作者： 来源： 阅读量： 发布时间：2017-10-30 10:38:17
姓名：成红
职称：教授
联系邮箱：chengh@smu.edu.cn
v 学习经历
2008.9-2012.7 中南大学，应用化学专业，学士
2012.9-2017.6 武汉大学，高分子化学与物理专业，博士
v 工作经历
2017.7至今 南方医科大学，教授
v 研究方向
癌症因其难以治愈、易转移复发、患者死亡率高等特点，已经成为威胁人类生命健康的主要疾病之一。但传统肿瘤治疗方式在实际应用过程中面临着诸多问题，如何将药物安全有效地递送至病灶部位，在提高药效的同时降低其对正常组织的毒副作用，一直是该领域研究人员致力于解决的关键问题之一。基于此，我们长期关注生物医用材料应用于肿瘤诊断和治疗的相关研究及动态，通过结合材料学、化学、医学、分子生物学等学科，开发了一系列适应于肿瘤微环境的多功能纳米药物载体，实现药物的可控释放，同时利用并改善肿瘤微环境，增强药物的肿瘤靶向治疗效率，以提高癌症患者的生存率和生活质量。
v 主要学术任职
Nano-Micro Lett.，Biomaterials，ACS Appl. Mater. Interfaces，Acta Biomater.，J. Mater. Chem. B.，Colloid Surf. B-Biointerfaces等国际期刊独立评审。
v 主要获奖情况（科研获奖、人才类奖项）
广东省药理学会科技成果奖，“调控细胞微环境靶向治疗肿瘤心脏病的研究”（一等奖，排名第五），2020年
v 主要科研课题
1、国家自然科学基金-青年科学基金项目，51803086，“肿瘤微环境响应逐级靶向型光控释金属有机框架纳米药物的构建及生物医学应用”，2019.01-2021.12，26万，主持。
2、广东省自然科学基金-博士启动纵向协同项目，2018030310283，“肿瘤微酸环境响应型光控释纳米药物载体的构建及其在肿瘤精准治疗中的研究”，2018.01-2021.04，10万，主持。
3、广东省普通高校特色创新项目，“双靶向自传递嵌合肽的制备及生物医学应用”，2019.01-2020.12，6万，主持。
4、广州市科技计划项目-基础研究计划，202002030178，“光控细胞核靶向自传递纳米药物用于肿瘤精准协同治疗”，2020.04-2023.03，20万，主持。
5、南方医科大学优青培育计划，G619309590，“用于肿瘤靶向精准治疗的多功能生物医用材料”，2020. 01-2021. 12，20万，主持。
v 代表性论文
1. Zhao LP#, Zheng RR#, Chen HQ, Liu LS, Zhao XY, Liu HH, Qiu XZ, Yu XY*, Cheng H*, Li SY*, Self-delivery nanomedicine for O2-economized photodynamic tumor therapy. Nano Lett. 2020, 20, 2062-2071. (IF: 11.238)
2. Cheng H, Zhu JY, Li SY, Zeng JY, Lei Q, Chen KW, Zhang C, Zhang XZ*. An O2 self-sufficient biomimetic nanoplatform for highly specific and efficient photodynamic therapy. Adv. Funct. Mater. 2016, 26, 7847-7860. (IF: 16.836)
3. Cheng H#, Fan GL#, Fan JH, Yuan P, Deng FA, Qiu XZ, Yu XY, Li SY*, Epigenetics-inspired photosensitizer modification for plasma membrane-targeted photodynamic tumor therapy. Biomaterials 2019, 224, 119497. (IF: 10.317)
4. Cheng H#, Fan JH#, Zhao LP, Fan GL, Zheng RR, Qiu XZ, Yu XY*, Li SY*, Zhang XZ. Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy. Biomaterials 2019, 211, 14-24. (IF: 10.317)
5. Cheng H*, Jiang XY, Zheng RR, Zuo SJ, Zhao LP, Fan GL, Xie BR, Yu XY, Li SY*, Zhang XZ. A biomimetic cascade nanoreactor for tumor targeted starvation therapy amplified chemotherapy. Biomaterials 2019, 195, 75-85. (IF: 10.317)
6. Cheng H#, Zheng RR#, Fan GL, Fan JH, Zhao LP, Jiang XY, Yang B, Yu XY*, Li SY*, Zhang XZ. Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy. Biomaterials 2019, 188, 1-11. (IF: 10.317)
7. Cheng H#, Yuan P#, Fan GL, Zhao LP, Zheng RR, Yang B, Qiu XZ, Yu XY, Li SY, Zhang XZ. Chimeric peptide nanorods for plasma membrane and nuclear targeted photosensitizer delivery and enhanced photodynamic therapy. Appl. Mater. Today 2019, 16, 120-131. (IF: 8.352)
8. Cheng H#, Fan GL#, Fan JH, Zhao LP, Zheng RR, Yu XY, Li SY*. Ratiometric theranostic nanoprobe for pH imaging-guided photodynamic therapy. Nanoscale 2019, 11, 9008-9014. (IF: 6.895)
9. Li SY#, Jiang XY#, Zheng RR, Zuo SJ, Zhao LP, Fan GL, Fan JH, Liao YH, Yu XY*, Cheng H*. An azobenzene-based heteromeric prodrug for hypoxia-activated chemotherapy by regulating subcellular localization. Chem. Commun. 2018, 54, 7983-7986. (IF: 5.996)
10. Cheng H, Zhu JY, Xu XD, Qiu WX, Lei Q, Han K, Cheng YJ, Zhang XZ*. Activable cell-penetrating peptide (ACPP) conjugated prodrug for tumor targeted drug delivery. ACS Appl. Mater. Interfaces 2015, 7, 16061-16069. (IF: 8.758)
11. Cheng H, Li SY, Zheng HR, Li CX, Xie BR, Chen KW, Li B, Zhang XZ*. Multi-forster resonance energy transfer-based fluorescent probe for spatiotemporal matrix metalloproteinase-2 and caspase-3 imaging. Anal. Chem. 2017, 89, 4349-4354. (IF: 6.785)
12. Cheng H, Cheng YJ, Bhasin S, Zhu JY, Xu XD*, Zhuo RX, Zhang XZ*. Complementary hydrogen bonding interaction triggered co-assembly of amphiphilic peptide and anti-tumor Drug. Chem. Commun. 2015, 51, 6936-6939. (IF: 5.996)
13. Fan JH, Fan GL, Yuan P, Deng FA, Liu LS, Zhou X, Yu XY*, Cheng H*, Li SY*. A theranostic nanoprobe for hypoxia imaging and photodynamic tumor therapy. Front. Chem. 2019, 7, 868. (IF: 3.693）
14. Li SY#, Zhao LP#, Zheng RR, Fan GL, Liu LS, Zhou X, Chen XT, Qiu XZ, Yu XY*, Cheng H*. Tumor Microenvironment Adaptable Nanoplatform for O2 Self-Sufficient Chemo/Photodynamic Combination Therapy. Part. Part. Syst. Charact. 2020, 37, 1900496. (IF: 3.099)
15. Fan GL, Yuan P, Deng FA, Liu LS, Miao YL, Wang C, Qiu XZ, Yu XY, Cheng H*, Li SY*. Self-delivery photodynamic nanoinhibitors for tumor targeted therapy and metastasis inhibition. ACS Appl. Bio Mater. 2020, doi.org/10.1021/acsabm.0c00706.
16. Li SY#, Cheng H#, Qiu WX, Zhang L, Wan SS, Zeng JY, Zhang XZ*. Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy. Biomaterials 2017, 142, 149-161. (IF: 10.317)
17. Li SY#, Cheng H#, Xie BR, Qiu WX, Song LL, Zhang XZ*. A ratiometric theranostic probe for tumor targeting therapy and self-therapeutic monitoring. Biomaterials 2016, 104, 297-309. (IF: 10.317)
18. Li SY#, Cheng H#, Qiu WX, Liu LH, Chen S, Hu Y, Xie BR, Li B, Zhang XZ*. Protease-activable cell-penetrating peptide-protoporphyrin conjugate for targeted photodynamic therapy in vivo. ACS Appl. Mater. Interfaces 2015, 7, 28319-28329. (IF: 8.758)
