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研究方向

本系主要研究方向为传染病流行病学、分子流行病学、老年流行病学、医学大数据研究、临床流行病学和评价流行病学。


科研项目

本系主要科研方向为感染性疾病流行病学、管理和评价流行病学、临床流行病学、分子流行病学、老年流行病学、医学大数据等。承担了国家、军队和省市科研课题和横向合作项目共67项,累计资助经费:3100多万。

主要科研课题如下:

课题名称

来源

时间

传染性非典型肺炎传播来源和传播机制的流行病学研究

国家自然科学基金

2003~2004

干扰素预防SARS的临床效果评价

国家863项目

2003~2004

广东地区人类杯状病毒感染的流行病学和临床特点研究

广东省医学科研基金课题

2003~2006

SARS冠状病毒从动物到人的研究

国家863项目分题

2004~2005

表达HBV外膜大蛋白的2型重组腺相关病毒的免疫原性研究

广东省医学科研基金课题

2004~2007

广州市突发公共卫生事件预警支撑体系技术体系的研究

广州市科技攻关重点项目

2006~2008

蝙蝠携带重要医学病毒及其流行病学意义研究

国家自然科学基金

2006~2008

霍乱毒素B亚单位在番茄果实中高效表达的研究

广东省自然科学基金

2006~2009

一种新发现的可能病原菌香港海鸥型菌的流行病学研究

国家自然科学基金

2007~2010

高致病性G-4型诺如病毒P颗粒的表达与结构功能研究

国家自然科学基金

2007~2010

广州市登革热媒介监测和流行预警研究

广州市医药卫生科技项目

2006~2009

广东省艾滋病、病毒性肝炎社区综合防治研究-新发、突发传染病社区综合防治研究

卫生部十一五重大科技专项分题

2009~2012

华南地区城市家栖鼠重要人类病毒性疾病病原体携带和分子特征的流行病学研究

国家自然科学基金

2014~2017

一种新发现的腹泻病原菌—"香港海鸥菌"感染危险因素的新探索及感染溯源等研究

国家自然科学基金

2014~2017

艾滋病早期筛查及监测体系建立

广州市科技产学研协同创新重大专项(民生科技)

2014~2016

新发突发烈性传染病防控及治疗新技术研究分课题

广州市健康医疗协同创新重大专项

2015~2018

人双埃可病毒感染自然史的研究

国家自然科学基金

2016~2019

VP1蛋白A289T变异、VIM多态性与EV71神经系统感染的相关性和机制研究

国家自然科学基金

2016~2019

性传播疾病防控新技术研究和应用

广州市科技计划重点项目

2016~2019

特异性IgY微胶囊防治诺如/轮状病毒腹泻的成药性研究

广州市科技产学研协同创新重大专项(民生科技)

2016~2018

HIV-1感染者血清抗-P24抗体谱特征及其与感染时间的关系研究

广东省卫计委省医学基金

2016~2018

性传播疾病防控新技术研究和应用

广州市科技计划项目

2017~2020

京津冀及周边地区大气污染对普通人群、特定人群的急性健康影响研究子课题:大气污染对人群健康影响加密调查

中华人民共和国生态环境部大气重污染成因与治理攻关项目管理办公室

2017~2019

中国健康长寿大人群多队列的系统研究分课题

国家重点研发计划

2018~2022

突发急性传染病诊断试剂的研制分课题

“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项

2018~2020

GII.4型诺如病毒全人广谱中和单抗及其保守表位研究

国家自然科学基金

2018~2021

广东省高水平大学建设-引进高层次人才科研经费

广东省教育厅、广东省财务厅

2018~2020

广东省高水平大学建设计划--南方医科大学临床流行病学支持中心建设

广东省教育厅、广东省财务厅

2018

新发人持续性G病毒II型复制和感染细胞培养模型的建立及与HCV/HIV共感染的机制研究

国家自然科学基金

2019~2022

HIV-1 CRF07_BC 病毒P6Gag蛋白变异的病毒学特征及其分子机制研究

国家自然科学基金

2019~2021

外泌体长链非编码RNA与老年人认知功能受损的分子流行病学研究

国家自然科学基金

2020~2023

家栖鼠在几种新发腹泻病毒传播中作用机制的研究

国家自然科学基金

2020~2023

科研成果、专利

科研奖励:

1. 国家科技进步三等奖1

2. 军队科技进步二等奖3

3. 军队科技进步三等奖6

4. 广东省科技进步二等奖3

专利:

1. 一种伊蚊的诱捕、诱卵器(实用新型,授权公告号:CN201238543Y

2. 淡水鱼粪便中香港海鸥型菌的检测方法(发明专利,专利公开号:CN101519691A

3. 用于高通量抗体快速检测的荧光素酶免疫吸附方法(发明专利,专利公开号:CN107884371A

4. 用于区分HIV-1新近与慢性感染的免疫吸附检测方法(发明专利,专利公开号:CN108828214A

5. 一种海藻酸钠-壳聚糖P-VP8*IgY微胶囊制备方法及微胶囊(发明专利,专利公开号:CN107961228A

6. 一种GII.4型诺如病毒广谱单克隆抗体的制备方法及用途(发明专利,专利公开号:N109734801A

7.  HIV-1 RNA定量检测的实时荧光定量PCR引物和探针及其应用(发明专利,专利公开号:CN109722491A

科研专著、论文

科研专著:

1. 主编《军队流行病学》,全军高等医学院教材(临床医学专业本科用),人民军医出版社,1994

2. 主编《医学生考试指导丛书-流行病学分册》,人民军医出版社,2004

3. 主编《常见传染病防治》(部队卫生防疫丛书),军事医学科学出版社,2006

4. 主编《现代热带医学》,2012,军事医学科学出版社,

5. 副主编《军事预防医学概论》,人民军医出版社,2006

6. 主编《临床流行病学》,2004,本校内部使用

7. 主编《流行病学实习教材》,2000,本校内部使用

8. 主编《Epi I Info流行病学软件应用教程》,2005,本校内部使用

9. 参编《军队流行病学》,全军高等医学院教材(临床医学专业本科用),人民军医出版社,1994

10. 参编《SPSS8.0统计软件应用教程》,2000,人民军医出版社

11. 参编《SPSS10.0统计软件应用教程》,2002,人民军医出版社

12. 参编《SPSS10.0统计软件高级应用教程》,2004,人民军医出版社

13. 参编《流行病学》(第六版),普通高等教育“十一五”国家级规划教材,人民卫生出版社,2007

14. 参编《现代流行病学》,人民卫生出版社,2007

15. 主编《现代热带医学》,北京:军事医学科学出版社,2012

16. 主编《流行病学》,北京大学医学出版社,2013

17. 参编《系统综述与Meta分析》,北京:人民卫生出版社,2017

18. 副主编《老年卫生学》,北京:科学出版社,2018

学术论文(近三年):

1. Li ZH, Zhang XR, Lv YB, Shen D, Li FR, Zhong WF, Huang QM, Wu XB, Zeng Y, Gao X, Shi XM, Mao C. Leisure Activities and All-Cause Mortality Among the Chinese Oldest-Old Population: A Prospective Community-Based Cohort Study. J Am Med Dir Assoc. 2019 Oct 3. pii: S1525-8610(19)30612-7. doi: 10.1016/j.jamda.2019.08.003. IF=4.8991区)

2. Yuan JQ, Lv YB, Chen HS, Gao X, Yin ZX, Wang WT, Kraus VB, Luo JS, Wang JN, Zeng Y, Mao C, Shi XM. Association Between Late-Life Blood Pressure and the Incidence of Cognitive Impairment: A Community-Based Prospective Cohort Study. J Am Med Dir Assoc. 2019, 20(2):177-182.e2. IF=4.8991区)

3. Xiong YQ, You FF, Chen XJ, Chen YX, Wen YQ, Chen Q. Detection and phylogenetic analysis of porcine bocaviruses carried by murine rodents and house shrews in China. Transbound Emerg Dis. 2019, 66(1):259-267. IF=3.5541区)

4. Lv YB, Kraus VB, Gao X, Yin ZX, Zhou JH, Mao C, Duan J, Zeng Y, Brasher MS, Shi WY, Shi XM. Higher dietary diversity scores and protein-rich food consumption were associated with lower risk of all-cause mortality in the oldest old. Clinical Nutrition. 2019. IF=6.4021区)

5. Li FR, Zhang XR, Zhong WF, Li ZH, Gao X, Kraus VB, Lv YB, Zou MC, Chen GC, Chen PL, Zhang MY, Kur AKA, Shi XM, Wu XB, Mao C. Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes. J Clin Endocrinol Metab. 2019, 104(8):3345-3354.IF=5.6052区)

6. Li ZH, Lv YB, Zhong WF, Gao X, Byers Kraus V, Zou MC, Zhang XR, Li FR, Yuan JQ, Shi XM, Wu XB, Mao C. High-Density Lipoprotein Cholesterol and All-Cause and Cause-Specific Mortality Among the Elderly. J Clin Endocrinol Metab. 2019, 104(8):3370-3378.IF=5.6052区)

7. Mao C, Li ZH, Lv YB, Gao X, Kraus VB, Zhou JH, Wu XB, Shi WY, Li FR, Liu SM, Yin ZX, Zeng Y, Shi XM. Specific Leisure Activities and Cognitive Functions Among the Oldest-Old: the Chinese Longitudinal Healthy Longevity Survey. J Gerontol A Biol Sci Med Sci. 2019, pii: glz086.IF=4.7112区)

8. Zhang PD, Lv YB, Li ZH, Yin ZX, Li FR, Wang JN, Zhang XR, Zhou JH, Wu XB, Duan J, Mao C, Shi XM. Age, period and cohort effects in activities of daily living, physical and cognitive functioning impairment among the oldest-old in China. J Gerontol A Biol Sci Med Sci. 2019, pii: glz196.IF=4.7112区)

9. Li ZH, Lv YB, Kraus VB, Yin ZX, Liu SM, Zhang XC, Gao X, Zhong WF, Huang QM, Luo JS, Zeng Y, Ni JD, Mao C, Shi XM. Trends in the Incidence of Activities of Daily Living Disability Among Chinese Elderly from 2002-2014. J Gerontol A Biol Sci Med Sci. 2019 Oct 11. pii: glz221.IF=4.7112区)

10. Mao C, Li FR, Yin ZX, Lv YB, Luo JS, Yuan JQ, Mhungu F, Wang JN, Shi WY, Zhou JH, Chen GC, Gao X, Kraus VB, Wu XB, Shi XM. Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged 80 Years. J Nutr. 2019, 149(6):1056-1064. IF=4.4162区)

11. Lv YB, Mao C, Gao X, Yin ZX, Kraus VB, Yuan JQ, Zhang J, Luo JS, Zeng Y, Shi XM. Triglycerides Paradox Among the Oldest Old: "The Lower the Better?" . J Am Geriatr Soc. 2019, 67(4):741-748. IF=4.1132区)

12. Li FR, Wu X, Yuan J, Wang J, Mao C, Wu X. Comparison of thoracic endovascular aortic repair, open surgery and best medical treatment for type B aortic dissection: A meta-analysis. Int J Cardiol. 2018, 250:240-246. IF=3.4712区)

13. Li ZH, Zhong WF, Lv YB, Kraus VB, Xiang Gao X, Chen PL, Huang QM, Ni JD, XM, Mao C, Wu XB. Associations of plasma high-sensitivity Creactive protein concentrations with all-cause and cause-specific mortality among middle-aged and elderly individuals. Immunity & Ageing. 2019, 16:28. IF=4.2503区)

14. Shui JW, Liu WP, Liang YH, Zhang J, Wan ZW, Wang HY, Qu XW, Tang SX. Infection of human pegivirus 2 (HPgV-2) is associated with hepatitis C virus but not hepatitis B virus infection in people who inject drugs. J Gen Virol. 2019, 100(6):968-974. IF=2.8093区)

15. Wang HY, Cai QD, Liang YH, Shui JW, Tang SX. A simple and high-throughput luciferase immunosorbent assay for both qualitative and semi-quantitative detection of anti-HIV-1 antibodies. Virus Res. 2019, 263:9-15. IF=2.7363区)

16. Cai QD, Wang HY, Huang LP, Yan HC, Zhu WC, Tang SX. Characterization of HIV-1 genotype specific antigens for the detection of recent and long-term HIV-1 infection in China. Virus Res. 2019, 264:16-21. IF=2.7363区)

17. Mao C, Yuan JQ, Lv YB, Gao X, Yin ZX, Kraus VB, Luo JS, Chei CL, Matchar DB, Zeng Y, Shi XM. Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study. BMC Geriatr. 2019, 19(1):104. IF=2.8183区)

18. Lv YB, Mao C, Yin ZX, Li FR, Wu XB, Shi XM. Healthy Ageing and Biomarkers Cohort Study (HABCS): a cohort profile. BMJ Open. 2019, 9: e026513. (IF=2.3763)

19. Qiu MS, Wang XW, Yao Y, Ge SQ, Liu HM, Dai YC, Zhou Y. Protocol of Jidong Women Health Cohort Study: Rationale, Design, and Baseline Characteristics. Biomed Environ Sci. 2019, 32(2):144-152. IF=1.9173区)

20. He WQ, Chen XJ, Wen YQ, Li YZ, He H, Chen Q. Detection of Hepatitis B Virus-Like Nucleotide Sequences in Liver Samples from Murine Rodents and Asian House Shrews. Vector Borne Zoonotic Dis. 2019. IF=1.9393区)

21. Lv YB, Gao X, Yin ZX, Chen HS, Luo JS, Brasher MS, Kraus VB, Li TT, Zeng Y, Shi XM. Revisiting the association of blood pressure with mortality in oldest old people in China: community based, longitudinal prospective study. BMJ. 2018 Jun 5;361:k2158. IF=27.6041区)

22. Wang HY, Wan ZW, Xu R, Guan YJ, Zhu NL, Li JP, Xie ZW, Lu AQ, Zhang FC, Fu YS, Tang SX. A Novel Human Pegivirus HPgV-2 (HHpgV-1) is Tightly Associated with HCV Infection and HCV/HIV-1 Co-Infection. Clin Infect Dis. 2018, 66(1):29-35. IF=9.0551区)

23. Wang HY, Wan ZW, Sun Q, Zhu NL, Li TY, Ren XQ, An XP, Deng SY, Wu Y, Li XF, Li L, Li JY, Tong YG, Tang SX. Second Human Pegivirus in Hepatitis C Virus-Infected and Hepatitis C Virus/HIV-1-Co-infected Persons Who Inject Drugs, China. Emerg Infect Dis. 2018, 24(5):908-911. IF=7.1851区)

24. Tang WP, Zhu NL, Wang HY, Gao YW, Wan ZW, Cai QD, Yu SY, Tang SX. Identification and genetic characterization of equine Pegivirus in China. J Gen Virol. 2018, 99(6):768-776. IF=2.8093区)

25. Xiong YQ, Mo Y, Chen MJ, Cai W, He WQ, Chen Q. Detection and phylogenetic analysis of torque teno virus (TTV) carried by murine rodents and house shrews in China. Virology. 2018, 516:189-195. IF=2.6573区)

26. Xiong YQ, Mo Y, Wen YQ, Cheng MJ, Huo ST, Chen XJ, Chen Q. Optical coherence tomography for the diagnosis of malignant skin tumors: a meta-analysis. J Biomed Opt. 2018, 23(2):1-10. IF=2.5553区)

27. Xu SQ, Zhang Y, Wang P, Liu W, Wu XB, Zhou JY. A statistical measure for the skewness of X chromosome inactivation based on family trios. BMC Genet. 2018, 19(1):109. IF=2.5473区)

28. He WQ, Wen Y, Xiong Y, Zhang M, Cheng M, Chen Q. The prevalence and genomic characteristics of hepatitis E virus in murine rodents and house shrews from several regions in China. BMC Vet Res. 2018, 14(1):414. IF=1.7923区)

29. Xiong YQ, Zhou JH, Zhang MY, You FF, Li DL, Chen Q. Presence of rat bocavirus in oropharyngeal and fecal samples from murine rodents in China. Arch Virol. 2018, 163(11):3099-3103. IF=2.2614区)

30. Yin D, Zhu YN, Wang KF, Wang J, Zhang XR, Han M, He YQ, Chen Q, Hu GF. Development and evaluation of a rapid recombinase polymerase amplification assay for the detection of human enterovirus 71. Arch Virol. 2018, 163(9):2459-2463. IF=2.2614区)

31. Zheng XY, Qiu M, Guan WJ, Li JM, Chen SW, Cheng MJ, Huo ST, Chen Z, Wu Y, Jiang LN, Chen Q.Viral metagenomics of six bat species in close contact with humans in southern China. Arch Virol. 2018, 163(1):73-88. IF=2.2614区)

32. Chen X, Shi T, Huang J, Xiao G, Huang J, Xiong Y, Li X, Chen H, Zheng X, Yu S, Chen Q. Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China. J Med Virol. 2018, 90(9):1444-1452. IF=2.0494区)

33. Jiang XL, Zhong W, An H, Fu M, Chen Y, Zhang Z, Xiao Z. Attenuated DHEA and DHEA-S response to acute psychosocial stress in individuals with depressive disorders. J Affect Disord. 2017, 215:118-124. IF=4.0842区)

34. Wang Z, Zhu J, Liu Z, Liu Y, Zheng N, Feng M, Chen Q, Yu W, Jiang L, Hu J. Multi-locus sequence typing of Laribacter hongkongensis isolates from freshwater animals, environment and diarrhea patients in southern China. Int J Food Microbiol. 2017, 245:98-104. IF=4.0062区)

35. Wu Y, Ren X, Yin D, Wang HY, Wan Z, Li X, Hu GF, Tang SX. Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China. PLoS One. 2017, 12(4):e0175770.IF=2.7763区)

36. Wu Y, Wang HY, Ren X, Wan Z, Hu GF, Tang SX. HIV-1 CRF07_BC with a Seven Amino Acid Deletion in the gag p6 Region Dominates in HIV-1-Infected Men Who Have Sex with Men in China. AIDS Res Hum Retroviruses. 2017, 33(9):977-983. IF=1.0854区)