职 称:副教授
通信地址:广州市广州大道北1838号,南方医科大学公共卫生学院7楼
Email:zhouzz418@smu.edu.cn
职称级别:副教授
学术任职:
1. 担任SCI期刊Chinese Chemical Letters(IF=4.632)、Asian Journal of Pharmaceutical Sciences(IF=4.016)青年编委
2. 中国晶体学会青年专业委员会委员、中国晶体学会药物晶体学专业委员会委员、中国化学会会员、广东省突发事件应急管理专家、广东省医学微量元素学会理事、广东省CMA资质认定评审专家
最高学历:博士
研究方向与兴趣:
1、难溶性药物固体化学(包括盐、多晶型、共晶、水合物热力学及其性质研究)
2、药(毒)物代谢组、金属组学研究
3、卫生分析化学
科研项目:
1. 项目负责人,国家自然科学青年基金国家自然科学基金,聚乙二醇在难溶性药物共晶合成中的作用及其溶解机理研究,81703438;
2. 项目负责人,广东省自然科学基金,METH手性对映异构体致大鼠急性中毒差异化的生物标志物发现与机制探讨,2017A030310051;
3.项目负责人,广东省医学科学基金,基于超分子自组装原理提高木犀草素成药性研究,A2016452;
4. 项目负责人,南方医科大学科研启动基金;
近3年代表性论文(第一/通讯作者):
2021年文章
1. Hongji Liu, Jinju Nie, Stephen H.C. Chan, Hailu Zhang, Hongqing Lin, Henry H.Y. Tong, Ande Ma, Zhengzheng Zhou*. Phase solubility diagrams and energy surface calculations support the solubility enhancement with low hygroscopicity of bergenin: 4-aminobenzamide (1: 1) cocrystal. Int. J. Pharmaceut. 2021, 60: 120537.
2. Dandan Huang, H.C. Stephen Chan*, Yunshan Wu, Liang Li, Li Zhang, Yang Lv, Xuemei Yang*, Zhengzheng Zhou*. Phase solubility investigation and theoretical calculations on drug-drug cocrystals of carbamazepine with emodin, paeonol. J. Mol. Liq. 2021, 329: 115604.
3. Hongji Liu, Hongqing Lin, Zhengzheng Zhou*, Liang Li*. Bergenin-isonicotinamide (1:1) cocrystal with enhanced solubility and investigation of its solubility behavior. J. Drug. Deliv. Sci. Tec. 2021, 102556.
2020年文章
4. Hongyu Guan, Yanhui Wu, Yang Han, Jiayou Liu, Dandan Huang, Zhishan Liang, Zhengzheng Zhou*, Fang Guo*. Furosemide adducts with hexamethylenetetramine, amantadine, and isoniazid: a structural case that demonstrates the effect of carboxylic acid dimer and sulfonic acid dimer on the solubility. Cryst. Growth. Des. 2020, 20 (7): 4395-4401.
5. Jianle Zhou, Liang Li, Hailu Zhang, Dandan Huang, Weili Han, Xuemei Yang*, Zhengzheng Zhou*. Crystal structures, dissolution and bioavailability study on a novel phosphodiesterase-4 inhibitor chlorbipram cocrystals. Int J Pharmaceut. 2020, 576: 118984.
2019年文章
6. Feiyuan Zhou, Jianle Zhou, Hailu Zhang, Henry H.Y. Tong, Jinju Nie, Liang Li, Yingyi Zhang, Juan Du, Ande Ma, Xuemei Yang*, Zhengzheng Zhou*. Structure determination and in vitro/vivo study on carbamazepine-naringenin (1:1) cocrystal. J Drug Deliv Sci Tec. 2019, 50: 101244.
7. Yumiao Luo, Siqi Chen, Jianle Zhou, Jiamei Chen, Liwen Tian, Wei Gao, Yingyi Zhang, Ande Ma, Liang Li*, Zhengzheng Zhou*. Luteolin cocrystals: characterization, evaluation of solubility, oral bioavailability and theoretical calculation. J Drug Deliv Sci Tec. 2019, 50: 248-254.
8. Yingyi Zhang, Liang Li, Qi Wang, Mei Shen, Weili Han, Xuemei Yang, Lingyun Chen, Ande Ma*, Zhengzheng Zhou*. Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS. Anal Bioanal Chem. 2019, 411: 3361-3372.
9. Jing Li, Haiyun Yang, Suinan Sha, Jiaquan Li, Zhengzheng Zhou*, Yi Cao*. Evaluation of in vitro toxicity of silica nanoparticles (NPs) to lung cells: influence of cell types and pulmonary surfactant component DPPC. Ecotox Environ Safe. 2019. 186: 109770.
10. Shuang Li, Hongji Liu, Zhengzheng Zhou*, Yi Cao*. Titanate nanotubes at non-cytotoxic concentrations affect NO signaling pathway in human umbilical vein endothelial cells. Toxicol in Vitro. 2019. 62: 104689.
11. Zhengzheng Zhou, Mónica Calatayud*, Julia Contreras-García, Liang Li, Henry H.Y. Tong, Ying Zheng*. X-ray diffraction and theoretical calculation-supported formation of polymorphic cocrystals discovered through thermal methods: a case study. J Pharm Sci. 2019. 108: 3340-3347.
更多论文信息:https://www.researchgate.net/profile/Zhengzheng-Zhou-3/research
教育背景:
2010.9-2013.7 北京协和医学院-清华大学医学部,医学博士
工作经历:
2015.9-至今 南方医科大学,副教授
2013.9-2015.9 澳门大学,博士后研究员