郭楠楠博士

教授，博士生导师

电子邮件:guo.nannan@outlook.com; guonannan@smu.edu.cn

电话：

通讯地址：广东省广州市白云区沙太南路1023号南方医科大学基础医学院（510515）

个人简介

南方医科大学2020年高层次引进人才，入选2020年人才计划。博士毕业于复旦大学神经生物学研究所，之后相继在复旦大学、日本东北大学和美国哈佛大学开展了不同层面的科研训练。期间在Nature Medicine, Neuron, Cell StemCell, Journal of Neuroscience, Neuron等多个领域核心期刊上发表论文；并受邀参与撰写了《Neurogenesis in the Adult brain》和《The role of adult-born neurons in mood regulation》英文书本章节。

研究方向

1. 记忆形成和巩固的神经环路和分子机制

2. 老年化引起认知功能损害的神经环路和分子机制

3. 成体神经干细胞在应急刺激和脑损伤中的功能研究

研究关键词

海马，记忆，神经环路，老年化，成体神经再生

Hippocampus, Memory, Neural circuit, Aging, Adult neurogenesis

代表性论著

1、Cinzia Vicidomini*, Nannan Guo* and Amar Sahay. Communication, Cross Talk, and Signal Integrationin the Adult Hippocampal Neurogenic Niche. Neuron. 2020 Jan 105(2):220-235.(*, Co-first authors who contributed equally to this work)

2、Nannan Guo, Marta E. Soden, Charlotte Herber, Michael TaeWoo Kim, Antoine Besnard, Paoyan Lin, Xiang Ma, Constance L. Cepko, Larry S. Zweifel, and Amar Sahay. Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization. Nature Medicine.2018 May 12;24(4):438-449.

Featured in Nature medicine and News and Views by Haubrich & Nader

Featured by NIH director, Dr. Francis Collins’s blog

Recommended by Dr. Sheena Josselyn in F1000Prime

3、Guo N, Sahay A. Neural Circuits Serve as Periscopes for NSCs. Cell Stem Cell. Preview. 2017 Nov 2;21(5):557-559. 

4、McAvoy KM, Scobie KN, Berger S, Russo C, Guo N, Decharatanachart P, Vega-Ramirez H, Miake-Lye S, Whalen M, Nelson M, Bergami M, Bartsch D, Hen R, Berninger B, Sahay A. Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits. Neuron. 2016 Sep 21;91(6):1356-1373.

5、Taruna Ikrar, Nannan Guo, Kaiwen He, Antoine Besnard, Sally Levinson, Alexis Hill, Hey-Kyoung Lee, Rene Hen, Xiangmin Xu, Amar Sahay. Adult neurogenesis modifies excitability of the dentate gyrus. Frontiers in Neural Circuits 2013; 7:204.

6、Nannan Guo, Kaichi Yoshizaki, Ryuichi Kimura, Fumikazu Suto, Yuchio Yanagawa, and Noriko Osumi. A sensitive period for GABAergic interneurons in the dentate gyrus in modulating sensorimotor gating. J Neurosci. 2013; 33(15):6691-704.

代表性课题

1. 广东省基础与应用基础研究基金, 面上项目，2021-01至2023-12，10万元，主持；

2. 国家自然科学基金委员会，面上项目，2022-01至2025-12，58万元，主持

荣誉奖励

南方医科大学高层次引进人才，入选2020年人才计划。