刘靖华博士

教授，博士生导师

教研室副主任

电子邮件:liujhua@smu.edu.cn

电话：020-61648392

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

现任南方医科大学基础医学院病理生理学教研室副主任，广东省蛋白质组学重点实验室副主任。1999年毕业于第三军医大学，获医学博士学位，曾在美国匹兹堡大学、爱尔兰国立大学留学。从事教学和科研工作20余年。

研究方向

炎症的细胞信号转导，脓毒症的发生机制，先天免疫训练

研究关键词

炎症（inflammation）；细胞信号转导（cell signal transduction）；脓毒症（sepsis）；先天免疫训练（innate immunity training）

代表性论著

1. Na Peng, Yan Geng, Jiafu Ouyang, Shuai Liu, Fangfang Yuan, Yantong Wan, Wenda Chen, BaoJun Yu, Youqing Tang, Lei Su, Huaping Liang*, Jiang Huai Wang* and Jinghua Liu*. Endothelial glycocalyx injury is involved in heatstroke-associated coagulopathy and protected by N-acetylcysteine. Front Immunol. 2023, 6;14:1159195. doi: 10.3389/fimmu.2023.1159195

2. Xiangjun Ji, Junwei Cai, Lixin Liang, Tieliu Shi* and Jinghua Liu*. Gene expression variability across cells and species shapes the relationship between renal resident macrophages and infiltrated macrophages. BMC Bioinformatics. 2023, 24:72 doi: 10.1186/s12859-023-05198-z.

3. Yantong Wan, Junyi Shen, Jiafu Ouyang, Peng Dong, Yinghao Hong, Lixin Liang, Jinghua Liu*. Bibliometric and Visual Analysis of Neutrophil Extracellular Traps from 2004 to 2022，Front. Immunol. 13:1025861. doi: 10.3389/fimmu.2022.1025861

4. Piao Luo, Qian Zhang, Tian‑Yu Zhong, Jia‑Yun Chen1, Jun‑Zhe Zhang, Ya Tian, Liu‑Hai Zheng, Fan Yang, Ling‑Yun Dai, Chang Zou, Zhi‑Jie Li, Zhijie Li*, Jinghua Liu*, Ji‑Gang Wang*. Celastrol mitigates infammation in sepsis by inhibiting the PKM2-dependent Warburg effect. Military Medical Research. 2022, 22(9):1-16

5. Hanhui Zhong, Haitao Lin, Qiongni Pang, Jinling Zhuang, Xiaolei Liu, Xiaolian Li, Jinghua Liu* & Jing Tang*. Macrophage ICAM-1 functions as a regulator of phagocytosis in LPS induced endotoxemia. Inflammation Research, 2021, 70(2), 193-203

6. Wenting Chen, Shuqi Zhao, Michael Ita, Yue Li, Jingjing Ji, Yong Jiang, H. Paul Redmond, Jiang Huai Wang*, and Jinghua Liu*. An early neutrophil recruitment into the infectious site is critical for BLP tolerance-afforded protection against microbial sepsis. Journal Immunology. 2020, 204(2):408-417

7. Yuyun Zhong, Ping Ye, Zhuzhong Mei, Sui Huang, Mengyi Huang, Li Yue, Shixian Niu, Shuqi Zhao, Junwei Cai, Juan Wang, Yong Jiang*, Jinghua Liu*. The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages. Molecular Immunology.2019, 114:179-188

8. Shuqi Zhao, Dalin Xi, Junwei Cai, Wenting Chen, Jing Xiang, Na Peng, Juan Wang, Yong Jiang, Zhuzhong Mei* and Jinghua Liu*. Rab20 is critical for bacterial lipoprotein tolerization-enhanced bactericidal activity in macrophages during bacterial infection. Sci China Life Sci. 2019, 63(3):401-409

9. Yue Li, Shixian Niu, Dalin Xi, Shuqi Zhao, Jiang Sun, Yong Jiang, Jinghua Liu*. Differences in LPS-induced inflammatory response between MEFs and BMDMs. J Interferon Cytokine Res. 2019, 39(6):375-382.

10. Shuqi Zhao, Yuyun Zhong, Xiaoxia Fu, Yiqian Wang, Ping Ye, Junwei Cai, Yun Liu, Jiang Sun, Zhuzhong Mei*, Yong Jiang*, and Jinghua Liu*. H3K4 methylation regulates LPS-induced proinflammatory cytokine expression and release in macrophages. Shock. 2019, 51(3):401-406

11. Wenting Chen, Hanhui Zhong, Xiaofei Wang, Qiongni Pang, Jinling Zhuang, Jian Hu, Yeming Chen, Jijie Hu, Jinghua Liu*, Jing Tang*. Mig6 reduces inflammatory mediators production by regulating the activation of EGFR in LPS-induced endotoxemia. J Cell Physiol. 2018, 233(9):6975-6983

12. Jinghua Liu*, Jing Xiang, Xue Li, Siobhan Blankson, Shuqi Zhao, Junwei Cai, Yong Jiang, H. Paul Redmond, Jiang Huai Wang*. NF-kB activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection. Sci. Rep. 2017, 7:40418

13. Jinghua Liu*, Juan Wang, Haihua Luo, Zhijie Li, Tianyu Zhong, Jing Tang, Yong Jiang*. Screening cytokine/chemokine profiles in serum and organs from an endotoxic shock mouse model by LiquiChip. SCIENCE CHINA Life Sciences, 2017, 60(11):1242-1250

14. Zhuzhong Mei, Xinyu Chen, Shuiwang Hu, Ni wang, Xiaoli Ou, Jingwang, Haihua Luo, Jinghua Liu*, Yong Jiang*. Kelch-like protein 21 (KLHL21) targets IκB kinase-β to regulate nuclear factor κ-light chain enhancer of activated B cells (NF-κB) signaling negatively. J Bio Chem. 2016, 291(35):18176-89.

15. Jinghua Liu, Julliette M. Buckley, H. Paul Redmond, Jiang Huai Wang. ST2 negatively regulates TLR2 signaling, but is not required for bacterial lipoprotein-induced tolerance. J Immunol. 2010, 184(10):5802-8.

代表性课题

1. 国家自然科学基金，重点项目，在研，2022-01至2026-12，参与

2. 广东省自然科学基金，面上项目，在研，2022-10至2024-09，主持

3. 广东省自然科学基金，面上项目，结题，2019-10至2023-09，主持

4. 广州市自然科学基金，一般项目，结题，2019-04至2022-3，主持

5. 广东省自然科学基金，重点项目，结题，2015-08至2018-08，主持

6. 国家自然科学基金，面上项目，结题，2015-01至2018-12，主持

7. 国家自然科学基金，面上项目，结题， 2013-01至2016-12，主持

8. 国家自然科学基金，面上项目，结题， 2011-01至2013-12，主持

9. 国家自然科学基金，面上项目，结题，2007-01至2009-12，主持

10. 国家自然科学基金，面上项目，结题，2003-01至2005-12，主持

学术任职

中国研究型医院休克与脓毒症专业委员会常务委员、中国病理生理学会休克专业委员会委员、中国病理生理学受体与细胞信号转导专业委员会委员、广东省病理生理学会危重病医学专业委员会副主任委员、广东省病理生理学会理事、《中国病理生理杂志》编辑委员会委员。