张月 理学博士 研究员

硕士生导师

电子邮件: yugi@smu.edu.cn

电 话：020-61647584

通讯地址：广东省广州市白云区沙太南路1023号（510515）

研究方向

细胞生物学，骨生物学

致力于探索和解析多核破骨细胞分化和功能相关的机体稳态维持关键机制。

研究关键词

骨质疏松，骨重塑，骨髓微环境

代表性论著

1. Osteoclasts control endochondral ossification via regulating acetyl-CoA availability. Bone Research. 2024 Aug 28;12(1):49. (Daizhao Deng#, Xianming Liu#, Wenlan Huang#, Sirui Yuan, Genming Liu, Shanshan Ai, Yijie Fu, Haokun Xu, Xinyi Zhang, Shihai Li, Song Xu*, Xiaochun Bai*, Yue Zhang*)

2. Rictor is a novel regulator of TRAF6/TRAF3 in osteoclasts. J Bone Miner Res. 2021 Jun 22. (Xu Song#, Li Shihai#, Liu Xianming, Tan Kang, Zhang Jiahuan, Li Kai, Bai Xiaochun*, Zhang Yue*)

3. mTORC1 inhibits NF-κB/NFATc1 signaling and prevents osteoclast precursor differentiation, in vitro and in mice. J Bone Miner Res. 2017 Sep;32(9):1829-1840. (Zhang Y^#, Xu S^#, Li K, Tan K, Liang K, Wang J, Shen J, Zou W, Hu L, Cai D, Ding C, Li M, Xiao G, Liu B, Liu A, Bai X*)

4. TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. Cell Death Differ. 2018 Sep;25(9):1549-1566 (Xu S^#, Zhang Y^#, Wang J^#, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M, Xiao G, Xu J, Jiang Y, Bai X*)

5. LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions. Cellular Signalling. 2022 Sep 14;110468. (Zhang JH#, Xu S#, Liang KY, Cao X, Ye ZX, Huang WL, Bai XC*, Zhang Y*)

6. Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes. J Biol Chem. 2017 Jan 6;292(1):100-111. (Zhang Y^#, Xu S^#, Liang KY#, Li K, Zou ZP, Yang CL, Tan K, Cao X, Jiang Y, Gao TM, Bai XC*)

7. Activation of mTORC1 in B lymphocytes promotes osteoclast formation via regulation of beta-catenin and RANKL/OPG. J Bone Miner Res. 2016 Jul;31(7):1320-33. (Xu S^#, Zhang Y^#, Liu B#, Li K, Huang B, Yan B, Zhang Z, Liang K, Jia C, Lin J, Zeng C, Cai D, Jin D, Jiang Y, Bai X*)

8. mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo. Breast Cancer Res Treat. 2012 Nov;136(2):379-88. (Zhang Y^#, Xu S^#, Lin J^#, Yao G, Han Z, Liang B, Zou Z, Chen Z, Song Q, Dai Y, Gao T, Liu A, Bai X*)

9. mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression. Oncogene. 2014 Sep 11;33(37):4548-57. (Chen Z^#, Zhang Y^#, Jia C^#, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Ren Z, Gao Q, Zhao Z, Zheng H, Wan Z, Gao T, Zhao A, Dai Y, Bai X)

10. Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway. Ann Rheum Dis. 2018 Jun;77(6):935-943. (Kai Li, Yue Zhang, Yuwei Zhang, Wenqing Jiang, Junhui Shen, Song Xu, Daozhang Cai, Jie Shen, Bin Huang, Mangmang Li, Qiancheng Song, Yu Jiang, Anling Liu, Xiaochun Bai)

执教课程

医学细胞生物学，细胞培养技术