职 称：
教授 博导
通信地址：
广州大道北1838号南方医科大学公共卫生学院6楼三级生物安全实验室
Email：
Zhang.Qiwei@yahoo.com
职 务：
职称级别：
正高
学术任职：
人腺病毒研究组(NCBI)委员；中国微生物学会病毒学专委会(青年委员)、中国微生物学会医学微生物学专委会(青年委员)
最高学历：
博士研究生
所属科室：
三级生物安全实验室
研究方向：
100103病原生物学（病毒）；1004J1传染病预防控制（病毒）
科研项目：
GRANTS as PI:
（9）国家自然科学基金面上项目31570155，2016.01-2019.12
（8）广州市健康医疗协同创新重大专项“呼吸道新发突发及重大传染病综合防诊治”方向三子课题（201400000002）2014.03-2017.02
（7）广东省高等学校优秀青年教师培养计划（YQ2013039），2014.01-2016.12
（6）国家自然科学基金面上项目31370199，2014.01-2017.12
（5）国家自然科学青年基金31100133，2012.01-2014.12
（4）广州市珠江科技新星专项2013J2200052，2013.5-2016.4
（3）广东省自然科学基金自由申请项目S2012010009261，2012.10-2014.10
（2）南方医科大学高层次人才引进启动项目，2011.3-2014.2
（1）香港大学博士后基金，2008.08-2010.10
成果奖励：
(8)广东省南山医药创新研究院特聘研究员(2015)
(7) Medical Virology Club Travel Award, 34th Annual Meeting of American Society for Virology, London, Canada, July 10-15, 2015.
(6)广东特支计划“百千万工程青年拔尖人才”(2014)
(5)广东省高等学校优秀青年教师（2014）
(4)广东省千百十人才工程校级培养对象 （2012）
(3)广州市珠江科技新星（2013）
(2)中华医学会全国儿科临床病毒学专题研讨会优秀论文二等奖(2005)
(1)武汉市科学技术成果奖(2004)
专利/Patents:
(1)《人呼吸道合胞病毒荧光定量PCR试剂盒及其检测方法》，授权号：ZL200310111382.7
(2)《一种同时检测靶基因序列及已知点突变的新技术》，申请号：CN200510102075.1
(3)《人工改造的缺陷型人3型腺病毒的应用》，申请号：200610035667.0
(4)《一种复制缺陷的人3型腺病毒疫苗》，申请号：CN200810025744.3
代表论文：
科普宣传：
（1）大风降温凶残来袭！如何远离冬季多发腺病毒感染？
（2）“疫苗研发”为传染病预防控制的关键一招
Google Scholar: https://scholar.google.com/citations?user=aV89laYAAAAJ&hl=en
Publications (*Corresponding Author)：
(1)Qiwei Zhang*, Donald Seto. Chimpanzee Adenovirus Vector Ebola Vaccine--Preliminary Report. New England Journal of Medicine. 2015, 373(8): 775-776. (IF: 72.406)
(2)Qiwei Zhang*, Shuping Jing, Zetao Cheng, Zhiwu Yu, Shoaleh Dehghan, Amirhossein Shamsaddini, Yuqian Yan, Min Li, and Donald Seto*. Comparative Genomic Analysis of Two Emergent Human Adenovirus Type 14 Respiratory Pathogen Isolates in China Reveals Similar yet Divergent Genomes. Emerging Microbes & Infections, 2017, 6, e93; doi:10.1038/emi.2017.78. (IF: 5.605)
(3)Zhiwu Yu, Zhiwei Zeng, Jing Zhang, Yuxian Pan, Manjun Chen, Yonghui Guo, Nan Yu, James Chodosh, Ning Fu, Xiaoyan Che & Qiwei Zhang*. Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate. Scientific Reports, 2016, 6:37216. （IF: 4.259）
(4)Suhui Zhao, Chengsong Wan, Changwen Ke, Jason Seto, Shoaleh Dehghan, Lirong Zou, Jie Zhou, Zetao Cheng, Shuping Jing, Zhiwei Zeng, Jing Zhang, Xuan Wan, Xianbo Wu, Wei Zhao, Li Zhu, Donald Seto*, Qiwei Zhang*. Re-emergent Human Adenovirus Genome Type 7d Caused an Acute Respiratory Disease Outbreak in Southern China After a Twenty-one Year Absence. Scientific Reports, 2014(4): 7365，DOI: 10.1038/srep07365. (IF: 4.259)
(5)Qiwei Zhang*, Donald Seto, Bin Cao, Suhui Zhao, and Chengsong Wan*. Genome Sequence of Human Adenovirus Type 55, a Re-Emergent Acute Respiratory Disease Pathogen in China. Journal of Virology, 2012，86(22)：12441-12442（IF：4.663）.
(6)Qiwei Zhang*, Seto D, Zhao S, Zhu L, Zhao W, Wan C*. Genome Sequence of the First Human Adenovirus Type 14 Isolated in China. Journal of Virology, 2012, 86(12): 7019-7020（IF：4.663）.
(7)Donald Seto, Chodosh J, Brister JR, Jones MS, Members of the Adenovirus Research Community (Qi-Wei Zhang et al). Using the Whole-Genome Sequence To Characterize and Name Human Adenoviruses. Journal of Virology, 2011, 85(11): 5701-5702. （IF: 4.663）.
(8)Qiwei Zhang, Su X, Seto D, Zheng B-j, Tian X, Sheng H, Li H, Wang Y, Zhou R. Construction and characterization of a replication-competent human adenovirus type 3-based vector as a live-vaccine candidate and a viral delivery vector. Vaccine, 2009, 27(8): 1145-1153. (IF:3.485)
(9)Qiwei Zhang, Su X, Gong S, Zeng Q, Zhu B, Wu Z, Peng T, Zhang C, Zhou R. Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China. Journal of General Virology 2006, 87(6): 1531-1541. (IF:3.529)
(10)Zhiwei Zeng, Jing Zhang, Shuping Jing, Zetao Cheng, Silvia Bofill-Mas, Carlos Maluquer de Motes, Ayalkibet Hundesa, Rosina Girones, Donald Seto*, Qiwei Zhang*. Genome Sequence of a Cynomolgus Macaque Adenovirus (CynAdV-1) Isolate from a Primate Colony in the United Kingdom. Genome Announcements. 2016, 4(6): e01193-01116.
(11)Xiangyu Wang, Qi Sun, Zhonghua Ye, Ying Hua, Na Shao, Yanli Du, Qiwei Zhang*, Chengsong Wan*. Computational approach for predicting the conserved B-cell epitopes of hemagglutinin H7 subtype influenza virus. Experimental and Therapeutic Medicine, 2016, 12(4): 2439-2446. （IF: 1.28）
(12)Qiwei Zhang*, Shoaleh Dehghan, Donald Seto. Pitfalls of restriction enzyme analysis in identifying, characterizing, typing, and naming viral pathogens in the era of whole genome data, as illustrated by HAdV type 55. Virologica Sinica, 2016, 31(5):448-453.（SCI-indexed）
(13)Guiyuan Han, Hongling Niu, Suhui Zhao, Bing Zhu, Changbing, Wang, Yungang Liu, Mingjie Zhang, Shu Yang, Feitong Liu, Chengsong Wan, Qiwei Zhang*. Identification and typing of respiratory adenoviruses in Guangzhou, Southern China using a rapid and simple method. Virologica Sinica, 2013, 28(2):103-108.
(14)Yi Chen, Fanghua Liu, Changbing Wang, Mingqi Zhao, Li Deng, Jiayu Zhong, Yingying Zhang, Jun Ye, Shuping Jing, Zetao Cheng, Yongxin Guan, Yi Ma, Yuanyuan Sun, Bing Zhu*, Qiwei Zhang*. "Molecular Identification and Epidemiological Features of Human Adenoviruses Associated with Acute Respiratory Infections in Hospitalized Children in Southern China, 2012-2013". PLoS ONE, 2016, 11(5): e0155412.
(15)Qiwei Zhang*, Xiaomin Zhang, Hao Wu, Donald Seto, Hao-Jie Zhang, Zhiwei Chen, Chengsong Wan and Bo-Jian Zheng*. Parental LTRs Are Important in a Construct of a Stable and Efficient Replication-Competent Infectious Molecular Clone of HIV-1 CRF08_BC. PLoS ONE, 2012, 7: e31233.
(16)Suhui Zhao, Ying Zhou, Chunhui Wang, Yu Yang, Xianbo Wu, Yao Wei, Li Zhu, Wei Zhao, Qiwei Zhang*, Chengsong Wan*. The N-Terminal Domain of EspF Induces Host Cell Apoptosis after Infection with Enterohaemorrhagic Escherichia coli O157:H7. PLoS ONE 2013, 8(1):e55164.
(17)Xiangyu Wang, Zhonglu Ren, Qi Sun, Xuan Wan, Yaqing Sun, Ying Hua, Muqing Fu, Na Shao, Yanli Du, Chengsong Wan*, Qiwei Zhang*. Evaluation and comparison of newly built linear B-cell epitope prediction software from a users’ perspective. Current Bioinformatics, 2017, 12:DOI: 10.2174/1574893612666170711154318 (IF: 0.6)
(18)Niittykoski M, von Und Zu Fraunberg M, Martikainen M, Rauramaa T, Immonen A, Koponen S, Leinonen V, Vaha-Koskela M, Zhang Qiwei, Kuhnel F, Mei YF, Yla-Herttuala S, Jaaskelainen JE, Hinkkanen A. Immunohistochemical Characterization and Sensitivity to Human Adenovirus Serotypes 3, 5, and 11p of New Cell Lines Derived from Human Diffuse Grade II to IV Gliomas. Transl Oncol, 2017, 10(5):772-779. (IF: 3.025)
(19)Jianhai Yu, Xuling Liu, Changwen Ke, Qinghua Wu, Weizhi Lu, Zhiran Qin, Xiaoen He, Yujing Liu, Jieli Deng, Suiqi Xu, Ying Li, Li Zhu, Chengsong Wan, Qiwei Zhang, Weiwei Xiao, Qian Xie, Bao Zhang*, Wei Zhao*. Effective Suckling C57BL/6, Kunming, and BALB/c Mouse Models with Remarkable Neurological Manifestation for Zika Virus Infection. Viruses, 2017, 9(7):165. (IF: 3.465)
(20)Xiangyu Wang, Yanli Du, Ying Hua, Muqing Fu, Cong Niu, Bao Zhang, Wei Zhao, Qiwei Zhang, Chengsong Wan. The EspF N-Terminal of Enterohemorrhagic Escherichia coli O157:H7 EDL933w Imparts Stronger Toxicity Effects on HT-29 Cells than the C-Terminal. Frontiers in Cellular and Infection Microbiology, 2017, 7(410): 10.3389/fcimb.2017.00410. (IF: 4.3)
(21)Xiao-Min Zhang, Hao Wu, Qiwei Zhang, Terrence Chi-Kong Lau, Hin Chu, Zhi-Wei Chen, Dong-Yan Jin and Bo-Jian Zheng. A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs. Journal of Antimicrobial Chemotherapy, 2015, 70(5): 1381-90. (IF: 5.439)
(22)Li H, Zhou R, Chen J, Tian X, Zhang Qiwei, Zeng Q, Gong S. A recombinant replication-defective human adenovirus type 3: A vaccine candidate. Vaccine 2009, 27(1): 116-122. (IF: 3.485)
(23)Seto, J., Walsh, M., Mahadevan, P., Zhang Qiwei. & Seto, D. Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery. Viruses 2010, 2(1):1-26. (IF: 3.465）
(24)Xiao-Min Zhang, Qiwei Zhang, Hao Wu, Terrence Chi-Kong Lau, Xuan Liu, Hin Chu, Ke Zhang, Jie Zhou, Zhiwei Chen, Dong-Yan Jin, Bo-Jian Zheng. "Novel Mutations L228i and Y232h Cause Nnrti Resistance in Combinational Pattern". AIDS Res Hum Retroviruses, 2016: 32(9): 909-917. （IF: 2.457）
(25)Hao Wu, Xiaomin Zhang, Haojie Zhang, Qiwei Zhang, Zhiwei Chen, Jiandong Huang, Shui-Shan Lee, Bo-Jian Zheng. "In Vitro Selection of Hiv-1 Crf08_Bc Variants Resistant to Reverse Transcriptase Inhibitors". AIDS Res Hum Retroviruses, 2015，31（2）：260-270 （IF: 2.457）
(26)Su, X., Tian, X., Zhang, Qiwei, Li, H., Li, X., Sheng, H., Wang, Y., Wu, H. & Zhou, R. Complete genome analysis of a novel E3-partial-deleted human adenovirus type 7 strain isolated in Southern China. Virology Journal 2011, 8(1):91. (IF: 2.089)
(27)Chan, K.-H., Zhang, A. J. X., To, K. K. W., Chan, C. C. S., Poon, V. K. M., Guo, K., Ng, F., Zhang, Qi-Wei, Leung, V. H. C., Cheung, A. N. Y., Lau, C. C. Y., Woo, P. C. Y., Tse, H., Wu, W., Chen, H., Zheng, B.-J. & Yuen, K.-Y. Wild Type and Mutant 2009 Pandemic Influenza A (H1N1) Viruses Cause More Severe Disease and Higher Mortality in Pregnant BALB/c Mice. PLoS ONE 2010, 5(10), e13757.
(28)Dongchi Zhao, Dan Peng, Lei Li, Qiwei Zhang, Chuyu Zhang. Inhibition of G1P3 expression found in the differential display study on respiratory syncytial virus infection. Virology Journal 2008, 5(1):114. (IF: 2.089)
(29)Li, L., Zhao, D., Zhang, C., Zhang, Qiwei & You, S. Prokaryotic expression and polyclonal antibody preparation of novel ZLG10 protein involved in infection of RSV on SPC-A1 cells. Protein Expression and Purification, 2005, 41(1), 170-176. (IF: 1.508)
教育背景：
2002/09-2007/06: 武汉大学生命科学学院病毒学国家重点实验室，博士 导师：张楚瑜；
1998/09-2002/06: 武汉大学生命科学学院微生物学专业，本科（学士）导师：方呈祥。
工作经历：
2016.12-至今: 南方医科大学，公共卫生学院，教授；
2015.10-至今：广东省南山医药创新研究院,特聘研究员;
2015.09-2016.09：哈佛大学医学院，访问学者（国家留学基金委公派）；
2010.10-2016.12: 南方医科大学，公共卫生学院，副教授；
2008.08-2010.10: 香港大学医学院微生物系，博士后；
2007.08-2008.08: 香港大学医学院微生物系，研究助理。
实习经历:
2003.11－2004.05 武汉市儿童医院检验科 实时荧光定量PCR的基础和临床应用研究
2004.09－2007.04 广州市儿童医院中心实验室 呼吸道病原体荧光定量PCR的研究
研究方向：
1.腺病毒疫苗及载体（Adenovirus vaccines and vectors）
近年来人3、4、 7、14、55型腺病毒感染在美洲、欧洲、亚洲，特别是在我国幼儿园、学校以及军队中的感染频频暴发，目前无安全的腺病毒疫苗，也无特效的治疗方法，因此迫切需要进行相关的疫苗研究。研制开发价格低廉、安全有效、具有我国自主知识产权的腺病毒疫苗，经济效益和社会效益巨大，应用前景广阔。本研究利用人5型复制缺陷型腺病毒载体，构建同时表达其他型别腺病毒六邻体蛋白的复制缺陷型重组腺病毒疫苗候选株，为今后腺病毒疫苗的应用研究奠定基础。同时，鉴于目前尚无合适的腺病毒动物感染模型，我们拟建立一种新的腺病毒小动物感染模型，以推动腺病毒疾病体内研究的飞速发展。目前该研究受国家自然科学基金、广东省自然科学基金和珠江科技新星项目支持。
2.腺病毒分子流行病学、基因组学、进化（Genomics, molecular epidemiology and evolution of adenoviruses）
近年来中国频频出现腺病毒的感染和暴发，大量的报道表明，腺病毒开始出现越来越多的基因组变异与重组，引起暴发的变异重组株显示出逃避机体免疫的能力。因此，本研究计划对我国当前流行的腺病毒进行全基因组测序和进化分析，构建腺病毒体内/体外基因组重组的模型，找出其流行及基因组变异重组的规律，并预测腺病毒的进化趋势，为今后腺病毒功能基因组学研究、开发腺病毒疫苗以及我国腺病毒疾病的防控提供科学依据。目前该研究受国家自然科学基金面上项目、广东省高等学校优秀青年教师培养计划支持。
RESEARCH INTERESTS：
My research interests are in the areas of genomics, epidemiology, and vaccines for human adenoviruses, especially for those causing children diseases, such as pink eye, pneumonia and other acute respiratory disease. Recently, there have been more and more human acute respiratory disease outbreaks in Chinese schools and militaries caused by adenoviruses. Homologous recombination appears to play a major role in generating new adenoviruses. So the comprehensive analysis of whole-genome sequences for these existing and emergent adenoviruses is an important approach to identify the homologous recombination and transmission chains in adenovirus evolution, which may lead to new and more severe human infections. In addition, adenovirus infections are very common in children aged 0.6-3, which pose a threat to their health. As a result, I am also interested in the development of effective vaccine candidates using new strategies for those pandemic adenoviruses, as well as the construction of optimal animal models.