白晓春 博士

教授，博士生导师

基础医学院院长

电子邮件：baixc15@smu.edu.cn

电 话：020-61648181

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

现任南方医科大学基础医学院院长、广东省骨与关节退行性疾病重点实验室主任。教育部特聘教授，国家杰青，担任J Bone Miner Res，JOT编委，NEJM，Lancet等期刊审稿人。主要从事(1)骨与关节退行病变的机制；(2)骨与软骨组织损伤与修复的研究，承担国家自然科学基金重大，重点等项目12项，代表性论文发表在Science，Cell Stem Cell、Cell Metab、Dev Cell、Nat Aging、Ann Rheum Dis、PNAS等期刊，获国家科技进步二等奖，中华医学科技一等奖和广东省自然科学一等奖各一项。

关键词

骨生物学；细胞代谢；细胞信号转导；骨关节炎；骨质疏松；骨与软骨再生与修复；骨生物材料

Bone biology; Cell metabolism; Signal transduction; Osteoarthritis；Osteoporosis；Bone and cartilage regeneration and repair；Bone biomaterials

代表性论著

1. Wei X, Qiu J, Lai R, Wei T, Lin Z, Huang S, Jiang Y, Kuang Z, Zeng H, Gong Y, Xie X, Yang J, Zhang Y, Zhang S, Zou Z, Gao X*, Bai X*. A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration. Cell Stem Cell, 2024 Sep 27:S1934-5909(24)00315-1, online 

2. Xie J, Liu X, Wu B, Chen B, Song Q, Guan Y, Gong Y, Yang C, Lin J, Huang M, Tan X, Lai R, Lin X, Zhang S, Xie X, Chen X, Zhang C, Yang M, Nong H, Zhao X, Xia L, Zhou W, Xiao G, Jiang Q, Zou W, Chen D, Lu D*, Liu J*, Bai X*. Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients. Cell Reports Medicine, 2024 May 22;5(6):101588. 

3. Liang W, Wei T, Hu L, Chen M, Tong L, Zhou W, Duan X, Zhao X, Zhou W, Jiang Q, Xiao G, Zou W, Chen D*, Zou Z*, Bai X*. An integrated multi-omics analysis reveals osteokines involved in global regulation. Cell Metabolism, 2024 May 7;36(5):1144-1163.e7. 

4. Hu H, Luo S, Lai P, Lai M, Mao L, Zhang S, Jiang Y, Wen J, Zhou W, Liu X, Wang L, Huang M, Hu Y, Zhao X, Xia L, Zhou W, Jiang Y, Zou Z, Liu A*, Guo B*, Bai X*. ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation. Proc Natl Acad Sci U S A, 2024 Jan 2;121(1):e2310685120.

5. Hu Z, Xie Y, Lu J, Yang J, Zhang J, Jiang H, Li H, Zhang Y, Wu D, Zeng K, Bai X, Yu X. VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation. Science advances, 2023 Jun 23;9(25):eadg2339.

6. Xie X, Zhang W, Xiao M, Wei T, Qiu Y, Qiu J, Wang H, Qiu Z, Zhang S, Pan Y, Mao L, Li Y, Guo B, Yang W, Hu Y, Hu S, Gong Y, Yang J, Xiao G*, Zhang Y*, Bai X*. TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice. Blood, 2023 Jun 29;141(26):3184-3198. 

7. Gong Y, Zou S, Deng D, Wang L, Hu H, Qiu Z, Wei T, Yang P, Zhou J, Zhang Y, Zhu W, Xie X, Liao Z, Yang J, Zhang S, Liu A, Jiang Y, Zou Z*, Bai X*. Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma. Dev Cell, 2023 Feb 6;58(3):192-210.e11.

8. Zou W, Lai M, Jiang Y, Mao L, Zhou W, Zhang S, Lai P, Guo B, Wei T, Nie C, Zheng L, Zhang J, Gao X, Zhao X, Xia L, Zou Z, Liu A, Liu S, Cui ZK*, Bai X* Exosome Release Delays Senescence by Disposing of Obsolete Biomolecules. Adv Sci (Weinh). 2023 Jan 22:e2204826. 

9. Cao H, Zhong Y, Zhou L, Lin S, Hou X, Ding Z, Li Y, Yao Q, Cao H, Zou X, Chen D, Bai X*, Xiao G*. Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function. Elife. 2023 Jan 9;12: e81792. 

10. Guo D, Lin C, Lu Y, Guan H, Qi W, Zhang H, Shao Y, Zeng C, Zhang R, Zhang H, Bai X*, Cai D*. FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis. Bone Res. 2022 Jun 22;10(1):45. Nat Rev Rheum评述 (highlight)

11. Zhang H, Shao Y, Yao Z, Liu L, Zhang H, Yin J, Xie H, Li K, Lai P, Zeng H, Xiao G, Zeng C*, Cai D*, Bai X*. Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7. Annals of the rheumatic diseases, 2022 May;81(5):676-686.

12. Wu X, Lai Y, Chen S, Zhou C, Tao C, Fu X, Li J, Tong W, Tian H, Shao Z, Liu C, Chen D, Bai X *, Cao H *, Xiao G *. Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. Nat Aging. 2022 Feb 10. 

13. Gong Y, Li Z, Zou S, Deng D, Lai P, Hu H, Yao Y, Hu L, Zhang S, Li K, Wei T, Zhao X, Xiao G, Chen Z, Jiang Y, Bai X*, Zou Z*. Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells. Dev Cell. 2021 Jul 26;56(14):2103-2120. F1000推荐

14. Xiao M#, Zhang W#, Li W#, Mao L, Yang J, Hu L, Zhang S, Zheng Y, Liu A, Song Q, Li Y, Xiao G, Zou Z*, Bai X*. Osteocytes regulate neutrophil development through IL-19: A potent cytokine for neutropenia treatment. Blood. 2021 Jun 24;137(25):3533-3547. 配Blood专题评述

15. Lai M, Zou W, Han Z, Zhou L, Qiu Z, Chen J, Zhang S, Lai P, Li K, Zhang Y, Liang L, Jiang Y, Zou Z*, Bai X*. Tsc1 regulates tight junction independent of mTORC1. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2020891118. 

16. Xia W, Xie J, Cai Z, Liu X, Wen J, Cui ZK, Zhao R, Zhou X, Chen J, Mao X, Gu Z, Zou Z, Zou Z, Zhang Y, Zhao M, Mac M, Song Q*, Bai X*. Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors. Nat Commun. 2021 Oct 15;12(1):6043. F1000推荐

17. Zhang H, Cai D*, Bai X*; Macrophages regulate the progression of osteoarthritis. Osteoarthritis and Cartilage. 2020, 28(5)：555-561. 高被引论文

18. Lin C, Liu L, Zeng C, Cui Z, Chen Y, Lai P, Wang H, Shao Y , Zhang H, Zhang R, Zhao C, Fang H, Cai D*, Bai X*. Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12. Bone Res. 2019，7: 5. Nat Rev Rheum评述 (highlight) 

19. Guo J, Tian X, Xie D, Rahn K, Gerhard E, Kuzma M, Zhou D, Dong C, Bai X*, Lu Z*, Yang J*. Citrate‐Based Tannin‐Bridged Bone Composites for Lumbar Fusion. Adv Funct Mater. 2019; 30(27):2070179. 

20. Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D*, Bai X*. Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum Dis. 2018 Oct;77(10):1524-1534. 高被引论文

21. Li K, Zhang Y, Zhang Y, Jiang W, Shen J, Xu S, Cai D, Shen J, Huang B, Li M, Song Q, Jiang Y, Liu A, Bai X*. Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway. Ann Rheum Dis. 2018 Jun;77(6):935-943. Nat Rev Rheum评述(highlight)

22. Zou W, Lai M, Zhang Y, Zheng, Xing Z, Li T, Zou Z, Song Q,Zhao X, Xia L, Yang J, Liu A,Zhang H, Cui Z*, Jiang Y*, Bai X*. Exosome Release Is Regulated by mTORC1. Adv Sci. 2018 Dec 11;6(3):1801313.

23. Ma C, Tian X, Kim JP, Xie D, Ao X, Shan D, Lin Q, Hudock MR, Bai X*, Yang J*. Citrate-based materials fuel human stem cells by metabonegenic regulation. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11741-E11750.

24. Xu S, Zhang Y, Wang J, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M, Xiao G, Xu J, Jiang Y, Bai X*. TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. Cell Death Differ. 2018 Jan 22. doi: 10.1038/s41418-017-0049-4. 

25. Lu J, Zhang H, Cai D, Zeng C, Lai P, Shao Y, Fang H, Li D, Ouyang J, Zhao C, Xie D, Huang B, Yang J, Jiang Y, Bai X*. Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice. J Bone Miner Res. 2018 May;33(5):909-920. Cover Story

26. Xiao M, Wang Y, Tao C, Wang Z, Yang J, Chen Z, Zou Z, Li M, Liu A, Jia C, Huang B, Yan B, Lai P, Ding C, Cai D, Xiao G, Jiang Y, Bai X*. Osteoblasts support megakaryopoiesis through production of interleukin-9. Blood. 2017 Jun 15;129(24):3196-3209.

27. Zhang Y, Xu S, Liang KY, Li K, Zou ZP, Yang CL, Tan K, Cao X, Jiang Y, Gao TM, Bai XC*. Neuronal mTORC1 is required for maintaining the nonreactive state of astrocytes. J Biol Chem. 2017 Jan 6;292(1):100-111.

28. Huang B, Wang W, Li Q, Wang Z , Yan B, Zhang Z, Wang L , Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D*, Bai X*. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone, Nat Commun. 2016 Dec 14;7:13885. F1000推荐

29. Yang J, Zhou X, Fan X, Xiao M, Yang D, Liang B, Dai M, Shan L, Lu J, Lin Z, Liu R, Liu J, Wang L, Zhong M, Jiang Y, Bai X*. mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation. Blood. 2016 Aug 4;128(5):615-24. with commentary

30. Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X*. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016 Apr 4;7:11151. 

31. Zou Z, Chen J, Liu A, Zhou X, Song Q, Jia C, Chen Z, Lin J, Yang C, Li M, Jiang Y, Bai X*. mTORC2 promotes cell survival through c-Myc-dependent up-regulation of E2F1. J Cell Biol. 2015 Oct 12;211(1):105-22. In this issue, with commentary

32. Huang B, Wang Y, Wang W, Chen J, Lai P, Liu Z, Yan B, Xu S, Zhang Z, Zeng C, Rong L, Liu B, Cai D, Jin D, Bai X*. mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway. PLoS Genet. 2015 Aug 4;11(8):e1005426. 

33. Chen Z, Kang X, Wang L, Dong H, Wang C, Xiong Z, Zhao W, Jia C, Lin J, Zhang W, Yuan W, Zhong M, Du H*, Bai X*. Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure. J Biol Chem. 2015 Mar 6;290(10):6387-96.

34. Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC*. Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice. Ann Rheum Dis, 2014, 73(9):1719-27.

35. Chen Z, Dong H, Jia C, Song Q, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Liu M, Lin J, Yang C, Li M, Gao T, Bai X*. Activation of mTORC1 in collecting ducts causes hyperkalemia. J Am Soc Nephrol, 2014, 25(3):534-45. 

36. Song Q, Xu Y, Yang C, Chen Z, Jia C, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Lin J, Li M, Ma W, Luo S, Bai X*. miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM. Cancer Res, 2014 ,74(11):3031-42. 高被引论文

37. Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Ren Z, Gao Q, Zhao Z, Zheng H, Wan Z, Gao T, Zhao A, Dai Y*, Bai X*. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression. Oncogene, 2014, 33(37):4548-57.

38. Jia CH, Li M, Liu J, Zhao L, Lin J, Lai PL, Zhou X, Zhang Y, Chen ZG, Li HY, Liu AL, Yang CL, Gao TM, Jiang Y, Bai X*. IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1. Cell Death Differ, 2013, 20(2):248-58. 

39. Wen ZH, Su YC, Lai PL, Zhang Y, Xu YF, Zhao A, Yao GY, Jia CH, Lin J, Xu S, Wang L, Wang XK, Liu AL, Jiang Y, Dai YF*, Bai X*. Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis. Oncogene, 2013, 32(2):160-70. 

40. Bai X*, Jiang Y*. Key factors in mTOR regulation. Cell Mol Life Sci, 2010, 67(2):239-53. 

41. Bai X, Ma DZ, Liu AL, Shen XY, Wang QM, Liu YJ, Jiang Y*. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science, 2007, 318(5852): 977-980. Highlight，F1000推荐，with commentary，引用302次

42. Bai X*, Lu D, Liu AL, Zhang ZM, Li XM, Zou ZP, Zeng WS, Cheng BL, Luo SQ. Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast. J Biol Chem. 2005 Apr 29;280(17):17497-506. 引用268次

43. Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ*. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun. 2004 Jan 30;314(1):197-207. 引用439次

代表性课题

学术任职

广东省细胞生物学会 副理事长

中华医学会骨科分会基础组 委员

中华医学会医学细胞生物学分会 委员

中华医学会骨质疏松分会基础与转化医学组 常务委员

国际矫形与创伤外科学会(SCIOT)中国部骨科基础学会 常务委员

广东省骨与关节退行性疾病重点实验室 主任

器官衰竭防治国家重点实验室 PI

执教课程

本科生：医学细胞生物学（广东省一流线下课程）、基础医学新进展讲座

研究生：细胞生物学

参编教材：

医学细胞生物学，科学出版社，主编

荣誉奖励

1、慢性肾病进展的机制和临床防治，国家科技进步二等奖，2016，第十完成人

2、骨关节退行性疾病治疗策略与关键技术创新和应用，中华医学科技一等奖， 2021， 第二完成人

3、原发性骨质疏松症的信号网络调控机制及其干预策略，云南省自然科学一等奖，2018，第二完成人

4、细胞增殖分化若干关键信号通路调控机制及其意义的研究，广东省科技进步二等奖，2011，第一完成人

5、细胞增殖分化若干关键信号通路调控机制及其意义的研究，广东市科技进步一等奖，2011，第一完成人

6、基础医学拔尖人才培养体系构建与实践, 广东省教育教学成果奖一等奖，2022，第二完成人

7、教育部2021年度基础学科拔尖学生培养计划2.0优秀管理人员奖(2022年)