师资队伍


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徐伟

发布时间:2019年09月12日 浏览次数:

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姓名: 徐伟

职称: 教授,博士生导师

联系邮箱:xuwei3322@smu.edu.cn

 

 

学习经历:

2006/09-2009/06,中国科学院研究生院,生物技术与医药,博士

2000/09-2003/06,华南农业大学,生物化学与分子生物学,硕士

1996/09-2000/06,湖北农学院,农学,本科

工作经历:

2019/09-至今, 南方医科大学药学院,教授

2017/03-2019/08,广州市第八人民医院,研究员

2015/09-2017/02,美国圣路易斯华盛顿大学医学院,研究科学家

2012/08-2015/08,美国圣路易斯华盛顿大学医学院,博士后

2010/09-2012/07,美国印第安纳大学医学院,博士后

2009/07-2010/08,中科院广州生物医药与健康研究院,助理研究员

2005/09-2006/08,中科院广州生物医药与健康研究院,研究实习员

2003/07-2005/08,广东天普生化医药股份有限公司,项目经理

研究方向:

1.结构导向的靶向药物设计及筛选。

2.病毒感染的结构基础。

3.抗病毒药物设计及其作用机制研究。

主要获奖情况:

广东省杰出青年医学人才,广东省卫生健康委员会,2018

主要科研课题:

1.广东省自然科学基金项目。2018A030313056。靶向埃博拉病毒RNA合成的抗病毒抑制剂的筛选及作用机制研究。2018.5-2021.4。主持。

2.病原微生物生物安全国家重点实验室开放课题。SKLPBS1828。靶向埃博拉病毒NP及VP30蛋白结合界面的抗病毒策略研究。2018.11-2020.10。主持。

3.广州市科技创新委员会。201803040006。广州登革热流行的病原学、媒介控制与临床救治研究。2018.4-2021.3。分项目负责人。

4.广州市科学技术局。201904010477。广谱抗埃博拉病毒单克隆抗体的研究。2019.4-2022.3。主持。

5.广东省生物医药计算重点实验室开放课题。靶向埃博拉病毒VP30的抗病毒小分子化合物研究。2018.9-2020.8。主持。

代表性论文:

1.Yupeng Feng, Chufang Li, Peiyu Hu, Qian Wang, Xuehua Zheng, Yongkun Zhao, Yi Shi, Songtao Yang, Changhua Yi, Ying Feng, Chunxiu Wu, Linbing Qu,Wei Xu, Yao Li, Caijun Sun, Fu George Gao, Xianzhu Xia, Liqiang Feng, Ling Chen. An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques. Emerging Microbes & Infections. 2018,7:101

2.Ying Feng, Xihui Sun, Xianmiao Ye, Yupeng Feng, Jinlin Wang, Xuehua Zheng, Xinglong Liu, Changhua Yi, Mingli Hao, Qian Wang, Feng Li,Wei Xu, Liang Li, Chufang Li, Rong Zhou, Ling Chen, Liqiang Feng. Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity. Virology. 2018,518,272-283

3.Britney Johnson#, Laura A. VanBlargan#,Wei Xu#,James P. White, Chao Shan, Pei-Yong Shi, Rong Zhang, Jagat Adhikari, Michael L.Gross, Daisy W. Leung, Michael S. Diamond, Gaya K. Amarasinghe. Human IFIT3 modulates IFIT1 RNA binding specificity and protein stability. Immunity. 2018,48:1-13

4.Wei Xu,Priya Luthra, Chao Wu, Jyoti Batra, Daisy W. Leung. Christopher F. Basler, Gaya K. Amarasinghe. Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis. Nature Communications. 2017,8:15576.

5.Wei Xu, Megan R. Edwards, Dominika M. Borek, Alicia R. Feagins, Anuradha Mittal, Joshua B. Alinger, Kayla N. Berry, Benjamin Yen, Jennifer Hamilton, Rohit V.Pappu, Tom J. Brett, Daisy W. Leung, Christopher F. Basler, Gaya K. Amarasinghe. Ebola virus VP24 targets a unique NLS-binding site on karyopherin alpha5 to selectively compete with nuclear import of phosphorylated STAT1. Cell Host & Microbe.2014, 16(2):187-200

6.Megan R. Edwards,Britney Johnson,Chad E. Mire,Wei Xu,Reed S. Shabman,Lauren N. Speller,Daisy W. Leung, Thomas W. Geisbert,Gaya K. Amarasinghe,Christopher F. Basler.The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway. Cell Reports.2014, 27;6(6):1017-25

7.Craig S Brown, Michael S Lee, Daisy W Leung, Tianjiao Wang,Wei Xu, Priya Luthra, Manu Anantpadma, Reed S Shabman, Lisa M Melito, Karen S Macmillan, Dominika M Borek, Zbyszek Otwinowski, Parameshwaran Ramanan, Alisha J Stubbs, Dayna S Peterson, Jennifer M Binning, Marco Tonelli, Mark A Olson, Rob Davey, Joseph M Ready, Christopher F Basler, Gaya K Amarasinghe. In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase co-factor activity. J Mol Biol. 2014 15;426(10):2045-58

8.Jennifer M Binning, Tianjiao Wang, Priya Luthra, Reed S Shabman, Dominika M Borek, Gai Liu,Wei Xu, Daisy W Leung, Christopher F Basler, Gaya K Amarasinghe. Development of RNA aptamers targeting Ebola virus VP35. Biochemistry. 2013,26;52(47): 8406-19.

9.Wei Xu, Jingping Lu, Qi-zhuang Ye. Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.J. Med. Chem., 2012,55(18), 8021–8027.

10.Sanling Liu, Jianmei Dong, Guoqiang Mei, Guiyun Liu,Wei Xu, Zhong Su, Jinsong Liu. Crystallization and preliminary crystallographic studies of a cysteine protease inhibitor from the human nematode parasite Ascaris lumbricoides. Acta Cryst. F. 2011. 67, 228–230

11.Wei Xu#, Lina Yi#, Yumei Feng, Ling Chen, Jinsong Liu. Structural Insight into the Activation Mechanism of Human Pancreatic Prophospholipase A2. J Biol Chem. 2009,284,16659-16666.

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