段晓品博士

教授，博士生导师

电子邮件:dxpwww654@i.smu.edu.cn

电话：020-61647594

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

段晓品，教授，博士生导师，基础医学院肿瘤研究所副所长，国家海外高层次引进青年人才。2008年河北大学药学院获学士学位，2013年沈阳药科大学与上海药物研究所联合培养获药剂博士学位，2014年1月至2018年8月在美国芝加哥大学进行博士后研究，2018年9月以高层次人才引进南方医科大学。主要研究方向为新型智能药物输送系统的开发及其在肿瘤免疫治疗和体内肿瘤/免疫细胞示踪方面的应用。迄今为止共发表SCI论文25篇，7篇入选为ESI“高被引论文”，第一作者或通讯作者16篇，其中IF>10论文8篇，包括J. Am. Chem. Soc.，ACS Nano，Angew. Chem. Int. Ed.，Nat. Commun.，Small，Biomaterials。获授权中国发明专利1项，申请PCT专利1项，研发的两款药物制剂正在美国进行I期临床试验。另特邀成为Biomaterials, Theranostics, J. Control. Release, J. Mater. Chem. B, Acta Biomater., Int. J. Pharm., Eur. J. Pharm. Sci., J. Pharm. Sci.等知名杂志审稿人。

研究方向

1.新型药物输送系统的开发；

2.新型药物输送系统用于肿瘤诊疗；

3.新型药物输送系统用于体内细胞示踪。

研究关键词

药物输送系统、肿瘤治疗、细胞示踪

代表性论著

1. Xiaotian Ji, Yousheng Mo, Haishan Li, Wanling Zhao, Aiqi Zhong, S. Li, QiWang,*Xiaopin Duan*, Jisheng Xiao*, Gender-dependentreproductive toxicity of copper metal–organic frameworks and attenuation by surface modification. Nanoscale, 2021, 13: 7389.

2. Xiaopin Duan#, Christina Chan#, Wenbo Han#, Nining Guo, Ralph R Weichselbaum, Wenbin Lin*, Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors. Nat Commun. 2019, 10: 1899

3. Xiaopin Duan#, Christina Chan#, Wenbin Lin*, Nanoparticle-mediated immunogenic cell death enables and potentiates cancer immunotherapy.Angew. Chem. Int. Ed. 2019, 58: 670-680.

4.Xiaopin Duan, Christina Chan, Nining Guo, Wenbo Han, Ralph RWeichselbaum, Wenbin Lin*, Photodynamic therapy mediated by nontoxic core-shell nanoparticles synergize with immune checkpoint blockade to elicit antitumor immunity and antimetastatic effect on breast cancer. J. Am. Chem. Soc. 2016, 138: 16686-16695.

5.Chunbai He#, Xiaopin Duan#, Nining Guo#, Christina Chan, Christopher Poon, Ralph R Weichselbaum, Wenbin Lin*, Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy. Nat. Commun. 2016, 7: 12499.

6.Xiaopin Duan, Demin Liu, Christina Chan, Wenbin Lin*, Polymeric Micelle-Mediated Delivery of DNA-Targeting Organometallic Complexes for Resistant Ovarian Cancer Treatment. Small2015, 11: 3962-3972.

7.Zhi-Ming Zhang#, Xiaopin Duan#, Shuang Yao, Zhishu Wang, Zekai Lin, Yang-Guang Li, La-Sheng Long, En-Bo Wang*, Wenbin Lin*, Cation-mediated optical resolution and anticancer activity of chiral polyoxometalates built from entirely achiral building blocks. Chem. Sci. 2016, 7: 4220-4229.

8.Xiaopin Duan, Chunbai He, Steven J. Kron, Wenbin Lin*, Nanoparticle formulations of cisplatin for cancer therapy. WIRES Nanomed. Nanobi. 2016, 8: 776-791.

9. Christopher Poon#, Xiaopin Duan#, Christina Chan, Wenbo Han, Wenbin Lin*, Nanoscale coordination polymers codeliver carboplatin and gemcitabine for highly effective treatment of platinum-resistant ovarian cancer. Mol. Pharma.2016, 13: 3665-3675.

10.Xiaopin Duan#, Jisheng Xiao#, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li*, Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram. ACS Nano 2013, 7: 5858-5869.

11. Jisheng Xiao#, Xiaopin Duan#, Qingshuo Meng, Qi Yin, Zhiwen Zhang, Haijun Yu, Lingli Chen, Wangwen Gu, Yaping Li*, Effective delivery of p65 shRNA by optimized Tween 85-polyethyleneimine conjugate for inhibition of tumor growth and lymphatic metastasis. Acta Biomater. 2014, 10: 2674-2683.

12.Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li*, Multi-targeted inhibition of tumor growth and metastasis by disulfiram-loaded redox-sensitive shell crosslinked micelles. Nanotechnology2014, 25: 125102.

13. Jisheng Xiao#, Xiaopin Duan#, Qi Yin, Zhiwen Zhang, Haijun Yu, Yaping Li*, Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer. Biomaterials2013, 34: 9648-9656.

14. Jisheng Xiao, Xiaopin Duan, Qi Yin, Zehong Miao*, Haijun Yu, Chunying Chen, Zhiwen Zhang*, Jun Wang, Yaping Li*, The inhibition of metastasis and growth of breast cancer by blocking the NF-kB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles. Biomaterials2013, 34: 5381-5390.

15. Xiaopin Duan, Yaping Li*, Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking. Small2013, 9: 1521-1532.

16. Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Shirui Mao*, Yaping Li*, Amphiphilic graft copolymer based on poly(styrene-co-maleic anhydride) with low molecular weight polyethylenimine for efficient gene delivery. Int. J. Nanomed. 2012, 7: 4961-4972.

17.Jisheng Xiao, Xiaopin Duan, Qi Yin, Lingli Chen, Zhiwen Zhang, Yaping Li*, Low molecular weight polyethylenimine-graft-tween 85 for effective gene delivery: synthesis and in vitro characteristics. Bioconjugate Chem.2011, 23: 222-231.

18.Xiaopin Duan, Shirui Mao*, New strategies to improve the intranasal absorption of insulin. Drug Discov. Today 2010, 15: 416-427.

19.Kaiyuan Ni#, Guangxu Lan#, Samuel S Veroneau, Xiaopin Duan, Yang Song, Wenbin Lin*, Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy. Nat. Commun.2018, 9: 4321

20. Ruoyu Xu#, Youfu Wang#, Xiaopin Duan, Kuangda Lu, Daniel Micheroni, Aiguo Hu, Wenbin Lin*, Nanoscale metal–organic frameworks for ratiometric oxygen sensing in live cells. J. Am. Chem. Soc. 2016, 138: 2158–2161

21.Christina Chan#, Nining Guo#, Xiaopin Duan, Wenbo Han, Lai Xue, Darren Bryan, Sean C Wightman, Nikolai N Khodarev, Ralph R Weichselbaum, Wenbin Lin*, Systemic miRNA delivery by nontoxic nanoscale coordination polymers limits epithelial-to-mesenchymal transition and suppresses liver metastases of colorectal cancer, Biomaterials 2019, 210: 94-104

22.Kaiyuan Ni#, Guangxu Lan#, Christina Chan, Xiaopin Duan, Nining Guo, Samuel S Veroneau, Ralph R Weichselbaum, Wenbin Lin*, Ultrathin Metal-Organic-Layer Mediated Radiotherapy-Radiodynamic Therapy, Matter 2019, 1:1331-1353

专利

1.李亚平，段晓品，肖计生，顾王文，张志文。一种用作非病毒基因载体的两亲性梳状SMA-PEI接枝共聚物及其制备方法和用途。中国科学院上海药物研究所，专利号：201210102333.6

2.W. Lin, X. Duan, C. Chan, W. Han, C. He. Nanoparticles for Chemotherapy, Targeted Therapy, Photodynamic Therapy, Immunotherapy, and Any Combination Thereof. Application No. PCT/US2017/033822, Publication No. WO/2017/201528

代表性课题

1.国家海外高层次人才青年项目，主持

2.国家自然科学基金委青年科学家项目，2021-01至2023-12，主持

3.高水平大学建设-引进高层次人才科研经费，2018.09-2021.08，主持

4.广东省自然科学基金面上项目，2019.10-2022.09，主持

5.广州市科学技术局，2020.04-2023.03，主持

学术任职

中国抗癌协会纳米肿瘤学专业委员会委员

执教课程（课程及教材建设）

《医学发育生物学》、《科研设计与方法》、《医学研究与医学发展》

荣誉奖励

1. ACS-Yao Yuan Award of Medicinal Chemistry （2017）

2. 中国药学会科技奖一等奖（2015）

3. 康缘药业奖学金（2012）

4. 卡乐康奖学金（2010）