肖东 博士

研究员，博士生导师

电子邮件: xiaodong@smu.edu.cn, Xiao_d@hotmail.com

电 话：020-62789439

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

2009.12–至今 广东广州市南方医科大学基础医学院肿瘤研究所、实验动物管理中心研究员

2008.01–2009.11 广东广州市南方医科大学基础医学院肿瘤研究所、实验动物中心副研究员

2006.07–2007.12 广东广州市南方医科大学实验动物中心副研究员

2004.04–2005.05 美国密苏里州斯托瓦斯医学研究所博士后

2001.11–2003.12 广东广州市中山大学实验动物中心讲师、博士后

2001.01–2001.10 广东广州市中山医科大学实验动物中心讲师、博士后

2000.07–2000.12 广东广州市中山医科大学基础医学院生理教研室讲师、博士后

1997.09–2000.06 广东广州市中山大学生命科学学院攻读动物学博士学位

1994.09–1997.06 湖北武汉市华中农业大学水产学院攻读水生生物学硕士学位

1990.09–1994.06 湖北武汉市华中农业大学水产学院攻读学士学位

研究方向

1. 鼻咽癌发病机制

2. 肝脏再生与肝脏相关疾病（如脂肪肝、肝纤维化和肝癌等）发病机制

3. RNA甲基化修饰(如m⁶A)与自噬、鼻咽癌和肝脏再生及肝脏相关疾病

4. 糖脂代谢

5. 基于遗传工程猪创制人类疾病大动物模型

研究关键词

1. 肿瘤发病机制 Cancer pathogenesis

2. 肝脏相关疾病（如脂肪肝、肝纤维化和肝癌）发病机制

Pathogenesis of liver-related diseases (i.e., fatty liver, liver fibrosis and HCC)

3. 糖脂代谢 Glucose and lipid metabolism

4. 人类疾病大动物模型 Large animal models of human diseases

代表性论著

1. Hao W*, Dian M*, Zhou Y, Zhong Q, Pang W, Li Z, Zhao Y, Ma J, Lin X, Luo R, Li Y, Jia J, Shen H, Huang S, Dai G, Wang J^#, Sun Y^#, Xiao D(肖东)^#. Autophagy induction promoted by m⁶A reader YTHDF3 through translation upregulation of FOXO3 mRNA. Nat Communications, 2022, 13(1):5845.

2. Hao W*, Dian M*, Wang J^#, Sun Y^#, Xiao D(肖东)^#. Epitranscriptomic turbo for autophagy boost: m⁶A reader YTHDF3. Autophagy, 2022, 29:1-3.

3. Xu K*, Xie R*, Lin X*, Jia J, Zeng N, Li W, Xiao D(肖东)^#, Du T^#. Brown Adipose Tissue: A Potential Site for Islet Transplantation. Transplantation, 2020, 104(10):2059-2064.

4. Chen BZ, Gu P, Jia JS, Liu W, Liu YM, Liu W, Xu T, Lin XL, Lin TY, Liu Y, Chen HW, Xu MC, Yuan J, Zhang JN, Zhang Y^#, Xiao D(肖东)^#, Gu WW^#. Optimization strategy for generating gene-edited Tibet Minipigs by synchronized oestrus and cytoplasmic microinjection. International Journal of Biological Sciences, 2019, 15(12):2719-2732.

5. Chen Y, Deng X, Chen W, Shi P, Lian M, Wang H, Wang K, Qian D, Xiao D(肖东)^#, Long H^#. Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/b-catenin pathway in glioma. Cell Death Dis, 2019, 10(6):448.

6. Zhao WT, Lin XL, Liu Y, Han LX, Li J, Lin TY, Shi JW, Wang SC, Lian M, Chen HW, Sun Y, Xu K, Jia JS^#, Luo RC^#, Xiao D(肖东)^#. miR-26a promotes hepatocellular carcinoma invasion and metastasis by inhibiting PTEN and inhibits cell growth by repressing EZH2. Lab Invest, 2019, 99(10):1484-1500.

7. Shi JW, Zhang TT, Liu W, Yang J, Lin XL, Jia JS, Shen HF, Wang SC, Li J, Zhao WT, Gu WW^#, Sun Y^#, Xiao D(肖东)^#. Direct conversion of pig fibroblasts to chondrocyte-like cells by c-Myc. Cell Death Discov, 2019, 5:55.

8. Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D(肖东)^#, Gu WW^#. TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway. J Transl Med, 2019, 17(1):72.

9. Lin X, Chen L, Li H, Liu Y, Guan Y, Li X, Jia Z, Lin X, Jia J, Sun Y, Xiao D(肖东)^#. miR-155 accelerates proliferation of mouse hepatocytes during liver regeneration by directly targeting SOCS1. Am J Physiol Gastrointest Liver Physiol, 2018, 315(4):G443-G453.

10. Lin XL, Qin YJ, Jia JS, Lin TY, Lin X, Chen L, Zeng H, Han YJ, Wu LH, Huang S, Wang M, Huang SH, Xie RY, Liang LQ, Liu Y, Liu RY, Zhang TT, Li J, Wang SC, Sun PH, Huang WH, Yao KT^#, Xu K^#, Du T^#, Xiao D(肖东)^#. miR-155 enhances insulin sensitivity by coordinated regulation of multiple genes in mice. PLoS Genetics, 2016, 12(10):e1006308.

11. Rong XX, Wei F, Lin XL, Qin YJ, Chen L, Wang HY, Shen HF, Jia LT, Xie RY, Lin TY, Hao WC, Yang J, Yang S, Chen YS, Huang WH, Li AM, Sun Y^#, Luo RC^#, Xiao D(肖东)^#. Recognition and killing of cancer stem-like cell population in hepatocellular carcinoma cells by cytokine-induced killer cells via NKG2d-ligands recognition. Oncoimmunology, 2016, 5(3):e1086060.

12. Li J, Yang S, Yan W, Yang J, Qin YJ, Lin XL, Xie RY, Wang SC, Jin W, Gao F, Shi JW, Zhao WT, Jia JS, Shen HF, Ke JR, Liu B, Zhao YQ, Huang WH, Yao KT^#, Li DJ^#, Xiao D(肖东)^#. MicroRNA-19 triggers epithelial-mesenchymal transition of lung cancer cells accompanied by growth inhibition. Lab Invest, 2015, 95(9):1056-1070.

13. Lin X, Jia J, Du T, Li W, Wang X, Wei J, Lin X, Zeng H, Yao L, Chen X, Zhuang J, Weng J, Liu Y, Lin J, Wu Q, Wang W, Yao K^#, Xu K^#, Xiao D(肖东)^#. Overexpression of miR-155 in the liver of transgenic mice alters the expression profiling of hepatic genes associated with lipid metabolism. PLoS One, 2015, 10(3): e0118417.

14. Gao F^#, Zhang Y, Wang S, Liu Y, Zheng L, Yang J, Huang W, Ye Y, Luo W^#, Xiao D(肖东)^#. Hes1 is involved in the self-renewal and tumourigenicity of stem-like cancer cells in colon cancer. Scientific Reports (Sci Rep), 2014, 4:3963.

15. Shi JW, Liu W, Zhang TT, Wang SC, Lin XL, Li J, Jia JS, Sheng HF, Yao ZF, Zhao WT, Zhao ZL, Xie RY, Yang S, Gao F, Fan QR, Zhang MY, Yue M, Yuan J^#, Gu WW^#, Yao KT^#, Xiao D(肖东)^#. The enforced expression of c-Myc in pig fibroblasts triggers mesenchymal-epithelial transition (MET) via F-actin reorganization and RhoA/Rock athway inactivation. Cell Cycle, 2013, 12(7):1119 -1127.

16. Sun Y, Chen XG^#, Xiao D(肖东)^#. Tetracycline-inducible expression systems: new strategies and practices in the transgenic mouse modeling. Acta Biochim Biophys Sin, 2007, 39(4):235-246.

17. Xiao D(肖东)^#, Sun Y, Gu WW, Chen XG^#. Tetracycline-controlled transcriptional regulation systems: countermeasures to eliminate basal transgene leak of Tet-based systems. Progress in Natural Science, 2007, 17(1):11-19.

18. Guo ZM, Xu K, Yue Y, Huang B, Tang H, Deng XY, Zhong LQ, Hong X, Chen XG^#, Xiao D(肖东)^#. Temporal control of Cre recombinase-mediated in vitro DNA recombination by the Tet-on system. Acta Biochim Biophys Sin, 2005, 37(2):133-138.

19. Xiao D(肖东), Lin HR. Cysteamine—a somatostatin-inhibiting agent—induced growth hormone secretion and growth acceleration in juvenile grass carp (Ctenopharyngodon idellus). Gen Comp Endocrinol, 2003, 134(3):285-295.

20. Xiao D(肖东), Lin HR. Effects of cysteamine—a somatostatin-inhibiting agent on serum growth hormone (GH) levels and growth in juvenile grass carp (Ctenopharyngodon idellus). Comp Biochem Physiol A, 2003, 134(1):91-97.

21. Xiao D(肖东), Chu MM, Lee EK, Lin HR, Wong AOL. Regulation of growth hormone release in common carp pituitary cells by pituitary adenylate cyclase-activating polypeptide: Signal transduction involves cAMP- and calcium-dependent mechanisms. Neuroendocrinology, 2002, 76(5):325-338.

22. Xiao D(肖东), Wong AOL, Lin HR. Lack of growth hormone-releasing peptide-6 (GHRP-6) action on in vivo and in vitro growth hormone secretion in sexually immatured grass carp (Ctenopharyngodon idellus). Fish Physiol Biochem, 2002, 26:315-327.

代表性课题

1. 广东省科学技术厅，广东省基础与应用基础研究基金，2022A1515012477，2022-01至2024-12，10万元，在研，主持。

2. 国家自然科学基金委员会，面上项目，82173299，2022-01至2025-12，54.7万元，在研，主持。

3. 国家自然科学基金委员会，面上项目，81872209，2019-01至2022-12，57万元，在研，主持。

4. 国家自然科学基金委员会，面上项目，81672689，2017-01至2020-12，60万元，结题，主持。

5. 广东省科学技术厅，广东省科技计划项目，2017A010105017，2017-07至2020-06，30万元，结题，主持。

6. 广东省科学技术厅，广东省自然科学基金自由申请项目，2014A030313294，2014-10至2017-10，10万元，结题，主持。

7. 国家自然科学基金委员会，面上项目，81372896，2014-01至2017-12，70万元，结题，主持。

8. 广东省科学技术厅，广东省科技计划项目，2013B060300013，2014-06至2017-05，100万元，结题，主持。

9. 国家自然科学基金委员会，面上项目，81172587，2012-01至2015-12，63万元，结题，主持。

学术任职

1. 中国研究型医院学会病毒肿瘤学专业委员会，常务委员；

2. 中国整形美容协会干细胞研究与应用分会，常务理事；

3. 中国实验小型猪专业委员会，委员；

4. 广东省精准医学应用学会疾病模型分会，委员。

执教课程（课程及教材建设）

1.《实验动物学》

2.《肿瘤学前沿》

3.《肿瘤生物治疗学》

4.《系统肿瘤学》