连森 博士

副教授，硕士生导师

电子邮件:senlian@i.smu.edu.cn

电 话：020-62789385

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

2017.5-2019.10南方医科大学基础医学院生物化学与分子生物学教研室讲师

2019.10-至今南方医科大学基础医学院生物化学与分子生物学教研室副教授

研究方向

肿瘤学，重点研究消化道肿瘤发病分子机制与抗肿瘤新靶点研究。

研究关键词

消化道肿瘤(gastrointestinal cancer), 分子机制 (molecular mechanism), 信号通路(cell signaling pathway), 抗肿瘤靶点 (anticancer targets)

代表性论著

第一作者

1. Sen Lian#, Yong Xia, Pham Ngoc Khoi, TrongThuan Ung, Hyun Joong Yoon, Nam Ho Kim, Kyung Keun Kim, and Young Do Jung,Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology2015 Dec 2, (IF: 4.099，2区)

3. Sen Lian#, Yong Xia, TrongThuan Ung, Pham Ngoc Khoi, Hyun Joong Yoon, Nam Ho Kim, Kyung Keun Kim, and Young Do Jung,Carbon monoxide releasing molecule-2 ameliorates IL-1β-induced IL-8 in human gastric cancer cells. Toxicology 2016 Jun15, (IF=4.099，2区)

4. Sen Lian#, Jung Sun Park, Yong Xia, ThiThinh Nguyen, Young EunJoo, Kyung Keun Kim, Hark Kyun Kim, and Young Do Jung,MicroRNA-375 functions as a tumor-suppressor gene in gastric cancer by targeting Recepteusd’Origine Nantais. International Journal of Molecular Sciences 2016Sep 27, (IF= 4.556，3区)

5. Sen Lian#, Yong Xia, ThiThinh Nguyen, TrongThuan Ung, Hyun Joong Yoon, Nam Ho Kim, Kyung Keun Kim, and Young Do Jung,Docosahexaenoic acid inhibits tumor promoter-induced urokinase-type plasminogen activator receptor by suppressing PKCδ- and MAPKs-mediated pathways in ECV304 human endothelial cells. PLOS ONE 2016 Sep 21,(IF=2.74，3区)

6.Sen Lian#, Yong Xia, TrongThuan Ung, Pham Ngoc Khoi, Hyun Joong Yoon, Sam Gyu Lee, Kyung Keun Kim, and Young Do Jung,Prostaglandin E2 Stimulates Urokinase-Type Plasminogen Activator Receptor via EP2 Receptor-Dependent Signaling Pathways in Human AGS Gastric Cancer Cells. Molecular Carcinogenesis 2017Feb, (IF=3.825，2区)

通讯作者

1.TiantianZhang , Jufeng Ye, Changhu Xue, Yuming Wang, Wenzhen Liao, Limei Mao, Miaomiao Yuan* , Sen Lian* ,Structural characteristics and bioactive properties of a novel polysaccharide from Flammulinavelutipes.Carbohydrate Polymers2018 Oct, (IF=7.182, 1区)

2. Miaomiao Yuan, Wei Meng, Wenzhen Liao, Sen Lian*, AndrographolideAntagonizes TNF-α-induced IL-8viaInhibition of NADPHOxidase/ROS/NF-κB and Src/MAPKs/AP-1Axis in HumanColorectalCancerHCT116Cells.Journal of Agricultural and Food Chemistry 2018 Apr 19, (IF=4.192, 1区)

3. Yong Xia, Miaomiao Yuan, Shinan Li, Ung TrongThuan, Taek Won Kang, Wenzhen Liao, Sen Lian*, Young Do Jung*, Apigenin Suppresses the IL-1β-Induced Expression of the Urokinase-Type Plasminogen Activator Receptor by Inhibiting MAPK-Mediated AP-1 and NF-κB Signaling in Human Bladder Cancer T24 Cells. Journal of Agricultural and Food Chemistry 2018 Jul25, (IF=4.192, 1区)

4. Miaomiao Yuan, Xiaoxia Song, Wei Lv, Qi Xin1, Li Wang1, Qi Gao1, Guochao Zhang1, Wenzhen Liao,Sen Lian*, Tao Jing*, Effect of anacardic acid against echinococcosis through inhibition of VEGF‑induced angiogenesis.Veterinary Research 2019Jan14,(IF=3.357, 1区)

5. YongXia, Taek Won Kang, Young Do Jung, Sen Lian*, Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1α-Mediated Glycolysis in Hypoxia. Journal of Agricultural and Food Chemistry 2019 Jul 9, (IF=4.192, 1区)

代表性课题

1.2018.1.1-2020.12.31国家自然科学青年基金项目主持

2.2019.10.01-2022.9.30广东省基础与应用基础研究项目主持

学术任职

广东省生物化学与分子生物学学会青年委员

执教课程（课程及教材建设）

《生物化学》《分子生物学》