区彩文

姓名：区彩文

职称：研究员

联系邮箱：1284572007@qq.com

v 学习经历

2010/9–2013/6，广州医科大学，心血管内科学，博士

2001/9–2004/6，广州医科大学，心血管内科学，硕士

1996/9–2001/6，河北医科大学，临床医学，学士

v 工作经历

2016/09-至今，南方医科大学，研究员，博士生导师，博士后合作导师

v 研究方向

组织工程与生物材料，人工智能

v 招生方向

v 主要学术任职

中华医学会健康管理学分会青年委员、中国生物材料纳米生物技术分会委员、中国解剖学会血管分会委员、中国生物材料学会康复器械与生物材料分会委员、广东省医师协会医学科研管理分会副主任委员、广东省健康管理学会食品安全与营养健康学会常务委员、粤港澳大湾区心血管基础与临床分会副主任委员，广东省发改委恶性肿瘤硼中子治疗技术与应用工程中心主任、广东省心功能与微循环重点实验室副主任。

v  主要获奖情况

1、广东特支计划，广东省人力资源与社会保障厅，2020年

2、中华医学会第二届中青年心血管病学菁英（临床科研创新奖），2020年

v  主要科研课题

1、干细胞及其来源外囊泡调控组织器官再生修复的研究，2023B1515130005，2024年，广东省粤莞联合基金团队项目，200万，2024.03-2027.07，主持，在研。

2、导电粘附型心脏补片的仿生构建及其对室壁瘤的修复作用研究,32371428，2023年，国家自然科学基金面上项目，50万，2024.01.01-2026.12.31，主持，在研。

3、硅锶掺杂GelMA-PEG微球/EPC-exosomes支架调控心肌常驻巨噬细胞功能分化促进心肌再生，82172103 ，2021年，国家自然科学基金面上项目，55万，2022.01-2025.12，主持，在研。

4、基于干细胞及其微环境调控生物活性陶瓷对心肌再生修复的机制与应用研

究， 2022B1515120065，2022年，广东省粤莞联合基金重点项目，100万，2022.10-2025.9，主持，在研。

5、基于生物陶瓷等仿生材料调控干细胞及外囊泡用于器官再生修复的应用研究，2023年，东莞市社会发展科技项目高水平医院建设专项（第二批）立项项目，450万，主持，在研。

v 代表性论文

[1] Shaohui Deng^#, Lijun Hu^#, Guo Chen^#, Jujian Ye, Zecong Xiao, Tianwang Guan, Shuai Guo, Wei Xia, Du Cheng, Xiaochun Wan*, Ke Cheng*, Caiwen Ou*. A PD-L1 siRNA-Loaded Boron Nanoparticle for Targeted Cancer Radiotherapy and Immunotherapy. Advanced Materials, 2025, doi:10.1002/adma.202419418. (IF:29, 1区)

[2] Shuai Guo^#, Tianwang Guan^#, Rundong Tai ^#, Long Ma*, Yushen Ke, Jujian Ye, Huiwan Chen, Yuxuan Pan, Xiaodong Ning, Xueqin Shi, Zhilin Deng, Yafang Xiao, Shaohui Deng, Peier Chen, Zhenhua Li, Xiaozhong Qiu, Kelong Fan*, Zheyu Shen*, Caiwen Ou*. Nuclei Bombing Nano-system Improves STING-activated Cancer Immunotherapy. Nano Today.2025.  (IF:13.2, 1区)

[3] Tianwang Guan^#, Zhenxing Lu^#, Rundong Tai^#, Shuai Guo^#, Zhaowenbin Zhang*, Shaohui Dengc, Jujian Ye, Kaiyi Chi, Binghua Zhang, Huiwan Chen, Zhilin Deng, Yushen Ke, Andong Huang, Peier Chen*, Chunming Wang*, Caiwen Ou*. Silicified Curcumin Microspheres Combats Cardiovascular Diseases via Nrf2/HO-1 Pathway. Bioactive Materials.2025. (IF:18.0, 1区)

[4] Wang Hao^#, Tianwang Guan^#, Rong Hu^#, Zhongjie Huang, Zhao Liang, Xiaonan Lin, Yingqi Qiu, Peiyun Liao, Xiongbo Guo, Yushen Ke, Honghao Zhang, Caiwen Ou*, Yuhua Li*. 2025. Targeting KAT7 Inhibits the Progression of Colorectal Cancer. Theranostics 15(4):1478–95. doi: 10.7150/thno.106085. (IF:12.4, 1区)

[5] Ruomei Cheng^#, Xiaopeng Tang^#, Qiyu Zhao^#, Yuming Wang^#, Wenlin Chen, Gan Wang, Chenxi Wang, James Mwangi, Qiumin Lu, DawitAdisu Tadese, Xudong Zhao*, Caiwen Ou*, Ren Lai*. Transferrin Disassociates TCR from CD3 Signaling Apparatus to Promote Metastasis. Research (Wash D C). 2025 Jan 13;8:0578. (IF:8.5, 1区)

[6] Zhou Hongxia^#, Wenbo Huang^#, Jieting Li^#, Peier Chen, Lihan Shen, Wenjing Huang, Kailin Mai, Heyan Zou, Xueqin Shi, Yunceng Weng, Yuhua Liu, Zifeng Yang*, Caiwen Ou*. Oral Probiotic Extracellular Vesicle Therapy Mitigates Influenza A Virus Infection via Blunting IL-17 Signaling. Bioactive Materials 45:401–16. doi: 10.1016/j.bioactmat.2024.11.016. (IF:18.0, 1区)

[7] Guan Tianwang^#, Yanting Jiang^#, Peinan Tu^#, Baokui Ye^#, Liangjia Zeng, Zehao Luo, Kaiyi Chi, Haowen Liang, Yuting Yang, Jinqi Huang, Binghua Zhang, Rundong Tai, Jujian Ye, Zhilin Deng, Yushen Ke, Huiwan Chen, Zhiling Zhang*, Zhigang Liu*, Caiwen Ou*. 2024. Risk Classification for Non-Cancer Death in Middle-Aged Cancer Patients. Journal of Advanced Research doi: 10.1016/j.jare.2024.12.039. (IF:11.4, 1区)

[8] Shuai Guo^#, Tianwang Guan ^#, Yushen Ke ^#, Yuping Lin, Rundong Tai, Jujian Ye, Zhilin Deng, Shaohui Deng*, Caiwen Ou*. Biologically Logic-Gated Trojan-Horse Strategy for Personalized Triple-Negative Breast Cancer Precise Therapy by Selective Ferroptosis and STING Pathway Provoking .Biomaterials 2024, 315, 122905. (IF:12.8, 1区)

[9] Peier Chen^#, Xiaodong Ning^#, Weijing Feng, Yajing Li, Xu Shi, Xueqin Shi, Yafang Xiao, Yuhua Liu, Guoxia Zhang^∗, Feiran Zhou^#∗, Caiwen Ou^∗. Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF-κB/NLRP3 Pathway. Advanced science.2024: e2404142 (IF:14.3, 1区)

[10] Fu C^#, Li Q^#, Li M^#, Zhang J, Zhou F, Li Z, He D, Hu X, Ning X, Guo W, Li W, Ma J, Chen G, Xiao Y*, Ou C*, Guo W*. An Integrated Arterial Remodeling Hydrogel for Preventing Restenosis After Angioplasty. Advanced science .2024: e2307063. (IF:14.3, 1区)

[11] Chen P^#, Zhang W^#, Fan X^#, Shi X, Jiang Y, Yan L, Li H, Wang C, Han L*, Lu X*, Ou C*. A polyphenol-derived redox-active and conductive nanoparticle-reinforced hydrogel with wet adhesiveness for myocardial infarction repair by simultaneously stimulating anti-inflammation and calcium homeostasis pathways. Nano Today 2024, 55. (IF:13.2, 1区)

[12] Guo S^#, Li Z^#, Zhou R^#, Feng J*, Huang L, Ren B, Zhu J, Huang Y, Wu G, Cai H, Zhang Q, Ke Y, Guan T, Chen P, Xu Y, Yan C*, Ou C*, Shen Z*. MRI-Guided Tumor Therapy Based on Synergy of Ferroptosis, Immunosuppression Reversal and Disulfidptosis. Small.2024: e2309842. (IF:13, 1区)

[13] Guan T^#, Monteiro O, Chen D, Luo Z, Chi K, Li Z, Liang Y, Lu Z, Jiang Y, Yang J, Lin W, Yi M, Zhang K*, Ou C*. Long-term and short-term cardiovascular disease mortality among patients of 21 non-metastatic cancers. J Adv Res. 2024 Mar 26:S2090-1232(24)00117-6. (IF:11.4, 1区)

[14] Ding D^#, Mo S, Li Q, Wang F, Wang X*, Ou C*, Li Z*. Fluorinated BPA derivatives enhanced 10B delivery in tumors. J Mater Chem B. 2024 Jun 27. (IF: 6.1, 1区)

[15] Fu C^#, Tao Y^#, Chen H, Li M, Xiao Y, Yao Y, Ma J, Ning X, Li W, Zheng J, Dong S, Chen G, Cao F, Ou C*, Liu L*, Guo W*. Monocyte Differentiation-Surveilling Nano-Shuttles for Activatable Targeted Inhibition of Atherosclerotic Plaque Progression. Adv Funct Mater 2023, 33(37): 2303150. (IF:18.5, 1区)

[16] Feng W^#, Teng Y^#, Zhong Q, Zhang Y, Zhang J, Zhao P, Chen G, Wang C, Liang XJ*, Ou C*. Biomimetic Grapefruit-Derived Extracellular Vesicles for Safe and Targeted Delivery of Sodium Thiosulfate against Vascular Calcification. ACS nano 2023, 17(24): 24773-24789. (IF:15.8, 1区)

[17] Yu B^#, Li H^#, Zhang Z^#, Chen P, Wang L, Fan X, Ning X, Pan Y, Zhou F, Hu X, Chang J*, Ou C*. Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice. Nature communications 2023, 14(1): 2094. (IF:14.7, 1区)

[18] Wang L^#, Chen P^#, Pan Y^#, Wang Z, Xu J, Wu X, Yang Q, Long M, Liu S, Huang W*, Ou C*, Wu Y*. Injectable photocurable Janus hydrogel delivering hiPSC cardiomyocyte-derived exosome for post-heart surgery adhesion reduction. Science advances. 2023, 9(31): eadh1753. (IF:11.7, 1区)

[19] Chen P^#, Pan Y^#, Ning X^#, Shi X, Zhong J, Fan X, Li W, Teng Y, Liu X, Yu B, Yang Y*, Li H*, Ou C*. Targeted heart repair by Tβ4-loaded cardiac-resident macrophage-derived extracellular vesicles modified with monocyte membranes. Acta Biomaterialia 2023, 169: 372-386. (IF:9.4, 1区)