陈鹏 博士

教授，博士生导师

病理生理学教研室副主任

电子邮件:perchen@smu.edu.cn/perchen@163.com

电 话：020-61648172-839

通讯地址：广东省广州市白云区沙太南路1023号（510515）生命科学楼13楼

个人简介

2003—2007, 南京理工大学本科

2007—2012, 南京理工大学博士

2012—2015, 加州大学圣地亚哥分校博士后

2015-至今南方医科大学基础医学院教授，博士生导师

研究方向

肠道菌群；肝脏衰竭；脓毒症

研究关键词

Gut microbiota, Liver failure, Sepsis

代表性论著

1. Li D, Chen Y, Wan M, Mei F, Wang F, Gu P, Zhang X, Wei R, Zeng Y, Zheng H, Chen B, Xiong Q, Xue T, Guan T, Guo J, Tian Y, Zeng LY, Liu Z, Yuan H, Yang L, Liu H, Dai L, Yu Y, Qiu Y, Wu P, Win S, Than TA, Wei R, Schnabl B, Kaplowitz N, Jiang Y*, Ma Q*, Chen P*. Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism. Cell Host Microbe. 2024; 32(1): 48-62.

2. Li D, Wan M, Xue L, Zhang Z, Qiu Y, Mei F, Tang N, Yu C, Yu Y, Chen T, Ding X, Yang Q, Liu Q, Gu P, Jia W*, Chen Y*, Chen P*. Zinc promotes microbial p-coumaric acid production that protects against cholestatic liver injury. Cell Host Microbe. 2024; 32(12): 2195-2211.

3. Zeng Y, Wu R, Wang F, Li S, Li L, Li Y, Qin P, Wei M, Yang J, Wu J, Chen A, Ke G, Yan Z, Yang H, Chen Z, Wang Z, Xiao W, Jiang Y, Chen X, Zeng Z*, Zhao X*, Chen P*, Gong S*. Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice. Cell Host Microbe. 2023; 31(5): 766-780.

4. Li J, Xie S, Chen M, Hong C, Chen Y, Lyu F, Tang N, Chen T, Zhao L, Zou W, Peng H, Bao J, Gu P, Schnabl B, Chen J*, Chen P*. Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice. J Clin Invest. 2025; Accepted, In Press.

5. Xie S, Li J, Lyu F, Xiong Q, Gu P, Chen Y, Chen M, Bao J, Zhang X, Wei R, Deng Y, Wang H, Zeng Z, Chen Z, Deng Y, Lian Z, Zhao J, Gong W, Chen Y, Liu KX, Duan Y*, Jiang Y*, Zhou HW*, Chen P*. Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis. Gut. 2024; 73(1): 78-91.

6. Gu P, Xie L, Chen T, Yang Q, Zhang X, Liu R, Guo J, Wei R, Li D, Jiang Y, Chen Y*, Gong W*, Chen P*. An engineered Escherichia coli Nissle strain prevents lethal liver injury in a mouse model of tyrosinemia type 1. J Hepatol. 2024; 80(3): 454-466.

7. Gu P, Liu R, Yang Q, Xie L, Wei R, Li J, Mei F, Chen T, Zeng Z, He Y, Zhou H, Peng H, Nandakumar KS, Chu H, Jiang Y, Gong W*, Chen Y*, Schnabl B, Chen P*. A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis. Cell Mol Immunol. 2023; 20(10): 1156-1170.

8. Gu P, Wei R, Liu R, Yang Q, He Y, Guan J, He W, Li J, Zhao Y, Xie L, He J, Guo Q, Hu J, Bao J, Wang W, Guo J, Zeng Z, Chen Z, Jiang Y*, Liu Z*, Chen P*. Aging-induced alternation in the gut microbiota impairs host antibacterial defense. Adv Sci (Weinh). 2025; 12(12): e2411008.

9. Li J, Chen Y, Li R, Zhang X, Chen T, Mei F, Liu R, Chen M, Ge Y, Hu H, Wei R, Chen Z, Fan H, Zeng Z, Deng Y, Luo H, Hu S, Cai S, Wu F, Shi N, Wang Z, Zeng Y, Xie M, Jiang Y, Chen Z*, Jia W*, Chen P*. Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis. Mol Ther. 2023; 31(4):1017-1032.

10. Gong S, Lan T, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y*, Kaplowitz N, Chen P*. Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018; 69(1): 51-59.

11. Gong S, Yan Z, Liu Z, Niu M, Fang H, Li N, Huang C, Li L, Chen G, Luo H, Chen X, Zhou H, Hu J, Yang W, Huang Q, Schnabl B, Chang P*, Billiar TR, Jiang Y*, Chen P*. Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice. Hepatology. 2019; 69(4): 1751-1767.

12. Chen P*. Targeting gut microbiota to counteract acetaminophen-induced acute liver injury. Trends Microbiol. 2024; 32(5): 419-421. (Invited forum article)

代表性课题

1、国家自然科学基金面上项目：54万；2023.01-2026.12 主持

2、国家自然科学基金面上项目：58万；2021.01-2024.12 主持

3、国家自然科学基金面上项目：57万；2019.01-2022.12 主持

4、国家自然科学基金青年项目：24万；2016.01-2018.12 主持

5、广东省自然科学国家高端人才基金：100万；2016.06-2020.06 主持

6、国家青年学者配套经费；150万元；2020-2023 主持

学术任职

中国病理生理学会青年委员

执教课程（课程及教材建设）

病理生理学；高级病理生理学；基础医学引论；蛋白质组学技术

荣誉奖励

2016，广东省高端人才

2020，教育部青年高端人才