学院机构

主要从事蚊媒及蚊媒传染病、人兽共患弓形虫病的致病机制与防控的研究

（一）在研科研课题：

1. 国家自然科学基金委员会，重点项目，弓形虫感染激活小胶质细胞导致小鼠神经精神异常的机制研究，2024.01-2028.12，220万元，在研，彭鸿娟主持

2. 广东省自然科学基金委员会，面上项目，弓形虫慢性感染小鼠通过肠脑轴引发神经精神异常症状机制的研究， 2024.01-2026.12，15.0万元，在研，彭鸿娟主持

3. 国家自然科学基金委员会，面上项目，弓形虫顶质体膜蛋白FtsH1参与虫体脂代谢及免疫逃避的机制研究，2023.01-2026.12，52.0万元，在研，彭鸿娟主持

4. 彭鸿娟，广东省自然科学基金，面上项目，宿主波形蛋白Vimentin促进弓形虫入侵血脑屏障致脑损伤机制的研究，2023.01.01-2025.12.31，10.0万元，在研，彭鸿娟主持

5. 郑学礼，广州市科技计划，重点项目，新发或再发蚊媒传染病预警平台建设与新

型灭蚊剂的研发，200万，在研，郑学礼主持。

（二）最新发表论文：

1. 彭鸿娟(通讯). Cbl-b negatively regulates TLR/MyD88-mediated anti-Toxoplasma gondii immunity. Microbiol Spectr.2023 Dec 12;11(6):e0007423. doi: 10.1128/spectrum.00074-23.

2. 彭鸿娟(通讯). Toxoplasma gondii gra5 deletion mutant protects hosts against Toxoplasma gondii infection and breast tumors. Frontiers in Immunology. 2023 Jun 23;14:1173379.

3. 彭鸿娟(通讯).Insect-specific Viruses Used in Bio-control of Mosquito-borne Diseases. Interdiciplinary Medicine. 2023, e20220001.

4. 彭鸿娟(通讯).Advances in Spectral Techniques for Detection of Pathogenic Microorganisms. Zoonoses. 2022; 2:8.

5. 彭鸿娟(通讯).Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth. Frontiers in Cellular and Infection Microbiology. 2022 Aug 31;12:959300.

6. 彭鸿娟(通讯). A Bright Monomeric Near-Infrared Fluorescent Protein with an Excitation Peak at 633 nm for Labeling Cellular Protein and Reporting Protein-Protein Interaction. ACS Sens. 2022 Jul 22;7(7):1855-1866.

7. 彭鸿娟(通讯).Toxoplasma gondii ROP18I Inhibits Host Innate Immunity through cGAS-STING Signaling. FASEB Journal. 2022 Feb;36(2):e22171.

8. 顾金保(通讯).Aal-circRNA-407 regulates ovarian development of Aedes albopictus, a major arbovirus vector, via the miR-9a-5p/Foxl axis PLoS Pathogens 19(5):e1011374.

9. 顾金保(通讯). Mosquito densovirus significantly reduces the vector susceptibility to dengue virus serotype 2 in Aedes albopictus mosquitoes (Diptera: Culicidae) Infectious Diseases of Poverty 12(1):48

10. 刘敏(共同一作). A type II protein arginine methyltransferase regulates merozoite invasion in Plasmodium falciparum COMMUNICATIONS BIOLOGY 2023 Jun 22;6(1):659

11. 陈晓光(通讯). CRISPR/Cas9-mediated F1534S substitution in the voltage-gated sodium channel reveals its necessity and sufficiency for deltamethrin resistance in Aedes albopictus Journal of Pest Science 2022,96(3).

12. 陈晓光(通讯). Development and evaluation of an efficient and real-time monitoring system for the vector mosquitoes, Aedes albopictus and Culex quinquefasciatus. PLOS NEGLECTED TROPICAL DISEASES 2022,16(9).

13. 陈晓光(通讯). Clock genes regulate mating activity rhythms in the vector mosquitoes, Aedes albopictus and Culex quinquefasciatus PLOS NEGLECTED TROPICAL DISEASES 2022 Dec 1;16(12):e0010965

14. 陈晓光(通讯). Metagenomic analysis reveals the virome profiles of Aedes albopictus in Guangzhou, China. Frontiers in cellular and infection microbiology 2023.13.

15. 陈晓光(通讯). A DBHS family member regulates male determination in the filariasis vector Armigeres subalbatus nature communications 2023 Apr 21;14(1):2292

16. 郑学礼(通讯). Isobaric tags for relative and absolute quantification-based proteomic analysis of host-pathogen protein interactions in the midgut of Aedes albopictus during dengue virus infection Front.Microbiol.,2022.0.9

17 郑学礼(作者与通讯).Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China.Parasites Vectors.2022. DOI：10.1186/s13071-022-05241-7

18.郑学礼(通讯). Effects of Guangzhou seasonal climate change on the development of Aedes albopictus and its susceptibility to DENV-2.PLoS One. 2022 ，1;17(4):e0266128. doi: 10.1371/journal.pone.0266128

19.郑学礼(通讯) . Genome-wide SNPs reveal novel patterns of fine-grained spatial genetic structure in Aedes albopictus (Diptera Culicidae) populations in China. Front Public Health. 2022,10:10:1028026. doi: 10.3389/fpubh.2022.1028026.

20.郑学礼(通讯) .Insecticide susceptibility status and knockdown resistance (kdr) mutation in Aedes albopictus in China. P arasites & Vectors (2021) 14:609 https://doi.org/10.1186/s13071-021-05095-5

21郑学礼(通讯) Vector Competence for DENV-2 Among Aedes albopictus (Diptera: Culicidae) Populations in China. Frontiers in Cellular and Infection Microbiology ,2021 doi: 10.3389/fcimb.2021.649975

22.郑学礼(作者与通讯).VECTOR-BORNE AND ZOONOTIC DISEASES，2020，DOI: 10.1089/vbz.2019.2584.

23.郑学礼(作者与通讯).Unveiling mosquito cryptic species and their reproductive isolation. Insect Molecular Biology. (2020) doi: 10.1111/imb.

24.郑学礼(作者与通讯). Seasonality modeling of the distribution of Aedes albopictus in China based on climatic and environmental suitability[J]. Infectious Diseases of Poverty.2019, 8:98. https://doi.org/10.1186/s40249-019-0612-y.

25.郑学礼(通讯) . Patterns of spatial genetic structures in Aedes albopictus (Diptera: Culicidae)populations in China. Parasites Vectors (2019) 12:552.

26郑学礼(通讯) . Molecular evidence for new sympatric cryptic species of Aedes albopictus (Diptera: Culicidae) in China: A new threat from Aedes albopictus subgroup?. Parasites & Vectors (2018) 11:22

27周晓红(通讯). A cross-sectional survey on the malaria control and prevention knowledge, attitudes, and practices of caregivers of children under-5 in the Western Area of Sierra Leone. Tropical Medicine and Infectious Disease 2022,7,120

28.周晓红(通讯). An experimental evaluation of effects of sodium chloride on oviposition behaviour, hatch, and larval toxicity of Aedes albopictus Pathogens 2022,11,262

29.周晓红(通讯). A unified global genotyping framework of dengue virus serotype-1 for a stratified coordinated surveillance strategy of dengue epidemics Infectious diseases of Poverty. 2022,11,107