1. Tang S, Yu GL, Chen SR. Intrauterine infection with Hepatitis B virus. Lancet 1990; 335:302 2. Tang S, Collier AJ, and Elliott RM. Alterations to both the primary and predicted secondary structure of stem-loop IIIc of the HCV 1b 5’UTR lead to mutants severely defective in translation which cannot be complemented in trans by the wild type 5’UTR sequence. J. Virol. 1999;73:2359-2364. 3. Tang S, Murakami T, Agresta BE, Campbell S, Freed EO, Levin JG. Human immunodeficiency virus type 1 N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cells. J. Virol. 2001;75:9357-9366. 4. Tang S, Murakami T, Cheng N, Steven AC, Freed EO, and Levin JG. Human immunodeficiency virus type 1 N-terminal capsid mutants containing cores with abnormally high levels of capsid protein and virtually no reverse transcriptase. J. Virol. 2003;77:12592-12602 5. Tang S, Ablan S, Dueck M, Ayala-López W, Soto B, Caplan M, Nagashima, Hewlett IK, Freed EO, Levin JG. A Second-Site Suppressor Significantly Improves the Defective Phenotype Imposed by Mutation of an Aromatic Residue in the N-terminal Domain of the HIV-1 Capsid Protein. Virology. 2007; 359:105-115 6. Tang S, Zhao J, Storhoff J, Norris, P., Little R., Yarchoan R., Stramer S, Patno T, Domanus M, Dhar D., Mirkin C A, Hewllett I K. Nanoparticle-based biobarcode amplification assay (BCA) for sensitive detection of human immunodeficiency virus Type 1 (HIV-1) capsid (p24) antigen. J. AIDS, 2007; 46(2):231-7 7. Tang S, Moayeri M, Chen Z, Harma H, Zhao J, Purcell RH, Leppla SH, Hewlett IK. Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles. Clinical and Vaccine Immunology. 2009; 16 (3):408-413 8. Tang S, Moayeri M, Chen Z, Harma H, Zhao J, Purcell RH, Leppla SH, Hewlett IK. Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles. Clinical and Vaccine Immunology. 2009; 16 (3):408-413 9. Tang S and Hewlett I. Nanoparticle-based Immunoassay for Sensitive and Early Detection of Human Immunodeficiency Type 1 Capsid (p24) Antigen. J. Infect. Dis. 2010; 210(s1): S59-S64. 10. Tang S, Zhao J, Wang A, Viswanath R, Harma H, Little RF, Yarchoan R, Stramer SL, Lee S, Wood O, Wong EY, Wang X, Hewlett IK. Characterization of immune responses to capsid protein (p24) of human immunodeficiency virus type 1: implications for detection. Clinical Vaccine Immunology, 2010; 17(8):1244-51 11. Tang S and Hewlett I. Europium nanoparticle-based immunoassays for sensitive detection of pathogens. Chemistry Today, 2009; 27(6):50-52 12. Tang S, Zhao J, Viswanath R, Nyambi PN, Redd AD, Dastyar A, Spacek LA, Quinn TC, Wang X, Wood O, Gaddam D and Hewlett IK. Absence of Detectable Xenotropic Murine Leukemia Virus-related Virus in Plasma or Peripheral Blood Mononuclear Cells of Human Immunodeficiency Virus Type One Infected Blood donors or Individuals in Africa. Transfusion 2011; 51(3):463-8 13. Tang S, Zhao J, Haleyurgirisetty M, Gaddam D, Viswanath R, Wood O, Devadas K, Zhang P, Hewlett IK. Absence of Detectable XMRV and other MLV-related Virus in Healthy Blood donors in the United States. PLoS One 2011; 6(11):e27391 14. Sastalla I, Tang S, Crown D, Liu S, Eckhaus M, Hewlett I, Leppla S, and Moayeri M. Anthrax edema toxin impairs protein clearance in mice. Infection and Immunity 2012; 80(2):529-38 15. Zhao J, Tang S, Ragupathy V, Gaddam D, Wang X, Zhang P, Nyambi PN, Hewlett I. CRF22_01A1 is involved in the emergence of new HIV-1 recombinants in Cameroon. J Acquir Immune Defic Syndr. 2012 Apr 30. 60(4):344-50 16. Kang K, Chen L, Zhao X, Qin C, Zhan Z , Wang J, Li W, Dzakah EE , Huang W, Shu Y, Jiang T, Cao W, Xie Q, Luo X, Tang S. Developemnt of Rapid Immunochromatographic Test for Detecting Hemagglutinin Antigen of H7 Subtype in Patients Infected with Novel Avian Influenza A (H7N9) Virus. PLoS One 2014; 9(3):e92306 17. Li X, Wu Y, Ren X, Deng S, Hu G, Yu S, Tang S. Characterization of Humoral Immune Responses against Capsid Protein p24 and Transmembrane Glycoprotein gp41 of Human Immunodeficiency Virus Type 1 in China. PLoS One. 2016;11(11):e0165874 18. Wu Y, Ren X, Yin D, Wang H, Wan Z, Li X, Hu G, Tang S. Characterization of a novel HIV-1 unique 1 recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China. PLoS One 2017; 12(4): e0175770. 19. Yue Wu, Haiying Wang, Xuqi Ren2,3, Zhengwei Wan, Guifang Hu1, Shixing Tang. HIV-1 CRF07_BC with a Seven Amino Acid Deletion in the gag p6 Region Dominates in HIV-1-Infected Men Who Have Sex with Men in China. AIDS Res Hum Retroviruses 2017; accepted 20. Haiying Wang, Zhengwei Wan, Qiang Sun, Yue Wu, Xiufen Li, Xiaoping An, Shuyun Deng, Nalin Zhu, Xuqi Ren, Yigang Tong, Shixing Tang. Identification of a Novel hepegivirus HHpgV-1 in China Associated with Coinfection of HCV and HIV-1. Emerging Infect Dis 2017; under review 21. Haiying Wang, Zhengwei Wan, Ru Xu, Yujuan Guan, Nalin Zhu, Jianping Li, Zhiwei Xie, Aiqi Lu, Fuchun Zhang, Yongshui Fu, Shixing Tang. A Novel Human Pegivirus HHpgV-1 is Tightly Associated with HCV and HIV-1 Infection but Does Not Worsen HCV-related Liver Damage.Clin Infect Dis 2017; under review
教育背景： 1990/8–1993/7， 北京军事医学科学院流行病学博士 1986/8–1989/7， 广州第一军医大学流行病学硕士 1981/8–1986/7， 广州第一军医大学临床医学学士 工作经历： 2014/12-至今，南方医科大学，公共卫生学院，教授 2011/7-2014/9，广州万孚生物技术股份有限公司副总经理首席科学家 2004/3-2011/6，美国食品药物管理局（FDA）生物产品评审中心资深科学家 1997/10-2004/3，美国健康研究院（NIH）资深科学家 1996/10-1997/10，英国格拉斯哥大学（Univ. of Glasgow）病毒学研究所助研 1995/8-1996/10，军事医学科学院微生物流行病研究所，助研 1993/8-1995/7，北京医科大学博士后 研究方向： 1. HIV分子流行病学与复制机制研究 2. 性传播疾病与艾滋病病原体共感染研究 3. 新发传染病研究 4. 传染病新型检测技术与方法研究 RESEARCH INTERESTS： 1. Molecular epidemiology and virology of HIV infection and replication 2. Co-infection and interaction of sexually transmitted diseases and HIV infection 3. Identification and characterization of emerging and re-emerging infectious diseases 4. Development of novel diagnostic technologies for infectious diseases |