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研究方向
  1. 热应激、热损伤与热耐受的分子机制  运用分子生物学技术、蛋白质组学技术、膜片钳技术及生物信息学手段研究中枢性体温调节以及热应激、热损伤和热耐受发生发展的分子机制，并提出热损伤的具体措施。具体内容包括：中枢神经对温度信息的整合机制、热适应基因差异表达与克隆、HSP90相互作用底物蛋白谱的鉴定、围绕HSP90建立应激与耐受的信号传递网络系统、中暑内毒素血症研究、发热病理学研究、热损伤的病理生理学研究。目前此研究方向由“973”课题和1项教育部博士点基金支持。
  2. 环境与基因组相互作用机制研究  运用分子生物学、蛋白质组学技术及生物信息学研究机体对特殊环境适应性的分子机制。具体内容包括：依赖于HIF-1的低氧信号通路研究、钙信号的调控机制及特殊环境易感性的基因水平研究（编码区的突变机制以及表观遗传学改变）。目前此研究方向由“973”课题和1项国家自然科学基金支持。
  3. Hsp90对氧化应激信号转导通路的调控作用  采用实时荧光蛋白标记监测氧化应激状态、定量蛋白质组学（SILAC）标记质谱分析技术比对底物蛋白谱变化，结合生物信息学分析手段，探讨不同氧化应激状态下，HSP90对细胞网络通路的交叉调控，阐明氧化应激的分子机制，为探讨相关疾病的机理及治疗、预防奠定理论基础。目前此研究方向由“973”课题、1项国家自然科学基金和1项广东省自然科学基金支持。
  4. 环境应激条件下炎性细胞的定向迁移机制  运用单细胞分子成像技术、蛋白质组学技术及电生理技术，探讨关键膜蛋白分子特别是TRP对细胞骨架分子聚合和解聚的调节机制，分析TRP与PIP2和PIP3等磷脂酰肌醇分子之间的相互作用，阐述环境应激条件下参与炎性细胞的信号转导机制。目前此研究方向由“973”课题和1项国家自然科学基金支持。
 
主要科研项目
科室承担了军队指令性课题：“七﹒五”、“八﹒五”、“九﹒五”；国家自然科学基金：海外合作重点项目；国家自然科学基金：面上项目；省部级及协作课题；973计划。
累计资助经费：1千万余元

高原低氧等环境因素损伤适应机理与干预措施

973计划分题

邹飞

适度低氧对健康促进作用的机制

973计划分题

邹飞

ATP敏感性钾通道的非电导功能在神经元缺氧损伤中的保护机制

教育部博士点基金

邹飞

结合SSH和单细胞RT-PCR技术研究热适应差异显示的基因

国家自然科学基金

邹飞

用SSH和单细胞RT-PCR技术研究热适应差显基因与功能

广东省自然科学基金

邹飞

体温调节中枢神经元细胞信号转导的研究

国家骨干教师资助项目

邹飞

NO和离子通道信号系统对神经可塑性调控的分子机制（39929001）

国家自然科学基金

邹飞

离子通道参与温敏神经元信号转导的分子机制（39970810）

国家自然科学基金

邹飞

温敏神经元信号转导的离子通道机制及干预药物

军队面上项目

邹飞

提高热区部队野战生存与军事作业能力的研究（01L051）

军队指令性课题

邹飞

罗炳德

部队急进热区卫生保障综合预案（JZL200201）

军队指令性课题

邹飞

罗炳德

热带卫勤保障技术信息系统

军队指令性课题

邹飞

广州市自来水高亚硝酸盐氮生物模式的研究

广东省科技计划项目

邹飞

肥大细胞脱颗粒中Ca2+时空变化调控研究

教育部博士点基金

李文军

环境铅暴露致儿童脑发育损伤的机制研究

973计划分题子课题

孟晓静

TRPC1蛋白分子参与中性粒细胞极性化的作用机制

国家自然科学基金

孟晓静

Prevention of Breast Cancer Progression with Conjugated Linoleic Acid

美国肿瘤研究协会-雅芳国际基金

孟晓静

热休克蛋白90对氧化应激信号转导通路的交叉调控作用

广东省自然科学基金

陈雪梅

氧化应激诱导的G2/M期阻滞中Hsp90对26S蛋白酶体的调控机制

国家自然科学基金

陈雪梅

氧化应激中热休克蛋白90相互作用蛋白谱及信号网络调控作用(30500580)

国家自然科学基金

陈雪梅

Hsp90对氧化应激信号网络的调控机制

留学回国人员科研启动基金

陈雪梅

TRP和HCN离子通道参与下丘脑神经元温度敏感机制作用的研究

国家自然科学基金

蔡春青

中枢温度敏感分子参与热环境下内环境稳态调控的研究

国家自然科学基金

蔡春青

线粒体ATP敏感性钾通道对胶质瘤细胞增殖调控机制的研究

国家自然科学基金

黄潋滟

ATP敏感性钾通道对胶质瘤细胞增殖调控机制的研究

广东省医学科研基金

黄潋滟

线粒体ATP敏感性钾通道对胶质瘤细胞增殖调控机制的研究

广东省自然科学基金

黄潋滟

线粒体ATP敏感性钾通道对胶质瘤细胞增殖调控机制的研究

广东高校优秀青年创新人才培养项目 

黄潋滟

片足近膜区钙时空信号调控HER2介导的乳腺癌细胞迁移的分子机制

国家自然科学基金

王斌

TRPC1调控缺氧胶质瘤细胞VEGF表达的机制研究

广东高校优秀青年创新人才培养项目

王斌
科研成果
军队科技进步二等奖3项
军队科技进步三等奖3项
广东省科技进步二等奖1项
广东省科技进步三等奖1项
科研论文
截止2015年，以第一作者单位或通讯作者单位发表SCI论文近80篇，主要如下所示：
  1. Lianyan Huang, Wenjun Li, Boxing Li and Fei Zou：ATP-Sensitive K+channel protects hippocampal CA1 neurons against chronic severe hypoxia by regulating expression of p53. Neuroscience Letters，2006；398：34-38
  2. Hong-Yan Han，Wei-An Xu，Zhi-Rong Lü，Fei Zou，Sen Li：Activation and Inactivation of Horseradish Peroxidase by Cobalt Ions. J Biomol Struct Dyn，2008 Aug;26(1):83-92.
  3. Zou HC, Lü ZR, Wang YJ, Zhang YM, Zou F, Park YD. Effect of Cysteine Modification on Creatine Kinase Aggregation. Appl Biochem Biotechnol. 2009;152(1):15-28.
  4. Lin Gou, Zhi-Rong Lü，Daeui Park，Sang Ho Oh，Long Shi，Seong Jin Park，Jong Bhak，Yong-Doo Park，Zhen-Long Ren，Fei Zou：The Effect of Histidine Residue Modification on Tyrosinase Activity and Conformation: Inhibition Kinetics and Computational Prediction. J Biomol Struct Dyn，2008 Dec;26(3):395-402；
  5. Lü ZR, Park TH, Lee ES, Kim KJ, Park D, Kim BC, Cho SW, Bhak J, Park YD, Zou F, Yang JM.：Dysregulated genes of extrinsic type of atopic dermatitis: 34K microarray and interactomic analyses. J Dermatol Sci 2009；53 (2) 146–150
  6. Zhi-Rong Lü, He-Chang Zou,Seong Jin Park, Daeui Park, Long Shi, Sang Ho Oh, Yong-Doo Park,Jong Bhak,and Fei Zou：The effects of acrylamide on brain creatine kinase: inhibition kinetics and computational docking simulation. Int J Biol Macromol 2009 Mar 1;44(2):128-32.
  7. Zhi-Rong Lü,Ye-Jing Wang,Dong-Youn Lee,Yong-Doo Park,He-Chang Zou, and Fei Zou：The effect of zn(2+) on human brain creatine kinase: unfolding and aggregation studies. J Biomol Struct Dyn，2009 26(5):567-74.
  8. Zhi-Rong Lü, Sang Ho Oh, Shan-Shan Zhou,He-Chang Zou,Daeui Park, Seong Jin Park,Hong-Wei Zhou, Jong Bhak,Yong-Doo Park,and Fei Zou：Structural analysis and inhibitory kinetics of brain type creatine kinase by sodium dodecyl sulfate. Appl Biochem Biotechnol. 2010 Mar;160(3):831-42.
  9. Wu XQ, Zhu WJ, Lu ZR, Xia Y, Yang JM, Zou F, Wang XY：The effect of rutin on arginine kinase: Inhibition kinetics and thermodynamics merging with docking simulation. Int J Biol Macromol. 2009 Mar 1;44(2):149-55.
  10. Zhi-Rong Lü, Daeui Park, Kyung-A Lee, Jea-Woon Ryu, Jong Bhak, Long Shi, Dong-Youn Lee, Yong-Doo Park, Fei Zou, and Jun-Mo Yang: Profiling the dysregulated genes of keratinocytes in atopic dermatitis patients: cDNA microarray and interactomic analyses. J Dermatol Sci，2009 54（2）126-129
  11. Hang Mu,Zhi-Rong Lu,Daeui Park,Byoung-Chul Kim,Jong Bhak,Fei Zou,Jun-Mo Yang,Sen Li,Yong-Doo Park,He-Chang Zou,Hai-Meng Zhou:Kinetics of Zn(2+)-induced Brain Type Creatine Kinase Unfolding and Aggregation.Appl Biochem Biotechnol.2010 Mar 160:1309–1320.
  12. Xue-Qiang Wu,Jun Wang, Zhi-Rong Lu,Hong-Min Tang, Daeui Park,Sang-Ho Oh,Jong Bhak,Long Shi, Yong-Doo Park, and Fei Zou：Alpha-glucosidase folding during urea denaturation: enzyme kinetics and computational prediction. Appl Biochem Biotechnol. 2010 Mar;160(5):1341-55.
  13. Lü ZR, Kim WS, Cho IH, Park D, Bhak J, Shi L, Zhou HW, Lee DY, Park YD, Yang JM, Zou F. DNA microarray analyses and interactomic predictions for atopic dermatitis. J. Dermatol. Sci. 2009 Aug;55(2):123-5.
  14. Sheng Q, Lu ZR, Mu H, Zou HC, Zou F, Yao SJ.The effect of ag(+) on arginine kinase: inhibition kinetics.J Biomol Struct Dyn. 2009 Aug;27(1):59-64
  15. Lu ZR, Shi L, Wang J, Park D, Bhak J, Yang JM, Park YD, Zhou HW, Zou F.The Effect of Trifluoroethanol on Tyrosinase Activity and Conformation: Inhibition Kinetics and Computational Simulations. Appl Biochem Biotechnol. 2010 Apr;160(7):1896-908.
  16. Cho IH, Lü ZR, Yu JR, Park YD, Yang JM, Hahn MJ, Zou F. Towards profiling the gene expression of tyrosinase-induced melanogenesis in HEK293 cells: a functional DNA chip microarray and interactomics studies. J Biomol Struct Dyn. 2009 Dec;27(3):331-46.
  17. Sheng Q, Zou HC, Lü ZR, Zou F, Park YD, Yan YB, Yao SJ. Effects of acrylamide on the activity and structure of human brain creatine kinase.Int J Mol Sci. 2009 Nov 2010(10):4210-22.
  18. Shi L, Xia Y, Zhang M, Yin SJ, Si YX, Qian GY, Lü ZR, Zhou HM, Zou F, Park YD. Trifluoroethanol-Induced Activity and Structural Changes in Bos Taurus Copper- and Zinc-Containing Superoxide Dismutase.Protein Pept Lett. 2011;18(7):726-32.
  19. Xuemei Chen, Hongyun Kang, Fei Zou: Low concentration of GA activates a preconditioning response in HepG2 cells during oxidative stress-roles of Hsp90 and vimentin. Cell Stress Chaperon.2009 Jul;14(4):381-9.
  20. Lianyan Huang, Boxing Li, Wenjun Li, Hongbo Guo, Fei Zou: ATP-sensitive Potassium Channels Control Glioma Cells Proliferation by Regulating ERK Activity. Carcinogenesis，2009；30(5):737–744
  21. Dongliang Zhao，Xiaojing Meng, Chunqing Cai, Chunhua Yuan, Fei Zou：Temperature pretreatment alters the polarization response of human neutrophils to the chemoattractant N-formyl-Met-Leu-Phe. Inflammation，2009;32 (1):47-56
  22. Bin Wang, Wenjun Li, Xiaojing Meng, Fei Zou: Hypoxia up-regulates vascular endothelial growth factor in U-87 MG cells:involvement of TRPC1. Neurosci lett. 2009 Aug 14;459(3):132-6.
  23. Lin XJ, Li YL, Mei GP, Zou F, He DD, Liu XQ, Li YJ, Zhao TB, Lin MT.Activated protein c can be used as a prophylactic as well as a therapeutic agent for heat stroke in rodents.Shock，2009 Nov;32(5):524-529
  24. Lin XJ, Li YJ, Li ZL, Zou F, Lin MT.Pre-existing Lipopolysaccharide May Increase the Risk of Heatstroke in Rats.Am J Med Sci.2009 Apr;337 (4): 265-270
  25. Wang Z, Liu Y, Han N, Chen X, Yu W, Zhang W, Zou F. Profiles of oxidative stress-related microRNA and mRNA expression in auditory cells.Brain Res.2010；1346:14-25
  26. Zhifeng ZHOU, Jufeng YE, Lingyun CHEN, Ande MA and Fei ZOU*, Simultaneous Determination of Ropivacaine, Bupivacaine and Dexamethasone in Biodegradable PLGA Microspheres by High Performance Liquid Chromatography, YAKUGAKU ZASSHI,2010, 130(8)：1061-1068
  27. Zhou Z, Chen L, Liu P, Shen M, Zou F. Simultaneous Determination of Isoniazid, Pyrazinamide,Rifampicin and Acetylisoniazid in Human lasma by High-Performance Liquid Chromatography. Anal Sci. 2010;26(11):1133-1138
  28. Zhou ZF, Chen LY, Shen M, Ma AD, Yang XM, Zou F*.Analysis of the Essential Oils of Coriandrum sativum Using GC-MS Coupled with Chemometric Resolution Methods. Chem Pharm Bull(Tokyo). 2011;59(1):28-34.
  29. Guo HB, Huang LY, Zou YX, Zou F.Up-regulation of the transient A-type K+ current (IA) in the differentiation of neural stem cells of the early postnatal rat hippocampus.Chin Med J (Engl). 2010 Jul;123(13):1731-5.
  30. Zhou HW, Luan TG, Zou F, Tam NF. Different bacterial groups for biodegradation of three- and four-ring PAHs isolated from a Hong Kong mangrove sediment. J Hazard Mater. 2008；152(3):1179-1185.
  31. Jin-Ya Wu, Xiao-Tao Jiang, Yun-Xia Jiang, Su-Ying Lu, Fei Zou and Hong-Wei Zhou. Effects of polymerase, template dilution and cycle number on PCR based 16S rRNA diversity analysis using the deep sequencing method. BMC Microbiology 2010, 10:255-261
  32. Lu SY, Zhang YL, Geng SN, Li TY, Ye ZM, Zhang DS, Zou F, Zhou HW.High Diversity of Extended-spectrum Beta-lactamase-producing Bacteria in an Urban River Sediment Habitat.Appl Environ Microbiol. 2010 Sep;76(17):5972-6. Epub 2010 Jul 16.
  33. Zhou HW, Li DF, Tam NF, Jiang XT, Qin J, Zhang H, Sheng HF, Liu X, Zou F (2010) BIPES, a Cost-Effective High-Throughput Method for Assessing Microbial Diversity. ISME Journal 2011；5：741–749
  34. Jiang YX, Wu JG, Yu KQ, Ai CX, Zou F, Zhou HW.Integrated lysis procedures reduce extraction biases of microbial DNA from mangrove sediment. J Biosci Bioeng. 2011 Feb;111(2):153-7.
  35. Jiang XT, Zhang H, Sheng HF, Wang Y, He Y, Zou F, Zhou HW.Two-Stage Clustering (TSC): A Pipeline for Selecting Operational Taxonomic Units for the High-Throughput Sequencing of PCR Amplicons.PLoS One. 2012;7(1):e30230.
  36. Yang Q, Jie Z, Cao H, Greenlee AR, Yang C, Zou F, Jiang Y. Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C.Carcinogenesis. 2011 May;32(5):713-22.
  37. Zhao H, Peng H, Cai SX, Li W, Zou F, Tong W. Toluene diisocyanate enhances human bronchial epithelial cells’ permeability partly through the vascular endothelial growth factor pathway. Clin Exp Allergy. 2009；39：1532–1539
  38. Hou C, Zhao H, Liu L, Li W, Zhou X, Lv Y, Shen X, Liang Z, Cai S, Zou F. High mobility group protein B1 (HMGB1) in Asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls.Mol Med. 2011,17(7-8)：807-815
  39. Sun S, Li W, Zhang H, Zha L, Xue Y, Wu X, Zou F. Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells.Biosci Rep. 2012 Feb 1;32(1):83-90.
  40. Hou C, Zhao H, Li W, Liang Z, Zhang D, Liu L, Tong W, Cai SX, Zou F. Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients. Cell Stress Chaperones. (2011) 16；663–671
  41. Xiao M, Liu Y, Zou F.Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D.Exp Cell Res. 2012，318:43-52
  42. Wu SJ, Wang YJ, Guo KY, Chen C, Zhao TF, Sun MB, Gu WW, Gao YY, Han HJ, Zou F. Effect of Total Body X-ray Irradiation on Lymph Node in Tibet Minipig.J Radiat Res. 2012 Feb 2;53(1):18-23.
  43. Chen C, Yan LM, Guo KY, Wang YJ, Zou F, Gu WW, Tang H, Li YL, Wu SJ. The diagnostic value of [18F]-FDG-PET/CT in hematopoietic radiation toxicity: a Tibet minipig model.J Radiat Res. 2012 Jul 1;53(4):537-44. Epub 2012 Jun 6.
  44. Wang YJ, Wu SJ, Guo KY, Chen C, Xie Q, Gu WW, Cai L, Zou F.(18)F-FDG uptake by spleen helps rapidly predict the dose level after total body irradiation in a Tibetan minipig model.Eur Radiol. 2012 Sep;22(9):1844-51. Epub 2012 May 2.
  45. Cai C, Meng X, He J, Wu H, Zou F. Effects of ZD7288 on firing pattern of thermosensitive neurons isolated from hypothalamus.Neurosci Lett. 2012 Jan 11;506(2): 336-341.
  46. Zhang H, Li W, Sun S, Yu S, Zhang M, Zou F. Inhibition of sphingosine kinase 1 suppresses proliferation of glioma cells under hypoxia by attenuating activity of extracellular signal-regulated kinase.Cell Prolif. 2012 Apr;45(2):167-75.
  47. Liang Z, Zhao H, Lv Y, Li R, Dong H, Liu L, Xia Y, Hou C, Cai S, Zou F. Moderate accuracy of peripheral eosinophil count for predicting eosinophilic phenotype in steroid-naïve non-atopic adult asthmatics.Intern Med. 2012;51(7):717-22.
  48. Zou W, Chu X, Cai C, Zou M, Meng X, Chen H, Zou F. AKT-mediated regulation of polarization in differentiated human neutrophil-like HL-60 cells.Inflamm Res. 2012 Aug;61(8):853-62.
  49. Zou W, Meng X, Cai C, Zou M, Tang S, Chu X, Wang X, Zou F. Store-operated Ca Entry (SOCE) Plays a Role in the Polarization of Neutrophil-like HL-60 Cells by Regulating the Activation of Akt, Src, and Rho Family GTPases.Cell Physiol Biochem.2012;30(1):221-37. 
  50. Cai C, Tang S, Wang X, Cai S, Meng X, Zou W, Zou F.Requirement for both receptor-operated and store-operated calcium entry in N-formyl-methionine-leucine-phenylalanine-induced neutrophil polarization. Biochem Biophys Res Commun. 2013 Jan 11;430(2):816-21.
  51. Meng X, Cai C, Wu J, Cai S, Ye C, Chen H, Yang Z, Zeng H, Shen Q, Zou F. TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway.Cancer Lett. 2013 Jun 1;333(1):96-102.
  52. Song J, Zhao H, Dong H, Zhang D, Zou M, Tang H, Liu L, Liang Z, Lv Y, Zou F, Cai S.Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells. Toxicol Lett. 2013 Apr 6;220(1):8-14.
  53. Zhang D, Peng C, Zhao H, Xia Y, Zhang D, Dong H, Song J, Zhou L, Cai S, Zou F. Induction of thymic stromal lymphopoietin expression in 16-HBE human bronchial epithelial cells by 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3.
  54. Zhou Z, Wu X, Wei Q, Liu Y, Liu P, Ma A, Zou F. Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the simultaneous determination of five first-line antituberculosis drugs in plasma. Anal Bioanal Chem. 2013 May 30, 405:6323–6335
  55. Li W, Zhang M, Xu L, Lin D, Cai S, Zou F.The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1. Exp Toxicol Pathol. 2013 Nov;65(7-8):1073-81
  56. Ou Z, Wang G, Li Q, Ma Z, Lin D, Dai M, Zou F. The genetic polymorphisms of Cathepsin S were associated with metabolic disorders in a Chinese Han population.Gene.2013 Sep 10;526(2):385-9.
  57. Wang Y, Chu X, Meng X, Zou F.Association of TGF-β1 -509C/T polymorphisms with breast cancer risk: evidence from an updated meta-analysis. Tumour Biol. 2013 Aug 28. [Epub ahead of print]
  58. Wang Y, Chu X, Meng X, Zou F.Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis. PLoS One. 2013 Oct 30;8(10):e77898.
  59. Ou Z, Wang G, Li Q, Ma Z, Dai M, Zou F. CRTC3 polymorphisms were associated with the plasma level of total cholesterol and the risks of overweight and hypertriglyceridemia in a Chinese Han population.Mol Biol Rep.2014 Jan; 41(1): 125-30
  60. Ma S, Cai C, Ma Y, Bai Z, Meng X, Yang X, Zou F, Ge R.Store-operated Ca2+ entry mediated regulation of polarization in differentiated human neutrophil-like HL-60 cells under hypoxia. Mol Med Rep.2014 Mar;9(3):819-24.
  61. Wu JJ, Yang T, Li X, Xia Y, Zhao Y, Zou F, Jiang YG.4-(methylnitrosamino)-1-(3-pyridyl) -1-butanone Induces Circulating MicroRNA Deregulation in Early Lung Carcinogenesis.Biomed Environ Sci. 2014 Jan;27(1):10-6. 
  62. Zhang W, Hu D, Ji W, Yang L, Yang J, Yuan J, Xuan A, Zou F, Zhuang Z.Histone modifications contribute to cellular replicative and hydrogen peroxide-induced premature senescence in human embryonic lung fibroblasts.Free Radic Res. 2014 Mar 10.
  63. Xiao M, Liu YG, Zou MC, Zou F. Sodium Butyrate Induces Apoptosis of Human Colon Cancer Cells by Modulating ERK and Sphingosine Kinase 2.Biomed Environ Sci. 2014 Mar;27(3):197-203.
  64. Zhang W, Hu D, Ji W, Yang L, Yang J, Yuan J, Xuan A, Zou F, Zhuang Z. Histone modifications contribute to cellular replicative and hydrogen peroxide-induced premature senescence in human embryonic lung fibroblasts.Free Radic Res. 2014 May;48(5):550-9
  65. Xiao M, Liu YG, Zou MC, Zou F. Sodium Butyrate Induces Apoptosis of Human Colon Cancer Cells by Modulating ERK and Sphingosine Kinase 2. Biomed Environ Sci.  2014 Mar;27(3):197-203.
  66. Wang B, Xiao JL, Ling YH, Meng XJ, Wu B, Yang XY, Zou F. BNIP3 Upregulation by ERK and JNK Mediates Cadmium-Induced Necrosis in Neuronal Cells. Toxicol Sci. 2014 May 13；140(2)：393–402
  67. Tang H, Zhao H, Song J, Dong H, Yao L, Liang Z, Lv Y, Zou F, Cai S. Ethyl pyruvate decreases airway neutrophil infiltration partly through a high mobility group box 1-dependent mechanism in a chemical-induced murine asthma model. Int Immunopharmacol. 2014 May 9;21(1):163-170.
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