高学飞 博士

教授，博士生导师

生理教研室主任

电子邮件: xgao2019@smu.edu.cn

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

高学飞，教授，博士生导师。中国科学院广州生物医药与健康研究院博士，英国剑桥Sanger研究所博士后，现南方医科大学基础医学院生理学教研室主任。课题组主要利用多能干细胞与基因组遗传修饰技术，致力于研究人体细胞谱系分化及其功能异常的调控机制。相关成果以通讯作者或第一作者身份在多个知名学术期刊上发表。目前主持国家自然科学基金项目4项。

研究方向

人多能干细胞多能性维持及滋养层谱系分化调控

研究关键词

人多能干细胞 Human pluripotent stem cell；多能性维持Pluripotent maintenance；滋养层细胞 Trophoblasts；谱系特化 Lineage specification；命运决定 Fate commitment.

代表性论著

1. Pang C*, Yang Q* Zhong Y*, Ye J*, Lv Y, Xie S, Tang Y, Ye X, Zhang F, Li C, Zhang J,  Sun L#, Ai S#, Gao X#. HAND1 controls the lineage bifurcation of trophoblast and amnion from human pluripotent stem cells. CELL MOL LIFE SCI. 2026 Jan. (JCR 1区).

2. Chen Y*, Ye X*, Zhong Y*, Kang X*, Tang Y, Zhu H, Pang C, Ning S, Liang S, Zhang F, Li C, Li J, Gu C, Cheng Y, Kuang Z, Qiu J, Jin J, Luo H, Fu M, Hui HX, Li L, Ruan D, Liu P, Chen X, Sun L#, Ai S#, Gao X#. SP6 controls human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements. Developmental Cell. 2024 Apr 5. (JCR 1区).

3.Wei X*, Qiu J*, Lai R*, WeiT, Lin Z, HuangS, Jiang Y, Kuang Z, Gong Y, Xie X, Yang J, Zhang Y, Zhang S, Zou Z, Gao X#, Bai X#. A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration. Cell Stem Cell. 2024 Sep 27. (JCR 1区).

4. Ruan D*, Xuan Y*, Tam TTK, Li Z, Wang X, Xu S, Herrmann D, Niemann H, Lai L, Gao X#, Nowak-Imialek M#, Liu P#. An optimized culture system for efficient derivation of porcine expanded potential stem cells from preimplantation embryos and by reprogramming somatic cells. Nature Protocols. 2024 Mar 20. (JCR 1区).

5. Zhao L*, Gao X*, Zheng Y*, Wang Z, Zhao G, Ren J, Zhang J, Wu J, Wu B, Chen Y, Sun W, Li Y, Su J, Ding Y, Gao Y, Liu M, Bai X, Sun L, Cao G, Tang F, Bao S, Liu P#, Li X#. Establishment of bovine expanded potential stem cells. Proc Natl Acad Sci U S A. 2021 Apr 13. (JCR 1区).

6. Gao X*, Nowak-Imialek M*, Chen X*, Chen D, Herrmann D, Ruan D, Andy Chen CH Andy, Eckersley-Maslin M, Shakil A, Lee YL,Kobayashi T, Ryan D, Tam PL P, Ahmed A, Wu D, Nie T, Pei D, Surani A, Shang Z, Lai L, Yeung SBW, Teichmann S, Niemann H#, Liu P#. Establishment of Porcine and Human Expanded Potential Stem Cells. Nature Cell Biology (2019). 21, p687–699. (JCR 1区).

7. Gao X*, Jason CH Tsang*, Fortis Gaba, Donghai Wu and Pentao Liu. Comparison of TALE Designer Transcription Factors and the CRISPR/dCas9 in Regulation of Gene Expression by Targeting Enhancers. Nucleic Acids Res (2014). e155:1-14. (JCR 1区).

8. Gao X, Yang J, Tsang JC, Ooi Jolene, Wu D, Liu P. Reprogramming to Pluripotency Using Designer TALE Transcription Factors Targeting Enhancers. Stem Cell Reports (2013).11;1(2):183-97. (JCR 1区).

9. Gao X, Li K, Hui X, Kong X, Sweeney G, Wang Y, Xu A, Teng M, Liu P, Wu D. Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase. Biochem J (2011) .435(3):723-32.  (JCR 2区).

10. Gao X, Chen W, Kong XP, Xu AM, Wang ZG, Sweeney G, Wu D. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake. Diabetologia (2009). 52(5):912-20. (JCR 1区).

代表性课题

国家自然基金青年项目；资助金额20万元；2013-12 主持

国家自然基金面上项目；资助金额58万元；2024-12 主持

国家自然基金面上项目；资助金额54万元；2026-12 主持

国家自然基金面上项目；资助金额50万元；2029-12 主持

国家重点研发计划项目；资助金额140万；2029-12 项目骨干

学术任职

中国生理学会整合生理学分会专业委员

广东省器官医学与技术学会干细胞与再生医学分会常务委员

执教课程

生理学，细胞生物学，基因组学