陈荣清 博士

教授，博士生导师

电子邮件: rchen@smu.edu.cn

电 话：020-62789021

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

在山东大学获学士学位，在德国美因茨大学获博士学位，2014年10月至今任南方医科大学神经生物学教研室教授。

研究方向

神经兴奋性异常及其导致癫痫、抑郁症等神经精神疾病发生的细胞和分子机制。

研究关键词

兴奋性（exitability）；突触传递（synaptic transmission）；离子通道（ion channels）；大麻素系统（endocannabinoid system）；癫痫（epilepsy）；抑郁症（depression）

代表性论著

1. Zou W*, Guo Z*, Suo L*, Zhu J, He H, Li X, Wang K#, Chen R#: Nucleus accumbens shell modulates seizure propagation in a mouse temporal lobe epilepsy model. Frontiers in cell and developmental biology 2022, 10:1031872.

2. Liang W*, Hou Y*, Huang W*, Wang Y*, Jiang T, Huang X, Wang Z, Wu F, Zheng J, Zhang J, Ou H, Li S, Ping J, Zhang Y, Ye J, Li Z, Yang Q, Zhang J, Zheng X, Li S, Zhu XH, Chen R#, Zhao C#: Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission. Science advances 2022, 8:eabn7357.

3. Cong J*, Lu K*, Zou1 W*, Li Z, Guo Z, Tong X, Zheng J, Zhu J, Li S, Zhang W, Guo Y#, Gao T-M#, Chen R#: Astroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice. Frontiers in cellular neuroscience 2021, 15:772549.

4. Huang W*, Ke Y*, Zhu J, Liu S, Cong J, Ye H, Guo Y, Wang K, Zhang Z, Meng W, Gao TM, Luhmann HJ, Kilb W#, Chen R#: TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures. Cell reports 2021, 36:109404.

5. Qu Q, Wang J, Li G, Chen R#, Qu S#: The Conformationally Sensitive Spatial Distance Between the TM3-4 Loop and Transmembrane Segment 7 in the Glutamate Transporter Revealed by Paired-Cysteine Mutagenesis. Frontiers in cell and developmental biology 2021, 9:737629.

6. Liu M*, Jiang L*, Wen M, Ke Y, Tong X, Huang W, Chen R#: Microglia depletion exacerbates acute seizures and hippocampal neuronal degeneration in mouse models of epilepsy. American journal of physiology Cell physiology 2020, 319:C605-C10.

7. Kolbaev SN, Mohapatra N, Chen R, Lombardi A, Staiger JF, Luhmann HJ, Jedlicka P, Kilb W#: NKCC-1 mediated Cl(-) uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs. Scientific reports 2020, 10:18399.

8. Chen R*, Okabe A*, Sun H, Sharopov S, Hanganu-Opatz IL, Kolbaev SN, Fukuda A, Luhmann HJ, Kilb W#: Activation of glycine receptors modulates spontaneous epileptiform activity in the immature rat hippocampus. The Journal of physiology 2014, 592:2153-68.

9. Chen R*, Zhang J*, Fan N*, Teng ZQ*, Wu Y*, Yang H, Tang YP, Sun H, Song Y, Chen C#: Delta9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell 2013, 155:1154-65.

10. Chen R*, Zhang J*, Wu Y, Wang D, Feng G, Tang YP, Teng Z, Chen C#: Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. Cell reports 2012, 2:1329-39.

11. Chen RQ*, Wang SH*, Yao W, Wang JJ, Ji F, Yan JZ, Ren SQ, Chen Z, Liu SY, Lu W#: Role of glycine receptors in glycine-induced LTD in hippocampal CA1 pyramidal neurons. Neuropsychopharmacology 2011, 36:1948-58.

代表性课题

1. 国家自然科学基金面上项目（82271859），起止年月2023.01-2026.12，主持。

2. 国家自然科学基金面上项目（31771127），起止年月2018.01-2021.12，主持。

3. 国家自然科学基金面上项目（31571035），起止年月2016.01-2019.12，主持。

学术任职

中国细胞生物学学会神经细胞生物学分会委员

广东省脑发育与脑病防治学会癫痫病学分会常务委员

执教课程（课程及教材建设）

生理学、神经生物学