刘俊珊

教授

博士生导师

中医药学院

中药药理教研室

Email:liujunshanty@163.com

个人简介

刘俊珊，南方医科大学中医药学院中药系副主任，副教授，博士生导师，博士后合作导师。主要研究方向为1.中医药特色的斑马鱼疾病模型的建立；2.解毒方药抗炎/抗肿瘤活性成分的发现及作用机制研究。主持了国家、广东省自然科学基金等省部级以上项目14项，并入选“广东省自然科学杰出青年基金”、“广东省青年珠江学者”、“广东省高校优秀青年创新人才”、全国博管办和香港学者协会“香江学者”、广州市“珠江科技新星”、中华中医药学会“青年托举”人才项目等；申请中国发明专利20项（12项已授权），发表研究论文90篇（SCI收录70篇），包括 J Exp Clin Cancer Res、Sci China Chem、Phytomedicine、J Med Chem 等权威杂志。目前担任广东省药理学会中药药理学会副主任委员、广东省中医药学会中药实验药理专业委员会常务委员、中华中医药学会中药实验药理分会委员、TMR-现代中药编委、Frontiers in Pharmacology编委等。

研究领域

1.中医药特色的斑马鱼疾病模型的建立；

2.解毒方药抗炎/抗肿瘤活性成分的发现及作用机制研究。

个人成果

1.Lei X, Li Z, Huang M, Huang L, Huang Y, Lv S, Zhang W, Chen Z, Ke Y, Li S, Chen J, Yang X, Deng Q*, Liu JS*, Yu X*. Gli1-mediated tumor cell-derived bFGF promotes tumor angiogenesis and pericyte coverage in non-small cell lung cancer. J Exp Clin Cancer Res, 2024, 43(1):83. (IF: 11.4, TOP)

2.Luo ZF#, Jiang JX#, Zou LF#, Zhou XY, Liu JS*, Ke ZF*, Chen FJ, Jiang HF, Zeng W*. Rh(II)-catalyzed intermolecular carboamination of pyridines viadouble Csp2-H bond activations. Sci China Chem, 2023. (IF: 10.4)

3.Zou LF#, Liu DF#, Yang H#, Zhou CH, Deng SB, Xu NS, He XM, Liu YQ, Shao M*, Yu LZ*, Liu JS*. Salvianolic acids from Salvia miltiorrhiza Bunge and their anti-inflammatory effects through the activation of α7nAchR signaling. J Ethnopharmacol, 2023, 317: 116743. (IF: 5.4，1区，TOP)

4.Chen X#, Yang JB#, Cao HH#, Fang XC, Liu SH, Zou LF, Yu JH, Zuo JP, Zhao W, Lu ZB*, Liu JS*, Yu LZ*. Liang-Ge-San inhibits dengue virus serotype 2 infection by reducing caveolin1-induced cytoplasmic heat shock protein 70 translocation into the plasma membrane. Phytomedicine, 2023, 119:154977. (IF: 7.9，1区，TOP)

5.He XM#, Zheng YR#, Tian CY#, Wen T, Yang TJ, Yu JT, Fang XC, Fan CL*, Liu JS*, Yu LZ*. Quassinoids from Eurycoma longifolia with antiviral activities by inhibiting dengue virus replication. Phytomedicine, 2023, 110:154650. (IF: 7.9，1区，TOP)

6.Zheng YR#, Fan CL#, Chen Y#, Quan JY, Shi LZ, Tian CY, Shang X, Xu NS, Ye WC, Yu LZ*, Liu JS*. Anti-inflammatory, anti-angiogenetic and antiviral activities of dammarane-type triterpenoid saponins from the roots of Panax notoginseng. Food Funct, 2022, 13(6):3590-3602. (IF: 6.1, TOP)

7.Zhou SW#, Quan JY#, Li ZW, Ye G, Shang Z, Chen ZP, Wang L, Li XY, Zhang XQ, Li J*, Liu JS*, Tian HY*. Bufadienolides from the eggs of the toad bufo bufo gargarizans and their antimelanoma activities. J Nat Prod, 2021, 84(5):1425-1433. (IF: 5.1，1区，TOP)

8.Gu JH#, Zhang W#, Cai WY, Fu XX, Zhou HL, Li NP, Tian HY, Liu JS*, Ye WC*, Wang L*. Gelserancines A-E, monoterpenoid indole alkaloids with unusual skeletons from Gelsemium elegans. Org Chem Front, 2021, 8(9): 1918-1925. (IF: 5.4)

9.Li NP#, Liu JS#, Liu JW, Tian HY, Zhou HL, Zheng YR, Huang XJ, Cao JQ, Ye WC*, Wang L*. Monoterpenoid indole alkaloids from the fruits of Gelsemium elegans and their anti-inflammatory activities. Bioorg Chem, 2021, 107:104624. (IF: 5.1，1区，TOP)

10.Deng LJ#, Lei YH#, Quan JY#, Li BJ, Zhang DM, Tian HY, Chen Y, Zhang EX, Chen L, Ye WC, Ning WM, Yu LZ*, Liu JS*. 1β-OH-arenobufagin induces mitochondrial apoptosis in hepatocellular carcinoma through the suppression of mTOR signaling pathway. J Ethnopharmacol, 2021, 266:113443. (IF: 5.4，1区，TOP)

11.Cao HH#, Liu DY#, Lai YC, Chen YY, Yu LZ*, Shao M*, Liu JS*. Inhibition of the STAT3 Signaling Pathway Contributes to the Anti-Melanoma Activities of Shikonin. Front Pharmacol, 2020, 11:748. (IF: 5.6)

12.Fan CL#, Zhang YB#, Chen Y#, Xie P, Wang GC, Tian HY, Li YL, Huang XJ, Zhang XQ, Li ZY, Liu JS*, Ye WC*, Chen WM*. Alopecuroides A−E, Matrine-Type Alkaloid Dimers from the Aerial Parts of Sophora alopecuroides. J Nat Prod, 2019, 82(12):3227-3232. (IF: 5.1，1区，TOP)

13.Liu JS#, Huo CY#, Cao HH, Fan CL, Hu JY, Deng LJ, Lu ZB, Yang HY, Yu LZ, Mo ZX*, Yu ZL*. Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling Pathway. Phytomedicine, 2019, 61:152843. (IF: 7.9，1区，TOP)

14.Lu ZB#, Xie P#, Zhang DM, Sun PH, Yang HY, Ye JX, Cao HH, Huo CY, Zhou HL, Chen YY, Ye WC*, Yu LZ*, Liu JS*. 3-Dehydroandrographolide protects against lipopolysaccharide-induced inflammation through the cholinergic anti-inflammatory pathway. Biochem Pharmacol, 2018, 158:305-317. (IF: 5.8)

Liu JS#, Wei XD#, Wu YF, Wang YN, Qiu YW, Shi JM, Zhou HL, Lu ZB, Shao M*, Yu LZ*, Tong L*. Giganteaside D induces ROS-mediated apoptosis in human hepatocellular carcinoma cells through the MAPK pathway. Cell Oncol, 2016, 39(4):333-342. (IF: 6.6)

15.Liu JS#, Zhang DM#, Li Y, Chen WM, Ruan ZX, Tian HY, Deng LJ, Fan CL, Wang Y, Xiao GK, Chen LX*, Ye WC*. Discovery of bufadienolides as a novel class of ClC-3 chloride channel activators with antitumor activities. J Med Chem, 2013, 56(14): 5734-5743. (IF: 6.6，1区，TOP)