周欣

姓名：周欣

职称：研究员

联系邮箱：xinzhou@wipm.ac.cn

课题组网站链接：http://www.zhougroup.org

导师简介

周欣，男，博士，中国科学院精密测量科学与技术创新研究院（由原中国科学院武汉物理与数学研究所和中国科学院测量与地球物理研究所融合组建）院长，研究员，博导。基金委创新研究群体项目负责人，国家杰出青年基金、国家重大科研仪器设备研制专项（部委推荐）和国家重点研发计划首席科学家。现任基金委国家重大科研仪器设备研制项目专家委员会委员，中国物理学会波谱专业委员会常务副主任委员，中国生物物理学会分子影像学专委会副主任委员。曾获"CCTV 2018年度全国十大科技创新人物"、全国创新争先奖、"2020年中国科学院年度创新人物"、湖北省技术发明一等奖、首届"科学探索奖"、"中国科学院青年科学家奖"、"王天眷波谱学奖"等多项荣誉。

主要从事医学影像的新仪器、新技术及活体分子成像方面的研究。自主研制了世界上增强倍数最高的人体肺部气体磁共振成像（MRI）仪器，成功"点亮"肺部，解决了传统MRI对肺部空腔无法清晰成像的难题，应用至武汉市金银潭医院、北京301医院等全国多家三甲医院，合作开展了新冠肺炎、慢阻肺、肿瘤等临床研究。发展了多核MRI新技术，研制了系列新型造影剂，为脑部重大疾病和肿瘤的早期检测提供了全新的医学影像仪器与手段。在PNAS、Science子刊、Angew Chem等学术刊物上发表论文150余篇，授权及受理国内外发明专利100余件。

学习经历

1999.9-2004.6    中国科学院武汉物理与数学研究所   博士

工作经历

2004.7-2004.12 中国科学院武汉物理与数学研究所, 助理研究员

2005.1-2007.9 美国哈佛大学，美国Brigham Women's Hospital, 博士后

2007.9-2009.9 美国加州大学伯克利分校；美国劳伦斯国家实验室, 研究助理

2009.10 -至今 中国科学院精密测量科学与技术创新研究院, 研究员

研究方向

超极化肺部和脑部MRI的方法和技术研究

超灵敏分子探针与分子影像学研究

原子磁力计和激光探测磁共振技术研究

招生专业

0831 生物医学工程

0854 电子信息

招生方向

磁共振成像新方法，医学成像科学，医学影像人工智能，医学信号检测及装置搭建等

主要学术任职

基金委国家重大科研仪器设备研制项目，专家委员会委员

中国物理学会波谱专业委员会，常务副主任委员

中国生物物理学会分子影像学专委会，副主任委员

国际华人医学磁共振学会（OCSMRM），大会秘书

中国生物医学工程学会生物医学光子学分会，常委委员

中国科学院磁共振技术联盟，常务副理事长

《中国激光》，第十届编委会编委

《Magnetic Resonance Letters》（磁共振快报）期刊，副主编

《物理学报》和《Chinese Physics B》，第二十届编委会委员

《生物医学转化》，第一届编委会委员

主要获奖情况（科研获奖、人才类奖项）

1、CCTV 2018年度全国十大科技创新人物

2、全国创新争先奖

3、湖北省技术发明一等奖

4、首届科学探索奖

5、中国科学院青年科学家奖

6、“国家高层次人才特殊支持计划”科技创新领军人才

7、国家科技部“创新人才推进计划”中青年科技创新领军人才

主要科研课题

1、国家自然科学基金委员会，国家杰出青年科学基金，超灵敏磁共振成像，2017-1至2021-12，主持

2、国家自然科学基金委员会，国家重大科研仪器设备研制专项（部委推荐），用于人体肺部重大疾病研究的磁共振成像仪器系统研制，2013-1至2017-12，主持

3、国家科学技术部，变革性技术国家重点研发计划项目，肺癌的超高灵敏谱学与成像新技术研究，2019-9至2024-8，主持

4、中国科学院，基础前沿科学研究计划 从0-1原始创新项目，肺的异构功能性数据获取与智能融合，2019-9至2029-8，主持

5、中国科学院，关键技术研发团队，超（高）灵敏磁共振波谱与成像技术研发团队，2020-1至2022-12，主持

生物医学影像相关的代表性论文（近五年）

[1] Haidong Li^#, Xiuchao Zhao^#, Yujin Wang^#, Xin Lou^#, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S. Bouchard, Liming Xia*, Xin Zhou*. Damaged Lung Gas Exchange Function of Discharged COVID-19 Patients Detected by Hyperpolarized ¹²⁹Xe MRI. Science Advances, Vol 7(1), eabc8180. (2021). DOI: 10.1126/sciadv.abc8180.

[2] Xin Zhou, Dominic Graziani, Alexander Pines*. Hyperpolarized Xenon NMR and MRI Signal Amplification by Gas Extraction. Proceedings of the National Academy of Sciences of the United States of America, Vol 106(40), 16903-16906. (2009). DOI: 10.1073/pnas.0909147106. Highlighted by Science Daily, Future Medicine, DOTMed News, New York Academy of Sciences, etc.

[3] He Deng, Xianping Sun, Xin Zhou*. A Multiscale Fuzzy Metric for Detecting Small Infrared Targets Against Chaotic Cloudy/Sea-Sky Backgrounds. IEEE Transactions on Cybernetics, Vol 49(5), 1694-1707. (2019). DOI: 10.1109/TCYB.2018.2810832.  

[4] Sa Xiao^#, He Deng^#, Caohui Duan, Junshuai Xie, Haidong Li, Xianping Sun, Chaohui Ye, Xin Zhou*. Highly and Adaptively Undersampling Pattern for Pulmonary Hyperpolarized ¹²⁹Xe Dynamic MRI. IEEE Transactions on Medical Imaging, vol 38(5), 1240-1250. (2019). DOI: 10.1109/TMI.2018.2882209.

[5] Cheng Wang^#, Lu Huang^#, Sa Xiao^#, Zimeng Li, Chaohui Ye, Liming Xia*, Xin Zhou*. Early Prediction of Lung Lesion Progression in COVID‑19 Patients with Extended CT Ventilation Imaging. European Journal of Nuclear Medicine and Molecular Imaging, Vol 48, 4339-4349. (2021). DOI: 10.1007/s00259-021-05435-8.  

[6] Shizhen Chen^#, Long Xiao^#, Yu Li, Maosong Qiu, Yaping Yuan, Rui Zhou, Conggang Li, Lei Zhang, Zhongxing Jiang, Maili Liu, Xin Zhou*. In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent ¹⁹F NMR. Angewandte Chemie International Edition, Vol 61(50), e202213495. (2022). DOI: 10.1002/anie.202213495. Highlighted as a cover article, and VIP (Very Important Paper).

[7] Haonan He^#, Kelu Zhao^#, Long Xiao, Yi Zhang, Yi Cheng, Sikang Wan, Shizhen Chen, Lei Zhang*, Xin Zhou*, Kai Liu*, Hongjie Zhang. Detection and Chiral Recognition of α-hydroxyl Acid Through ¹H and CEST NMR Using a Ytterbium Macrocyclic Complex. Angewandte Chemie International Edition, Vol 58(50), 18286-18289. (2019). DOI: 10.1002/anie.201912072.  

[8] Weitao Yang^#, Chenyang Xiang^#, Yan Xu, Shizhen Chen, Weiwei Zeng, Kai Liu, Xiao Jin, Xin Zhou*, Bingbo Zhang*. Albumin-constrained Large-scale Synthesis of Renal Clearable Ferrous Sulfide Quantum Dots for T₁-Weighted MR Imaging and Phototheranostics of Tumors. Biomaterials, Vol 255, 120186. (2020). DOI: 10.1016/j.biomaterials.2020.120186.

[9] Qingbin Zeng^#, Binglin Bie^#, Qianni Guo*, Yaping Yuan, Qi Han, Xiaocang Han, Mingwei Chen, Xu Zhang, Yunhuang Yang, Maili Liu, Pan Liu, Hexiang Deng*, Xin Zhou*. Hyperpolarized Xe NMR Signal Advancement by Metal-organic Framework Entrapment in Aqueous Solution. Proceedings of the National Academy of Sciences of the United States of America, Vol 117(30), 17558-17563. (2020). DOI:10.1073/pnas.2004121117.

[10] Yuqi Yang^#, Shizhen Chen^#, Haidong Li, Yaping Yuan, Zhiying Zhang, Junshuai Xie, Dennis.W Hwang, Aidong Zhang, Maili Liu, Xin Zhou*. Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging. Nano Letters, Vol 19(1), 441-448. (2019). DOI: 10.1021/acs.nanolett.8b04252.

[11] Sha Li, Weiping Jiang, Yaping Yuan, Meiju Sui, Yuqi Yang, Liqun Huang, Ling Jiang, Maili Liu,Shizhen Chen*, Xin Zhou*. Delicately Designed Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted ¹⁹F MR/PA/FL Imaging-Guided Photothermal Therapy. ACS Applied Materials & Interfaces, Vol 12(51), 57290-57301. (2020). DOI:10.1021/acsami.0c13865. Highlighted as a cover article.

[12] Zhichao Liu^#, Ying Zhu^#, Liming Zhang^#, Weiping Jiang^#, Yawei Liu^#, Qiaowei Tang, Xiaoqing Cai, Jiang Li, Lihua Wang, Changlu Tao, Xianzhen Yin, Xiaowei Li, Shangguo Hou, Dawei Jiang, Kai Liu, Xin Zhou*, Hongjie Zhang*, Maili Liu*, Chunhai Fan*, Yang Tian*. Structural and Functional Imaging of Brains. Science China Chemistry, Vol 66(2), 324-366. (2023). DOI: 10.1007/s11426-022-1408-5.

[13] Qian Zhou^#, Haidong Li^#, Qiuchen Rao^#, Ming Zhang, Xiuchao Zhao, Luyang Shen, Yuan Fang, Hongchuang Li, Xiaoling Liu, Sa Xiao, Lei Shi, Yeqing Han, Chaohui Ye, Xin Zhou*. Assessment of Pulmonary Morphometry using Hyperpolarized ¹²⁹Xe Diffusion-Weighted MRI with Variable-Sampling-Ratio Compressed Sensing Patterns. Medical Physics, Vol 50(2), 867-878. (2023). DOI: 10.1002/mp.16018.  

[14] 李海东^#，陈世桢^#，娄昕，张定宇，周欣*. 多核磁共振成像助力新冠肺炎疫情防控. 中国科学基金，Vol 36(4), 644-653. (2022). DOI: 10.16262/j.cnki.1000-8217.2022.04.005.

[15] Shizhen Chen, Yina Lan, Haidong Li, Liming Xia, Chaohui Ye, Xin Lou*, Xin Zhou*. Relationship between Lung and Brain Injury in COVID-19 Patients: A Hyperpolarized ¹²⁹Xe-MRI-based 8-Month Follow-Up. Biomedicines, Vol 10(4), 781-789. (2022). DOI: 10.3390/biomedicines10040781.

[16] Cheng Wang^#, Haidong Li^#, Sa Xiao, Zimeng Li, Xiuchao Zhao, Junshuai Xie, Chaohui Ye, Liming Xia, Xin Lou, Xin Zhou*. Abnormal Dynamic Ventilation Function of COVID-19 Survivors Detected by Pulmonary Free-Breathing Proton MRI. European Radiology, Vol 32, 5297-5307. (2022). DOI: 10.1007/s00330-022-08605-w.  

[17] Yi Ding^#, Lu Yang^#, Qian Zhou^#, Jianping Bi, Ying Li, Guoliang Pi, Wei Wei, Desheng Hu, Qiuchen Rao, Haidong Li, Li Zhao, An Liu, Dongsu Du, Xiao Wang, Xin Zhou*, Guang Han*, Kun Qing. A Pilot Study of Function-based Radiation Therapy Planning for Lung Cancer Using Hyperpolarized Xenon-129 Ventilation MRI. Journal of Applied Clinical Medical Physics, Vol 23(3), e13502. (2022). DOI: 10.1002/acm2.13502.

[18] Yuepeng Zhou, et al., William J. Britt*, Xin Zhou*, Xuan Jiang*, Minhua Luo*. A Congenital CMV Infection Model for Follow-up Studies of Neurodevelopmental Disorders, Neuroimaging Abnormalities, and Treatment. JCI Insight, Vol 7(1), e152551. (2022). DOI: 10.1172/jci.insight.152551.  

[19] Caohui Duan^#, He Deng^#, Sa Xiao, Junshuai Xie, Haidong Li, Xiuchao Zhao, Dongshan Han, Xianping Sun, Xin Lou, Chaohui Ye, Xin Zhou*. Accelerate Gas Diffusion-Weighted MRI for Lung Morphometry with Deep Learning. European Radiology, Vol 32, 702-713. (2022). DOI: 10.1007/s00330-021-08126-y.  

[20] Qian Zhou^#, Qiuchen Rao^#, Haidong Li, Ming Zhang, Xiuchao Zhao, Lei Shi, Chaohui Ye, Xin Zhou*. Evaluation of Injuries Caused by Coronavirus Disease 2019 Using Multi-Nuclei Magnetic Resonance Imaging. Magnetic Resonance Letters, Vol 1(1), 2-10. (2021). DOI:10.1016/j.mrl.2021.100009.

[21] 叶朝辉*，骆清铭*，周欣*. 影像揭示生命奥秘. 中国科学：生命科学，Vol 50(11), 1155-1157. (2020). DOI: 10.1360/SSV-2020-0313.

[22] Lu Huang^#, He Deng^#, Liming Xia*, Xin Zhou*. Progressive CT Findings and Positive RT-PCR Again of Recovered and Discharged Patients with COVID-19. Journal of Thoracic Disease, Vol 12(6), 3439-3441. (2020). DOI: 10.21037/jtd-20-1417.  

[23] Yiqi Hu^#, He Deng^#, Lu Huang, Liming Xia, Xin Zhou*. Analysis of Characteristics in Death Patients with COVID-19 Pneumonia without Underlying Diseases. Academic Radiology, Vol 27(5), 752. (2020). DOI: 10.1016/j.acra.2020.03.023.

[24] Ming Zhang^#, Haidong Li^#, Hongchuang Li, Xiuchao Zhao, Qian Zhou, Qiuchen Rao, Yeqing Han, Yina Lan, He Deng, Xianping Sun, Xin Lou, Chaohui Ye, Xin Zhou*. Quantitative Evaluation of Lung Injury Caused by PM2.5 Using Hyperpolarized Gas Magnetic Resonance. Magnetic Resonance in Medicine, Vol 84(2), 569-578. (2020). DOI:10.1002/mrm.28145.

[25] Caohui Duan^#, He Deng^#, Sa Xiao, Junshuai Xie, Haidong Li, Xianping Sun, Lin Ma, Xin Lou^#, Chaohui Ye, Xin Zhou*. Fast and Accurate Reconstruction of Human Lung Gas MRI with Deep Learning. Magnetic Resonance in Medicine, Vol 82(6), 2273-2285. (2019). DOI: 10.1002/mrm.27889.

[26] Xiaoxiao Zhang^#, Yaping Yuan^#, Sha Li, Qingbin Zeng, Qianni Guo, Na Liu, Minghui Yang, Yunhuang Yang, Maili Liu, Michael T. McMahon, Xin Zhou*. Free‐Base Porphyrins as CEST MRI Contrast Agents with Highly Upfield Shifted Labile Protons. Magnetic Resonance in Medicine, Vol 82, 577-585. (2019). DOI: 10.1002/mrm.27753.  

[27] Junshuai Xie, Haidong Li, Huiting Zhang, Xiuchao Zhao, Lei Shi, Ming Zhang, Sa Xiao, He Deng, Ke Wang, Hao Yang, Xianping Sun, Guangyao Wu, Chaohui Ye, Xin Zhou*. Single Breath‐Hold Measurement of Pulmonary Gas Exchange and Diffusion in Humans with Hyperpolarized ¹²⁹Xe MR. NMR in Biomedicine, Vol 32, e4068. (2019). DOI: 10.1002/nbm.4068. Highlighted as Editor's Pick.

[28] He Deng, Caohui Duan, Sa Xiao, Junshuai Xie, Huiting Zhang, Xianping Sun, Xin Zhou*. k-Space-Based Enhancement of Pulmonary Hyperpolarized ¹²⁹Xe Ventilation Images. IEEE Transactions on Instrumentation and Measurement. Vol 68(10), 3950-3961. (2019). DOI: 10.1109/TIM.2018.2886097.