甄鑫

姓名：甄鑫

职称：教授

联系邮箱：xinzhen@smu.edu.cn

学习经历（学士、硕士、博士）：

2000.9-2005.6 南方医科大学，生物医学工程，学士

2005.9-2008.6 南方医科大学，生物医学工程，硕士

2010.9-2013.6 南方医科大学，生物医学工程，博士

2011.7-2012.8美国加州大学圣地亚哥分校Moores 肿瘤中心CART 实验室访问学者

2016.2-2017.8美国德州大学西南医学中心肿瘤放射治疗系访问助理教授

工作经历：

2008.07-2010.12 南方医科大学生物医学工程学院医疗仪器研究所，助教

2010.12-2014.12 南方医科大学生物医学工程学院医疗仪器研究所，讲师

2014.12-2022.01 南方医科大学生物医学工程学院医疗仪器研究所，副教授

2022.01-至今    南方医科大学生物医学工程学院医疗仪器研究所，教授

研究方向：

医学图像处理，自适应放射治疗，肿瘤放射物理，机器学习在放疗中的应用研究等

主要获奖情况：

2012年，AAPM California Chapter Norm Baily Award 2012, best student paper.

2013年，获中国人民解放军医疗成果奖三等奖

2014年，获美国近距离放射治疗2014年会（American Brachytherapy Society 2014 Meeting）4篇最优摘要-最优物理奖（Top Four Abstract- Best in Physics）

2017年，获美国美国医学物理学家协会（American Association of Physicists in Medicine，AAPM）2017年会Science Council Session论文奖

主要科研课题：

1. 2017年，国家自然科学基金海外及港澳学者合作研究基金-基于深度学习的宫颈癌放疗并发症预测模型研究（2018年01月01日 -- 2019年12月31日，在研，18万，主持，项目编号：81728016）

2.2015 年，广东省自然科学基金面上项目—应用于宫颈癌自适应近距离

放疗的精确变形配准模型研究（2015-08-01 至 2018-08-01，在研，10 万，主持，项目编号：2015A030313302）；

3.2014 年，广州市科技计划项目-珠江科技新星专项—自适应近距离放

疗中治疗分次间CT 图像变形配准算法研究（2015-04-01到2018-03-31，在研，30 万，主持，项目编号：201506010096）；

4.2013 年，国家自然科学基金青年基金项目—自适应放疗中CT 和信息缺失CBCT 图像快速变形配准方法的研究（2014年1月-2016年12月，结题，23 万，主持，项目编号：81301940）；

代表性论文：

1. Zhen X, Chen J, Zhong Z, Hrycushko B, Zhou L, Jiang S, Albuquerque K, Gu X: Deep convolutional neural network with transfer learning for rectum toxicity prediction in cervical cancer radiotherapy: a feasibility study. Phys Med Biol 2017, 62(21):8246-8263.

2.  Zhen X, Zhao B, Wang Z, Timmerman R, Spangler A, Kim N, Rahimi A, Gu X: Comprehensive target geometric errors and margin assessment in stereotactic partial breast irradiation. Radiation oncology 2017, 12(1):151.

3.  Liao Y, Wang L, Xu X, Chen H, Chen J, Zhang G, Lei H, Wang R, Zhang S, Gu X, Zhen X, Zhou L: An anthropomorphic abdominal phantom for deformable image registration accuracy validation in adaptive radiation therapy. Med Phys 2017, 44(6):2369-2378.

4.  Li X, Zhang Y, Shi Y, Wu S, Xiao Y, Gu X, Zhen X, Zhou L: Comprehensive evaluation of ten deformable image registration algorithms for contour propagation between CT and cone-beam CT images in adaptive head & neck radiotherapy. PloS one 2017, 12(4):e0175906.

5.  Liao YL, Chen HB, Zhou LH, Zhen X: Construction of an anthropopathic abdominal phantom for accuracy validation of deformable image registration. Technology and health care : official journal of the European Society for Engineering and Medicine 2016, 24 Suppl 2:S717-723.

6.  Li X, Zhang YY, Shi YH, Zhou LH, Zhen X: Evaluation of deformable image registration for contour propagation between CT and cone-beam CT images in adaptive head and neck radiotherapy. Technology and health care : official journal of the European Society for Engineering and Medicine 2016, 24 Suppl 2:S747-755.

7.  Chen H, Zhong Z, Liao Y, Pompos A, Hrycushko B, Albuquerque K, Zhen X*, Zhou L, Gu X: A non-rigid point matching method with local topology preservation for accurate bladder dose summation in high dose rate cervical brachytherapy. Phys Med Biol 2016, 61(3):1217-1237.

8.  Xiao, Y., L.H. Zhou*, and X. Zhen*, FISER: Feature Image Space Enhanced Random Walker Algorithm for Brain Tumor Segmentation in Multimodal MR Images. Journal of Medical Imaging and Health Informatics, 2015. 5(8): p. 1977-1981.

9.  Zhen X, Chen H, Yan H, Zhou L, Mell LK, Yashar CM, Jiang S, Jia X, Gu X, Cervino L: A segmentation and point-matching enhanced efficient deformable image registration method for dose accumulation between HDR CT images. Phys Med Biol 2015, 60(7):2981-3002.

10. H. Chen, X. Zhen*, X. Gu, H. Yan, L. Cervino, Y. Xiao, L. Zhou*, "SPARSE: Seed Point Auto-Generation for Random Walks Segmentation Enhancement in medical inhomogeneous targets delineation of morphological MR and CT images," Journal of Applied Clinical Medical Physics 16, 387-402 (2015).

11. Yan H, Zhen X, Folkerts M, Li Y, Pan T, Cervino L, Jiang S B and Jia X 2014 A hybrid reconstruction algorithm for fast and accurate 4D cone-beam CT imaging Medical Physics 41 071903

12. Zhen X, Chen H, Yan H, Zhou L, Mell L, Yashar C M, Jiang S B, Jia X, Gu X and Cervino L 2014a A Deformable Image Registration Method for Dose Accumulation between HDR CT Images Brachytherapy 13 S15-S6

13. Zhen X, Pompoš A, Chen H, Yan H, Zhou L, Jiang S B and Gu X 2014 Towards Accurate OAR Dose Accumulation in Cervix Brachytherapy: Applying a Non-Rigid Point Matching Method for Bladder Deformation Brachytherapy 13 S26-S7

14. Li N, Zarepisheh M, Uribe-Sanchez A, Moore K, Tian Z, Zhen X, Graves Y J, Gautier Q, Mell L, Zhou L, Jia X and Jiang S 2013 Automatic treatment plan re-optimization for adaptive radiotherapy guided with the initial plan DVHs Phys Med Biol 58 8725-38

15. Zhen X, Yan H, Zhou L, Jia X and Jiang S B 2013 Deformable image registration of CT and truncated cone-beam CT for adaptive radiation therapy Physics in Medicine and Biology 58 7979-93

16. Zhen X, Yan H, Hu J, Zhou L, Jia X, Jiang S and Cervino L 2013 SU-E-J-86: A Deformable Image Registration Method for Dose Accumulation Between IMRT and HDR CT Images. AAPM) pp 000170-170

17. Yan H, Zhen X, Cervino L, Jiang S and Jia X 2013a WE-G-141-06: Progressive Cone Beam CT Dose Control in Image-Guided Radiation Therapy. AAPM) pp 000508-508

18. Yan H, Zhen X, Folkerts M, Pan T, Cervino L, Jiang S and Jia X 2013b TH-C-103-08: BEST IN PHYSICS (IMAGING) --- A Hybrid 4D Cone Beam CT Reconstruction Algorithm for Highly Under-Sampled Projections From the 1-Minute Cone Beam Scan. AAPM) pp 000543-543

19. Zhen X, Gu X, Yan H, Zhou L*, Jia X*, Jiang SB*: CT to cone-beam CT deformable registration with simultaneous intensity correction. Physics in Medicine and Biology 57(21):6807-6826, 2012.(SCI收录, IF 2.829)

20. Yan H, Zhen X, Cerviño L, Jiang S B and Jia X 2013 Progressive cone beam CT dose control in image-guided radiation therapy Medical Physics 40 060701 (SCI收录, IF 2.83)

21. Zhen X, Graves Y, Yan H, Zhou L*, Jia X*, Jiang S*: WE-E-213CD-07: Deformable Registration Between CT and Truncated CBCT for Adaptive Therapy Dose Calculation. AAPM 2012: 3961-3961, Charlotte, USA. 2012.7.29-8.2. (Oral presentation, SCI收录)

22. Zhen X, Yan H, Gu X, Zhou L*, Jia X*, Jiang S*: WE-E-213CD-04: CT to Cone-Beam CT Deformable Registration With Simultaneous Intensity Correction. AAPM 2012: 3960-3960, Charlotte, USA. 2012.7.29-8.2. (Oral presentation, SCI收录)

23. Graves Y, Zhen X, Kim G, Gautier Q, Tian Z, Cervino L, Lambrecht M, Jia X*, Jiang S*: SU-E-T-340: Estimation of the Delivered Fractional and Accumulative Patient Dose in IMRT and VMAT. AAPM 2012: 3782-3782, Charlotte, USA. 2012.7.29-8.2. (Oral presentation, SCI收录)

24. Kearney V, Wang X, Gu X, Yan H, Zhen X, Jia X, Jiang S, Cervino L: SU-C-BRA-02: Evaluation of 2D DIR from CBCT to 4DCT Projections as a Tool for IGART. AAPM 2012: 3602-3603, Charlotte, USA. 2012.7.29-8.2. (Oral presentation, SCI收录)

25. 周露, 甄鑫, 卢文婷, 窦建洪, 周凌宏*: 基于改进Demons算法的非刚性配准及其在肿瘤放疗中的应用. 南方医科大学学报 2012(01):40-45.

26. Zhen X, Zhou L*, Lu W, Zhang S: Deformable Registration for Re-Contouring and Phase Prediction in 4D CT. In: Biomedical Engineering and Computer Science (ICBECS), 2010 International Conference on: 1-4, Wuhan, China,2010.4.24-4.25. (EI收录)

27. 甄鑫, 周凌宏*, 卢文婷, 张书旭, 周露: 改进Demons算法的验证及其在4D-CT轮廓线推衍中的应用. 南方医科大学学报 2010(12):2619-2624.

28. 甄鑫, 陈海斌, 肖阳, 胡洁, 周凌宏: HDR后装治疗CT图像至IMRT CT图像变形配准算法研究. 中华放射肿瘤学杂志 2015, 24(2):209-212.

29. 甄鑫, 周凌宏: CT和信息缺失CBCT图像变形配准方法研究. 国外电子测量技术 2014(06):61-65.

30. 甄鑫, 陈海斌, 肖阳, 胡洁, 周凌宏: 调强放疗CT图像至高剂量率后装治疗CT图像变形配准算法研究. 中国辐射卫生 2014(04):293-297.