郭家松 博士

三级教授、博士生导师

教研室副主任

电子邮件:jiasongguo@smu.edu.cn

电 话：020-61648211

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

南方医科大学基础医学院组胚学教研室（国家重点学科）副主任、三级教授、博士生导师和博士后合作导师。

2003年博士毕业于中山大学，先后到香港大学和美国范德堡大学从事博士后工作。现任中国解剖学会再生医学分会副主任委员、中国解剖学会组胚分会委员、中国研究型医院学会神经再生与修复专业委员会常委兼基础学组副组长、广东省解剖学会常务理事、广东省脑发育与脑病防治学会干细胞分会副主委、Neural Regeneration Research（IF=6.058）、中国临床解剖学杂志、中国组织化学与细胞化学杂志等期刊编委、Advanced Science等50余个SCI杂志的审稿人。国家重点研发项目、国家自然科学基金以及安徽、浙江、陕西、湖南等多个省的自然基金项目评审专家。

主持国家自然科学基金面上项目6项，作为子课题负责人参与科技部973项目、中国脑计划（2030-“脑科学与类脑研究”重大项目）及广东省自然基金团队项目等。在Annals of Neurology等期刊发表SCI论文60余篇，获授权专利8项，主编教材6本、副主编或参编教材或专著21本。曾评为解放军总后优秀教师和广东省高校千百十人才计划省级对象。

2009.12- 现在南方医科大学组织学与胚胎学教研室教授

2010.04-2012.03 美国Vanderbilt 大学神经学系博士后

2007.08-2007.12 香港大学解剖学系访问学者

2005.02-2006.08 香港大学解剖学系访问学者

2004.08-2009.12南方医科大学组织胚胎学教研室副教授

2000.09-2003.06 中山大学中山医学院，博士

1997.05-2004.08 原第一军医大学分校解剖组胚学教研室讲师

1995.05-1997.05 原解放军广州医高专解剖组胚学教研室助教

1992.09-1995.05 南昌大学生命科学学院，硕士

1988.09-1992.06 原江西大学生物学系，本科

研究方向

神经损伤与再生相关,干细胞与组织工程

研究关键词

神经损伤，再生，轴突， 髓鞘， 施万细胞， 干细胞， 组织工程

代表性论著

1. Liu J, Ma X, Hu X, Wen J, Zhang H, Xu J, He Y, Wang X, Guo J(郭家松)*. Schwann cell-specific RhoA knockout accelerates peripheral nerve regeneration via promoting Schwann cell dedifferentiation. Glia, 2023, Accepted

2. Li M, Xu J , Zou Y, Lu J, Ou A, Ma X, Zhang J, Xu Y, Fu L, Liu J, Wang X, Zhou L, Guo J(郭家松)*. Motor neuron specific RhoA knockout delays degeneration and promotes regeneration of dendrites in spinal ventral horn after brachial plexus injury. Neural Regeneration Research, 2023 Accepted

3. Hu X, Xu Y, Xu Y, Li Y, Guo J(郭家松)*. Nanotechnology and nanomaterials in peripheral nerve repair and reconstruction. Nanomedicine, Edited by Gu N. Springer 2023, ISBN: 978-981-16-8984-0

4. Xu J, Fu L, Deng J, Zhang J, Zou Y, Liao L, Ma X, Li Z, Xu Y, Xu Y, Xu S, Liu J, Wang X, Ma X, Guo J(郭家松)*. miR-301a Deficiency Attenuates the Macrophage Migration and Phagocytosis through YY1/CXCR4 Pathway. Cells. 2022 Dec 7;11(24):3952. doi: 10.3390/cells11243952. PMID: 36552718; PMCID: PMC9777533.

5. Hu X, Zhang P, Liu J， Guan H, Xie R, Cai L, Guo J(郭家松), Wang L, Tian Y*, Qiu X*. A Self-Association Cross-Linked conductive zwitterionic hydrogel as a myocardial patch for restoring cardiac function. Chemical Engineering Journal, 2022 Oct 15. 446 (2), 136988. doi.org/10.1016/j.cej.2022.136988

6. Yang L, Ren Z, Yan S, Zhao L, Liu J, Zhao L, Li Z, Ye S, Liu A, Li X, Guo J(郭家松), Zhao W, Kuang W, Liu H, Chen D. Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation. Commun Biol. 2022 May 25;5(1):495. doi: 10.1038/s42003-022-03420-x.

7. Jiang C, Liu C, She Z, Tan R, Wang D, Liang J, Zheng H, Guo J(郭家松)*, Zhu L*. Application of collagen-chondroitin sulfate scaffolds with different pore sizes combined with acidic fibroblast growth factor in repairing full thickness skin defects in nude mice. Biomed Mater. 2022 Oct 17;17(6). doi: 10.1088/1748-605X/ac95e8

8. Xie C, Wang Y, Wang J, Xu Y, Liu H, Guo J(郭家松)*, Zhu L*. Perlecan Improves Blood Spinal Cord Barrier Repair Through the Integrin β1/ROCK/MLC Pathway After Spinal Cord Injury. Molecular Neurobiology. 2022 Oct 10. doi: 10.1007/s12035-022-03041-9.

9. Liu C, Peng Z, Xu H, Gao H, Li J, Jin Y, Wang Y, Wang C, Liu Y, Hu Y, Jiang C,Guo J(郭家松)*, Zhu L*. 3D print Platelet-rich plasma loaded scaffold with sustained cytokine release for bone defect repair. Tissue Eng Part A. 2022 Feb 12. doi: 10.1089/ten.TEA.2021.0211.

10. Zou Y, Zhang J, Liu J, Xu J, Fu L, Ma X, Xu Y, Xu S, Wang X, Guo J(郭家松)*. SIRT6 Negatively Regulates Schwann Cells Dedifferentiation via Targeting c-Jun During Wallerian Degeneration After Peripheral Nerve Injury. Molecular Neurobiology. 2022 Jan;59(1):429-444. doi: 10.1007/s12035-021-02607-3.

11. Liu J, Li L, Fu L, Zhang H, Xu Y, Zou Y, Ma X, Xu J, Zhang J, Li M, Hu X, Li Z, Wang X, Sun H, Zheng H, Zhu L, Guo J (郭家松) *，Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury，Neural Regeneration Research, 2022 Mar;17(3):673-681. doi: 10.4103/1673-5374.320997.

12. Xu H, Wang C, Liu C, Li J, Peng Z, Guo J (郭家松) *, Zhu L*. Stem Cell-Seeded 3D-Printed Scaffolds Combined with Self-Assembling Peptides for Bone Defect Repair.Tissue Eng Part A. 2022 Feb;28(3-4):111-124. doi: 10.1089/ten.TEA.2021.0055.

13. Xu J, Wen J, FuL, LiaoL, ZouY, ZhangJ, DengJ, ZhangH, LiuJ, WangX, ZuoD, Guo J(郭家松)*, Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice. J Neuroinflammation.2021:18, 234.doi: 10.1186/s12974-021-02292-y

14. Zou Y, Zhang J, Xu J, Fu L, Xu Y, Wang X, Li Z, Zhu L, Sun H, Zheng H, Guo J(郭家松)*.SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages. Cell and Bioscience. 2021:11:210 Dec 14. doi: 10.1186/s13578-021-00725-y

15. Zhang Z, Rong Z, Wu G, Wang Y, Tan Z, Zheng J, Jin Y, Liang Z, Liu C, Guo J(郭家松)*, Zhu L*. Gelatin-CaO₂/SAP/PLGA composite scaffold enhances the reparation of critical-sized cranial defects by promoting seed cell survival. Applied Materials today. 2021:22 Mar; doi.org/10.1016/j.apmt.2021.100960

16. Xu H#, Wang C#, Liu C#, Peng Z, Li J, Jin Y, Wang Y, Guo J(郭家松)*, Zhu L*. Cotransplantation of mesenchymal stem cells and endothelial progenitor cells for treating steroid-induced osteonecrosis of the femoral head. Stem Cells Translational Medicine. 2021 May;10(5):781-796. doi: 10.1002/sctm.20-0346.

17. Wang C#, Xu H#, Liu C#, Peng Z, Min R, Zhang Z, Li J, Jin Y, Wang Y, Li Z, Guo J(郭家松)*, Zhu L*. CaO2/Gelatin Oxygen Slow-Releasing Microspheres Facilitate Tissue Engineering Efficiency for Osteonecrosis of Femoral Head via Enhancing Angiogenesis and Survival of Grafted Bone Marrow Mesenchyml Stem Cells, Biomaterials Science, 2021 Apr 21;9(8):3005-3018. doi: 10.1039/d0bm02071k

18. Peng Z, Wang C, Liu C, Xu H, Wang Y, Liu Y，Hu Y，Li J, Jin Y, Jiang C, Liu L, Guo J(郭家松)*, Zhu L*. 3D printed Polycaprolactone/ beta-tricalcium phosphate/ magnesium peroxide oxygen releasing scaffold enhances osteogenesis and implanted BMSCs survival in repairing large bone defect. Journal of Materials Chemistry B，2021 Jul 21;9(28):5698-5710. doi: 10.1039/d1tb00178g

19. Li L, Xu Y, Wang X, Hu X, Tan D, Li Z, Guo J (郭家松) *. Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury, Neural Regeneration Research, 2021 Jun;16(6):1078-1085. doi: 10.4103/1673-5374.300459

20. Hu X, Wang X, Xu Y, Li L, Liu J, He Y, Zou Y, Yu L, Qiu X, Guo J(郭家松) *.Electric Conductivity on Aligned Nanofibers Facilitates the Transdifferentiation of Mesenchymal Stem Cells into Schwann Cells and Regeneration of Injured Peripheral Nerve，Advanced Healthcare Materials,2022 Jun;9(11):e1901570:1-12. doi: 10.1002/adhm.201901570

21. Bu Y^#, Wang X^#, Li L, Hu X , Tan D, Li Z, Lai M, Qiu X, Sun F, Wang H, Yang F*, Wu D*, Guo J(郭家松) *. Lithium loaded octa-poly(ethylene glycol) based adhesive facilitates axon regeneration and reconnection of transected peripheral nerves. Advanced Healthcare Materials, 2020 Jul;9(13):e2000268:1-12；doi:10.1002/adhm.202000268.

22. Lai M^#, Pan M^#,, Ge L, Liu J, Deng J, Wang X, Li L, Wen J, Tan D, Zhang H, Hu X, Fu L, Xu Y, Li Z, Qiu X, Chen G, Guo J(郭家松)*. NeuroD1 overexpression in spinal neurons accelerates axonal regeneration after sciatic nerve injury. Experimental Neurology. 2020 Jan 25;327:113215. doi: 10.1016/j.expneurol.2020.113215.

23. Tan D, Zhang H, Deng J, Liu J, Wen J, Li L, Wang X, Pan M, Hu X, Guo J(郭家松)*. RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin. Cells. 2020 Jan 16;9(1):230. doi: 10.3390/cells9010230

24. Li L#, Li Y#，Fan Z#，Wang X, Li Z, Wen J, Deng J, Tan D, Pan M, Hu X, Zhang H, Lai M, Guo J (郭家松)*.Ascorbic acid facilitates neural regeneration after sciatic nerve crush injury. Frontiers in Cellular Neuroscience. 2019 Mar 21;13:108. doi: 10.3389

25. Yang M, Liu H, Wang Y, Wu G, Qiu S, Liu C,Tan Z, Guo J(郭家松)*, Zhu L*. Hypoxia reduces the osteogenic differentiation ofperipheral blood mesenchymal stem cells by upregulating Notch-1 expression, Connective Tissue Research. 2019 Nov;60(6):583-596. doi: 10.1080/03008207.2019.1611792

26. Liu H, Yang M, Wu G, Yang L, Cao Y, Liu C, Tan Z, Jin Y, Guo J(郭家松)*, Zhu L*. Effectsof different oxygen concentrations on the proliferation, survival, migration, andosteogenic differentiation of MC3T3-E1 cells. Connective Tissue Research. 2019 May;60(3):240-253. doi: 10.1080/03008207

27. Tan D, Wen J, Li L, Wang X, Qian C, Pan M, Lai M, Deng J, Hu X, Zhang H, Guo J(郭家松)*.Inhibition of RhoA-Subfamily GTPases Suppresses Schwann Cell Proliferation Through Regulating AKT Pathway Rather Than ROCK Pathway. Frontiers in Cellular Neuroscience. 2018 Nov 20;12:437. doi: 10.3389/fncel.2018.00437.

28. Wen J, Tan D, Li L, Wang X, Pan M, Guo J(郭家松)*. RhoA regulates Schwann cell differentiation through JNK pathway. Experimental Neurology, 2018 Oct;308:26-34.

29. Zhang Z, Wu G, Yang L, Cao Y, Liu C, Jin Y, Wang Y, Yang L, Guo J(郭家松)*, Zhu L*.Self-assembling peptide and nHA/CTS composite scaffolds increase seed cell adhesion and promote femoral condylar bone regeneration. Materials Science & Engineering C, 2018 Dec 1, 93：445-454

30. Qian C^#, Tan D^#, Wang X, Li L, Wen J, Pan M, Li Y, Wu W, Guo J(郭家松)*.Peripheral nerve injury induced astrocyte activation in spinal ventral horn contributes to nerve regeneration, Neural Plasticity. 2018 Apr 3;doi: 10.1155/2018/8561704.

31. Wen J, Qian C, Pan M, Wang X, Li Y, Lu Y, Zhou Z, Yan Q, Li L, Liu Z, Wu W, Guo J(郭家松)*. Lentivirus-Mediated RNA Interference Targeting RhoA Slacks the Migration, Proliferation, and Myelin Formation of Schwann Cells. Molecular Neurobiology, 2017; 54(2): 1229-1239.

32. Pan M, Wang X, Chen Y, Cao S, Wen J, Wu G, Li Y, Li L, Qian C, Qin Z, Li Z, Tan D, Fan Z, Wu W, Guo J(郭家松)*. Tissue engineering with peripheral blood-derived mesenchymal stem cells promotes the regeneration of injured peripheral nerves. Experimental Neurology, 2017 Jun;292:92-101. doi: 10.1016/j.expneurol.2017.03.005，

33. Zeng Y, Cheng S, Lin X, Hu X, Wang X, Guo J(郭家松)*. A Mini Review on the Progress of Using Extracts of Traditional Chinese Medicines (Tcm) to Facilitate the Peripheral Nerve Regeneration. Biomed J Sci&Tech Res 5(5)- 2018. BJSTR.MS.ID.001269.DOI: 10.26717/ BJSTR.2018.05.001269.

34. Wen J, Li L, Tan D, Guo J(郭家松)*. Preparation of Teased Nerve Fibers from Rat Sciatic Nerve. Bio-protocols，2017; 7(19) DOI:10.21769/BioProtoc.2572.

35. Wen J, Tan D, Li L, Guo J(郭家松)*. Isolation and Purification of Schwann Cells from Spinal Nerves of Neonatal Rat. Bio-protocols，2017; 7(20) DOI:10.21769/BioProtoc.2588. ,

36. Qin ZQ, Zheng H, Zhou L, Ou YH, Huang B, Yan B, Qin ZS, Yang CL, Su YC, Bai XC*,Guo J(郭家松)*, Lin J*. Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins. Scientific Reports, 2016 Jan 22;6:19587. doi: 10.1038/srep19587

37. Qian CH, Wen JK,Guo J(郭家松)*. Inhibiting the RhoA signaling pathway promotes regeneration of axons and myelin sheath. Neural Regen Res. 2015; 10(12):1957.

38. Wang XH, Guo J(郭家松)*. Significance and strategy of promoting seed cell survival in tissue-engineered artificial nerve construction. Neural Regen Res. 2015; 10(11):1795.

39. Wu G, Pan M, Wang X, Wen J, Cao S, Li Z, Li Y, Qian C, Liu Z, Wu W, Zhu L*,Guo J(郭家松)*. Osteogenesis of peripheral blood mesenchymal stem cells in self assembling peptide nanofiber for healing critical size calvarial bony defect，Sci Rep, 2015; 5:16681. doi: 10.1038/srep16681.

40. Guo J(郭家松)*, Qian CH, Ling EA, Zeng YS*. Nanofiber scaffolds for treatment of spinal cord injury. Current Medical Chemistry. 2014; 21:4282-4289.

41. Wang XH, Pan MJ, Wen JK, Tang YJ, Hamilton AD, Li YY, Qian CH, Liu ZY, Wu WT,Guo J(郭家松)*. A novel artificial nerve graft for repairing long-distance sciatic nerve defects: a self-assembling peptide nanofiber scaffold-containing poly(lactic-co-glycolic acid) conduit. Neural Regen Res. 2014; 9(24):2132-2141.

42. Zhan XD, Gao MY, Jiang YW, Zhang WW, Wong WM, Yuan Q, Su H, Kang X, Dai X, Zhang W, Guo J(郭家松)*, Wu W*. Nanofiber nerve scaffolds facilitate functional regeneration of peripheral nerve injury, Nanomedicine-Nanotechnology Biology and Medicine, 2013;9(3):305-315.

43. Zhang WW, Zhan XD, Gao MY, Hamilton AD, Liu ZY, Jiang Y, Su H, Dai X, He B, Kang XN, Zeng YS, Wu W*, Guo J(郭家松)*. Self assembling peptide nanofiber scaffold enhanced with RhoA inhibitor CT04 improves axonal regeneration in the transected spinal cord，Journal of Nanomaterials, 2012; doi:10.1155/2012/724857.

44. Kang XN, Wen JK, Wang XH, Pan MJ, Zhang WW, Zhan XD, Liu ZY, Wu WT, Guo J(郭家松)*. Temporal and spatial pattern of RhoA expression in injured spinal cord of adult mice. J South Med Univ. 2013; 33(4):463-468.

45. Guo J(郭家松), Wang L, Zhang Y, Wu J, Arpag S, Hu B, Imhof BA, Tian X, Carter BD, Suter U, Li J*. Abnormal junctions and permeability of myelin in PMP22-deficient nerves. Annals of Neurology.2014; 75(2):255-265.

46. Guo J(郭家松), Ma YH, Yan Q, Wang L, Zeng YS, Wu JL, Li J*. Fig4 Expression in the Nervous System and Its Protection against Abnormal Lysosomal Accumulation. Journal of Neuropathology and Experimental Neurology, 2012;71(1),28-39.

47. Guo J(郭家松), Leung KKG, Su H, Yuan QJ, Wang L, Chu TH, Zhang W, Pu JKS, Ng GKP, Wong WM, Dai X, Wu WT*. Self assembling peptide nanofiber scaffold promotes the reconstruction of acutely injured brain. Nanomedicine-Nanotechnology Biology and Medicine, 2009; 5(3):345-351

48. Guo J(郭家松), Su H, Zeng Y, Liang YX, Ellis-Behnke RG, So KF, Wu W*. Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold. Nanomedicine-Nanotechnology Biology and Medicine, 2007; 3(4):311-321.

49. Guo J(郭家松), Zeng YS*, Li HB, Huang WL, Liu RY, Li XB, Ding Y, Wu LZ, Cai DZ. Cotransplant of neural stem cells and NT-3 genetically modified Schwann cells promote the recovery transected spinal cord injury. Spinal Cord, 2007; 45(1): 15-24.

50. Guo J(郭家松), Zeng Y, Liang YX, Wang L, Su H, Wu W*. Cyclosporine affects the proliferation and differentiation of neural stem cells in culture. Neuroreport, 2007;18(9):863-868.Cover story

51. Guo J(郭家松), So KF, Wu W. Self assembling peptides mediate neural regeneration. In So KF, Xu XM. Edited《Neural Regeneration》 Elsevier, 2015

52. Guo J(郭家松), Leung KKG, Wu W. Bridging the Gap for Regeneration after CNS Injury by Nanofiber Scaffolds: use of SAPNS for Traumatic Brain and Spinal Cord Injury. In Martin CR, Preedy VR, Hunter RJ, edited 《Nanomedicine and the Nervous System》. Science Publishers, New York, 2012:330-346

53. Li X, Xie Y, Li K, Wu A, Xie H, Guo Q, Xue P, Maleshibek Y, Zhao W, Guo J(郭家松), Chen D*. Antioxidation and Cytoprotection of Acteoside and Its Derivatives: Comparison and Mechanistic Chemistry. Molecules. 2018;23(2). pii: E498.doi: 10.3390/ molecules23020498

54. Yuan Q, Su H, Guo J(郭家松), Wu W*, Lin ZX*. Induction of phosphorylated c-Jun in neonatal spinal motoneurons after axonal injury is coincident with both motoneuron death and regeneration. Journal of Anatomy. 2014; 224(5):575-582.

55. Zhang Y, Zhao S, Dong W, He S, Wang H, Zhang L, Tang Y, Guo J(郭家松), Guo S. Cloning and bioinformatical analysis of the N-terminus of the sonic hedgehog gene. Neural Regen Res. 2013 Jan 25;8(3):258-63. doi: 10.3969/j.issn.1673-5374.2013.03.008.

56. Peltier AC, Myers MI, Artibee KJ, Hamilton AD, Yan Q,Guo J(郭家松), Shi Y, Wang L, Li J*. Evaluation of dermal myelinated nerve fibers in diabetes mellitus. Journal of the Peripheral Nervous System. 2013;18(2):162-167

57. Li J*, Parker B, Martyn C, Natarajan C, Guo J(郭家松). The PMP22 Gene and Its Related Diseases (invited review), Mol Neurobiol, 2013;47(2):673-698

58. Gao MY, Guo J(郭家松), Leung GKK, Wu W. Use of Self-Assembly Nanofibre Biomaterials for Neural Repair After Injury, in《Advances in Nanofibers》, In Tech, 2013: 185-197

59. Yan Q, Guo J(郭家松), Zhang X, Bai Y, Wang L, Li J*. Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice. Journal of the Neurological Sciences, 2012; 312(1-2):102-107.

60. Yuan Q, Su H,Guo J(郭家松), Tsang KY, Cheah KS, Chiu K, Yang J, Wong WM, So KF, Huang JD, Wu W*, Lin ZX*. Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush. Experimental Gerontology, 2012; 47(4),329-336.

61. Wang C, Xie J, Guo J(郭家松), Manning HC, Gore JC, Guo N*. Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer. Oncol Rep, 2012; 28(4),1301-1308.

62. Su H, Wu Y, Yuan Q, Guo J(郭家松), Zhang W, Wu W*. Optimal time point for neuronal generation of transplanted neural progenitor cells in injured spinal cord following root avulsion. Cell Transplant, 2011; 20(2),167-176

63. Li X, Su H, Fu QL,Guo J(郭家松), Lee DH, So KF*, Wu W*. Soluble NgR Fusion Protein Modulates the Proliferation of Neural Progenitor Cells via the Notch Pathway. Neurochemistry Research, 2011; 36(12),2363-2372.

64. Katona I, Zhang X, Bai Y, Shy ME,Guo J(郭家松), Yan Q, Hatfield J, Kupsky WJ, Li J*. Distinct pathogenic processes between Fig4-deficient motor and sensory neurons. European Journal of Neuroscience, 2011; 33(8),1401-1410.

65. Ellis-Behnke RG*, Liang Y X,Guo J(郭家松), Tay D KC, Schneider GE, Teather LA, Wu W, So KF*. Forever Young: How to Control the Elongation, Differentiation, and Proliferation of Cells Using Nanotechnology. Cell Transplantation, 2009; 18(9): 1047-1058

66. Su H, Zhang W, Guo J(郭家松), Guo A, Yuan Q, Wu W*. Neural progenitor cells enhance the survival and axonal regeneration of injured motoneurons after transplantation into the avulsed ventral horn of adult rats. J Neurotrauma, 2009; 26(1): 67-80.

67. Su H, Zhang W, Guo J(郭家松), Guo A, Yuan Q, Wu W*. Lithium enhances the neuronal differentiation of neural progenitor cells in vitro and after transplantation into the avulsed ventral horn of adult rats through the secretion of brain-derived neurotrophic factor. Journal of Neurochemistry, 2009;108：1385-1398.

68. Mi S*, Hu B, Hahm K, Luo Y, Hui SK, Yuan Q, Wong W, Wang L, Su HX, Chu TH, Guo J(郭家松), Zhang WM, So KF, Pepinsky B, Shao ZH, Graff C, Garber E, Jung V, Wu XK, Wu W*. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nature Medicine, 2007;13(10):1228-1233 Cover story

69. Mi S*, Hu B, Hahm K, Luo Y, Hui SK, Yuan Q, Wong WM, Wang L, Su HX, Chu TH, Guo J(郭家松), Zhang WM, So KF, Pepinsky B, Shao ZH, Graff C, Garber E, Jung V, Wu XK, Wu W*: Rodent EAE model for the study of axon integrity and remyelination. Nature Protocols, 2007;DOI:10.1038 /nprot.2007.389

70. Zeng YS, Ding Y, Wu LZ, Guo J(郭家松), Li HB, Wong WM, Wu WT*. Co-transplantation of schwann cells promotes the survival and differentiation of neural stem cells transplanted into the injured spinal cord. Developmental Neuroscience. 2005; 27(1): 20-26.

代表性课题

1. 国家自然科学基金委员会，面上项目，82271393, SIRT6通过SREBPs/FDFT1信号通路调控周围神经髓鞘形成的作用及机制研究,2023-01至2026-12，在研，主持

2. 科技部科技创新2030-“脑科学与类脑研究”重大项目，2022ZD0204700，胶质细胞在中枢神经系统稳态和功能维持中的作用， 2022.8-2027.7，在研，项目骨干

3. 广东省自然科学基金委员会，面上项目，2023A15150117，巨噬细胞特异性敲除FDFT1对神经损伤修复的影响及机制研究，2023-01至2025-12，在研，主持

4. 国家自然科学基金委员会，面上项目，82071386，miR301a通过PTEN和RUNX3信号通路影响周围神经髓鞘形成的作用及机制研究，2021-01至2024-12，在研，主持

5. 广东省自然科学基金委员会，团队项目，2017A030312009，中药小分子调控iPSCs成软骨分化的网络共激活机制，2017-5至2023-5，300万，在研，子课题负责人

6. 国家自然科学基金委员会，面上项目，81870982，RhoA调控施万细胞微管动态及其在髓鞘化过程的作用与机制研究，2019-01至2022-12，结题，主持

7. 国家自然科学基金委员会，面上项目，81571182，维生素C对周围神经损伤修复的作用及机制研究，2016-01至2019-12，结题，主持

8. 国家自然科学基金委员会，面上项目，81371354，抑制RhoA表达与活化对周围神经缺损后再生轴突髓鞘化的作用及机制研究， 2014-01至2017-12， 结题，主持

9. 国家自然科学基金委员会，面上项目，30973095, 自聚合肽纳米材料介导siRNA干扰RhoA表达促进脊髓损伤修复的实验研究, 2010-01至2012-12，结题，主持

10. 国家科技部，国家重点基础研究计划（973计划）项目，2014CB542202，周围神经损伤及修复后神经再生与中枢神经重塑的机制研究，2014-1至2018-12,结题，子课题负责人

11. 广州再生医学与健康广东省实验室，重点研发项目，2018GZR110104008，基于EMET理论研究细胞命运转换的具体机制； 2018-12至2021-12，结题，子课题负责人

12. 广东省科技厅，省科技计划项目，2015A020212024，基于外周血间充质干细胞与仿生胶原支架材料构建人工神经修复周围神经缺损的研究，2016-01至2018-12，结题，主持

13. 广东省重大精神疾病研究重点实验室,开放课题，N201904，microRNA 301a对髓鞘致密结构的调控及机制研究，2019-11至2021-10，结题，主持

14. 广东省自然科学基金委员会，面上项目，S2013010014697，RhoA信号通路在施万细胞再髓鞘化中的作用及机制研究，2013-10至2015-10，结题，主持

15. 广东省高层次人才专项基金, 2050205, 外周血源性基质干细胞与自聚合肽纳米纤维材料构建人工神经的研究,2012/1至2014/12,结题，主持

学术任职

中国解剖学会再生医学分会副主委

创伤救治与神经再生教育部重点实验室学术委员会委员

中国研究型医院学会神经再生与修复专业委员会常委

中国研究型医院学会神经再生与修复专业委员会基础学组副组长

中国解剖学会组织学与胚胎学分会委员

广东省解剖学会常务理事

广东省脑发育与脑病防治学会干细胞分会副主委

《Neural Regeneration Research》(IF=6.058)编委

《中国临床解剖学杂志》编委

《中国组织化学与细胞化学杂志》编委

广州再生医学与健康广东省实验室双聘教授

南方医科大学珠江医院脊柱外科双聘教授

广东省组织构建与检测重点实验室副主任

广东省骨科研究院骨生物学研究所副所长

执教课程（课程及教材建设）

1. 主编，组织学与胚胎学实验教程， 华中科技大学出版社， 2023

2. 主编，人体解剖与组织胚胎学（第五版），科学出版社， 2023，ISBN978-7-03-072202-7

3. 主编，组织学与胚胎学（第三版），科学出版社，2018.6 ISBN978-7-03-057677-4, 29.6万字

4. 主编，组织学与胚胎学同步精讲精炼，世界图书出版社，2018.11 ISBN978-7-5192-4948-9 36.9万字

5. 主编，形态实验学，中国科技文献出版社，2019.3 ISBN978-7-5189-5390-5, 14万字

6. 主编，组织学与胚胎学，中国科技文献出版社，2019.12ISBN978-7-5189-6387-4, 46.5万字

7. 副主编，组织学与胚胎学（电子书包），曾园山主编，人民军医出版社，2015.9

8. 副主编，组织学与胚胎学要点提示与习题，白咸勇主编， 人民军医出版社，2007.7

9. 副主编，人体结构学，尹保国主编，广东科技出版社， 2004.9

10. 参编，组织学与胚胎学（长学制，第4版），人民卫生出版社， 李和主编，2021

11. 参编，组织学与胚胎学（英文版），科学出版社， 李和主编，2020

12. 参编，人体形态学，人民卫生出版社， 李和主编，2020

13. 参编，中国大百科全书第三版，大百科全书出版社， 曾园山主编，2018

14. 参编，再生医学第二版，人民卫生出版社， 丁斐， 刘伟， 顾晓松主编，2017

15. 参编，组织学与胚胎学实验指导彩色图谱及微视频，人民卫生出版社卢晓晔，夏潮涌主编，2017

16. 参编，临床实用基础组织学图谱，人民卫生出版社，周莉主编，2018

17. 参译，格氏解剖学中文版，山东科技出版社，丁自海主编，2017

18. 参编，八年制《组织学与胚胎学》网络版(PPT、视频). 人民卫生出版社，李和主编，2015

19. 参编，组织胚胎学学习要点与习题集，人民卫生出版社， 李和主编，2015

20. 参编，人体组织学数字切片图谱，董为人、马保华、李和主编， 西安交通大学出版社，2015.6

21. 参编，再生医学，丁斐、刘伟、顾晓松主编，人民卫生出版社， 2012.3

22. 参编，组织胚胎学实验指导与对照图谱，段斐主编,中国科学技术出版社， 2011.10

23. 参编，组织学与胚胎学（第二版），曾园山主编，科学出版社， 2010.6

24. 参编，发育生物学学习指导与习题集，李质馨主编，人民卫生出版社， 2010.3

25. 参编，组织学与胚胎学，牟兆新主编，人民军医出版社， 2007.7

荣誉奖励

1. 解放军总后优秀教师 2004

2. 广东省高校千百十人才计划（省级） 2010

3. 南方医科大学教学优秀一等奖 2004

4. 第一军医大学教学优秀二等奖 1998，2018