白晓春 博士
教授,博士生导师
基础医学院院长
电子邮件:baixc15@smu.edu.cn
电 话:020-61648181
通讯地址:广东省广州市白云区沙太南路1023号(510515)
个人简介
现任南方医科大学基础医学院院长,广东省骨与关节退行性疾病重点实验室主任;教育部特聘教授,国家杰出青年科学基金获得者,万人计划科技创新领军人才,入选国家百千万人才工程;全国首批黄大年式教师团队和全国教育系统先进集体核心成员,获国务院政府特殊津贴,国家有突出贡献中青年专家,南方医科大学立德树人好导师等荣誉称号。
主要从事:(1)骨与关节退行病变的机制;(2)骨与软骨组织损伤与修复的研究。近年承担国家自然科学基金重大项目、重大研究计划重点项目、杰青、重点项目等项目13项,获国家科技进步二等奖、中华医学科技一等奖、云南省自然科学一等奖、广东省科技进步二等奖和广州市科技进步一等奖各1项,以第一或通讯作者在Science、Dev Cell、Nat Aging、Blood、PNAS、Ann Rheum Dis、J Cell Biol、Nat Commun等期刊上发表论文101篇,论文他引5000多次,入选中国高被引学者。
关键词
骨生物学;细胞代谢;细胞信号转导;骨关节炎;骨质疏松;骨与软骨再生与修复;骨生物材料
Bone biology; Cell metabolism; Signal transduction; Osteoarthritis;Osteoporosis;Bone and cartilage regeneration and repair;Bone biomaterials
代表性论著
1.Gong Y, Zou S, Deng D, Wang L, Hu H, Qiu Z, Wei T, Yang P, Zhou J, Zhang Y, Zhu W, Xie X, Liao Z, Yang J, Zhang S, Liu A, Jiang Y, Zou Z*, Bai X*. Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma. Dev Cell, 2023 Jan 24, online(*共同通讯作者,中科院细胞生物学小类1区,IF: 13.417)
2.Zou W, Lai M, Jiang Y, Mao L, Zhou W, Zhang S, Lai P, Guo B, Wei T, Nie C, Zheng L, Zhang J, Gao X, Zhao X, Xia L, Zou Z, Liu A, Liu S, Cui ZK*, Bai X* Exosome Release Delays Senescence by Disposing of Obsolete Biomolecules. Adv Sci (Weinh). 2023 Jan 22:e2204826. (*共同通讯作者,中科院材料科学小类1区,IF: 17.52)
3.Cao H, Zhong Y, Zhou L, Lin S, Hou X, Ding Z, Li Y, Yao Q, Cao H, Zou X, Chen D, Bai X*, Xiao G*. Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function. Elife. 2023 Jan 9;12: e81792. (*共同通讯作者,中科院生物学学小类1区,IF: 8.71)
4.Guo D, Lin C, Lu Y, Guan H, Qi W, Zhang H, Shao Y, Zeng C, Zhang R, Zhang H, Bai X*, Cai D*. FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis. Bone Res. 2022 Jun 22;10(1):45.(*共同通讯作者,中科院细胞与组织工程小类1区,IF: 13.36)Nat Rev Rheum评述 (highlight)
5. Wu X, Lai Y, Chen S, Zhou C, Tao C, Fu X, Li J, Tong W, Tian H, Shao Z, Liu C, Chen D, Bai X *, Cao H *, Xiao G *. Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. Nat Aging. 2022 Feb 10. .(*共同通讯作者)
6. Gong Y, Li Z, Zou S, Deng D, Lai P, Hu H, Yao Y, Hu L, Zhang S, Li K, Wei T, Zhao X, Xiao G, Chen Z, Jiang Y, Bai X*, Zou Z*. Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells. Dev Cell. 2021 Jul 26;56(14):2103-2120. (*共同通讯作者,中科院细胞生物学小类1区,IF: 13.417) F1000推荐
7. Xiao M#, Zhang W#, Li W#, Mao L, Yang J, Hu L, Zhang S, Zheng Y, Liu A, Song Q, Li Y, Xiao G, Zou Z*, Bai X*. Osteocytes regulate neutrophil development through IL-19: A potent cytokine for neutropenia treatment. Blood. 2021 Jun 24;137(25):3533-3547.(*共同通讯作者,中科院血液学小类1区,IF:25.67)配Blood专题评述
8. Lai M, Zou W, Han Z, Zhou L, Qiu Z, Chen J, Zhang S, Lai P, Li K, Zhang Y, Liang L, Jiang Y, Zou Z*, Bai X*. Tsc1 regulates tight junction independent of mTORC1. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2020891118. (*共同通讯作者,中科院综合期刊小类1区,IF:12.78)
9. Xia W, Xie J, Cai Z, Liu X, Wen J, Cui ZK, Zhao R, Zhou X, Chen J, Mao X, Gu Z, Zou Z, Zou Z, Zhang Y, Zhao M, Mac M, Song Q*, Bai X*. Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors. Nat Commun. 2021 Oct 15;12(1):6043. F1000推荐(*共同通讯作者,中科院综合性期刊小类1区,IF:17.69)
10. Zhang H, Cai D*, Bai X*; Macrophages regulate the progression of osteoarthritis. Osteoarthritis and Cartilage. 2020, 28(5):555-561. 高被引论文(*共同通讯作者,中科院骨科学小类1区,IF:7.51)
11. Lin C, Liu L, Zeng C, Cui Z, Chen Y, Lai P, Wang H, Shao Y , Zhang H, Zhang R, Zhao C, Fang H, Cai D*, Bai X*. Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12. Bone Res. 2019,7: 5. (IF=13.362) Nat Rev Rheum评述 (highlight) (*共同通讯作者,中科院细胞与组织工程小类1区,IF: 13.36)
12. Guo J, Tian X, Xie D, Rahn K, Gerhard E, Kuzma M, Zhou D, Dong C, Bai X*, Lu Z*, Yang J*. Citrate‐Based Tannin‐Bridged Bone Composites for Lumbar Fusion. Adv Funct Mater. 2019; 30(27):2070179. (*共同通讯作者,中科院物理化学小类1区,IF:19.93)
13. Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D*, Bai X*. Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum Dis. 2018 Oct;77(10):1524-1534(*共同通讯作者,中科院风湿病学小类1区,IF:28.01)高被引论文
14. Li K, Zhang Y, Zhang Y, Jiang W, Shen J, Xu S, Cai D, Shen J, Huang B, Li M, Song Q, Jiang Y, Liu A, Bai X*. Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway. Ann Rheum Dis. 2018 Jun;77(6):935-943. (中科院风湿病学小类1区,IF:28.01)Nat Rev Rheum评述(highlight)
15. Zou W, Lai M, Zhang Y, Zheng, Xing Z, Li T, Zou Z, Song Q,Zhao X, Xia L, Yang J, Liu A,Zhang H, Cui Z*, Jiang Y*, Bai X*. Exosome Release Is Regulated by mTORC1. Adv Sci. 2018 Dec 11;6(3):1801313(*共同通讯作者,中科院材料科学小类1区,IF: 17.521)
16. Ma C, Tian X, Kim JP, Xie D, Ao X, Shan D, Lin Q, Hudock MR, Bai X*, Yang J*. Citrate-based materials fuel human stem cells by metabonegenic regulation. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11741-E11750(*共同通讯作者,中科院综合期刊小类1区,IF:12.78)
17. Xu S, Zhang Y, Wang J, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M, Xiao G, Xu J, Jiang Y, Bai X*. TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. Cell Death Differ. 2018 Jan 22. doi: 10.1038/s41418-017-0049-4. (中科院细胞生物学小类2区,IF: 14.6)
18. Lu J, Zhang H, Cai D, Zeng C, Lai P, Shao Y, Fang H, Li D, Ouyang J, Zhao C, Xie D, Huang B, Yang J, Jiang Y, Bai X*. Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice. J Bone Miner Res. 2018 May;33(5):909-920. Cover Story(中科院内分泌学与代谢学小类1区,IF:6.39)
19. Xiao M, Wang Y, Tao C, Wang Z, Yang J, Chen Z, Zou Z, Li M, Liu A, Jia C, Huang B, Yan B, Lai P, Ding C, Cai D, Xiao G, Jiang Y, Bai X*. Osteoblasts support megakaryopoiesis through production of interleukin-9. Blood. 2017 Jun 15;129(24):3196-3209.(IF= 25.476)(*共同通讯作者,中科院血液学小类1区,IF:25.67)
20. Zhang Y, Xu S, Liang KY, Li K, Zou ZP, Yang CL, Tan K, Cao X, Jiang Y, Gao TM, Bai XC*. Neuronal mTORC1 is required for maintaining the nonreactive state of astrocytes. J Biol Chem. 2017 Jan 6;292(1):100-111(中科院生化与分子生物学小类2区,IF:5.485)
21. Huang B, Wang W, Li Q, Wang Z , Yan B, Zhang Z, Wang L , Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D*, Bai X*. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone, Nat Commun. 2016 Dec 14;7:13885.F1000推荐(*共同通讯作者,中科院综合性期刊小类1区,IF:17.69)
22. Yang J, Zhou X, Fan X, Xiao M, Yang D, Liang B, Dai M, Shan L, Lu J, Lin Z, Liu R, Liu J, Wang L, Zhong M, Jiang Y, Bai X*. mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation. Blood. 2016 Aug 4;128(5):615-24. with commentary(中科院血液学小类1区,IF:25.67)
23. Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X*. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016 Apr 4;7:11151. (中科院综合性期刊小类1区,IF:17.69)
24. Zou Z, Chen J, Liu A, Zhou X, Song Q, Jia C, Chen Z, Lin J, Yang C, Li M, Jiang Y, Bai X*. mTORC2 promotes cell survival through c-Myc-dependent up-regulation of E2F1. J Cell Biol. 2015 Oct 12;211(1):105-22. (中科院细胞生物学学小类2区,IF:8.07)In this issue, with commentary
25. Huang B, Wang Y, Wang W, Chen J, Lai P, Liu Z, Yan B, Xu S, Zhang Z, Zeng C, Rong L, Liu B, Cai D, Jin D, Bai X*. mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway. PLoS Genet. 2015 Aug 4;11(8):e1005426. (中科院遗传学小类2区,IF:6.02)
26. Chen Z, Kang X, Wang L, Dong H, Wang C, Xiong Z, Zhao W, Jia C, Lin J, Zhang W, Yuan W, Zhong M, Du H*, Bai X*. Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure. J Biol Chem. 2015 Mar 6;290(10):6387-96.( *共同通讯作者,中科院生化与分子生物学小类2区,IF:5.485)
27. Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC*. Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice. Ann Rheum Dis, 2014, 73(9):1719-27.(中科院风湿病学小类1区,IF:28.01)
28. Chen Z, Dong H, Jia C, Song Q, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Liu M, Lin J, Yang C, Li M, Gao T, Bai X*. Activation of mTORC1 in collecting ducts causes hyperkalemia. J Am Soc Nephrol, 2014, 25(3):534-45. (中科院泌尿学与肾脏学小类1区,IF:14.98)
29. Song Q, Xu Y, Yang C, Chen Z, Jia C, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Lin J, Li M, Ma W, Luo S, Bai X*. miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM. Cancer Res, 2014 ,74(11):3031-42. (中科院肿瘤学小类1区,IF:13.3) 高被引论文
30. Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Ren Z, Gao Q, Zhao Z, Zheng H, Wan Z, Gao T, Zhao A, Dai Y*, Bai X*. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression. Oncogene, 2014, 33(37):4548-57. ( *共同通信作者,中科院肿瘤学小类1区,IF:9.4)
31. Jia CH, Li M, Liu J, Zhao L, Lin J, Lai PL, Zhou X, Zhang Y, Chen ZG, Li HY, Liu AL, Yang CL, Gao TM, Jiang Y, Bai X*. IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1. Cell Death Differ, 2013, 20(2):248-58. (中科院细胞生物学小类2区,IF: 14.6)
32. Wen ZH, Su YC, Lai PL, Zhang Y, Xu YF, Zhao A, Yao GY, Jia CH, Lin J, Xu S, Wang L, Wang XK, Liu AL, Jiang Y, Dai YF*, Bai X*. Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis. Oncogene, 2013, 32(2):160-70. ( *共同通信作者,中科院肿瘤学小类1区,IF:9.4)
33. Bai X*, Jiang Y*. Key factors in mTOR regulation. Cell Mol Life Sci, 2010, 67(2):239-53. (*共同第一作者,中科院细胞生物学小类2区,IF:9.23)
34. Bai X, Ma DZ, Liu AL, Shen XY, Wang QM, Liu YJ, Jiang Y*. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science, 2007, 318(5852): 977-980. (中科院综合性期刊小类1区,IF:62.83)Highlight,F1000推荐,with commentary,引用302次
35. Bai X*, Lu D, Liu AL, Zhang ZM, Li XM, Zou ZP, Zeng WS, Cheng BL, Luo SQ. Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast. J Biol Chem. 2005 Apr 29;280(17):17497-506 (中科院生化与分子生物学小类2区,IF:5.485)引用268次
36. Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ*. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun. 2004 Jan 30;314(1):197-207. (中科院生化与分子生物学小类4区,IF:3.32) 引用439次
代表性课题
学术任职
广东省细胞生物学会 副理事长
中华医学会骨科分会基础组 委员
中华医学会医学细胞生物学分会 委员
中华医学会骨质疏松分会基础与转化医学组 常务委员
国际矫形与创伤外科学会(SCIOT)中国部骨科基础学会 常务委员
广东省骨与关节退行性疾病重点实验室 主任
器官衰竭防治国家重点实验室 PI
执教课程
本科生:医学细胞生物学(广东省一流线下课程)、基础医学新进展讲座
研究生:细胞生物学
参编教材:
医学细胞生物学,科学出版社,主编
荣誉奖励
1、慢性肾病进展的机制和临床防治,国家科技进步二等奖,2016,第十完成人
2、骨关节退行性疾病治疗策略与关键技术创新和应用,中华医学科技一等奖, 2021, 第二完成人
3、原发性骨质疏松症的信号网络调控机制及其干预策略,云南省自然科学一等奖,2018,第二完成人
4、细胞增殖分化若干关键信号通路调控机制及其意义的研究,广东省科技进步二等奖,2011,第一完成人
5、细胞增殖分化若干关键信号通路调控机制及其意义的研究,广东市科技进步一等奖,2011,第一完成人
6、基础医学拔尖人才培养体系构建与实践, 广东省教育教学成果奖一等奖,2022,第二完成人
7、教育部2021年度基础学科拔尖学生培养计划2.0优秀管理人员奖(2022年)