学院机构

研究方向

1.细胞应激反应的信号转导机制：主要关注辐射特别是紫外辐射作用下细胞应激反应的信号转导机制。在该领域已连续7次获得国家自然科学基金的支持，并形成了自己的研究特色。

2.突发公共卫生事件的医学应急救援：积极开展了放射性突发事件的预警、应急救援及支撑技术等的研究工作。在该领域我们和其他系所协作，已经先后申请并获得广州市科技计划项目和广东省专项反恐经费项目的支持。

3.非编码RNA在肿瘤发生发展过程中的功能和机理研究。 microRNA对皮肤鳞状细胞癌的致癌机理研究。长链非编码RNA调控放射相关肿瘤干细胞的机制研究。

4.衰老自由基生物学与抗衰老医学研究等。

5.湿热条件下急性辐射损伤的特点及其救治：在充分认识湿热环境下辐射损伤特点的基础上，我们致力于湿热气候条件下的辐射损伤所致器官损害、抗放药物的应用及综合救治等方面的研究。

主要课题

主要文章

1.Zhou Liang, Wang Yinghui, Zhou Meijuan, Zhang Ying, Wang Pengfei, Li Xiaoxing, Yang Jing, Wang Hongmei, Ding Zhenhua. HOXA9 inhibits HIF-1 alpha-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development [J]. Nature Communications, 2018, 9.

2.Zhang Ying, Gao Lin, Ma Shudong, Ma Ji, Wang Yinghui, Li Shanshan, Hu Xia, Han Shuo, Zhou Meijuan, Zhou Liang, Ding Zhenhua. MALAT1-KTN1-EGFR regulatory axis promotes the development of cutaneous squamous cell carcinoma [J]. Cell Death and Differentiation, 2019, 26(10): 2061-73.

3.Ma ji, Ma Shudong, Zhang Ying, Shen Yi, Huang Lei, Lu Tianhao, Wang Lu, Wen Yunhan, Ding Zhenhua. Kinectin1 depletion promotes EGFR degradation via the ubiquitin-proteosome system in cutaneous squamous cell carcinoma [J]. Cell Death & Disease, 2021, 12(11):995.

4.Liu Hao, Wang Hao, Wu Jianhua, Wang Yiming, Zhao Liying, Li Guoxin, Zhou Meijuan. Lymphocyte nadir predicts tumor response and survival in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: Immunologic relevance [J]. Radiotherapy and Oncology, 2019, 131: 52-9.

5.Du Jie, Chen Fuqiang, Yu Jiahua, Jiang Lijun, Zhou Meijuan. The PI3K/mTOR Inhibitor Ompalisib Suppresses Nonhomologous End Joining and Sensitizes Cancer Cells to Radio- and Chemotherapy [J]. Molecular Cancer Research, 2021, 19(11): 1889-99.

6.He Xiaolong, Gao Jie, Peng Liang, Hu Tongtong, Wan Yu, Zhou Meijuan, Zhen Peilin, Cao Hong. Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice [J]. Gut, 2021, 70(10): 1872-83.

7.Li Xiangzhi, Zhou Cheng, Zhang Chen, Xie Xiongxiong, Zhou Zhaoming, Zhou Meijuan, Chen Longhua, Ding Zhenhua. MicroRNA-664 functions as an oncogene in cutaneous squamous cell 1 carcinomas (cSCC) via suppressing interferon regulatory factor 2 [J]. Journal of Dermatological Science, 2019, 94(3): 330-8.

8.Zhou Liang, Gao Ruirui, Wang Yinghui, Zhou Meijuan, Ding Zhenhua. Loss of BAX by miR-365 Promotes Cutaneous Squamous Cell Carcinoma Progression by Suppressing Apoptosis [J]. International Journal of Molecular Sciences, 2017, 18(6).

9.Zhou Liang, Wang Yinghui, Ou Chengshan, Lin Zhixiang, Wang Jianyu, Liu Hongxia, Zhou Meijuan, Ding Zhenhua. microRNA-365-targeted nuclear factor I/B transcriptionally represses cyclin-dependent kinase 6 and 4 to inhibit the progression of cutaneous squamous cell carcinoma [J]. International Journal of Biochemistry & Cell Biology, 2015, 65: 182-91.

10.Meijuan Zhou, Liang Zhou, Li Zheng, Ling Guo, Yinghui Wang, Hongxia Liu, Chengshan Ou, Zhenhua Ding. miR-365 Promotes Cutaneous Squamous Cell Carcinoma (CSCC) through Targeting Nuclear Factor I/B (NFIB) [J]. PLoS One. 2014; 9(6): e100620. Published online 2014 June 20. doi: 10.1371/journal.pone.0100620

11.Zhou M, Zhou L, Zheng L, Guo L, Wang Y, Liu H, Ou C, Ding Z. miR-365 Promotes Cutaneous Squamous Cell Carcinoma (CSCC) through Targeting Nuclear Factor I/B (NFIB). PloS one. 2014, 9 (6):e100620.

12.Zhou M, Liu W, Ma S, Cao H, Peng X, Guo L, Zhou X, Zheng L, Guo L, Wan M, Shi W, He Y, Lu C, Jiang L, Ou C, Guo Y, Ding Z.. A novel onco-miR-365 induces cutaneous squamous cell carcinoma[J]. Carcinogenesis. 2013，34(7):1653-9.

13.Zhou meijuan，zheng li，Guo ling，Liu wei Ling, LV chao，JIANG lihong，Ou chengshan，Ding zhenhua. Differential responses to UVB irradiation in human keratinocytes and epidermoid carcinoma cells. biomedical and environment sciences，2012，25（5）：583-589.

14.Fang Gao, Xiaoqun Duan, Xi Lu, Yongming Liu, Li Zheng, Zhenhua Ding*, Jun Li*. Novel binding between pre-membrane protein and claudin-1 is required for efficient dengue virus entry. Bioche Biophy Res Commu. 2010, 391: 952–957

15.Ding kexiang,Dong Ping,Zeng Yongchen,et al..Cloning and sequence analysis of the human obesity-related NPY receptor Y2 gene[J]. Int. J Nurs, 2009;28(3):423-426.

16.Ding kexiang, Dong Ping, Zeng Yongchen, et al. Cloning and sequence analysis of the human obesity-related neuropeptide Y receptor Y1 gene[J].Int.J Nurs,2009;28(4):557-560.

17.Ding kexiang,Dong Ping,Zeng Yongchen, et al. Cloning and sequence analysis of the human obesity-related neuropeptide Y receptor Y5 gene[J].Int.J Nurs, 2009;28(5):366-369.

18.Ding Kexiang, Han jinyun, Dong Ping,et al. Molecular Biological Characteristic of Human NPY and Its Receptors, the Regulation Factors of Obesity Metabolism[J]. Int. Journal Geriatrics, 2010, 31(1):12-16.

专著

1.核辐射与核污染—公众防护与应对[M].人民卫生出版社， 2012.03，第1版.

2.医学放射防护学[M].原子能出版社，2010，12，第1版.

3.预防医学导论[M].人民卫生出版社，2010.09，第1版.

4.核化生恐怖医学应对处置[M].人民卫生出版社，2010.04，第1版.

5.放射卫生学[M].原子能出版社，2014，07，第1版.

专利：

1.一种抗皮肤鳞状细胞癌药物antagomir-365-2(专利号：ZL 2012 1 0219955.7)

2.基于磁性纳米微粒的人胸苷激酶(hTK1)荧光免疫分析新方法(专利号：ZL200810030614.9)

3.便快速测定人类I型胸苷激酶(hTK1)基因蛋白的乳癌预警芯片(专利号：ZL200810031281.1)

4.皮肤外用抗氧化网络功效纳米乳及其制备方法(专利号：ZL200910192989.X)

5.长波紫外线皮肤损伤同步修复及防晒复合纳米乳及其制备方法(专利号：ZL2010101080924.6)

6.可直接皮肤外用的聚乙二醇化超氧化物歧化酶(mPEG-SOD)纳米乳及其制备方法(专利号：ZL201010265116.X)