王栋 博士

教授，博士生导师

电子邮件:wangdong79@smu.edu.cn

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

教授，博士生导师，闽江学者。长期致力于造血干细胞生物学大数据分析研究，近年来运用计算系统生物学技术解析RNA代谢在造血调控中的重要生物学功能。以通讯作者（含共同通讯作者）在Cell Stem Cell、Nucleic Acids Research、Science Advances、Nature Communications、The EMBO Journal、Autophagy、Briefings in Bioinformatics和Bioinformatics等学术期刊发表SCI论文44篇，累积影响因子大于570，发表论文总被引用2500 余次，ESI高被引论文8篇。主持和参与国家重点研发计划专项、国家自然科学基金面上项目、广东省自然科学基金项目等多项课题。

研究方向

发育与干细胞计算系统生物学

研究关键词

计算系统生物学（Computational systems biology）；发育与干细胞（Development and stem cell）

代表性论著

1. Jia Chen, Jiahao Lin, Yongfei Hu, Meijun Ye, Linhui Yao, Le Wu, Wenhai Zhang, Meiyi Wang, Tingting Deng, Feng Guo, Yan Huang, Bofeng Zhu*, Dong Wang *. RNADisease v4.0: an updated resource of RNA-associated diseases, providing RNA-disease analysis, enrichment and prediction. Nucleic Acids Research. 2022. doi: 10.1093/nar/gkac814. (SCI, IF=19.160, 小类1区)

2. Fang Wang, Puwen Tan, Pengcheng Zhang, Yue Ren, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*, Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Science Advances. 2022. 8(1):eabg5369. (SCI, IF=14.957, 小类1区)

3. Tianyu Cui, Yiying Dou, Puwen Tan, Zhen Ni, Tianyuan Liu, DuoLin Wang, Yan Huang, Kaican Cai, Xiaoyang Zhao, Dong Xu*, Hao Lin*, Dong Wang*. RNALocate v2.0: an updated resource for RNA subcellular localization with increased coverage and annotation. Nucleic Acids Research. 2022. 50(D1):D333-D339. (SCI, IF=19.160, 小类1区)

4. Juanjuan Kang, Qiang Tang, Jun He, Le Li, Nianling Yang, Shuiyan Yu, Mengyao Wang, Yuchen Zhang, Jiahao Lin, Tianyu Cui, Yongfei Hu, Puwen Tan, Jun Cheng, Hailong Zheng, Dong Wang*, Xi Su*, Wei Chen*, Yan Huang*. RNAInter v4.0: RNA interactome repository with redefined confidence scoring system and improved accessibility. Nucleic Acids Research. 2022. 50(D1):D326-D332. (SCI, IF=19.160, 小类1区)

5. Jun Cheng, Yunqing Lin, Linfu Xu, Kechen Chen, Qi Li, Kaixin Xu, Lin Ning, Juanjuan Kang, Tianyu Cui, Yan Huang, Xiaoyang Zhao, Dong Wang*, Yanhui Li*, Xi Su*, Bin Yang*. ViRBase v3.0: a virus and host ncRNA-associated interaction repository with increased coverage and annotation. Nucleic Acids Research. 2022. 50(D1):D928-D933. (SCI, IF=19.160, 小类1区)

6. Haibo Zhu, Hao Fu, Tianyu Cui, Lin Ning, Huaguo Shao, Yehan Guo, Yanting Ke, Jiayi Zheng, Hongyan Lin, XinWu, Guanghao Liu, Jun He, Xin Han, Wenlin Li, Xiaoyang Zhao, Huasong Lu, Dong Wang*, Kongfa Hu*, Xiaopei Shen*. RNAPhaSep: a resource of RNAs undergoing phase separation. Nucleic Acids Research. 2022. 50(D1):D340-D346. (SCI, IF=19.160, 小类1区)

7. Jingyuan Tong, Ting Sun, Shihui Ma, Yanhong Zhao, Mankai Ju, Yuchen Gao, Ping Zhu, Puwen Tan, Rongfeng Fu, Anqi Zhang, Ding Wang, Di Wang, Zhijian Xiao, Jiaxi Zhou, Renchi Yang, Stephen Loughran, Juan Li, Anthony R. Green, Emery H. Bresnick, Dong Wang*, Tao Cheng*, Lei Zhang*, Lihong Shi*. Hematopoietic stem cell heterogeneity is linked to the initiation and therapeutic response of myeloproliferative neoplasms. Cell Stem Cell. 2021. 28(3):502-513. (SCI, IF=25.269, 小类1区)

8. Lin Ning, Tianyu Cui, Boyang Zheng, Nuo Wang, Jiaxin Luo, Beilei Yang, Mengze Du, Jun Cheng, Yiying Dou, Dong Wang*. MNDR v3.0: mammal ncRNA–disease repository with increased coverage and annotation. Nucleic Acids Research. 2021. 49(D1):D160-D164. (SCI, IF=19.160, 小类1区, ESI高被引论文)

9. Yang Zhang, Tianyuan Liu, Jing Wang, Bohao Zou, Le Li, Linhui Yao, Kechen Chen, Lin Ning, Bingyi Wu*, Xiaoyang Zhao*, Dong Wang*. Cellinker: a platform of ligand-receptor interactions for intercellular communication analysis. Bioinformatics. 2021. 37(14):2025–2032. (SCI, IF=6.931, 小类1区)

10. Yang Zhang,*, Tianyuan Liu, Xuesong Hu, Mei Wang, Jing Wang, Bohao Zou, Puwen Tan, Tianyu Cui, Yiying Dou, Lin Ning, Yan huang, Shuan Rao, Dong Wang*, Xiaoyang Zhao*. CellCall: integrating paired ligand-receptor and transcription factor activities for cell-cell communication. Nucleic Acids Research. 2021. 49(15):8520-8534. (SCI, IF=19.160, 小类1区)

11. Yan Huang, Jing Wang, Yue Zhao, Huafeng Wang, Tianyuan Liu, Yuhe Li, Tianyu Cui, Weiyi Li, Yige Feng, Jiaxin Luo, Jiaqi Gong, Lin Ning, Yong Zhang*, Dong Wang*, Yang Zhang*. cncRNAdb: a manually curated resource of experimentally supported RNAs with both protein-coding and noncoding function. Nucleic Acids Research. 2021. 49(D1):D65-D70. (SCI, IF=19.160, 小类1区, ESI高被引论文)

12. Duolin Wang, Zhaoyue Zhang, Yuexu Jiang, Ziting Mao, Dong Wang*, Hao Lin*, Dong Xu*. DM3Loc: Multi-label mRNA Subcellular Localization Prediction and Analysis Based on Multi-head Self-attention Mechanism. Nucleic Acids Research. 2021. 49(8):e46. (SCI, IF=19.160, 小类1区, ESI高被引论文)

13. Xue Wang, Changyun Ping, Puwen Tan, Chenguang Sun, Guang Liu, Tao Liu, Shuchun Yang, Yanmin Si, Lijun Zhao, Yongfei Hu, Yuyan Jia, Xiaoshuang Wang, Meili Zhang, Fang Wang, Dong Wang*, Jia Yu*, Yanni Ma*and Yue Huang*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. EMBO JOURNAL. 2021. 40(4):e104729. (SCI, IF=14.012, 小类1区)

14. ZhaoYue Zhang, YuHe Yang, Hui Ding, Dong Wang*, Wei Chen*, Hao Lin*. Design powerful predictor for mRNA subcellular location prediction in Homo sapiens. Briefings in Bioinformatics. 2021. 22(1):526-535. (SCI, IF=13.994, 小类1区, ESI高被引论文)

15. Yunqing Lin, Tianyuan Liu, Tianyu Cui, Zhao Wang, Yuncong Zhang, Puwen Tan, Yan Huang, Jia Yu, Dong Wang*. RNAInter in 2020: RNA interactome repository with increased coverage and annotation. Nucleic Acids Research. 2020. 48(D1):D189-197. (SCI, IF=19.160, 小类1区, ESI高被引论文)

16. Zhengyi Zhang, Jingnan Pi, Dongling Zou, Xiaoshuang Wang, Jiayue Xu, Shan Yu, Ting Zhang, Feng Li, Xianxie Zhang, Hualu Zhao, Fang Wang, Dong Wang*, Yanni Ma*, Jia Yu*. microRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression. Nature Communications. 2019. 10(1): p. 4397. (SCI, IF=17.694, 小类1区)

17. Yang Zhang, Tianyuan Liu, Liqun Chen, Jinxurong Yang, Jiayi Yin, Yuncong Zhang, Zhixi Yun, Hao Xu, Lin Ning, Fengbiao Guo, Yongshuai Jiang, Hao Lin, Dong Wang*, Yan Huang*, Jian Huang*. RIscoper: a tool for RNA-RNA interaction extraction from the literature. Bioinformatics. 2019. 35(17):3199-3202. (SCI, IF=6.931, 小类1区)

18. Tianyu Cui, Lin Zhang, Yan Huang, Ying Yi, Puwen Tan, Yue Zhao, Yongfei Hu, Liyan Xu*, Enmin Li*, Dong Wang*. MNDR v2.0: an updated resource of ncRNA–disease associations in mammals. Nucleic Acids Research. 2018. 46(D1):D371-D374. (SCI, IF=19.160, 小类1区, ESI高被引论文)

19. Yan Huang, Puwen Tan, Xiaoshuang Wang, Ying Yi, Yongfei Hu*, Dong Wang*, Fang Wang*. Transcriptomic insights into temporal expression pattern of autophagy genes during monocytic and granulocytic differentiation. Autophagy. 2018. 14(3): 558-559. (SCI, IF=13.391, 小类2区)

20. Hongmei Zhao, Xiaoshuang Wang, Ping Yi, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang*, Fang Wang*, Jia Yu*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nature Communications. 2017. 8(1):1428. (SCI, IF=17.694, 小类1区)

21. Ting Zhang, Puwen Tan, Liqiang Wang, Nana Jin, Yana Li, Lin Zhang, Huan Yang, Zhenyu Hu, Lining Zhang, Chunyu Hu,Chunhua Li, Kun Qian, Changjian Zhang, Yan Huang, Kongning Li*, Hao Lin*, Dong Wang*. RNALocate: a resource for RNA subcellular localizations. Nucleic Acids Research. 2017. 45(D1):D135-D138. (SCI, IF=19.160, 小类1区, ESI高被引论文)

22. Ying Yi, Yue Zhao, Chunhua Li, Lin Zhang, Huiying Huang, Yana Li, Lanlan Liu, Ping Hou, Tianyu Cui, Puwen Tan, Yongfei Hu, Ting Zhang, Yan Huang, Xiaobo Li*, Jia Yu*, Dong Wang*. RAID v2.0: an updated resource of RNA-associated interactions across organisms. Nucleic Acids Research. 2017. 45(D1):D115-D118. (SCI, IF=19.160, 小类1区, ESI高被引论文)

23. Yongfei Hu, Yan Huang, Ying Yi, Hongwei Wang, Bing Liu*, Jia Yu*, Dong Wang*. Single-cell RNA sequencing highlights transcription activity of autophagy-related genes during haematopoietic stem cell formation in mouse embryos. Autophagy. 2017. 13(4): 770-771. (SCI, IF=13.391, 小类2区)

24. Yanhui Li, Changliang Wang, Zhengqiang Miao, Xiaoman Bi, Deng Wu, Nana Jin, Liqiang Wang, Hao Wu, Kun Qian, Chunhua Li, Ting Zhang, Chunrui Zhang, Ying Yi, Hongyan Lai, Yongfei Hu, Lixin Cheng, Kwong-Sak Leung, Xiaobo Li, Fengmin Zhang,Kongning Li*, Xia Li*, Dong Wang*. ViRBase: a resource for virus-host ncRNA-associated interactions. Nucleic Acids Research. 2015. 43(Database issue): D578-D582. (SCI, IF=19.160, 小类1区)

25. Deng Wu, Yan Huang, Juanjuan Kang, Kongning Li, Xiaoman Bi, Ting Zhang, Nana Jin, Yongfei Hu, Puwen Tan, Lu Zhang, Ying Yi, Wenjun Shen, Jian Huang, Xiaobo Li, Xia Li*, Jianzhen Xu*, Dong Wang*. ncRDeathDB: a comprehensive bioinformatics resource for deciphering network organization of the ncRNA-mediated cell death system. Autophagy. 2015. 11(10): 1917-1926. (SCI, IF=13.391, 小类2区)

26. Yifei Li, Liwei Zhuang, Yuting Wang, Yongfei Hu, Yun Wu, Dong Wang*, Jianzhen Xu*. Connect the dots: a systems level approach for analyzing the miRNA-mediated cell death network. Autophagy. 2013. 9(3): 436-439.(SCI, IF=13.391, 小类2区)

代表性课题

1.国家自然科学基金面上项目，2021.01-2024.12，55万元，主持

2. 科技部国家重点研发计划专项，2019.12-2024.11，51万元，骨干

3.广东省自然科学基金面上项目，2022.01-2024.12，10万元，主持

4.广东省自然科学基金面上项目，2019.10-2022.09，10万元，主持

5.国家自然科学基金面上项目，2018.01-2021.12，55万元，主持

学术任职

中国计算机学会生物信息学专业委员会 委员

中华预防医学会生物信息分会 委员

广东精准医学应用学会皮肤性病分会 副主任委员

执教课程

计算系统生物学导论

生物信息学

荣誉奖励

2020年美国大学生数学建模竞赛（MCM/ICM），二等奖（Honorable Mention），指导教师。