邓凡 博士

教授，博士生导师

教研室主任

电子邮件:fandeng@smu.edu.cn

电话：020-61647073

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

南方医科大学基础医学院细胞生物学教研室主任，博士，教授，博士生导师。美国匹兹堡大学医学院博士后。现任广东省细胞生物学学会常务理事、泌尿生殖协会转化医学分会常务理事，中国细胞生物学学会会员。担任国家自然科学基金函审专家和肿瘤学组二审专家。以第一作者或通讯作者在国际主流杂志发表论文近20篇，包括Cancer Res，Cell Mol life Sci, J Cell Sci, J Exp & Clin Cancer Res等, 单篇最高引用100余次。

研究方向

1.前列腺癌免疫微环境与肿瘤血管新生、肿瘤转移及休眠；

2.肿瘤代谢与肿瘤恶性进展

研究关键词

前列腺癌（prostate cancer）; 肿瘤微环境（tumor microenvironment）; 肿瘤血管新生（tumor angiogenesis）; 肿瘤转移与休眠（tumor metastasis & tumor dormancy）; 肿瘤代谢（tumor metabolism）

代表性论著

1.Xu W, Qian J, Zeng F, Li S, Guo W, Chen L, Li G, Zhang Z, Wang QJ, Deng F. Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment. J Exp Clin Cancer Res. 2019, 38(1):114 IF:11.161;小类二区；2019

2. Chen J#, Deng F#, Singh SV, Wang QJ. Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2. Cancer research. 2008;68(10):3844-53 （IF:8.378, JCR 一区）

3. Wanfu Xu#, Fangyin Zeng#, Songyu Li#, Guihuan Li, Xiaoju Lai, Q. Jane Wang, Fan Deng. Crosstalk of Protein kinase C ε with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis. Cellular and Molecular Life Sciences.2018 ;75（24）：4583-4598 ( IF: 6.496JCR二区).

4. Wanfu Xu#, Jiabi Qian#, Fangyin Zeng#, Songyu Li, Wenjing Guo, Liping Chen, Guihuan Li, Zhishuai Zhang, Qiming Jane Wang, Fan Deng*; Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment. Journal of Experimental & Clinical Cancer Research. 2019 Mar 6; 38(1):114. doi: 10.1186/s13046-019-1118-y. ( IF: 7.068, JCR二区).

5. Qu Q, Zeng F, Liu X, Wang QJ, Deng F. Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer. Cell death & disease. 2016;7:e2226(IF:6.304，JCR二区).

6. Zhicong Wu#, Hua Chen#, Yanling Liang, Wenyang Luo, Fan Deng*, Fangyin Zeng*. Alternative splicing implicated in immunity and prognosis of colon adenocarcinoma. International Immunopharmacology. 2020, 89,107075.( IF:3.943, JCR 二区) .

7. Zhicong Wu, Hua chen, Wenyang Luo, Hanyun zhang, Guihuan Li, Fangyin Zeng*, Fan Deng*. The landscape of immune cells infiltrating in prostate cancer. Frontiers in Oncology. 2020 Sep 20;10:544288.doi: 10.3389/fonc.2020.544288 (IF: 4.848, JCR 三区).

8. Wenjing Guo#, Zhishuai Zhang#, Guihuan Li, Xiaoju Lai, Ruonan Gu, Wanfu Xu, Hua Chen, Zhe Xing, Liping Chen, Jiabi Qian, Shiyuan Xu, Fangyin Zeng*, Fan Deng*. Pyruvate kinase M2 promotes prostate cancer metastasis through regulating ERK1/2-COX-2 signaling. Frontiers in Oncology. 2020 Sep 20;10:544288.doi: 10.3389/fonc.2020.544288 (IF: 4.848, JCR 三区).

9. Zou Z*, Zeng F*, Xu W, Wang C, Ke Z, Wang QJ, Deng F. PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-κB- and HDAC1-mediated expression and activation of uPA. J Cell Sci. 2012 Oct 15;125(Pt 20):4800-11(IF:4.573，JCR 三区).

10. Ling Li#, Liang Hua#, Huihui Fan, Yu He, Wanfu Xu, Lin Zhang, Jie Yang, Fan Deng*, Fang-yin Zeng*. Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells. Journal of Cancer . 2019;10(25):6395-6404(* co-corresponding author, IF: 3.565 ,JCR三区).

11. Zhibin Huang #, Guihuan Li #, Zhishuai Zhang#, Ruonan Gu, Wenyang Wang, Xiaoju Lai, Zhong-Kai Cui, Fangyin Zeng*, Shiyuan Xu*, Fan Deng*; β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells, BMC Cancer, 2019 Nov 26;19(1):1142( IF: 3.15, JCR三区).

12. Li S, Xu W, Xing Z, Qian J, Chen L, Gu R, Guo W, Lai X, Zhao W, Li S, Wang Y, Wang QJ, Deng F. A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development. Sci Rep. 2017;7:40505. doi: 10.1038/srep40505(IF:4.011，JCR三区).

13. Xu, W., Y. Wang, S. Li, Z. Ke, Y. Yan, S. Li, Z. Xing, C. Wang, F. Zeng, R. Liu, and F. Deng. Efficient gene and siRNA delivery with cationic polyphosphoramide with amino moieties in the main chain. RSC Adv., 2015. 5(62): 50425-50432(IF: 3.046，JCR 三区).

14. Pan L, Zhang Y, Zhao W, Zhou X, Wang C, Deng F. The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway. Cancer Chemother Pharmacol. 2017 Jul;80(1):91-100( IF:3.008，JCR三区).

15. Roy A, Ye J, Deng F, Wang QJ. Protein kinase D signaling in cancer: A friend or foe?. Biochim Biophys Acta Rev Cancer. 2017;1868(1):283-294. doi: 10.1016/j.bbcan.2017.05.008 ( IF:7.36, JCR: 二区)

16. Xu Q, Deng F, Xing Z, Wu Z, Cen B, Xu S, et al. Long non-coding RNA C2dat1 regulates CaMKIIdelta expression to promote neuronal survival through the NF-kappaB signaling pathway following cerebral ischemia. Cell death & disease. 2016;7:e2173(IF:5.959，JCR二区).

17. Xu Q, Deng F, Qin Y, Zhao Z, Wu Z, Xing Z, et al. Long non-coding RNA regulation of epithelial-mesenchymal transition in cancer metastasis. Cell death & disease. 2016;7(6):e2254(IF:5.959，JCR二区).

代表性课题

1.国家自然科学基金面上项目，2018.01-2021.12,主持

2.国家自然科学基金面上项目，2015.01-2018.12，主持

3.国家自然科学基金面上项目，2013.01-2016.12，主持

4.国家自然科学基金-海外及港澳学者合作项目,2014.01-2015.12，主持

5.国家自然科学基金面上项目, 2010.01-2012.12，主持

学术任职

1.中国细胞生物学学会会员；

2.广东省细胞生物学学会常务委员；

3.广东省泌尿生殖协会转化医学分会常务委员。

执教课程（课程及教材建设）

医学细胞生物学