研究方向

本学科的研究方向主要包括：

1. 膳食营养与慢性病：主要研究膳食营养与慢性代谢性疾病如糖尿病、肥胖、肿瘤等关系的分子机制及防治对策；中老年人群膳食营养干预研究等。该方向研究内容前沿，技术手段先进。主持的代表性科研项目有国家自然科学基金四项“Adiponectin及其受体表达的营养调节研究”、“膳食n6/n3脂肪酸构成对脂联素表达的调节及CDK5/PPARγ介导的机制研究”、“大豆皂甙经调节NF-кB信号通路抗慢性炎症机理”以及汤臣倍健营养科学研究基金“鱼油干预对中老年人血脂、免疫功能及炎性因子水平的影响”等。
2. 妇幼营养与健康：主要开展膳食营养与孕产妇、乳母、婴幼儿健康的关系及其营养干预措施的研究。近年主持的代表性科研项目有达能营养基金资助项目“妇女产褥期饮食行为习惯与健康关系的研究”、 “十一五”国家科技支撑计划项目“我国华南地区妇女产褥期膳食营养干预研究”、 中国营养学会营养科研基金项目“孕妇长链多不饱和脂肪酸水平与胎儿生长发育及其免疫功能关系研究”、 中国营养学会妇幼营养分会项目“孕期体重增长适宜值的多中心队列研究”等；参与的科研项目有国家十一五支撑项目分题“我国南方重点人群（青春期儿童、哺乳期妇女和绝经期妇女）钙需要和膳食评估应用研究”等。
3. 食物中生物活性成分与疾病关系的分子机制：本方向主要研究食物中生物活性成分如大豆及其制品中大豆皂甙、膳食纤维等在抗炎、抗肿瘤等防治方面的作用及机制。近年主持的代表性科研项目有国家自然科学基金“大豆皂甙经调节NF-kB信号通路抗慢性炎症的机理研究”， 广东省医学科研基金“基于NF-kB调控的大豆皂甙抗炎性作用构效关系及机制研究”；国家自然科学基金和广东省自然科学基金“钙池调控钙内流对丁酸钠诱导大肠癌细胞凋亡调控机制的研究”。
4. 微量元素与健康：开展了补铁改善贫血效果、富硒酵母拮抗铁铜过量损伤的保护机制、三价铬纳米微粒对糖尿病防治机理等研究。目前主要利用稳定同位素追踪法追踪各种微量元素（如铁，钙，镁，锌等）的代谢途径，探讨膳食中微量元素与各种慢性疾病之间的关系。与放射性同位素不同，稳定同位素不会危害人类健康，利用稳定同位素追踪法可测定膳食微量元素在人体内或动物体内的吸收，可作为研究人类营养的一个重要的工具。
5. 食品安全及保健食品功能评价：主要开展了食品中二甲基亚硝胺（NDMA）、二乙基亚硝胺（NDEA）、丙烯酰胺（AA）等污染物来源及毒理学安全性评价等研究工作。探索利用新技术如代谢组学等方法开展食品中化学性污染物N-亚硝基化合物（NOC）的相关研究。获得了国家自然科学基金课题“基于代谢组学探索动物性腌制品中NOC的安全性问题”资助。建立了现场快速和实验室食品安全检测平台，与食品企业合作开展保健食品功能检测与评价等。

主持科研项目

代表性文章

1. Xuefeng Yang, Yi Zhang, Jieyi Lin, Anfang Pen, Chenjiang Ying, Wenhong Cao, Limei Mao. A lower proportion of dietary saturated/monounsaturated/polyunsaturated fatty acids reduces the expression of adiponectin in rats fed a high-fat diet. Nutrition Research,32 (2012): 285 – 291. （通讯作者）
2. Wei Bao, Aiguo Ma, Limei Mao, Jianqiang Lai, Mei Xiao, Guoqiang Sun, Yingying Ouyang, Shuang Wu,Wei Yang, Nanping Wang, Yanting Zhao, Juan Fu, Liegang Liu. Diet and lifestyle interventions in postpartum women in China: study design and rationale of a multicenter randomized controlled trial. BMC Public Health ,2010, 10:103
3. Nian Liu, Limei Mao，Xiufa Sun,Liegang Liu,Ping Yao ,Banghua Chen The effect of health and nutrition education intervention on women's postpartum beliefs and practices:a randomized controlled trial. BMC Public Health, 2009, 9:45（通讯作者）
4. Nian Liu, Limei Mao*, Xiufa Sun, Liegang Liu, Banghua Chen，Qiang Ding: Postpartum practices of puerperal women and their influencing factors in three regions of Hubei, China. BMC Public Health 2006, 6:274.（*通讯作者）
5. Deng H, Gao H, Liu Y.Biotransformation enzyme-dependent formation of micronucleus and multinuclei in cell line V79-hCYP2E1-hSULT1A1 by 2-nitropropane and N-nitrosodimethylamine. Mutat Res. 2011 Nov 27;726(1):84-7
6. Yadong Wang, Xinwei Chu,Xiaojing Meng, Fei Zou. Association of TGF-β1 -509C/T polymorphisms with breast cancer risk: evidence from an updated meta-analysis. Tumor Biol. Tumor Biol., 2014，35（2）:935-942. (Co-author)
7. Yadong Wang, Xinwei Chu,Xiaojing Meng, Fei Zou. Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis. PLoS One. 2013; 8(10): e77898. (Co-author)
8. Wenying Zou, Xinwei Chu,Chunqing Cai,Mengchen Zou, Xiaojing Meng ,Haiyang Chen ,Fei Zou.AKT-mediated regulation of polarization in differentiated human neutrophil-like HL-60 cells. Inflamm. Res. 2012 Aug;61(8):853-62. (Co-author)
9. Wenying Zou, Xiaojing Meng, Chunqing Cai, Mengchen Zou, Shihao Tang, Xinwei Chu, Xubu Wang, Fei Zou. Store-operated Ca2+ entry (SOCE) plays a role in the polarization of neutrophil-like HL-60 cells by regulating the activation of Akt, Src, and Rho family GTPases. Cell Physiol Biochem. 2012;30(1):221-37.
10. Min Wu, Chen Mao, Qing Chen, Xin-Wei Chu, Wei-Seng Zhang. Serump 53 protein and anti-p53 antibodies are associated with increased cancer risk: a case-control study of 569 patients and 879 healthy controls. Mol Biol Rep,2010,37(1):339-43.
11. Zha LY*, Chen JD, Sun SX, Mao LM, Chu XW, Deng H, Cai JW, Li XF, Liu ZQ, Cao WH*. Soyasaponins can blunt inflammation by inhibiting the reactive oxygen species-mediated activation of PI3K/Akt/NF-kB pathway. PLOS ONE, 2014, 9(9): e107655.
12. Chen JD, Sun SX, Zha DS, Wu JG, Mao LM, Deng H, Chu XW, Luo HJ, Zha LY*. Soyasaponins prevent H2O2-induced inhibition of gap junctional intercellular communication by scavenging reactive oxygen species in rat liver cells. Nutr Cancer, 2014, online, DOI: 10.1080/01635581.2014.956245.
13. Yang XF, Mei S, Gu HH, Guo HL, Zha LY, Cai JW, Li XF, Liu ZQ, Cao WH*. Exposure to excess insulin (glargine) induces type 2 diabetes mellitus in mice fed on a chow diet. J Endocrinol, 2014, 221: 469-480.
14. Mei S, Yang XF, Guo HL, Gu HH, Zha LY, Cai JW, Li XF, Liu ZQ, Bennett BJ, He L, Cao WH*. A small amount of dietary carbohydrate can promote the HFD-induced insulin resistance to a maximal level. PLOS ONE, 2014, 9(7): e100875.
15. Zha LY*, Mao LM, Lu XC, Deng H, Ye JF, Chu XW, Sun SX, Luo HJ. Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW264.7 cells by attenuation of NF-κB-mediated nitric oxide synthase expression. Bioorgan Medicin Chem Lett 2011, 21: 2415-2418.
16. Wu JG, Jiang YX, Zha LY, Ye ZM, Zhou ZF, Ye JF, Zhou HW. Tetracycline degradation by ozonation, and evaluation of biodegradability and toxicity of ozonation byproducts. J Environ Sci Eng 2010, 37: 1485-1491.
17. Zha LY*, Zeng JW, Sun SX, Deng H, Luo HJ. Li WL. Chromium(III) nanoparticles affect hormone and immune responses in heat stressed rats. Biol Trace Elem Res 2009, 129(1-3): 157-169.
18. Zha LY*, Zeng JW, Chu XW, Mao LM, Luo HJ. Efficacy of trivalent chromium on growth performance, carcass characteristics and tissue chromium in heat stressed broiler chicks. J Sci Food Agr 2009, 89: 1782-1786.
19. Zha LY, Xu ZR*, Wang MQ, Gu LY. Chromium Nanoparticle exhibits higher absorption efficiency than chromium picolinate and chromium chloride in Caco-2 cell monolayers. J Anim Phys Anim Nutr 2008, 92:131-140.
20. Zha LY, Wang MQ*, Xu ZR, Gu LY. Efficacy of chromium(III) supplementation on growth, body composition, serum parameters, and tissue chromium in rats. Biol Trace Elem Res 2007, 119: 42-50.
21. Zha LY, Xu ZR*, Wang MQ, Gu LY. Effects of chromium nanoparticle dosage on growth, body composition, serum hormones and tissue chromium in Sprague-Dawley rats. J Zhejiang Univ Sci B 2007, 8(5): 323-330.
22. Wang MQ*, Xu ZR, Zha LY, Lindemann MD. Effect of chromium nanocomposite supplementation on blood metabolites, endocrine parameters and immune traits in finishing pigs. Anim Feed Sci Tech 2007, 139: 69-80.
23. Suxia Sun, Wenjun Li, He Zhang, Longying Zha, Yong Xue, Xianbo Wu, and Fei Zou. Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells. Bioscience reports. 2012; 32(1): 83-90. (Impactor Factor: 2.213)
24. He Zhang, Wenjun Li, Suxia Sun, Shaozhen Yu, Minhong Zhang and Fei Zou. Inhibition of sphingosine kinase 1 suppresses the growth of glioma cells under hypoxia by attenuating the activity of extracellular signal-regulated kinase. Cell Proliferation. 2012; 45(2): 167-75.（共同第一作者） (Impactor Factor: 2.742)
25. Zhang ZQ, He LP, Liu YH, Liu J, Su YX, Chen YM (2014). Dietary intake of flavonoid is positively associated with bone mineral density in middle-aged and elderly Chinese women and men. Osteoporos Int. (IF:4.165)
26. Zhang ZQ, Ma XM, Huang ZW, Yang XG, Chen YM, Su YX. (2014) Effects of milk salt supplementation on bone mineral gain in pubertal Chinese adolescents: A 2-year randomized, double-blind, controlled, dose-response trial. Bone 65: 69-76. (IF:4.461)
27. Zhang ZQ, Ho SC, Chen ZQ, Zhang CX, Chen YM. Reference values of bone mineral density and prevalence of osteoporosis in Chinese adults. Osteoporos Int, 2014. 25(2): p. 497-507. (IF:4.165)
28. Zhang ZQ, Deng J, He LP, Ling WH, Su YX, Chen YM. Comparison of variousanthropometric and body fat indices in identifying cardiometabolic disturbances in chinese men and women. PLoS One, 20138:e70893. (IF:3.534)
29. Zhang ZQ, Liu YH, Xu Y, Dai XW, Ling WH, Su YX, Chen YM. The validity of the body adiposity index in predicting percentage body fat and cardiovascular risk factors among Chinese. Clin Endocrinol (Oxf), 2013. (IF:3.353)
30. Zhang ZQ, He LP, Xie XY, Ling WH, Deng J, Su YX, Chen YM. Association of simple anthropometric indices and body fat with early atherosclerosis in Chinese adults. Plos one(IF:3.534)
31. J.-H. Chen, N. Singh, H.-M. Liu, T. Walczyk*. Imbalance of iron influx and efflux causes brain iron accumulation in the healthy adult rat. Metallomics. 2014, 6:1417-1426（IF: 4.1）
32. J.-H. Chen, S. Shahnavas, N. Singh, W.-Y. Ong, T. Walczyk*. Stable iron isotope tracing reveals significant brain iron uptake in the adult rat. Metallomics 2013, 5: 167-173.（IF: 4.1）
33. J. H. Chen, Y. Ren, J. Seow, T. Liu, W. S. Bang and H. G. Yuk*. Intervention technologies for ensuring microbiological safety of meat: Current and future trends. Comprehensive Reviews in Food Science and Food Safety 2012, 11(2): 119-132.（IF: 5.1）

代表性专著

1. 国家级实验教学示范中心教材《食品安全综合实习指导》主编，科学出版社，2013.02.
2. 卫计委“十二五”规划教材《卫生监督学》（第2版）， 编委，人民卫生出版社， 2013.09
3. “十二五”国家级规划教材配套教材：营养与食品卫生学实习指导（第4版），编委 ，人民卫生出版社，2013.03
4. 卫生部“十二五”规划教材《卫生法律制度与监督学》（第3版），编委，人民卫生出版社，2012.06
5. “十一五”国家级规划教材《临床营养学》（第2版），编委，科学出版社，2009.07
6. 外科名家精品系列《普通外科营养学》编委，人民军医出版社，2012.07
7. 高等医学院校创新教材《卫生生物化学》 编委，人民卫生出版社，2014.10

主要成果、专利
湖北省科技进步二等奖1项
湖北省科技进步三等奖1项
武汉市科技进步二等奖1项