周伟杰

教授/博士生导师

南方医科大学第一临床医学院

Email：weijiezhouum@163.com

跨学科招生专业1 外科学（普外） 招生层次类型1 学术学位博导

跨学科招生专业2 生物与医药 招生层次类型2 专业学位博导

个人简介

南方医科大学南方医院/基础医学院教授，主要从事肝肠损伤修复与再生及肿瘤研究。入选国家特支计划（万人计划）科技创新领军人才，科技部“创新人才推进计划”中青年科技创新领军人才，国家海外高层次人才引进青年项目，广东省杰出青年。获得第十三届吴孟超医学青年基金奖，国家自然科学奖二等奖（3/5）。以第一或通讯作者在Cell、Nature、Hepatology、Nature Comunications、Cell Research等期刊发表原创研究论文，申请多项发明专利并获得授权，主持国自然重大研究计划重点支持项目等项目。

研究领域

肿瘤发生、肿瘤免疫、肿瘤转移

肝肠稳态、肝肠损伤修复、肝再生、肝纤维化

血管、代谢

个人成果

1. Meng Xu#, Hong-Hai Xu#, Yuan Lin#, Xiangnan Sun, Li-Jing Wang, Zhe-Ping Fang, Xue-Han Su, Xiang-Jing Liang, Yang Hu, Zhi-Min Liu, Yuanxiong Cheng, Yuanyuan Wei, Jiabin Li, Li Li, Hong-Juan Liu, Zhiqiang Cheng, Na Tang, Chao Peng, Tingting Li, Tengfei Liu, Liang Qiao, Dalei Wu, Yan-Qing Ding*, Wei-Jie Zhou*. (2019) LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis. Cell. 178(6): 1478-1492.

2. Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou* (2022) A Strategy of Vascular-targeted Therapy for Liver Fibrosis. Hepatology. 76(3):660-675.

3. Yuan Lin#, Zhe-Ping Fang#, Hong-Juan Liu, Li-Jing Wang, Zhiqiang Cheng, Na Tang, Tingting Li, Tengfei Liu, Hai-Xiong Han, Guangwen Cao, Li Liang*, Yan-Qing Ding*, Wei-Jie Zhou*. (2017) HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells. Nature Communications. 8(1):1175. DOI: 10.1038/s41467-017-01341-6.

4. Yan-Ru Chen#, Wan-Ying Feng#, Yuan-Xiong Cheng, Hao Zhu, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou*. (2021) siRNAs targeting mouse-specific lncRNA AA388235 induce human tumor cell pyroptosis/apoptosis. Frontiers in Oncology. 11:662444. doi: 10.3389/fonc.2021.662444

5. Wei-Jie Zhou, Zhen H. Geng, Jason R. Spence, and Jian-Guo Geng*. (2013) Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection. Nature. 501(7465):107-111.

6. Wei-Jie Zhou#, Zhen H. Geng#, Shan Chi#, Wenli Zhang#, Xiao-Feng Niu#, Shu-Jue Lan#, Li Ma, Xuesong Yang, Li-Jing Wang, Yan-Qing Ding*, and Jian-Guo Geng*. (2011) Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Research. 21(4):609-626.