孙雨蒙 博士

副教授，硕士生导师

电子邮件：fengzhihualuo@163.com

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

孙雨蒙，基础医学院生化教研室副教授，硕士生导师。2019年于中山大学获得博士学位。2019-2025年先后在中山大学进行博士后和特聘副研究员工作。2025年以南方医科大学高层次人才引进基础医学院生化教研室。主要从事新型非编码RNA与肿瘤细胞理化特征研究。相关成果发表在Molecular Cell、Blood、Nature Communications、Journal of Hematology & Oncology、Clinical Cancer Research等杂志。

研究方向

非编码RNA与癌症

非编码RNA与朊病毒样蛋白质内稳态

关键词

非编码RNA、非经典翻译产物、蛋白质内稳态、白血病

代表性论著

1. Sun, Y., Zhu, S., Chen, X., Pan, Q., An, Y., Chen, T., Huang, H., Pu, K., Lian, J., Zhao, W., Wang, W.#, Chen, Y#. (2024). LncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing. Molecular Cell, 84(24):4878-4895 (IF: 16.6)

2. Sun, Y.*, Wang, W.*, Zeng, Z., Chen, T., Han, C., Pan, Q., Huang, W., Fang, K., Sun, L., Zhou, Y., Luo, X., Luo, C., Du, X., Chen, Y#. (2019). circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression. Blood, 134, 1533-1546. (IF: 25.4)

3. Chen, T.*, Sun, Y.*，Zhu, S.*, Chen, X., Pu, K., Huang, H., Pan, Q., Lian, J., Huang, W., Fang, K., Luo, X., Huang, L., Chen, Y. #, Wang, W#. RBM15B promotes progression of MLL-rearranged leukemia by orchestrating H3K79me2–m6A crosstalk. EMBO Journal (article accepted, IF:9.5)

4. Wang, W., Chen, T., Zeng, Z., Pan, Q., Huang, W., Han, C., Fang, K., Sun, L., Yang, Q., Wang, D., Luo, X., Sun, Y.#, Chen, Y#. (2020). The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia. Journal of Hematology & Oncology, 13, 78. (IF:40.4)

5. Zhou, Y.*, Zhang, Y.*, Sun, Y.*, Yu, Y., Lei, M., Yang, Y., Lian, J., Feng, Y., Zhang, Z., Yang, L., He, R., Huang, J., Cheng, Y., Liu, Y., Chen, Y#. (2021). The parent-of-origin lncRNA MISSEN regulates rice endosperm development. Nature Communications, 12, 6525. (IF:15.7)

6. Huang, W.*, Sun, Y.*, Pan, Q., Fang, K., Chen, X., Zeng, Z., Chen, T., Zhu, S., Huang, L., Luo, X., Wang, W.#, Chen, Y#. (2022). The snoRNA-like lncRNA LNC-SNO49AB drives leukemia by activating the RNA-editing enzyme ADAR1. Cell Discovery, 8, 117. (IF:14.8)

7. Wang, W.*, Han, C.*, Sun, Y.*, Chen, Z., Fang, K., Huang, W., Sun, L., Zeng, Z., Luo, X., Chen, Y#. (2019). Activation of the Lysosome-Associated Membrane Protein LAMP5 by DOT1L Serves as a Bodyguard for MLL Fusion Oncoproteins to Evade Degradation in Leukemia. Clinical Cancer Research, 25, 2795-2808. (IF:11.5)

8. Sun, Y.，Chen, Y#. (2020). Principles and innovative technologies for decrypting noncoding RNAs: from discovery and functional prediction to clinical application. Journal of Hematology & Oncology, 13, 109. (IF:40.4)

9. Sun, Y.，Lin, K., Chen, Y#. (2013). Diverse functions of miR-125 family in different cell contexts. Journal of Hematology & Oncology, 6, 6. (IF:40.4)

代表性课题

1. 国家自然科学基金委员会面上项目，2023.01-2026.12，主持

2. 南方医科大学高水平大学-引进人才项目，2025-2027，主持

3. 国家重点研发计划子课题，2022.12-2027,11，参与

4. 国家重点研发计划子课题，2021.12-2026.11，参与

5. 国家自然科学基金委员会青年科学基金项目，2021.01-2023.12，主持

6. 中国博士后科学基金特别资助（站中），2022.01 -2022.12，主持

执教课程

生物化学与分子生物学