个人信息

荆志成，男，北京协和医学院医学博士，法国巴黎第十一大学博士后，国家杰出青年科学基金获得者，“长江学者奖励计划”特聘教授；国家高层次人才特殊支持计划“万人计划”科技领军人才；百千万人才工程国家级人选暨有突出贡献的中青年专家；中国农工民主党中央委员，中国农工民主党北京市委员会副主任委员，中国农工民主党第十六届中央医疗卫生工作委员会副主任，第十三届北京市政协委员，第十四届北京市政协常委，北京市人民政协理论与实践研究会第五届理事会成员。

现任职务

广东省医学科学院副院长、心血管内科主任

截至2023年底，发表经同行评议SCI英文论文155篇，总影响因子2272分。作为课题负责人承担“十三·五”国家重点研发项目、国家自然科学基金重点项目暨重大国际合作项目、高端外国专家引进计划、北京市自然科学基金重点项目等国家和省部级纵向科研项目多项。领导多项国际、国内多中心新药、注册登记等临床试验。

学术及社会任职

研究领域

1、婴幼儿和成年人先天性心脏病，包括房间隔缺损，室间隔缺损，动脉导管未闭，以及卵圆孔未闭等的诊断和介入封堵治疗。

2、急性肺栓塞、深静脉血栓形成、慢性血栓栓塞性肺高血压症等疑难、危重血栓相关疾病的诊治。

3、主动脉瓣、二尖瓣、肺动脉瓣、三尖瓣等结构性心脏病诊断与介入治疗。

4、各类肺动脉高压、肺血管疾病的诊治，包括遗传性肺血管疾病的分子遗传诊断与干预。对先天性心脏病肺动脉高压、艾森曼格综合征的诊治评估有较高造诣。

个人成果

1.Li X-M, Zhu X-J, Jing Z-C. Reverse cardiac remodelling after balloon atrial septostomy for pulmonary arterial hypertension and end-stage heart failure. Eur Heart J. 2023:ehad822.( (IF = 39.3, Corresponding author)

2.Liu C., Zhou Y-P., Lian T-Y., et al. Clonal Hematopoiesis of Indeterminate Potential in Chronic Thromboembolic Pulmonary Hypertension: A Multicenter Study. Hypertension. 2023:10.1161/HYPERTENSIONAHA.123.22274. (IF = 8.3, Corresponding author)

3.He YZ, Wang YX, Ma JS, Li RN, Wang J, Lian TY, Zhou YP, Yang HP, Sun K, Jing ZC. MicroRNAs and their regulators: Potential therapeutic targets in pulmonary arterial hypertension. Vascul Pharmacol. 2023 Sep 10;153:107216. (IF = 4, Corresponding author)

4.Zhu XJ, Liu ZY, Wang PW, Wang J, Wen SD, Zhang JX, Zhu YJ, Sun ML, Xu XQ, Sun K, Lian TY, Cheng CY, Jing ZC. Congenital thrombophilia in East-Asian venous thromboembolism population: a systematic review and meta-analysis. Res Pract Thromb Haemost. 2023 Aug 2;7(6):102157. (IF =4.6, Corresponding author)

5.Lu D, Cheng CY, Zhu XJ, Li JY, Zhu YJ, Zhou YP, Qiu LH, Cheng WS, Li XM, Mei KY, Wang DL, Zhao ZY, Wang PW, Zhang SX, Chen YH, Chen LF, Sun K, Jing ZC. Heart Rate Response Predicts 6-Minutes Walking Distance in Pulmonary Arterial Hypertension. Am J Cardiol. 2023 Oct 1;204:207-214. (IF = 2.8, Corresponding author)

6.Sun ML, Zhu YJ, Zhou YP, Zhu XJ, Yang YJ, Cheng CY, Mei KY, Li XM, Liu C, Xu XQ, Sun K, Jing ZC. Percutaneous transluminal pulmonary angioplasty for Takayasu arteritis-associated pulmonary hypertension: A single-arm meta-analysis. Catheter Cardiovasc Interv. 2023 Sep;102(3):558-567. (IF = 2.3, Corresponding author)

7.Zhang ZJ, Wang HF, Lian TY, Zhou YP, Xu XQ, Guo F, Wei YP, Li JY, Sun K, Liu C, Pan LR, Ren M, Nie L, Dai HL, Jing ZC. Human Plasma IgG N-Glycome Profiles Reveal a Proinflammatory Phenotype in Chronic Thromboembolic Pulmonary Hypertension. Hypertension. 2023 Sep;80(9):1929-1939. (IF = 8.3, Corresponding author)

8.Wang TF, Khorana AA, Agnelli G, Bloomfield D, Bonaca MP, Büller HR, Connors JM, Goto S, Jing ZC, Kakkar AK, Khder Y, Raskob GE, Soff GA, Verhamme P, Weitz JI, Carrier M. Treatment of Cancer-Associated Thrombosis: Recent Advances, Unmet Needs, and Future Direction. Oncologist. 2023 Jul 5;28(7):555-564. (IF = 5.8, Co-author)

9.Wu XH, He YY, Chen ZR, He ZY, Yan Y, He Y, Wang GM, Dong Y, Yang Y, Sun YM, Ren YH, Zhao QY, Yang XD, Wang LY, Fu CJ, He M, Zhang SJ, Fu JF, Liu H, Jing ZC. Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype. Nat Commun. 2023 Mar 31;14(1):1820.( IF = 16.6, Corresponding author)

10.Lian TY, Zhou YP, Zhu YJ, Guo F, Jing ZC. Reply: Homocysteine and Thrombophilia in Pulmonary Hypertension. JACC Asia. 2022 Oct 18;2(5):651. (IF = 1.75, Corresponding author)

11.Wang HF, Wang YX, Zhou YP, Wei YP, Yan Y, Zhang ZJ, Jing ZC. Protein O-GlcNAcylation in cardiovascular diseases. Acta Pharmacol Sin. 2023 Jan;44(1):8-18. (IF = 8.2, Corresponding author)

12.Lian TY, Yan Y, Ding D, Ma YJ, Zhang X, Jing ZC. Building a modern six-dimensional biobank fosters the future of precision medicine. Science Bulletin. 2022 Dec 31;67(24):2490-2493. (IF = 18.9, Corresponding author)

13.Potere N, Barco S, Mahé I, Cesarman-Maus G, Angchaisuksiri P, Leader A, Okoye HC, Olayemi E, Ay C, Carrier M, Connors JM, Farmakis IT, Fumagalli RM, Jing ZC, Lee LH, McLintock C, Ní Ainle F, Giannakoulas G, Goto S, Guillermo Esposito MC, Jara-Palomares L, Szlaszynska M, Tan CW, Van Es N, Wang TF, Hunt BJ, Di Nisio M. Awareness of venous thromboembolism among patients with cancer: Preliminary findings from a global initiative for World Thrombosis Day. J Thromb Haemost. 2022 Dec;20(12):2964-2971. (IF = 10.4, Co-author)

14.Wang Y, Lin L, Li X, Cao J, Wang J, Jing ZC, Li S, Liu H, Wang X, Jin ZY, Wang YN. Native T1 Mapping-Based Radiomics for Noninvasive Prediction of the Therapeutic Effect of Pulmonary Arterial Hypertension. Diagnostics. 2022 Oct 14;12(10):2492. (IF = 3.6, Co-author)

15.Wu XH, Ma JL, Ding D, Ma YJ, Wei YP, Jing ZC. Experimental animal models of pulmonary hypertension: Development and challenges. Animal Model Exp Med. 2022 Mar 25. ( IF = 3.7, Corresponding author)

16.Jiang R, Jing ZC. Statin therapy in venous thromboembolism: How far from primary and secondary prevention? J Thromb Haemost. 2022 Aug;20(8):1781-1783. (IF = 10.4, Corresponding author)

17.Yu H, Rong W, Yang J, Lu J, Ma K, Liu Z, Yuan H, Xu L, Li Y, Jing ZC, Du J. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL): A Novel Biomarker for Prognostic Assessment and Risk Stratification of Acute Pulmonary Embolism. J Clin Med. 2022 Jul 5;11(13):3908. (IF =3.9, Co-author)

18.Wang JL, Liu H, Jing ZC, Zhao F, Zhou R. 18β-Glycyrrhetinic acid ameliorates endoplasmic reticulum stress-induced inflammation in pulmonary arterial hypertension through PERK/eIF2α/NF-κB signaling. Chin J Physiol. 2022 Jul-Aug;65(4):187-198. (IF = 1. 8, Co-author)

19.Liu B, Wei YP, Fan X, Hu X, Chen Z, Liu X, Xu Y, Wang L, Wang T, Ruiz M, Dupuis J, Yuan P, Liu J, Huang S, Zhu L, Jing ZC, Hu Q. Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility. Hypertension. 2022 Jul;79(7):1348-1360. (IF = 8.3, Co- Corresponding author)

20.He YY, Yan Y, Chen JW, Liu S, Hua L, Jiang X, Xu XQ, Lu D, Jing ZC, Yan FX, Han ZY. Plasma metabolomics in the perioperative period of defect repair in patients with pulmonary arterial hypertension associated with congenital heart disease. Acta Pharmacol Sin. 2021 Nov 30. (IF = 8.2, Co-author)

21.Lian TY, Liu JZ, Guo F, Zhou YP, Wu T, Wang H, Li JY, Yan XX, Peng FH, Sun K, Xu XQ, Han ZY, Jiang X, Wang DL, Miao Q, Jing ZC. Prevalence, Genetic Background, and Clinical Phenotype of Congenital Thrombophilia in Chronic Thromboembolic Pulmonary Hypertension. JACC: Asia. 2022 Jun, 2 (3_Part_1) 247–255. (IF = 1.75, Co- Corresponding author)

22.Zhou YP, Wei YP, Yang YJ, Xu XQ, Wu T, Liu C, Mei KY, Peng FH, Wang HP, Sun K, Li JY, Wang HF, Li MT, Wang DL, Miao Q, Jiang X, Jing ZC. Percutaneous Pulmonary Angioplasty for Patients With Takayasu Arteritis and Pulmonary Hypertension. J Am Coll Cardiol. 2022 Apr 19;79(15):1477-1488. (IF = 24, Corresponding author)

23.Chen Z, Zhou YP, Liu X, Jiang X, Wu T, Ghista D, Xu XQ, Zhang H, Jing ZC. A Personalized Pulmonary Circulation Model to Non-Invasively Calculate Fractional Flow Reserve for Artery Stenosis Detection. IEEE Trans Biomed Eng. 2022 Apr;69(4):1435-1448. (IF = 4.6, Co-Corresponding author)

24.Jiang R, Wang L, Zhao QH, Wu C, Yuan P, Wang S, Zhang R, Gong SG, Wu WH, He J, Qiu HL, Luo CJ, Liu JM, Jing ZC. Echocardiography Nomogram for Predicting Survival among Chronic Lung Disease Patients with Severe Pulmonary Hypertension. J Clin Med. 2022 Mar 14;11(6):1603. (IF = 3.9, Corresponding author)

25.Guo F, Jing ZC. Beyond medications: is pulmonary artery denervation the answer for pulmonary arterial hypertension?: PADN for PAH. AsiaIntervention. 2022 Mar;8(1):14-15. (Corresponding author)

26.Li JH, Xu XQ, Zhu YJ, Cheng CY, Lu MJ, Wang HY, Wang YN, Jing ZC, Zhao SH. Subendocardial Involvement as an Underrecognized Cardiac MRI Phenotype in Myocarditis. Radiology. 2022 Jan;302(1):61-69. (IF = 19.7, Co-author)

27.Yan Y, Jiang R, Yuan P, Wen L, Pang XB, Jing ZC, He YY, Han ZY. Implication of proliferation gene biomarkers in pulmonary hypertension. Animal Model Exp Med. 2021 Nov 22;4(4):369-380. (IF = 3.7, Co-author)

28.Jiang X, Zhou YP, Peng FH, Wang L, Ma W, Cao YS, Pan X, Zhang GC, Zhang F, Fan FL, Wu BX, Huang W, Yang ZW, Hong C, Li MT, Wang YN, Xu XQ, Wang DL, Zhang SY, Jing ZC. Clinical features and survival in Taksyasu's arteritis-associated pulmonary hypertension: a nationwide study. Eur Heart J. 2021 Nov 7;42(42):4298-4305. (IF = 39.3, Corresponding author)

29.He YY, Xie XM, Zhang HD, Ye J, Gencer S, van der Vorst EPC, Döring Y, Weber C, Pang XB, Jing ZC, Yan Y, Han ZY. Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary Hypertension. Front Pharmacol. 2021 Nov 5;12:753727. (IF = 5.6, Co-author)

30.Cheng W, Ma XD, Su LX, Long Y, Liu DW, Du B, Qiu HB, Guan XD, Chen DC, Kang Y, Tong ZH, Peng ZY, Shang Y, Zheng RQ, Li SS, Pan C, Huang XB, Zhan QY, Ding RY, Huang CL, Yin YJ, Li SQ, Li XY, Jiang L, Hu M, Li X, Zhou X, Jing ZC, Guo YH, Zhang SY. Retrospective Study of Critically Ill COVID-19 Patients With and Without Extracorporeal Membrane Oxygenation Support in Wuhan, China. Front Med. 2021 Oct 12;8:659793. (IF = 3.9, Co-author)

31.Benza RL, Ghofrani HA, Grünig E, Hoeper MM, Jansa P, Jing ZC, Kim NH, Langleben D, Simonneau G, Wang C, Busse D, Meier C, Ghio S. Effect of riociguat on right ventricular function in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. J Heart Lung Transplant. 2021 Oct;40(10):1172-1180. (IF = 8.9, Co-author)

32.Zhou B, Zhu YJ, Zhai ZQ, Weng SX, Ma YZ, Yu FY, Qi YJ, Jiang YZ, Gao X, Xu XQ, Jiang X, Jing ZC, Tang M. Radiofrequency Catheter Ablation of Supraventricular Tachycardia in Patients With Pulmonary Hypertension: Feasibility and Long-Term Outcome. Front Physiol. 2021 Jun 18;12:674909. (IF = 4.0 Co- Corresponding author)

33.Zhu YJ, Zhou YP, Wei YP, Xu XQ, Yan XX, Liu C, Zhu XJ, Liu ZY, Sun K, Hua L, Jiang X, Jing ZC. Association Between Anticoagulation Outcomes and Venous Thromboembolism History in Chronic Thromboembolic Pulmonary Hypertension. Front Cardiovasc Med. 2021 May 21;8:628284. (IF = 3.6, Corresponding author)

34.Angchaisuksiri P, Goto S, Farjat AE, Fryk H, Bang SM, Chiang CE, Jing ZC, Kondo K, Sathar J, Tse E, Phusanti S, Kayani G, Weitz JI, Ageno W, Goldhaber SZ, Kakkar AK. Venous thromboembolism in Asia and worldwide: Emerging insights from GARFIELD-VTE. Throm Res. 2021 Feb 24;201:63-72. (IF = 7.5, Co-author)