职 称：

教授 博导/博士后合作导师

通信地址：

广州大道北1838号南方医科大学公共卫生学院营养与食品卫生学系

Email：

lyzha@smu.edu.cn

职 务：

职称级别：

正高

学术任职：

广东医学微量元素学会副理事长兼副秘书长、广东省营养学会理事、广东省营养学会青年工作委员会副主任委员、广东省营养学会营养与慢病管理专业委员会常务委员、中华预防医学会自由基专业委员会委员、广东省中西医结合学会肥胖与体重管理专业委员会常委、美国营养学会会员、中国营养学会会员、广东省营养学会会员

最高学历：

博士（Ph.D.）

所属科室：营养与食品卫生学系

研究方向：食物中生物活性物质与慢性非传染性疾病防治、慢性非传染性疾病发病分子机制与防治

科研项目：

1.国家自然科学基金面上项目（No.81872621），大豆皂甙经调控肝脏-胆汁酸-肠道菌群代谢轴预防非酒精性脂肪肝病活性与机理研究，2019.01-2022.12，58万元，主持人。

2.国家自然科学基金面上项目（No.81573125），大豆皂甙调控TLR4信号通路关键靶点的发现及其抗慢性炎症机理，2016.01-2019.12，50万元，主持人。

3.国家青年自然科学基金（No.81102130），大豆皂甙经调节NF-κB信号通路抗慢性炎症的机理研究，2012.01-2014.12，23万元，主持人。

4.广东省自然科学基金（No.2014A030313313），大豆皂甙调控TLR4信号通路关键靶点的发现及其抗慢性炎症机理，2015.01-2018.01，10万元，主持人。

5.广东省医学科学技术研究基金（No.A2011357），基于NF-κB调控的大豆皂甙抗炎性作用构效关系及机制研究，2011.10-2013.10，1万元，主持人。

6.广东省医学科学技术研究基金（No.B2008104），大豆皂甙对促癌剂抑制细胞间隙连接通讯的拮抗作用研究，2008.01-2009.12，1万元，主持人。

成果奖励：

专利/Patents:

代表论文：

1.Xie QY#, Gu XF#, Chen JB#, Liu MS, Xiong F, Wu XL, Zhang YJ, Chen FP, Chen HE, Li MJ, Sun SX, Chu XW, Zha LY*. Soyasaponins reduce inflammation and improve serum lipid profiles and glucose homeostasis in high fat diet-induced obese mice. Molecular Nutrition and Food Research, 2018, 1800205 (DOI: 10.1002/mnfr.201800205). (SCI收录，IF=5.151, 中科院JCR分区I区)

2.Zhang YJ, Chen FP, Chen JD, Huang SQ, Chen JB, Huang J, Li N, Sun SX, Chu XW, Zha LY*. Soyasaponin Bb inhibits the recruitment of toll-like receptor 4 (TLR4) into lipid rafts and its signaling pathway by suppressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent generation of reactive oxygen species. Molecular Nutrition and Food Research, 2016, 60(7): 1532-1543. (SCI收录，IF=5.151, 中科院JCR分区I区)

3.Zhang JT, Yi N, Zha LY, Chen SQ, Li ZJ, Li C, Gong MX, Deng H, Chu XW, Chen JH, Zhang ZQ, Mao LM, Sun SX*. Sodium butyrate induces endoplasmic reticulum stress and autophagy in colorectal cells: implications for apoptosis. PLOS ONE, 2016, 11(1): e0147218. (SCI收录，IF=3.534, 中科院JCR分区III区)

4.Li WL, Zha LY, Li ZQ*, Huang YS, Zhou YP*. The expression profile of aquaporin 1 in rat myocardium after severe burns. Turkish Journal of Medical Sciences, 2015, 45(3):481-488. (SCI收录，IF=0.45, 中科院JCR分区IV区)

5.Zha LY*, Chen JD, Sun SX, Mao LM, Chu XW, Deng H, Cai JW, Li XF, Liu ZQ, Cao WH*. Soyasaponins can blunt inflammation by inhibiting reactive oxygen species (ROS)-mediated activation of PI3K/Akt/ NF-κB pathway. PLOS ONE, 2014, 9(9): e107655. (SCI收录，IF=3.534, 中科院JCR分区III区)

6.Chen JD#，Sun SX#, Zha DS, Wu JG, Mao LM, Deng H, Chu XW, Luo HJ, Zha LY*. Soyasaponins prevent H2O2-induced inhibition of gap junctional intercellular communication by scavenging reactive oxygen species in rat liver cells. Nutrition and Cancer, 2014, 66(8): 1342-1351. (SCI收录，IF=2.470, 中科院JCR分区III区)

7.He GZ, Chen JD, Hu YH, Chen JB, Lv JL, Zha LY*. Soyasaponins protect against palmitic acid-induced oxidative stress in primary mouse hepatocytes: structure-activity relationship. Acta Nutrimenta Sinca, 2014, 36(6): 570-576. (中文核心期刊营养学报英文版)

8.Yang XF#, Mei S#, Gu HH, Guo HL, Zha LY, Cai JW, Li XF, Liu ZQ, Cao WH*. Exposure to excess insulin (glargine) induces type 2 diabetes mellitus in mice fed on a chow diet. Journal of Endocrinology, 2014, 221: 469-480. (SCI收录，IF=3.718, 中科院JCR分区III区)

9.Mei S#, Yang XF#, Guo HL, Gu HH, Zha LY, Cai JW, Li XF, Liu ZQ, Bennett BJ, He L, Cao WH*. A small amount of dietary carbohydrate can promote the HFD-induced insulin resistance to a maximal level. PLOS ONE, 2014, 9(7): e100875. (SCI收录，IF=3.534, 中科院JCR分区II区)

10.Sun SX#, Li WJ#, Zhang H#, Zha LY, Xue Y, Wu XB, Zou F*. Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells. Bioscience Reports, 2012, 32: 83-90. (SCI收录，IF=2.853, 中科院JCR分区III区)

11.Zha LY*, Mao LM, Lu XC, Deng H, Ye JF, Chu XW, Sun SX, Luo HJ. Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW264.7 cells by attenuation of NF-κB-mediated nitric oxide synthase expression. Bioorganic and Medicinal Chemistry Letters, 2011, 21(8): 2415-2418. (SCI收录，IF=2.554, 中科院JCR分区III区)

12.Wu JG, Jiang YX, Zha LY, Ye ZM, Zhou ZF, Ye JF, Zhou HW*. Tetracycline degradation by ozonation, and evaluation of biodegradability and toxicity of ozonation byproducts. Canadian Journal of Civil Engineering, 2010, 37(11): 1485-1491. (SCI收录，IF=0.401, 中科院JCR分区IV区)

13.Zha LY*, Zeng JW, Sun SX, Deng H, Luo HJ. Li WL. Chromium (III) nanoparticles affect hormone and immune responses in heat stressed rats. Biological Trace Element Research, 2009, 129(1-3): 157-169. (SCI收录，IF=1.748, 中科院JCR分区IV区)

14.Zha LY*, Zeng JW, Chu XW, Mao LM, Luo HJ. Efficacy of trivalent chromium on growth performance, carcass characteristics and tissue chromium in heat stressed broiler chicks. Journal of the Science and Food Agriculture, 2009, 89: 1782-1786. (SCI收录，IF=1.714, 中科院JCR分区II区)

15.Zha LY, Xu ZR, Wang MQ*, Gu LY. Chromium Nanoparticle exhibits higher absorption efficiency than chromium picolinate and chromium chloride in Caco-2 cell monolayers. Journal of Animal Physiology and Animal Nutrition, 2008, 92:131-140. (SCI收录，IF=1.406, 中科院JCR分区III区)

16.Zha LY, Wang MQ, Xu ZR*, Gu LY. Efficacy of chromium (III) supplementation on growth, body composition, serum parameters, and tissue chromium in rats. Biological Trace Element Research, 2007, 119: 42-50. (SCI收录，IF=1.748, 中科院JCR分区IV区)

17.Zha LY, Xu ZR*, Wang MQ, Gu LY. Effects of chromium nanoparticle dosage on growth, body composition, serum hormones and tissue chromium in Sprague-Dawley rats. Journal of Zhejiang University Science B, 2007, 8(5): 323-330. (SCI收录，IF=1.679, 中科院JCR分区IV区)

18.Wang MQ, Xu ZR*, Zha LY, Lindemann MD. Effect of chromium nanocomposite supplementation on blood metabolites, endocrine parameters and immune traits in finishing pigs. Animal Feed Science and Technology, 2007, 139: 69-80. (SCI收录，IF=1.997, 中科院JCR分区II区)

【主编/副主编教材】

1.国家级实验教学示范中心教材、全国高等院校规划教材，食品安全综合实习指导，北京：科学出版社，2013年2月，参编/秘书（3.7万字/39.2万字）。