连森 博士

副教授 硕士生导师

电子邮件: senlian@i.smu.edu.cn; senlian@smu.edu.cn

电 话：020-62789385

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

2017.05 - 2019.10 南方医科大学 生物化学与分子生物学教研室 讲师

2019.10 - 至今 南方医科大学 生物化学与分子生物学教研室 副教授

研究方向

1. 消化道肿瘤发生与发展的分子机制研究

2. 抗癌化合物筛选与抗癌药理机制研究

研究关键词

肿瘤发生、分子机制、抗肿瘤靶点、抗肿瘤化合物、肿瘤代谢

代表性论著（^#第一作者，*通讯作者）

1. Zhang T, Ye J, Xue C, Wang Y, Liao W, Mao L, Yuan M*, Lian Sen*. Structural Characteristics and Bioactive Properties of a Novel Polysaccharide from Flammulina Velutipes. Carbohydrate Polymers 2018,197:147-156 (1区，IF:10.7)

2. Xia Y, Kang TW, Jung YD*, Zhang C*, Lian Sen*. Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1α-Mediated Glycolysis in Hypoxia. Journal of Agricultural and Food Chemistry 2019,67(28):7844-7854 (1区，IF：5.7)

3. Lian Sen^#, Li S^#, Zhu J, Xia Y, Jung YD*. Nicotine Stimulates IL-8 Expression via ROS/NF-κB and ROS/MAPK/AP-1 Axis in Human Gastric Cancer Cells. Toxicology 2022,466:153062 (2区，IF:4.8)

4.Xia Y, Yang JF, Li C,Hao XP, Fan HX, Zhao YY, Tang JF, Wan XF, Lian Sen*, Yang J*. TMT-Based Quantitative Proteomics Analysis Reveals the Panoramic Pharmacological Molecular Mechanism of β-Elemonic Acid Inhibition of Colorectal Cancer. Frontiers in Pharmacology 2022,13:830328 (2区，IF:4.4)

5．Li S,Pham NK, Yin H,Sah DK, Kim NH, Lian Sen*, Jung YD*. Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-κB Signaling in Human Gastric Cancer Cells. International Journal of Molecular Sciences 2022,23(9):5172 (2区，IF:4.9)

6.Xia Y, Liu Y, Jung YD*, Lian Sen*. Editorial: Discovering Novel Anticancer Molecules and Revealing the Pharmacological Mechanism of Gastrointestinal Carcinoma. Frontiers in Pharmacology 2022,13:1047705 (2区，IF:4.4)

7.Nguyen TT,Ung TT, Li S, Sah DK, Lian Sen*, Jung YD*. Lithocholic Acid Induces miR-21,Promoting PTEN Inhibition via STAT-3 and ERK1/2 Signaling in Colorectal Cancer Cells. International Journal of Molecular Sciences 2021,22(19):10209 (2区，IF：4.9)

8. Zhang C,Huo ST,Wu Z,Chen L, Wen C,Chen H,Du WW,Wu N, Lian Sen*, Yang BB*. Rapid Development of Targeting circRNAs in Cardiovascular Diseases. Molecular Therapy-Nucleic Acids 2020,21:568-576 (1区，IF:6.5)

9. Lian Sen#, Li S, Sah DK, Kim NH, Lakshmanan VK, Jung YD*. Suppression of Urokinase-Type Plasminogen Activator Receptor by Docosahexaenoic Acid Mediated by Heme Oxygenase-1 in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Human Endothelial Cells. Frontiers in Pharmacology 2020,11:577302 (2区，IF:4.9)

10. Yuan M, Song X, Lv W, Xin Q, Wang L, Gao Q, Zhang G, Liao W, Lian Sen*. Jing T*. Effect of Anacardic Acid Against Echinococcosis through Inhibition of VEGF-induced Angiogenesis.Veterinary Research 2019,50(1):3 (1区，IF:3.7)

11. Yuan M, Meng W, Liao W*, Lian Sen*. Andrographolide Antagonizes TNF-α-Induced IL-8 via Inhibition of NADPH Oxidase/ROS/NF-κB and Src/MAPKs/AP-1 Axis in Human Colorectal Cancer HCT116 Cells. Journal of Agricultural and Food Chemistry 2018,66(20):5139-5148 (1区，IF:5.7)

12. Xia Y, Yuan M, Li S, Thuan UT, Nguyen TT, Kang TW, Liao W, Lian Sen*, Jung YD*. Apigenin Suppresses the IL-1β-Induced Expression of the Urokinase-Type Plasminogen Activator Receptor by Inhibiting MAPK-Mediated AP-1 and NF-κB Signaling in Human Bladder Cancer T24 Cells. Journal of Agricultural and Food Chemistry 2018, 66(29):7663-7673(1区，IF:5.7)

13. Lian Sen#, Xia Y, Ung TT, Kho PN, Yoon HJ, Lee SG, Kim KK, Jung YD*. Prostaglandin E2 Stimulates Urokinase-Type Plasminogen Activator Receptor via EP2 Receptor-Dependent Signaling Pathways in Human AGS Gastric Cancer Cells. Molecular Carcinogenesis 2017,56(2)：664-680 (2区，IF:3.0)

14. Lian Sen#, Xia Y, Ung TT, Khoi PN, Yoon HJ, Kim NH, Kim KK, Jung YD*. Carbon Monoxide Releasing Molecule-2 Ameliorates IL-1β-Induced IL-8 in Human Gastric Cancer Cells. Toxicology 2016,361-362：24-38 (2区，IF:4.8)

15. Lian Sen#, Park JS^#, Xia Y, Nguyen TT, Joo YE, Kim KK, Kim HK, Jung YD*. MicroRNA-375 Functions as a Tumor-Suppressor Gene in Gastric Cancer by Targeting Recepteurd'Origine Nantais. International Journal of Molecular Sciences 2016,17(10):1633 (2区，IF:4.9)

16. Lian Sen#, Xia Y, Khoi PN, Ung, TT, Yoon HJ, Kim NH, Kim KK, Jung YD*. Cadmium Induces Matrix Metalloproteinase-9 Expression via ROS-dependent EGFR, NF-κB and AP-1 Pathways in Human Endothelial Cells. Toxicology 2015,338:104-116 (2区，IF:4.8)

17. Lian Sen#, Xia Y, Nguyen TT, Ung TT, Yoon HJ, Kim NH, Kim KK, Jung YD^*. Docosahexaenoic Acid Inhibits Tumor Promoter-Induced Urokinase-Type Plasminogen Activator Receptor by Suppressing PKCδ-and MAPKs-Mediated Pathways in ECV304 Human Endothelial Cells. PLOS One 2016,11(9):e0163395 (1区，IF:2.9)

代表性课题

1. 国家自然科学基金青年项目，25万元，2018.01-2020.12，主持

2. 广东省自然科学基金面上项目，10万元，2020.01-2022.12，主持

3. 广州市科技计划项目，5万元，2021.05-2023.05，主持

学术任职

广东省生物化学与分子生物学学会青年委员

执教课程

《生物化学》、 《分子生物学》、 《分子诊断学》