罗昕 博士

粤港澳大湾区脑科学和类脑研究中心教授，博士生导师

电子邮件：xin.luo21@hotmail.com

通讯地址：广东省广州市白云区沙太南路1023号南方医科大学基础医学院（510515）

个人简介

罗昕，香港大学李嘉诚医学院麻醉学系博士，美国杜克大学医学中心麻醉学系博士后。长期从事慢性疼痛发病机理的系统性研究，揭示了巨噬细胞等免疫细胞通过与外周感觉神经元互作调节病理性疼痛的分子机制。已发表SCI论文30余篇，以第一或通讯作者（含共同）在Neuron、Brain, Behavior, and Immunity、Nature Communications、Journal of Neuroscience等杂志发表论文11篇，受邀撰写英文书籍章节1章。获得国家自然科学基金委面上项目、广东省“珠江人才计划-青年拔尖人才”等项目的资助。是中国神经生物学会感觉和运动分会委员、广东省药理学会神经药理委员会委员。担任Frontiers in Pain Research、Frontiers in Pharmacology等学术期刊的编辑或客座编辑。被Neural Regeneration Research杂志评为2018年度优秀审稿人。

研究方向

1. 慢性疼痛的感觉神经-免疫互作调节机制

2. 组织损伤修复的感觉神经-免疫互作调节机制

3. 麻醉药物功能的感觉神经机制

研究关键词

慢性疼痛（Chronic pain）；神经免疫相互作用（Neuroimmune interaction）；巨噬细胞（Macrophage）

研究课题基金

1. 国家自然科学基金委面上项目，项目编号：32371043，2024-2027，主持

2. 广东省“珠江人才计划-青年拔尖人才”项目，项目编号：2021QN02Y169，2022-2025，主持

3. 南方医科大学高层次人才引进启动基金，2022-2027，主持

代表性论著

1.Xin Luo*, Jasmine Ji, Ru-Rong Ji (2023). Sex Differences in Pain with Emphasis on Neuroimmune Interactions. In: Ji, RR., Cheng, J., Ji, J. (eds) Neuroimmune Interactions in Pain . Springer Nature. (*correspondent authors)

2.Xin Luo*, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, Kenta Furutani, Qianru He, Xueshu Tao, Mei-Chuan Ko, Andrey Bortsov, Christopher R Donnelly, Yong Chen, Andrea Nackley, Temugin Berta, and Ru-Rong Ji*. IL-23/IL-17A/TRPV1 Axis Produces Mechanical Pain via Macrophage-Sensory Neuron Crosstalk in Female Mice (2021) Neuron 109: 2691-2706. (*co-correspondent authors) (IF=18.688)

3.Featured in Neuron by Dawes and Bennett (2021)

4.Featured in Neuroscience Bulletin by Tan et al. (2021)

Highlighted in the IASP Pain Research Forum (https://www.painresearchforum.org/news/183436-sex-specific-differences-pain-mechanism)

5.Sangsu Bang#, Christopher R Donnelly#, Xin Luo#, Maria Toro Moreno#, Xueshu Tao, Zilong Wang, Sharat Chandra, Andrey V Bortsov, Emily R. Derbyshire, and Ru-Rong Ji. Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. (2021) Nature Communications 12: 1704. (#co-first authors) (IF=17.694)

6.Jasmine Ji#, Qianru He#, Xin Luo#, Sangsu Bang, Aidan Mcginnis, Andrea G Nackley, and Ru-Rong Ji. Innate-Immune Sensing by Nociceptors IL-23 Enhances C-Fiber-Mediated and Blue Light-Induced Spontaneous Pain in Female Mice (2021) Frontiers in Immunology 12: 5009. (#co-first authors) (IF=8.786)

7.Christopher R Donnelly, Changyu Jiang, Amanda S Andriessen, Kaiyuan Wang, Zilong Wang, Huiping Ding, Junli Zhao, Xin Luo, Michael S Lee, Yu L Lei, William Maixner, Mei-Chuan Ko, Ru- Rong Ji. (2021) STING controls nociception via type I interferon signaling in sensory neurons. (2021) Nature 591(7849): 275-280. (IF=69.504)

8.Xin Luo*, Yul Hul, Sangsu Bang, Qianru He, Linlin Zhang, Megumi Matsuda, and Ru-Rong Ji*. Macrophage TLR9 Contributes to Chemotherapy-induced Neuropathic Pain in Male Mice. (2019) Journal of Neuroscience 39(35): 6848-6864. (*co-correspondent authors) (IF=6.709)

9.Xin Luo, Yun Gu, Xueshu Tao, Charles N Serhan, Ru-Rong Ji. Resolvin D5 inhibits neuropathic pain and inflammatory pain in male but not female mice: Distinct sex-dependence of D-series resolvins in pain regulation (2019) Frontiers in Pharmacology 10: 745. (IF=5.988)

10.Xin Luo*, Bethany Fitzsimmons, Apoorva Mohan, Linlin Zhang, Niccolo Terrando, Holly Kordasiewicz, Ru-Rong Ji*. Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice. (2018) Brain, Behavior, and Immunity 72: 34-44 (*co-correspondent authors). (IF=19.277)