职 称：

讲师

通信地址：

广州大道北1838号南方医科大学公共卫生学院

Email：

ghwang@smu.edu.cn

职 务：

职称级别：

学术任职：

最高学历：

医学博士

所属科室：职业卫生与职业医学系

研究方向：重金属中毒机制及防治，复杂疾病遗传易感性

科研项目：

广东省自然科学基金面上项目，2018A030313217，慢性镉中毒通过抑制PLD1介导的自噬作用引起肾近曲小管损伤的机制研究，2018/05-2021/04，主持

国家自然科学基金面上项目，81773473，小胶质细胞NLRP3炎症小体活化在铅神经毒性中的作用及机制，2018/01-2021/12，参与

国家自然科学基金面上项目，81741131，低氧适应中Bcl-2相关转录因子1调控HIF1α转录机制的研究，2018/01-2018/12，参与

国家自然科学基金面上项目，81671860，HSP90α调控Bclaf1蛋白稳定性及其在低氧适应中的作用机制研究，2017/01-2020/12，参与

国家自然科学基金面上项目，21677066，苯转化的恶性细胞外泌体miR-221在细胞增殖和凋亡抑制信号转导中的作用及机制，2017/01-2020/12，参与

国家自然科学基金面上项目，81673216，氧化应激中热休克蛋白90对MRN复合物相关的DNA双链断裂损伤修复通路的调控机制，2017/01-2020/12，参与

成果奖励：

代表论文：

(1) Dario R. Lemos *, Michael McMurdo, Gamze Karaca, Julia Wilflingseder, Irina A. Leaf, Navin Gupta, Tomoya Miyoshi, Koichiro Susa, Bryce G. Johnson, Kirolous Soliman, Guanghai Wang, Ryuji Morizane, Joseph V. Bonventre, Jeremy S. Duffield, Interleukin-1 beta Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2018, 29(6): 1690-1705

(2) Ou Z# , Wang G#, Li Q, Ma Z, Dai M*, Zou F*, CRTC3 polymorphisms were associated with the plasma level of total cholesterol and the risks of overweight and hypertriglyceridemia in a Chinese Han population., Mol Biol Rep., 2014, 41(1): 125-130

(3) Ma Z#, Wang G#, Chen X, Ou Z, Zou F*, Association of STAT3 Common Variations with Obesity and Hypertriglyceridemia: Protective and Contributive Effects., Int J Mol Sci., 2014, 15(7): 12258-12269

(4) Ou Z#, Wang G#, Li Q, Ma Z, Lin D, Dai M *, Zou F *, The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population, Gene, 2013, 526(2):385-9

(5) Dey S#, Maiti AK, Hegde ML, Hegde PM, Boldogh I, Sarkar PS, Abdel-Rahman SZ,Sarker AH, Hang B, Xie J, Tomkinson AE, Zhou M, Shen B, Wang G, Wu C, Yu D, Lin D, Cardenas V, Hazra TK *, Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2, DNA Repair (Amst)., 2012, 11(6):570-8

(6) Chen K# , Wang G#, Peng L, Liu S, Fu X, Zhou Y, Yu H, Li A, Li J, Zhang S, Bai Y* , Zhang Y*, CADM1/TSLC1 inactivation by promoter hypermethylation is a frequent event in colorectal carcinogenesis and correlates with late stages of the disease., Int J Cancer., 2011, 128(2): 266-273

(7) Tai J#, Yang M, Ni X, Yu D, Fang J, Tan W, Huang Z, Wu C, Chen X, Wang G, Zhou W, Chen X, Zhang W, Ma L, Lin D, Han D *, Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population. Cancer Genet Cytogenet., 2010, 196(1):76-82

(8) Wang G , Yu D, Tan W, Zhao D, Wu C, Lin D*, Genetic polymorphism in chemokine CCL22 and susceptibility to Helicobacter pylori infection-related gastric carcinoma., Cancer, 2009, 115(11): 2430-2437

(9) Yang M#, Guo H, Wu C, He Y, Yu D, Zhou L, Wang F, Xu J, Tan W, Wang G, Shen B, Yuan J, Wu T, Lin D *, Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk, Hum Mutat., 2009, 30(9):1320-8

(10) Wu C#, Wang G, Yang M, Huang L, Yu D, Tan W, Lin D *, Two genetic variants in prostate stem cell antigen and gastric cancer susceptibility in a Chinese population, Mol Carcinog., 2009, 48(12):1131-8