个人简介

长期从事移植免疫临床与基础研究，专注抗体介导的排斥（AMR）研究并取得了一系列原创性成果。共发表学术论文100 余篇，以第一或通讯作者发表含J Am Soc Nephrol、Kidney Int、J Heart Lung Transplant、Am J Transplant、Clin J Am Soc Nephrol、EBioMedicine、Transplantation等国际权威期刊在内的SCI 论文42篇；研究成果2次纳入国际权威指南，指导临床；两次在Lancet 撰文，介绍中国器官移植的进步；参编包括美国移植学会官方教材在内的国际著作3部；主持包括国家重点研发计划课题，国家自然科学基金在内的课题18项。入选国家第四批“万人计划”科技创新领军人才、科技部“创新人才推进计划”中青年科技创新领军人才、广东省医学领军人才、“广东特支计划”科技创新领军人才、江苏省首届杰青，获教育部科技进步二等奖。8 次在美国和国际移植大会做口头报告，先后获国际移植学会青年学者奖、美国移植学会基础研究青年基金，2 次获美国移植大会青年学者奖，具有国际影响力。目前担任中华医学会器官移植学分会全国委员，曾经担任国际肾脏病学会青年工作委员会委员、继续教育委员会委员、2013 世界肾脏病大会分会主席、Transplantation 等5家杂志编委、SCI 期刊Clin & Develop Immunology 移植专刊客座主编，目前担任Front Cell Dev Biol杂志审稿编辑，为包括Am J Transplant在内的7 家国际期刊审稿人，曾受国际移植学会全球通报表彰。

研究领域

主要研究方向（近5年）

1、移植排斥反应与免疫耐受方向研究，专注抗体介导的排斥反应

2、移植物缺血再灌注损伤机制研究

3、肾脏病发病机制与诊治策略研究

个人成果

主持科研项目/课题（近5年）

（1）国家自然科学基金面上项目，81970650，靶向供肾锚定map-PD-L1防治肾移植术后急性排斥的作用及其机制研究，2020.1.1-2023.12.31，55万元，在研，主持。

（2）国家万人计划科技创新领军人才，2019.7.26-2024.7.25，80万元，在研，主持。

（3）国家重点研发计划课题，2018YFA0108804，干细胞防治肾移植相关急性肾损伤和排斥的临床研究，2018.7.1-2022.12.31，420万，在研，主持。

（4）国家自然科学基金面上项目，81770753，TGF-β诱导产生的适应性调节性T细胞对抗体介导的移植肾排斥的防治作用及其作用机制研究，2018.1.1-2021.12.31，56万元，在研，主持。

（5）“广东特支计划”科技创新领军人才人口与健康领域，2015TX01R112，2016/06-2019/05，80万，已结题，主持。

（6）广州市科技计划民生科技产学研协同创新重大专项，201604020086，间充质干细胞用于预防公民身后捐献供肾移植功能延迟恢复的前瞻对照研究，2016/04-2019/03，100万，已结题，主持。

（7）广东省科技计划前沿与关键技术创新（重大科技专项），2015B020226005，间充质干细胞应用于防治公民身后捐献供肾移植排斥的多中心前瞻对照研究，2016/01-2018/12，500万，已结题，主持。

（8）广东省自然科学基金重点项目，2015A030311040，骨髓间充质干细胞防治移植肾体液性排斥的疗效及机制研究，2015/08-2018/08，30万，已结题，主持。

（9）国家自然科学基金面上项目，81470978，siRNA干扰T-bet表达对移植肾体液性排斥的干预作用及机制研究，2015/01-2018/12，73万元，已结题，主持。

发表SCI论文（近5年）

(1) Zihuan Luo(#), Tao Liao(#), Yannan Zhang(#), Haofeng Zheng, Qipeng Sun, Fei Han, Maolin Ma, Yongrong Ye, Qiquan Sun(*). Ex vivo anchored PD-L1 functionally prevent in vivo renal allograft rejection. Bioeng Transl Med. 2022;e10316.

(2) Yongrong Ye(#), Fei Han(#), Maolin Ma(#), Qipeng Sun, Zhengyu Huang, Haofeng Zheng, Zhe Yang, Zihuan Luo, Tao Liao, Heng Li, Liangqing Hong, Ning Na, Qiquan Sun(*). Plasma Macrophage Migration Inhibitory Factor Predicts Graft Function Following Kidney Transplantation: A Prospective Cohort Study. Front Med (Lausanne), 2021, 8:708316

(3) Haofeng Zheng(#), Yannan Zhang(#), Jiannan He(#), Zhe Yang, Rui Zhang, Lei Li, Zihuan Luo, Yongrong Ye, Qiquan Sun(*). Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury. Front. Immunol, 2021, 12:645100.

(4) Fei Han(#), Qipeng Sun(#), Zhengyu Huang(#), Heng Li, Maolin Ma, Tao Liao, Zihuang Luo, Lingling Zheng, Nana Zhang, Nan Chen, Liangqing Hong, Ning Na(*), Qiquan Sun(*). Donor plasma mitochondrial DNA is associated with antibody-mediated rejection in renal allograft recipients. Aging-US, 2021, 13(6):8440-8453.

(5) Zhe Yang(#), Fei Han(#), Tao Liao(#), Haofeng Zheng, Zihuan Luo, Maolin Ma, Jiannan He, Lei Li, Yongrong Ye, Rui Zhang, Zhengyu Huang(*), Yannan Zhang(*), Qiquan Sun(*). Artemisinin attenuates transplant rejection by inhibiting multiple lymphocytes and prolongs cardiac allograft survival. Front Immunol, 2021, 12:634368.

(6) Haofeng Zheng(#), Yannan Zhang(#), Lei Li(#), Rui Zhang, Zihuan Luo, Zhe Yang, Yongrong Ye, Jiannan He, Qiquan Sun(*). Depletion of Toll-Like Receptor-9

Attenuates Renal Tubulointerstitial Fibrosis After Ischemia-Reperfusion Injury. Front Cell Dev Biol, 2021, 9:641527.

(7) Tao Liao(#), Qiaojia Li(#), Yannan Zhang(#), Zhe Yang, Zhengyu Huang, Fei Han, Xiaolong Chen, Tinghui Yin, Jie Ren, Qiquan Sun(*). Precise treatment of acute antibody-mediated cardiac allograft rejection in rat using C4d targeted microbubbles loaded with nitric oxide. J Heart Lung Transplant, 2020, 39(5):481-490.

(8) Zihuan Luo(#), Tao Liao(#), Yannan Zhang, Haofeng Zheng, Qipeng Sun, Fei Han, Zhe Yang, Qiquan Sun(*). Triptolide Attenuates Transplant Vasculopathy Through Multiple Pathways. Front Immunol, 2020, 11: 612.

(9) Fei Han(#), Minzhuan Lin(#), Honglan Zhou, Heng Li, Qipeng Sun, Zhengyu Huang, Liangqing Hong, Gang Wang, Ruiming Cai, Qiquan Sun(*). Delayed graft function is correlated with graft loss in recipients of expanded-criteria rather than standard-criteria donor kidneys: a retrospective, multicenter, observation cohort study. Chin Med J. 2020, 133(5): 561-570.

(10) Fei Han(#), Shaogui Wan(#), Qipeng Sun, Nan Chen, Heng Li, Lingling Zheng, Nana Zhang, Zhengyu Huang, Liangqing Hong, Qiquan Sun(*). Donor Plasma Mitochondrial DNA is Correlated with Posttransplant Renal Allograft Function. Transplantation, 2019, 103(11):2347-2358.

(11) Tao Liao(#), Yannan Zhang(#), Jie Ren(#), Haofeng Zheng, Hongjun Zhang, Xiujie Li, Xiaonan Liu, Tinghui Yin, Qiquan Sun(*). Noninvasive Quantification of Intra-renal Allograft C4d Deposition with Targeted Ultrasound Imaging. Am J Transplant, 2019, 19(1): 259-268.

(12) Tao Liao(#), Xiaonan Liu(#), Jie Ren(#), Hongjun Zhang, Haofeng Zheng, Xiujie Li, Yannan Zhang, Fei Han, Tinghui Yin, Qiquan Sun(*). Noninvasive and quantitative measurement of C4d deposition for the diagnosis of antibody-mediated cardiac allograft rejection. EBioMedicine, 2018, 37: 236-245.

(13) Daqiang Zhao(#), SiwenLi(#), Tao Liao(#), Yuan Wei, Mingyu Liu, Fei Han, Zihuan Luo, Xiaonan Liu and Qiquan Sun(*). Triptolide Inhibits Donor Specific Antibody Production and Attenuates Mixed Antibody-Mediated Renal Allograft Injury. Am J Transplant, 2018, 18(5):1083-1095.

(14) Daqiang Zhao(#), Tao Liao, Siwen Li, Yannan Zhang, Haofeng Zheng, Jing Zhou, Fei Han, Yu Dong and Qiquan Sun(*).Mouse Model Established by Early Renal Transplantation After Skin Allograft Sensitization Mimics Clinical Antibody-Mediated Rejection. Front. Immunol, 2018,9:1356.

(15) Sun QP(#), Zhou H(#), Cao R, Lin M, Hua X, Hong L, Huang Z, Na N, Cai R, Wang G, Meng F, Sun QQ(*).Donation after brain death followed by circulatory death, a novel donation pattern, confers comparable renal allograft outcomes with donation after brain death. BMC Nephrol. 2018;19(1):164.

(16) Sun QP(#), Huang Z(#), Zhou H, Lin M, Hua X, Hong L, Na N, Cai R, Wang G, Sun QQ(*).New Factors Predicting Delayed Graft Function: a Multi-Center Cohort Study of Kidney Donation After Brain Death Followed by Circulatory Death. Kidney Blood Press Res. 2018;43(3):893-903.

(17) Qipeng Sun(#), Zhengyu Huang(#), Fei Han, Ming Zhao, Ronghua Cao, Daqiang Zhao, Liangqing Hong, Ning Na, Heng Li, Bin Miao, Jianmin Hu, Fanhang Meng, Yanwen Peng, Qiquan Sun(*). Allogeneic Mesenchymal Stem Cells as Induction Therapy Are Safe and Feasible in Renal Allografts: Pilot Results of a Multicenter Randomized Controlled Trial. J Transl Med, 2018; 16(1): 52.

(18) Zhulang Chu(#), Weilong Zou(#), Yanan Xu, Qiquan Sun(*), Yong Zhao(*). The regulatory roles of B cell subsets in transplantation. Expert Rev Clin Immunol, 2018, 14(2): 115-125.

(19) Yang XW(#), Xiong TW(#), Hua XF, Xu Q, Tang YE, Chen WJ, Sun QQ(*). Anxiety and Depression among Families of Deceased Donors in China. Chin Med J, 2018;131(1):99-102.

(20) Qipeng Sun(#), Liangqing Hong, Zhengyu Huang, Ning Na, Xuefeng Hua, Yanwen Peng, Ming Zhao, Ronghua Cao, Qiquan Sun(*). Allogeneic mesenchymal stem cell as induction therapy to prevent both delayed graft function and acute rejection in decreased donor renal transplantation study protocol for a randomized controlled trial. Trials, 2017, 18(1): 545.

(21) Liao T(#), Xue Y(#), Zhao D(#), Li S, Liu M, Chen J, Brand DD, Zheng H, Zhang Y, Zheng SG(*), Sun Q(*). In Vivo Attenuation of Antibody-Mediated Acute Renal Allograft Rejection by Ex Vivo TGF-β-Induced CD4+Foxp3+ Regulatory T Cells. Front Immunol, 2017, 8:1334. (IF 5.085)

(22) Zhou Y(#), Li X, Liu Y, Sun Q(*). Maintenance immunosuppressants in the management of antibody-mediated renal allograft rejection: which regimen is best?, Immunotherapy, 2017, 9(1): 47-55.