荣知立 博士

教授，博士生导师

肿瘤研究所所长，皮肤病医院皮肤病研究所所长

电子邮件: rongzhili@smu.edu.cn

电 话：无

通讯地址：广东省广州市白云区沙太南路1023号（510515）

个人简介

教授，博士生导师，海外高层次人才青年计划专家，南方医科大学肿瘤研究所所长，南方医科大学皮肤病医院皮肤病研究所所长。清华大学生物学学士、博士，美国加州大学圣迭戈分校（UCSD）博士后。主要研究方向为结合基因编辑技术、小鼠模型、人源类器官和病人样本，研究肺和皮肤的再生医学。以通讯作者或第一作者在Cell Stem Cell, Nucleic Acids Research, Nature Communications, Protein & Cell, Cell Reports, Journal of Investigative Dermatology等学术期刊发表论文26篇，发表论文总引用2900余次；参与撰写基因编辑专著1部，申请国际PCT专利3项，中国发明专利10项（授权5项）；曾任国际SCI期刊 Journal of Gene Medicine副主编，主持和参与国家科技重大专项、国家自然科学基金重点和面上项目、广东省和广州市重点项目等多项课题。

研究方向

干细胞与再生医学，基因编辑技术开发

Stem cell and regenerative medicine，Gene editing

研究关键词

Gene editing, Lung organoid, Skin disease

代表性论著

1. Xu, Y. ^{*, #}, Zhang, J. ^#, Hu, Y. ^#, Li, X. ^#, Sun, L., Peng, Y., Sun, Y., Liu, B., Bian, Z.^*, Rong, Z. ^* Single-cell transcriptome analysis reveals the dynamics of human immune cells during early fetal skin development. Cell Reports 36, 109524 (2021)

2. Huang, H. ^#, Hu, Y. ^#, Huang, G., Ma, S., Feng, J., Wang, D., Lin, Y^*., Zhou, J^*., Rong, Z.^* Tag-seq: a convenient and scalable method for genome-wide specificity assessment of CRISPR/Cas nucleases. Communications Biology 4, 830 (2021)

3. Deng, C.C. ^#, Hu, Y.F. ^#, Zhu, D.H. ^#, Cheng, Q., Gu, J.J., Feng, Q.L., Zhang, L.X., Xu, Y.P., Wang, D., Rong, Z.^* & Yang, B^*. Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases. Nature Communications 12, 3709 (2021)

4. Zhang, X.^#, Lv, S.^#, Luo, Z.^#, Hu, Y., Peng, X., Lv, J., Zhao, S., Feng, J., Huang, G., Wan, Q.L., Liu, J., Huang, H., Luan, B., Wang, D., Zhao, X., Lin, Y., Zhou, Q.^*, Zhang, Z.N.^* & Rong, Z.^* MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo. Nucleic Acids Res 49, 4171-4185 (2021).

5. Pei, R.^#, Feng, J.^#, Zhang, Y., Sun, H., Li, L., Yang, X., He, J., Xiao, S., Xiong, J., Lin, Y., Wen, K., Zhou, H., Chen, J., Rong, Z.^* & Chen, X^*. Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection. Protein & cell 12, 717-733 (2021).

6. Liu, J.^#, Chen, J.^#, Zhong, Y., Yu, X., Lu, P., Feng, J., Zhang, X., Ma, S., Yang, C., Yang, B.^* & Rong, Z.^* OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients. Protein & cell 12, 653-661 (2021).

7. Xue, Y.^#, Chen, W.^#, Mai, Z., Yu, X., Wu, Q., Wan, C., Su, X., Wu, Y., Rong, Z.^* & Zheng, H^*. Inhibition of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis infection. J Invest Dermatol 141, 852-862 (2021).

8. Ma, S., Wang, X., Hu, Y., Lv, J., Liu, C., Liao, K., Guo, X., Wang, D., Lin, Y.^* & Rong, Z. ^* Enhancing site-specific DNA integration by a Cas9 nuclease fused with a DNA donor-binding domain. Nucleic Acids Res 48, 10590-10601 (2020).

9. Huang, H.^#, Zhang, X.^#, Lv, J., Yang, H., Wang, X., Ma, S., Shao, R., Peng, X., Lin, Y.^* & Rong, Z.^* Cell-cell contact-induced gene editing/activation in mammalian cells using a synNotch-CRISPR/Cas9 system. Protein & cell 11, 299-303 (2020).

10. Wang, Y.P.^#, Ma, S.F.^#, Dai, Z.Y., Rong, Z. ^* & Liu, J. ^* Facile in situ synthesis of ultrasmall near-infrared-emitting gold glyconanoparticles with enhanced cellular uptake and tumor targeting. Nanoscale 11, 16336-16341 (2019).

11. Deng, C.C.^#, Zhu, D.H.^#, Chen, Y.J., Huang, T.Y., Peng, Y., Liu, S.Y., Lu, P., Xue, Y.H., Xu, Y.P., Yang, B.^* & Rong, Z.^* TRAF4 promotes fibroblast proliferation in keloids by destabilizing p53 via interacting with the deubiquitinase USP10. J Invest Dermatol 139, 1925-1935 (2019).

12. Zhang, X.^#, Wang, W.^#, Shan, L., Han, L., Ma, S., Zhang, Y., Hao, B., Lin, Y.^* & Rong, Z.^* Gene activation in human cells using CRISPR/Cpf1-p300 and CRISPR/Cpf1-SunTag systems. Protein & cell 9, 380-383 (2018).

13. Chen, Y., Feng, J., Zhao, S., Han, L., Yang, H., Lin, Y.^* & Rong, Z.^* Long-Term Engraftment Promotes Differentiation of Alveolar Epithelial Cells from Human Embryonic Stem Cell Derived Lung Organoids. Stem cells and development 27, 1339-1349 (2018). (Cover story)

14. Rong, Z., Wang, M., Hu, Z., Stradner, M., Zhu, S., Kong, H., Yi, H., Goldrath, A., Yang, Y.G., Xu, Y. & Fu, X. An effective approach to prevent immune rejection of human ESC-derived allografts. Cell stem cell 14, 121-130 (2014).

Commented by Cell Stem Cell (Cell Stem Cell 14: 3)

Reported by Fox News, China Daily, Science Daily, Medical news today, and UT San Diego et al.

15. Rong, Z.^#, Fu, X.^#, Wang, M. & Xu, Y. A scalable approach to prevent teratoma formation of human embryonic stem cells. J Biol Chem 287, 32338-32345 (2012).

代表性课题

1. 国家自然科学基金面上项目，2021/01-2024/12，主持，课题经费 55万

2. 国家自然科学基金面上项目，2019/01-2022/12，主持，课题经费 58万

3. 广州再生医学与健康广东省实验室前沿探索项目，2018/12-2021/12，主持 ，课题经费 150万元，结题

4. “艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项，子课题负责人，课题经费 120万元，结题

5. 国家自然科学基金面上项目，2017/01-2020/12，主持，课题经费 60万元，结题

6. 广州市科技计划项目产学研协同创新重大专项，2015/06-2018/05，主持，课题经费 100万元，结题

7. 广东省科技计划项目，2015/01-2017/12，主持，课题经费 100万元，结题

学术任职

国际细胞学会会员，中国细胞学会会员

执教课程（课程及教材建设）

基因编辑

基础医学新进展

荣誉奖励

2015年，入选第十一批海外高端人才计划