学院机构

研究方向

1. 环境与基因组相互作用机制研究 运用分子生物学、蛋白质组学技术及生物信息学研究机体对特殊环境适应性的分子机制。具体内容包括：依赖于HIF-1的低氧信号通路研究、钙信号的调控机制及特殊环境易感性的基因水平研究（编码区的突变机制以及表观遗传学改变）。目前此研究方向由“973”课题和5项国家自然科学基金支持。

2. 极端环境下热休克蛋白90 的在应激损伤与保护作用机制研究      采用实时荧光蛋白标记监测应激状态、定量蛋白质组学（SILAC）标记质谱分析技术比对底物蛋白谱变化，结合生物信息学分析手段，探讨不同环境应激状态下，HSP90对细胞网络通路的交叉调控，阐明环境应激的分子机制。关注热休克蛋白90新底物蛋白的发现及其在肿瘤药物治疗中的作用及其在特定临床疾病中的作用与功能研究。 为探讨相关疾病的机理及治疗、预防奠定理论基础。此研究方向由“973”课题、9项国家自然科学基金和1项广东省自然科学基金支持。

3. 环境应激条件下炎性细胞的定向迁移机制 运用单细胞分子成像技术、蛋白质组学技术及电生理技术，探讨关键膜蛋白分子特别是TRP对细胞骨架分子聚合和解聚的调节机制，分析TRP与PIP2和PIP3等磷脂酰肌醇分子之间的相互作用，阐述环境应激条件下参与炎性细胞的信号转导机制。目前此研究方向由“973”课题和3项国家自然科学基金支持。

4. 亚硝胺诱导的消化系统致癌机制 在食道细胞上平行构建了小剂量长期亚硝氨诱导的肿瘤细胞系，通过大数据多维组学分析，结合ATAC测序，动物成像，DNA与蛋白相互作用等技术，探讨从DNA，RNA到蛋白的肿瘤演化过程，分析从烷基化的分子损伤和DNA修复之间的动态平衡，揭示表观修饰在从ecDNA水平到顺式作用原件的调节机制，阐述亚硝氨诱导职业肿瘤过程中染色质的开放可及性的转化过程。此研究方向多项国家自然科学基金和广东省自然科学基金支持。

主要科研项目

科室承担了军队指令性课题：“七﹒五”、“八﹒五”、“九﹒五”；国家自然科学基金：重点项目、面上项目；国家自然科学基金：海外合作重点项目；省部级及协作课题；973计划。

累计资助经费：2千万余元

科研成果

军队科技进步一等奖1项

军队科技进步二等奖5项

军队科技进步三等奖4项

中华医学科技奖一等奖1项

广东省科技进步二等奖1项

广东省科技进步三等奖1项

科研论文

截止2024年，以第一作者单位或通讯作者单位发表SCI论文近300余篇，其中包括Hepatology, Redox Biology，Environment International，Science of The Total Environment，Oncogene, Aging cell, Journal of Neuroinflammation，Aquatic toxicology，Experimental Hematology & Oncology，Ecotoxicology and Environmental Safety, Cell Death Dis, Toxicol Sci等。主要代表作如下所示：

1. Zhou X, Wen Y, Tian Y, He M, Ke X, Huang Z, He Y, Liu L, Scharf A, Lu M, Zhang G, Deng Y, Yan Y, Mayer MP, Chen X, Zou F. Heat Shock Protein 90α-Dependent B-Cell-2-Associated Transcription Factor 1 Promotes Hepatocellular Carcinoma Proliferation by Regulating MYC Proto-Oncogene c-MYC mRNA Stability. Hepatology. 2019 Apr;69(4):1564-1581.

2. Liang X, Liu J, Liu X, Jin Y, Xu M, Han Z, Wang K, Zhang C, Zou F, Zhou L. LINP1 represses unfolded protein response by directly inhibiting eIF2α phosphorylation to promote cutaneous squamous cell carcinoma . Exp Hematol Oncol. 2023 Mar 14;12(1):31.

3. Zheng X, Lu S, He Z, Huang H, Yao Z, Miao Y, Cai C, Zou F.MCU-dependent negative sorting of miR-4488 to extracellular vesicles enhances angiogenesis and promotes breast cancer metastatic colonization. Oncogene. 2020 Nov;39(46):6975-6989.

4. Wen Y, Zhou X, Lu M, He M, Tian Y, Liu L, Wang M, Tan W, Deng Y, Yang X, Mayer MP, Zou F, Chen X. Bclaf1 promotes angiogenesis by regulating HIF-1α transcription in hepatocellular carcinoma. Oncogene. 2019 Mar;38(11):1845-1859.

5. Yuan G, Liu Y, Liu G, Wei L, Wen Y, Huang S, Guo Y, Zou F, Cheng J. Associations between semen phytoestrogens concentrations and semen quality in Chinese men. Environ Int. 2019 Aug;129:136-144.

6. Xu Y, Peng T, Xiang Y, Liao G, Zou F, Meng X. Neurotoxicity and gene expression alterations in zebrafish larvae in response to manganese exposure. Sci Total Environ. 2022 Jun 15;825:153778.

7.  Liu A, Li Y, Lu S, Cai C, Zou F, Meng X. Stanniocalcin 1 promotes lung metastasis of breast cancer by enhancing EGFR-ERK-S100A4 signaling. Cell Death Dis. 2023 Jul 4;14(7):395.

8. Xu Y, Yu Y, Zhou Q, Xiang Y, Chen L, Meng Y, She X, Zou F, Meng X. Disturbance of gut microbiota aggravates cadmium-induced neurotoxicity in zebrafish larvae through V-ATPase. Sci Total Environ. 2023 Sep 15; 891: 164074.

9. Tu H, Peng T, Liu J, Chen X, Fan C, Huang Z, Zhang Y, Zou F, Meng X. Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Aquat Toxicol. 2018 Jan;194:167-175.

10. Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F. p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease. J Neuroinflammation. 2021 Dec 20;18(1):295.

11. Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, Li W, Zou F.Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease. Cell Death Dis. 2018 Jun 13;9(6):700.

12.  Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W. Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease. Aging Cell. 2020 Jun;19(6):e13163.

13. Tianji L, Dingbang H, Xiao C, Xiaojing M, Fei Z, Bin W. Methylmercury induces lysosomal membrane permeabilization through JNK-activated Bax lysosomal translocation in neuronal cells. Toxicol Lett. 2022 Mar 1;357:73-83.

14. Lin T, Ruan S, Huang D, Meng X, Li W, Wang B, Zou F. MeHg-induced autophagy via JNK/Vps34 complex pathway promotes autophagosome accumulation and neuronal cell death. Cell Death Dis. 2019 May 21;10(6):399.

15. Liang L, Huang K, Yuan W, Liu L, Zou F, Wang G. Dysregulations of miR-503-5p and Wnt/β-catenin pathway coordinate in mediating cadmium-induced kidney fibrosis. Ecotoxicol Environ Saf. 2021 Aug 20;224:112667.

16. Zhang J, Liu L, Li Y, Huang Y, Xiao S, Deng Z, Zheng Z, Li J, Liang M, Xie G, Chen X, Deng Y, Tan W, Su H, Wu G, Cai C, Chen X, Zou F. HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma. Neoplasia. 2023 Oct;44:100935.

17. Tan W, Zhang J, Liu L, Liang M, Li J, Deng Z, Zheng Z, Deng Y, Liu C, Li Y, Xie G, Zhang J, Zou F, Chen X. Hsp90 Inhibitor STA9090 induced VPS35 related extracellular vesicle release and metastasis in hepatocellular carcinoma. Transl Oncol. 2022 Dec;26:101502.

18. Liu L, Deng Y, Zheng Z, Deng Z, Zhang J, Li J, Liang M, Zhou X, Tan W, Yang H, Neckers LM, Zou F, Chen X. Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription. Mol Cancer Ther. 2021 Oct;20(10):1880-1892.

19. Liu A, Li Y, Lu S, Cai C, Zou F, Meng X. Stanniocalcin 1 promotes lung metastasis of breast cancer by enhancing EGFR-ERK-S100A4 signaling. Cell Death Dis. 2023 Jul 4;14(7):395.

20. Huang D, Chen L, Ji Q, Xiang Y, Zhou Q, Chen K, Zhang X, Zou F, Zhang X, Zhao Z, Wang T, Zheng G, Meng X. Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17. Redox Biol. 2023 Dec 9;69:102990. doi: 10.1016/j.redox.2023.102990.

21. Ling He, Xiangjun Zhou, Jia Liu, Yina Yao, Junyuan Lin, Jialong Chen, Shizhen Qiu, Zeyu Liu, Yingzheng He, Yujie Yi, Xueqiong Zhou, Fei Zou.RAE1 promotes nitrosamine-induced malignant transformation of human esophageal epithelial cells through PPARα-mediated lipid metabolism. Ecotoxicol Environ Saf, 2023 Oct 15:265:115513. doi:10.1016/j.ecoenv. 2023.115513.

22. Yunting Li, Anfei Liu, Kaiju Chen, Lifan Li, Xiaoshun Zhang, Fei Zou, Xingmei Zhang, Xiaojing Meng. Sodium butyrate alleviates lead-induced neuroinflam- mation and improves cognitive and memory impairment through the ACSS2/H3K9ac/BDNF pathway. Environ Int. 2024 Feb:184:108479. doi: 10.1016/j.envint.2024.108479. Epub 2024 Feb 7.