and scalable method for genome-wide specificity assessment of CRISPR/Cas nucleases. Communications Biology 4, 830 (2021)

3. Deng, C.C. #, Hu, Y.F. #, Zhu, D.H. #, Cheng, Q., Gu, J.J., Feng, Q.L., Zhang, L.X., Xu, Y.P., Wang, D., Rong, Z.* & Yang, B*. Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases. Nature Communications 12, 3709 (2021)

4. Zhang, X.#, Lv, S.#, Luo, Z.#, Hu, Y., Peng, X., Lv, J., Zhao, S., Feng, J., Huang, G., Wan, Q.L., Liu, J., Huang, H., Luan, B., Wang, D., Zhao, X., Lin, Y., Zhou, Q.*, Zhang, Z.N.* & Rong, Z.* MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo. Nucleic Acids Res 49, 4171-4185 (2021).

5. Pei, R.#, Feng, J.#, Zhang, Y., Sun, H., Li, L., Yang, X., He, J., Xiao, S., Xiong, J., Lin, Y., Wen, K., Zhou, H., Chen, J., Rong, Z.* & Chen, X*. Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection. Protein & cell 12, 717-733 (2021).

6. Liu, J.#, Chen, J.#, Zhong, Y., Yu, X., Lu, P., Feng, J., Zhang, X., Ma, S., Yang, C., Yang, B.* & Rong, Z.* OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients. Protein & cell 12, 653-661 (2021).

7. Xue, Y.#, Chen, W.#, Mai, Z., Yu, X., Wu, Q., Wan, C., Su, X., Wu, Y., Rong, Z.* & Zheng, H*. Inhibition of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis infection. J Invest Dermatol 141, 852-862 (2021).

8. Ma, S., Wang, X., Hu, Y., Lv, J., Liu, C., Liao, K., Guo, X., Wang, D., Lin, Y.* & Rong, Z. * Enhancing site-specific DNA integration by a Cas9 nuclease fused with a DNA donor-binding domain. Nucleic Acids Res 48, 10590-10601 (2020).

9. Huang, H.#, Zhang, X.#, Lv, J., Yang, H., Wang, X., Ma, S., Shao, R., Peng, X., Lin, Y.* & Rong, Z.* Cell-cell contact-induced gene editing/activation in mammalian cells using a synNotch-CRISPR/Cas9 system. Protein & cell 11, 299-303 (2020).

10. Wang, Y.P.#, Ma, S.F.#, Dai, Z.Y., Rong, Z. * & Liu, J. * Facile in situ synthesis of ultrasmall near-infrared-emitting gold glyconanoparticles with enhanced cellular uptake and tumor targeting. Nanoscale 11, 16336-16341 (2019).

11. Deng, C.C.#, Zhu, D.H.#, Chen, Y.J., Huang, T.Y., Peng, Y., Liu, S.Y., Lu, P., Xue, Y.H., Xu, Y.P., Yang, B.* & Rong, Z.* TRAF4 promotes fibroblast proliferation in keloids by destabilizing p53 via interacting with the deubiquitinase USP10. J Invest Dermatol 139, 1925-1935 (2019).

12. Zhang, X.#, Wang, W.#, Shan, L., Han, L., Ma, S., Zhang, Y., Hao, B., Lin, Y.* & Rong, Z.* Gene activation in human cells using CRISPR/Cpf1-p300 and CRISPR/Cpf1-SunTag systems. Protein & cell 9, 380-383 (2018).

13. Chen, Y., Feng, J., Zhao, S., Han, L., Yang, H., Lin, Y.* & Rong, Z.* Long-Term Engraftment Promotes Differentiation of Alveolar Epithelial Cells from Human Embryonic Stem Cell Derived Lung Organoids. Stem cells and development 27, 1339-1349 (2018). (Cover story)

14. Rong, Z., Wang, M., Hu, Z., Stradner, M., Zhu, S., Kong, H., Yi, H., Goldrath, A., Yang, Y.G., Xu, Y. & Fu, X. An effective approach to prevent immune rejection of human ESC-derived allografts. Cell stem cell 14, 121-130 (2014).

Commented by Cell Stem Cell (Cell Stem Cell 14: 3)

Reported by Fox News, China Daily, Science Daily, Medical news today, and UT San Diego et al.

15. Rong, Z.#, Fu, X.#, Wang, M. & Xu, Y. A scalable approach to prevent teratoma formation of human embryonic stem cells. J Biol Chem 287, 32338-32345 (2012).


代表性课题

1. 国家自然科学基金面上项目,2021/01-2024/12,主持,课题经费 55万

2. 国家自然科学基金面上项目,2019/01-2022/12,主持,课题经费 58万

3. 广州再生医学与健康广东省实验室前沿探索项目,2018/12-2021/12,主持 ,课题经费 150万元,结题

4. “艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项,子课题负责人,课题经费 120万元,结题

5. 国家自然科学基金面上项目,2017/01-2020/12,主持,课题经费 60万元,结题

6. 广州市科技计划项目产学研协同创新重大专项,2015/06-2018/05,主持,课题经费 100万元,结题

7. 广东省科技计划项目,2015/01-2017/12,主持,课题经费 100万元,结题


学术任职

国际细胞学会会员,中国细胞学会会员


执教课程(课程及教材建设)

基因编辑

基础医学新进展


荣誉奖励

2015年,入选第十一批海外高端人才计划

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