官道刚博士

教授，博士生导师

电子邮件:guandg0929@hotmail.com

电话：13070246061

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

中山大学	生命科学学院	博士（直博）	2005.9‐2011.7
中山大学	生命科学学院	项目聘用	2011.7-2012.7
香港浸会大学	理学院生物系	高级研究助理	2012.8-2014.8
香港浸会大学	理学院生物系	研究助理教授	2014.9-2016.8
香港浸会大学	整合生物信息医学与转化科学研究所	助理教授	2016.9-2019.8

研究方向

高通量数据整合建模解析复杂疾病的分子机制

疾病发生、细胞命运决定、胚胎发育过程中复杂基因调控网络的数学建模及量化

非编码RNA探测及功能挖掘

系统生物学、转化医学和计算机辅助药物设计

研究关键词

多组学整合建模(multi-omics data modeling); 转化医学(Translational medicine);

代表性论著

1.Guan D,Yan B, Thieme C, Hua J, Zhu H, Boheler KR, Zhao Z, Kragler F, Xia Y, Zhang S. PlaMoM: a comprehensive database compiles plant mobile macromolecule. Nucleic Acids Res. 2017 Jan 4;45(D1): D1021-D1028.（一区，IF: 11.147）

2.Guan D, Xia Y, Zhang S. Analyzing and Predicting Phloem Mobility of Macromolecules with an Online Database; Methods Mol Biol. 2019; 2014:433-438;

3.Guan D, Shao J, Zhao Z, Wang P, Qin J, Deng Y, Boheler KR, Wang J, Yan B: PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data. Nucleic Acids Res 2014, 42:W130-136. (cover story) （一区，IF: 11.147）

4.Guan D, Shao J, Deng Y, Wang P, Zhao Z, Liang Y,Wang J, Yan B: CMGRN: a web server for constructing multilevel gene regulatory networks using ChIP-seq and gene expression data. Bioinformatics , 2014, 30(8): 1190-1192. （一区，IF: 4.531）

5.Guan DG, Liao JY, Qu ZH, Zhang Y, Qu mirExplorer: detecting microRNAs from genome and next generation sequencing data using the AdaBoost method with transition probability matrix and combined features. RNA Biol 2011, 8(5):922-934. （二区，IF: 5.477）

6.Yan B#, Guan D# (Co-first author), Wang C, Wang J, He B, Qin J, KR Boheler, Lu A, Zhang G, Zhu H. An integrative method to decode regulatory logics in gene transcription. Nature Communications, 2017, 8(1): 1044-1044. （一区，IF: 11.878）

7.Zhuo Z#, Wan Y#, Guan D# (Co-first author), Ni S#, Wang L#, Zhang Z, Liu J, Liang C, Yu Y, Lu A, Zhang G, Zhang B. A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA-mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice. Advanced Science, May 2020,DOI: 10.1002/advs.201903451. （一区，IF:15.804）

8.Zhang Z#, Li J#, Guan D# (Co-first author), Liang C#, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B. A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration. Journal of Cachexia, Sarcopenia and Muscle, 2018, 9(3): 613-626. （一区，IF: 10.754）

9.Zhang Z#, Li J#, Guan D# (Co-first author), Liang C#, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B. Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy Following Mechanical Unloading, Molecular Therapy , 2018, 26(11): 2669-2680. （一区，IF: 8.402）

10.Liang C#, Peng S#, Li J#, Lu J#, Guan D# (Co-first author), Jiang F#, Lu Cheng, Li F, He X, Zhu H, Au D, Yang D, Zhang B, Lu A, Zhang G. Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age2 related osteoporosis. Nature Communications, 2018, 9(1): 3428. （一区，IF: 11.878）

11.Ho VW#, Wong MK#, An X#, Guan D# (Co-first author), Shao J, Ng HC, Ren X, He K, Liao J, Ang Y, Chen L, Huang X, Yan B, Xia Y, Chan LL, Chow KL, Yan H, Zhao Z: Systems- level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry. Mol Syst Biol 2015, 11(6):814.（一区，IF: 9.800）

12.Wang C, Ren Q, Chen X, Song Z, Ning Z, Gan J, Ma X, Liang D, Guan D*(Co- corresponding author), Liu Z*, Lu A*. System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia. Front Pharmacol. 2018, 9, 841.（二区，IF: 3.845）

13.Chen X, Zheng C, Wang C, Guo Z, Gao S, Ning Z, Huang C, Lu C, Fu Y, Guan D*(Co- corresponding author), Lu A*, Wang Y*. Systems-Mapping of Herbal Effects on Complex Diseases Using the Network-Perturbation Signatures. Front Pharmacol. 2018 Oct. 9, 1174. （二区，IF: 3.845）

14.He K#, Li WX#, Guan D# (Co-first author), Gong M, Ye S, Fang Z, Huang JF, Lu A. Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets. FunctIntegr Genomics. 2019 Mar 12.

15.Zhang C, Guan D(Co-first author), Jiang M, Liang C, Li L, Zhao N, Zha Q, Zhang W, Lu C, Zhang G, Liu J, Lu A. Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial; Chin Med. 2019 Aug 2;14:26.

16.Kan He, Guoying Wu, Wen-Xing Li, DaogangGuan(Co-first author), WenwenLv, Mengting Gong, Shoudong Ye, AipingLu,A transcriptomic study of myogenic differentiation under the overexpression of PPARγ by RNA-Seq. Scientific reports,2017, 7(1):15308

17.Zheng Y, Wang X, Zhang Z, Guo B, Dang L, He B, Zhang C, Zhou J, Shi W, Zhao Y, Zhan H, Xu Y, Liang C, Liu J, Guan D, Wang L, Wu X, Li J, Zhuo Z, Lin Z, Qiu H, Zhong L, Bian Z, Shi Y, Zhang B, Zhang G, Lu A. Bushenyijing fang reduces fall risk in late postmenopausal women with osteopenia: a randomized double-blind and placebo-controlled trial. Scientific reports, 2019, 9(1): 2089.

18.Zhang C, Guan D, Jiang M, Liang C, Li L, Zhao N, Zha Q, Zhang W, Lu C, Zhang G, Liu J, Lu A. Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial; Chin Med. 2019 Aug 2;14:26.

19.Zhang Y, Guan DG, Yang JH, Shao P, Zhou H, Qu LH: ncRNAimprint: a comprehensive database of mammalian imprinted noncoding RNAs. RNA 2010, 16(10):1889-1901.

20.Zhang C, Zhou W, Guan DG, Wang YH, Lu AP. Network Intervention, a Method to Address Complex Therapeutic Strategies. Front Pharmacol. 2018 Jul 12;9:754.

21.ENY Poon*, B Hao, D Guan, MJ Li, J Lu, Y Yang, B Wu, SE Webb, SCM Wu, ALMiller, Y Liang, X Yao, J Wang, B Yan*, KR Boheler. Integrated transcriptomics and regulatory network analyses identify microRNA-200c as a novel repressor of differentiation and maturation of human pluripotent stem cell-derived cardiomyocytes. Cardiovascular Research . 2018, 114(6):894-906

22.Shao P, Liao JY, Guan DG, Yang JH, Zheng LL, Jing Q, Zhou H, Qu LH: Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation. RNA Biol 2012, 9(2):212-227. (cover story)

23.Li F, Lu J, Liu J, Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang Z, Li J, Lu Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang B, Lu A, Zhang G. A water-soluble nucleolin aptamer-paclitaxel conjugate fortumor-specific targeting in 1 ovarian cancer. Nature Communications 2017, 8(1):1390

24.Wang L, Liang C, Li F, Guan D, Wu X, Fu X, Lu A, Zhang G. PARP1 in carcinomas and PARP1 inhibitors as antineoplastic drugs. Int J Mol Sci. 2017. 18 (10), 2111

25.Lv Q, Meng Z, Yu Y, Jiang F, Guan D, Liang C, Zhou J, Lu A, Zhang G. Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer. Int J Mol Sci. 2016 Dec 14;17(12).

26.Lv H, Jiang F, Guan D, Lu C, Guo B, Chan C, Peng S, Liu B, Guo W, Zhu H, Xu X, Lu A,Zhang G. Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research. Int J Mol Sci. 2016 Dec 2;17(12).

27.Wong MK, Guan D, Ng HC, Ho VW, An X, Li R, Ren X, Zhao Z: Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis. Journal of Biological Chemistry,2016, 291(24):12501-12513

28.Zhang J, Yan B, Spath SS, Qun H, Cornelius S, Guan D, Shao J, Hagiwara K, Van WaesC, Chen Z, Su X, Bi Y: Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer. Cell Biosci 2015, 5:53.

29.Wang J, Yan B, Liu SM, Sun H, Pan Y, Guan D, Zhang X, Xu J, Ma H: Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor. J Cancer 2015, 6(10):930-937.

30.Wen JZ, Liao JY, Zheng LL, Xu H, Yang JH, Guan DG, Zhang SM, Zhou H, Qu LH: A contig-based strategy for the genome-wide discovery of microRNAs without complete genome resources. PLoS One 2014, 9(2):e88179.

31.Yan B, Li H, Yang X, Shao J, Jang M, Guan D, Zou S, Van Waes C, Chen Z, Zhan M: Unraveling regulatory programs for NF-kappaB, p53 and microRNAs in head and neck squamous cell carcinoma. PLoS One 2013, 8(9):e73656.

32.Shao P, Yang JH, Zhou H, Guan DG, Qu LH: Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs. BMC Genomics 2009, 10:86.

33.Liu N, Xiao ZD, Yu CH, Shao P, Liang YT, Guan DG, Yang JH, Chen CL, Qu LH, Zhou H: SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights. BMC Genomics 2009, 10:515.

代表性课题

1.香港浸会大学助理教授（研究）启动基金， 2014/09-2016/8，已结题，主持

2.香港浸会大学学院研究资助基金，2015/03-2016/09，已结题，主持

3.香港浸会大学学院研究资助基金，2016/09-2018/10，已结题，主持

4.香港研究资助局基金（GRF），2016/11-2019/10, 在研，共同主持

5.国家自然科学基金青年基金，2016/01-2018/12，已结题，主持

6.国家自然科学基金面上项目，2019/01-2022/12，在研，参与

7.国家自然科学基金重点项目， 2009/01-2012/12，已结题，参与

8.跨学科研究集群匹配基金， 2018/08-2020/08，在研， CO-I

9.策略发展基金， 2019/06-2021/06，在研， CO-I

10.广东省重大科技专项（精准医学与干细胞），2019/01-2021/12，在研，合作单位子课题负责人。 11.南方医科大学第三层次人才引进科研项目，2019/01-2021/12，在研，主持。 12.国自然面上项目；58万元； 2024-12。 13.省自然面上项目；10万元； 2024-12

执教课程（课程及教材建设）

海外以全英文授课形式讲述下列课程：

Translational Medicine andDrug Discovery: Theory&Practice (转化医

学与药物发现）

Bioinformatics（生物信息学）

Biostatistics（生物统计学）

AdvancedTopics inBiotechnology（生物技术前沿）

目前以中文授课形式讲述下列课程：

生物化学与分子生物学