一、基本信息
姓名：周基元
职称：教授
联系邮箱：zhoujiyuan5460@hotmail.com
二、学习经历
1994.4-1996. 6 中国人民解放军国防科技大学，数学专业，学士
2002.9-2005.3 东南大学，概率论与数理统计专业，硕士
2006.1-2009.9 香港大学，统计学与遗传学专业，博士
三、拟招收博士后开展的研究方向
1. 统计遗传学；
2. 生物统计学；
3. 统计学；
4. 应用统计学。
四、主要学术任职
1. SCI源期刊《BMC Genetics》，副编辑；
2. 中华预防医学会生物统计分会，委员；
3. 中国卫生信息学会统计理论与方法专业委员会，委员；
4．“器官衰竭防治”国家重点实验室，PI；
5. 广东省生物统计学会，常务理事。
五、主要获奖情况
1. 2006年11月获得由美国国家卫生研究院National Institute of General Medical Sciences 提供的1000美金奖学金；
2. 2006年11月获得由香港Bioinformatics Subtheme of the SRT on Genomics, Proteomics and Bioinformatics提供的3000港币奖学金。
六、代表性论文
1. Peng Wang, Si-Qi Xu, Bei-Qi Wang, Wing K. Fung*, Ji-Yuan Zhou*(共同通讯作者). A robust and powerful test for case-control genetic association study on X chromosome. Statistical Methods in Medical Research. 2019, 28(10-11): 3260-3272. [Full Text] [Software:Zmax]
2. Zhijiang Liang, Yin Yang, Jin Li, Xinhong Zhu, Zengliang Ruan, Shuilian Chen, Guanhao Huang, Hualiang Lin*, Ji-Yuan Zhou*(共同通讯作者), Qingguo Zhao*. Migrant population is more vulnerable to the effect of air pollution on preterm birth: results from a birth cohort study in seven Chinese cities. International Journal of Hygiene and Environmental Health. 2019, 222(7): 1047-1053. DOI: 10.1016/j.ijheh.2019.07.004. [Full Text] [PubMed]
3. Peng Wang#, Yu Zhang#, Bei-Qi Wang, Jian-Long Li, Yi-Xin Wang, Dongdong Pan, Xian-Bo Wu, Wing Kam Fung, Ji-Yuan Zhou*(通讯作者). A statistical measure for the skewness of X chromosome inactivation based on case-control design. BMC Bioinformatics. 2019, 20:11. DOI: 10.1186/s12859-018-2587-2 [Full_Text] [Software: SkewXCI]
4. Wei Liu, Bei-Qi Wang, Guojun Liu-Fu, Wing Kam Fung*, Ji-Yuan Zhou*(共同通讯作者). X-chromosome genetic association test incorporating X chromosome inactivation and imprinting effects. Journal of Genetics. 2019 (accepted).
5. Pui Yin Lau#, Kar Fu Yeung#, Ji-Yuan Zhou*(共同通讯作者), Wing Kam Fung*. Two powerful tests for parent-of-origin effects at quantitative trait loci on X chromosome. Human Heredity. 2017/2018, 83(5): 250–273 as DOI: 10.1159/000496987. [Full Text] [Software]
6. Ji-Yuan Zhou*(共同通讯作者), Xiao-Ping You, Ran Yang, Wing K Fung*. Detection of imprinting effects for qualitative traits on X chromosome based on nuclear families. Statistical Methods in Medical Research. 2018, 27(8): 2329-2343. [Full Text]
7. Zhijiang Liang#, Peng Wang#, Qingguo Zhao, Bei-Qi Wang, Yuanzhu Ma, Hualiang Lin, Jianpeng Xiao, Ji-Yuan Zhou*(通讯作者). Effect of the 2008 cold spell on preterm births in two subtropical cities of Guangdong Province, Southern China. Science of the Total Environment. 2018, 642:307–313. [Full Text]
8. Wing K Fung, KexinYu, Yingrui Yang, Ji-Yuan Zhou*(通讯作者）. Efficient Monte Carlo evaluation of resampling-based hypothesis tests with applications to genetic epidemiology. Statistical Methods in Medical Research. 2018, 27(5): 1437-1450. [Full Text]
9. Qi-Lei Zou#, Xiao-Ping You#, Jian-Long Li, Wing Kam Fung*, Ji-Yuan Zhou*(共同通讯作者). A powerful parent-of-origin effects test for qualitative traits on X chromosome in general pedigrees. BMC Bioinformatics. 2018, 19:8 as doi: 10.1186/s12859-017-2001-5. [Full Text]
10. Si-Qi Xu, Yu Zhang, Peng Wang, Wei Liu, Xian-Bo Wu*, Ji-Yuan Zhou*(共同通讯作者). A statistical measure for the skewness of X chromosome inactivation based on family trios. BMC Genetics. 2018, 19: 109. doi: 10.1186/s12863-018-0694-8 [Full_Text]
11. Ying Tang, Aimin Chen, Shuzhen Zhu, Li Yang, Jiyuan Zhou, Suyue Pan, Min Shao, Lianxu Zhao*. Repetitive transcranial magnetic stimulation for depression after basal ganglia ischaemic stroke: protocol for a multicentre randomised double-blind placebo-controlled trial. BMJ Open. 2018, 8(2):e018011, doi: 10.1136/bmjopen-2017-018011. [Full_Text]
12. Jian-Long Li, Peng Wang, Wing Kam Fung*, Ji-Yuan Zhou*(共同通讯作者). Generalized disequilibrium test for association in qualitative traits incorporating imprinting effects based on extended pedigrees. BMC Genetics. 2017, 18:90 as doi: 10.1186/s12863-017-0560-0. [Full Text] [Software: MCGDTI]
13. Kexin Yu, Ji-Yuan Zhou* (共同通讯作者), Wing K Fung*. Detection of imprinting effects for quantitative traits on X chromosome using nuclear families with multiple daughters. Annals of Human Genetics. 2017, 81(4): 147-160. [Full Text]
14. Xiao-Ping You, Qi-Lei Zou, Jian-Long Li, Ji-Yuan Zhou*(通讯作者）. Likelihood Ratio Test for Excess Homozygosity at Marker Loci on X Chromosome. PLoS ONE. 2015, 10(12):e0145032. doi:10.1371/journal.pone.0145032. [Full Text] [Software:XHWE]
15. Ji-Yuan Zhou*(共同通讯作者）, Hai-Qiang He, Xiao-Ping You, Shao-Zhan Li, Ping-Yan Chen, and Wing Kam Fung*. A powerful association test for qualitative traits incorporating imprinting effects using general pedigree data. Journal of Human Genetics. 2015, 60(2):77-83. [Full Text] [Software: MCPDTI]
16. Hai-Qiang He, Wei-Gao Mao, Dongdong Pan, Ji-Yuan Zhou*(通讯作者）, Ping-Yan Chen, and Wing Kam Fung. Detection of parent-of-origin effects for quantitative traits using general pedigree data. Journal of Genetics. 2014, 93(2):339-347. [Full Text] [Software: Q-MCPPAT]
17. Qiong Cao, Di Xie, Jiangmei Liu, Hongyan Zou, Yinze Zhang, Hong Zhang, Zhimei Zhang, Hao Xue, Jiyuan Zhou, Pingyan Chen. HLA Polymorphism and Susceptibility to End-Stage Renal Disease in Cantonese Patients Awaiting Kidney Transplantation. PLoS ONE. 2014, 9(3):e90869. doi:10.1371/journal.pone.0090869. [Full Text]
18. Wei-Gao Mao, Hai-Qiang He, Yan Xu, Ping-Yan Chen, and Ji-Yuan Zhou*(通讯作者）. Powerful Haplotype-Based Hardy-Weinberg Equilibrium Tests for Tightly Linked Loci. PLoS ONE. 2013, 8(10):e77399. doi:10.1371/journal.pone.0077399. [Full Text] [Software:HAP-HWE]
19. Dongdong Pan, Wen-Jun Xiong, Ji-Yuan Zhou, Ying Pan, Guoli Zhou, and Wing K. Fung. Robust Joint Analysis with Data Fusion in Two-stage Quantitative Trait Genome-wide Association Studies. Computational and Mathematical Methods in Medicine. 2013, Volume 2013, Article ID 843563, 12 pages [Full Text]
20. Fan Xia, Ji-Yuan Zhou, and Wing Kam Fung. Powerful Tests for Association on Quantitative Trait Loci Incorporating Imprinting Effects. Journal of Human Genetics. 2013, 58(6):384-390. [Abstract]
21. Ji-Yuan Zhou*(共同通讯作者), Wei-Gao Mao, Dan-Ling Li, Yue-Qing Hu*, Fan Xia, and Wing Kam Fung. A Powerful Parent-of-Origin Effects Test for Qualitative Traits Incorporating Control Children in Nuclear Families. Journal of Human Genetics. 2012, 57(8):500-507. [Abstract] [Software:C-PATu]
22. Fan Xia, Ji-Yuan Zhou, and Wing Kam Fung. A Powerful Approach for Association Analysis Incorporating Imprinting Effects. Bioinformatics. 2011, 27(18):2571-2577. [Full Text]
23. Feng He, Ji-Yuan Zhou*(通讯作者、共同第一作者), Yue-Qing Hu, Fengzhu Sun, Jingyuan Yang, Shili Lin, and Wing Kam Fung. Detection of Parent-of-Origin Effects for Quantitative Traits in Complete and Incomplete Nuclear Families With Multiple Children. American Journal of Epidemiology. 2011, 174(2):226-233. [Full Text] [Software:Q-C-PAT]
24. Yue-Qing Hu, and Ji-Yuan Zhou. Inferring haplotype/disease association by joint use of case-parents trios and case-parent pairs. Annals of Human Genetics. 2010, 74(3):263-274.
25. Ji-Yuan Zhou, Jie Ding, Wing K. Fung, and Shili Lin. Detection of parent-of-origin effects using general pedigree data. Genetic Epidemiology. 2010, 34(2):151-158. [软件:MC-PDT]
26. Ji-Yuan Zhou, Shili Lin, Wing K. Fung, and Yue-Qing Hu. Detection of parent-of-origin effects in complete and incomplete nuclear families with multiple affected children using multiple tightly linked markers. Human Heredity. 2009, 67(2):116-127.
27. Ji-Yuan Zhou, Yue-Qing Hu, Shili Lin, and Wing K. Fung. Detection of parent-of-origin effects based on complete and incomplete nuclear families with multiple affected children. Human Heredity. 2009, 67(1):1-12.
28. Yue-Qing Hu, Ji-Yuan Zhou, Fengzhu Sun, and Wing K. Fung. The transmission disequilibrium test and imprinting effects test based on case-parent pairs. Genetic Epidemiology. 2007, 31(4):273-287.
29. Yue-Qing Hu, Ji-Yuan Zhou, and Wing K. Fung. An extension of the transmission disequilibrium test incorporating imprinting. Genetics. 2007, 175(3):1489-1504.
30.Ji-Yuan Zhou, Yue-Qing Hu, and Wing K. Fung. A simple method for detection of imprinting effects based on case-parents trios. Heredity. 2007, 98(2):85-91.
31. Christopher W. Bartlett, Veronica J Vieland, Jacquelaine Bartlett, Jordana T. Bell, Samsiddhi Bhattacharjee, Franc-oise Clerget-Darpoux, William S. Bush, Todd L. Edwards, Guimin Gao, Indrani Halder, Yungui Huang, Salma Kotti, Emma K. Larkin, Hua Li, Alison A. Motsinger, Nandita Mukhopadhyay, Junghyun Namkung, Taesung Park, Marylyn D. Ritchie, Catherine M. Stein, Ji-Yuan Zhou. Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky. Genetic Epidemiology. 2007, 31(Supplement 1):S61-S67.
32. 王北琪，汪鹏，尹平，周基元*（通讯作者）. 偏态分布下多样本变异系数比较的平方秩检验. 中国卫生统计. 2018, 35(4): 515-517
33. 李剑龙，陈方尧，李丹玲，周基元*（通讯作者），陈平雁．具有相关关系的灵敏度和特异度的Monte Carlo模拟方法研究．中国卫生统计．2015, 32(3):417-420.
34. 汪鹏，周基元*（通讯作者）．非中心t分布非中心参数的最大似然估计．统计与决策．2014，第15期，9-13页.
35. 汪鹏，周怡，周基元*（通讯作者）．多样本变异系数比较的似然比检验．中国卫生统计．2013, 30(3):317-322.
36.周基元，张新华. X伴性遗传疾病易感性基因的定位问题. 数学理论与应用. 2005, 25(4):44-48.
37. 周基元,向泽恩. The power of the transmission/disequilibrium test (TDT) in the presence of the genetic imprinting. 怀化学院学报. 2004, 23(5):46-50.
38. 毛成敏，周基元，麻清华. 外婆在亲子鉴定中的作用. 怀化学院学报. 2004，23(2):46-49.
39. 钱峰，周基元，殷晓晖，缪雪琴. 椭球约束下混合模型的线性极小极大估计. 怀化学院学报. 2004，23(2):13-16.